Hotels in Santa Fe, FL - Best Santa Fe Hotels from £49 - Fully Refundable Options

Go beyond your typical stay in Santa Fe

Pet friendly

Apartment

Hot tub

Pool

Condo

Family friendly

Waterpark

Check prices for these dates

Tonight

Tomorrow

Next weekend

In two weeks

Our top choices for Santa Fe hotels

A modern kitchen area with a central counter, various food stations, and a chalkboard menu.

A reception desk with a "Welcome to the Sun Shine State" sign, a "Treats" sign, and a minibar area with a "Hilton" sign.

A hotel room with two beds, a desk, a chair, a TV, and a couch.

1. Hampton Inn & Suites Alachua I-75

Alachua

Duane

£85

includes taxes & fees

15 Nov - 16 Nov

A hotel with a covered entrance, stone facade, and blue lighting accents.

A lobby with a patterned carpet, two green armchairs, a white sofa, a small round table with a plant, and framed artwork on the wall.

A modern office space with a reception desk, several chairs, a large window, and a colorful abstract painting on the wall.

A hotel room with a bed, a desk with a chair, a television, and a blue sofa.

2. Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Alachua

Austin

£87

includes taxes & fees

1 Nov - 2 Nov

A modern hotel with a prominent 'La Quinta' sign, a covered entrance, and a well-maintained outdoor area with a parking lot.

A hotel lobby with a seating area featuring sofas and armchairs, a central coffee table, and a flat-screen TV mounted on the wall.

A modern lounge area with a flat-screen TV, a fireplace, teal and brown seating, patterned carpet, and a wall-mounted clock.

A modern kitchen with blue-tiled walls, stainless steel appliances, and a central island.

3. La Quinta by Wyndham Gainesville

Gainesville

Edwin

£83

includes taxes & fees

2 Nov - 3 Nov

A large, multi-story hotel with a central courtyard, palm trees, and an American flag.

A bar area with wooden chairs, a bar counter, and a television mounted on the wall.

A living room with a brown leather sofa, a glass-top coffee table, and a framed picture on the wall.

A spacious lobby with a large painting, a fireplace, a piano, and multiple seating areas.

4. Best Western Gateway Grand

Gainesville

Diane

£71

includes taxes & fees

2 Nov - 3 Nov

A cabin with a cozy interior, a dining area, and a view of the forest.

A cozy cabin interior with a wooden interior, a dining table with a chair, a window, and a hanging lantern.

A bedroom with a wooden headboard, a bed with white linens, a window with a view of green foliage, and a tray with breakfast items.

5. Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

High Springs

Katie

£156

includes taxes & fees

28 Oct - 29 Oct

A cozy restaurant with wooden beams, yellow walls, and a bar area with coffee machines.

A swimming pool with lounge chairs and umbrellas, a covered seating area, and a multi-story building with balconies.

A hotel room with a bed, a desk with a chair, a television, a mirror, and a wardrobe.

A spacious lobby with a dining area, a kitchen, and a large window providing a view of the outdoors.

6. Quality Inn Alachua - Gainesville Area

Alachua

Ivelisse

£61

includes taxes & fees

15 Nov - 16 Nov

A modern hotel room with a large bed, a desk, a chair, and a TV.

A motel with a covered entrance, multiple parking spaces, and a fire extinguisher on the wall.

A modern hotel lobby with a reception desk, seating area, and a wall-mounted television.

A modern hotel room with a wooden desk, a black office chair, a flat-screen TV mounted above the desk, and a coffee machine on the desk.

7. Clarion Pointe Alachua - Gainesville Area

Alachua

Josey

£54

includes taxes & fees

15 Nov - 16 Nov

A stone water feature with cascading water, surrounded by a brick wall and greenery.

A reception desk with a modern design, a ceiling fan, and a seating area with chairs and a table.

A covered outdoor area with a paved walkway leading to a seating area, surrounded by greenery and a clear sky.

A neatly arranged bedroom with a bed, bedside lamps, a TV, and a mirror.

8. BlueGem Motel

High Springs

Myra

£80

includes taxes & fees

28 Oct - 29 Oct

An outdoor patio with wicker furniture, stone walls, and a barbecue grill.

A modern hotel room with a flat-screen TV, a dining area with a table and chairs, a kitchenette, and a wardrobe with hanging space.

A modern living room with a sectional sofa, a standing lamp, a large window with sheer curtains, a flat-screen TV, and a built-in air conditioning unit.

TownePlace Suites Marriott with a modern exterior, multiple windows, and a covered entrance area.

9. TownePlace Suites by Marriott Gainesville Northwest

Gainesville

Tanya

£88

includes taxes & fees

26 Oct - 27 Oct

A modern dining area with a long wooden table set for a meal, a seating area with sofas and chairs, and large windows providing natural light.

A modern office space with two desks, each with a computer monitor, keyboard, and mouse. There are two chairs, a decorative wall with shelves, and a patterned floor.

A modern interior with a green sofa, a wooden dining table, and a seating area with chairs.

10. Hotel Indigo Gainesville-Celebration Pointe by IHG

Gainesville

Dalton

£83

includes taxes & fees

22 Nov - 23 Nov

A hotel room with a bed, bedside tables, a desk, a chair, a mirror, and a window.

A bathroom with a large mirror, a sink, and a towel rack.

A building with a Coca-Cola vending machine, a window with a 'OPEN' sign, and a red awning.

A corner room with two checkered chairs, a small table, a framed picture on the wall, and a floor lamp.

11. Palms Garden Inn

Lake City

Igor

£54

includes taxes & fees

24 Nov - 25 Nov

A modern hotel with a flat roof, multiple floors, and a prominent 'aloft' sign.

A modern outdoor seating area with multiple sofas and chairs, a covered section with umbrellas, and a view of a building with large windows.

A modern dining area with a pool table, chairs, and a colorful rug.

A modern bar area with a bar counter, stools, and seating including a sofa and chairs.

12. Aloft by Marriott Gainesville University Area

Gainesville

Esteban

£73

includes taxes & fees

23 Nov - 24 Nov

A poolside area with a fire pit, lounge chairs, and a glass of wine.

A modern interior with a staircase, a seating area, and a colorful abstract wall design.

A modern bar area with a marble countertop, bar stools, and pendant lighting.

A modern hotel lobby with a round table featuring two drinks, a sofa, and a colorful wall art piece.

13. Hyatt Place Gainesville Downtown

Downtown Gainesville

Brendon

£82

includes taxes & fees

2 Nov - 3 Nov

A swimming pool with a metal ladder, surrounded by a white fence and green chairs.

A refrigerated display case with beverages and snacks, and a shelf with bottled water and other beverages.

A living room with a curved sofa, a wooden cabinet, and a fish tank.

A hotel room with a bed, a sofa, a coffee table, and a small table with a lamp.

14. Best Western Waldo Inn and Suites

Waldo

Sarah

£71

includes taxes & fees

2 Nov - 3 Nov

A spacious lobby with a sectional sofa, a wooden cabinet, and a television mounted on the wall.

A modern kitchen with wooden cabinets, a granite countertop, and pendant lighting.

A hotel lobby with a stone wall, a flat-screen TV, orange upholstered seating, and a lamp.

A hotel room with two beds, a large headboard, bedside lamps, and a view of the outdoors through sheer curtains.

15. Drury Inn & Suites Gainesville

Gainesville

Michael

£89

includes taxes & fees

8 Nov - 9 Nov

A breakfast corner with a coffee machine, a refrigerator, and a sign reading "Breakfast Corner".

A hotel lobby with a reception desk, seating area, and a TV mounted on the wall.

A Baymont Inn & Suites building with a blue and beige color scheme, multiple balconies, and a parking lot.

A swimming pool with a lifeguard chair and a lifeguard stand.

16. Baymont By Wyndham Gainesville I-75

Gainesville

Alan

£52

includes taxes & fees

26 Oct - 27 Oct

A spacious living area with a curved ceiling, a large flat-screen TV, and a modern sofa.

A rooftop pool with a clear view of surrounding buildings.

A modern lounge area with seating arrangements, a flat-screen TV, and artwork on the walls.

A hotel room with a bed, desk, chair, TV, and large window with curtains.

17. Holiday Inn Gainesville - University Center by IHG

University Heights

Tonya

£83

includes taxes & fees

22 Nov - 23 Nov

A balcony with a table and chairs, overlooking a clear sky and distant buildings.

A living room with a blue sofa, a wooden coffee table, and a kitchen area with a large TV and cabinets.

A spacious indoor dining area with multiple tables and chairs, large windows, and a high ceiling with recessed lighting.

A pool table with balls and a cue stick, a digital screen displaying game options, and a neon sign in the background.

18. The Reitz Union Hotel

Gainesville

£98

includes taxes & fees

23 Nov - 24 Nov

A swimming pool with lounge chairs and a gazebo, surrounded by palm trees and a building with a stone facade.

A courtyard with outdoor seating, a fountain, and a pool.

A hotel lobby with a seating area, a dining section, and a television screen.

A Holiday Inn Express & Suites hotel with a modern design, featuring a large parking lot and a covered entrance.

19. Holiday Inn Express & Suites Gainesville I-75 by IHG

Gainesville

Meredith

£93

includes taxes & fees

22 Nov - 23 Nov

A modern bar area with a long counter, green bar stools, and a television displaying a golf game.

A modern hotel room with a large bed, a desk, a chair, and a TV mounted on the wall.

A modern kitchen with a central island, bar stools, pendant lighting, and a dining area with a sofa and chairs.

A Fairfield Inn & Suites Marriott hotel with a modern entrance, multiple floors, and a parking lot.

20. Fairfield Inn & Suites by Marriott Gainesville I-75

Gainesville

Robert

£100

includes taxes & fees

25 Oct - 26 Oct

View all properties

Save an average of 15% on thousands of hotels when you're signed in

Top Santa Fe Hotel Reviews

Drury Inn & Suites Gainesville

10/10 Excellent

"nice clean room with a comfortable bed. breakfast buffet was good."

HOM Hotel Gainesville, SureStay Collection by Best Western

10/10 Excellent

"Parking Clean Room"

Country Inn & Suites by Radisson, Gainesville, FL

10/10 Excellent

"Wonderful staff and very clean"

Sleep Inn & Suites University/Shands

10/10 Excellent

"Well maintained. Great value for the money."

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

10/10 Excellent

"What a lovely hotel! Very fresh and clean. The room was excellent. I especially liked the generous surface space to spread out any items you want to be able to get to quickly. Dove products in the bathroom. We ate our yummy breakfast in the outdoor patio next to the pool in the dazzling morning sunshine. Lastly, every single staff member was so kind. We were impressed. Highly recommend."

Comfort Suites Gainesville near University

10/10 Excellent

"Good"

Hotel Indigo Gainesville-Celebration Pointe by IHG

10/10 Excellent

"Clean room and facilities, helpful and pleasant staff. Easy checkin and checkout."

Gainesville Lodge

8/10 Good

"Lovely place very cute coffee shop and bar only issue was sewer vapor smell coming up from the shower"

Red Roof Inn PLUS+ Gainesville

10/10 Excellent

"Surprisingly good facility! Efficient and friendly front desk. Room was very nice. First time traveling with a pet, so received a "pet friendly" room, no carpet and nice area near a wall for our doggy bed. Quiet even though the Interstate was about 100 yards from the window. We often stay with Red Roof, and this was probably the nicest one we have stayed at."

More cheap stays in Santa Fe

Red Roof Inn PLUS+ Gainesville

3500 Southwest 42nd St Gainesville FL

£49

2 Nov - 3 Nov

includes taxes & fees

7.4/10 Good! (1,325 reviews)

Quality Inn Gainesville near University

2435 Sw 13th Street Gainesville FL

£61

18 Nov - 19 Nov

includes taxes & fees

Days Inn by Wyndham Gainesville University I-75

920 Nw 69th Ter Gainesville FL

£61

26 Oct - 27 Oct

includes taxes & fees

HOM Hotel Gainesville, SureStay Collection by Best Western

3905 Sw 43Rd St Gainesville FL

£61

2 Nov - 3 Nov

includes taxes & fees

8.6/10 Excellent! (2,153 reviews)

Sleep Inn & Suites University/Shands

4110 SW 40th Boulevard Gainesville FL

£71

18 Nov - 19 Nov

includes taxes & fees

8.8/10 Excellent! (1,320 reviews)

Comfort Suites Gainesville near University

2603 SW 13TH STREET Gainesville FL

£72

23 Nov - 24 Nov

includes taxes & fees

9.2/10 Wonderful! (1,542 reviews)

Frequently asked questions

What's the best place for a stay in Santa Fe?

Located 18.6 mi (30 km) from the heart of Santa Fe, Drury Inn & Suites Gainesville is a top choice for your stay, based on our traveller data. Other good choices for your stay in the area are Sleep Inn & Suites University/Shands and Country Inn & Suites by Radisson, Gainesville, FL. See all available top hotels, or vacation rentals in Santa Fe.

What are some of the best holiday rentals that Santa Fe has to offer?

5BR UF Family Retreat with Private Pool, Pond, Game Room – Sleeps 10: This holiday home rental outside of Santa Fe is located on a lake, and has an outdoor pool, a fireplace and a BBQ to put you at ease in your new surroundings. It has 5 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. It offers a patio, a garden and a selection of games so that you can immerse yourself in your holiday. See all vacation rentals in Santa Fe.

If I need to cancel my hotel reservation in Santa Fe, will I receive a refund?

Yes! Most hotel room reservations are fully refundable if cancelled before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and get a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in Santa Fe.

What is staying in Santa Fe like?

Travellers to Santa Fe will find plenty to explore and enjoy. There are 796 hotels and other accommodation options in the surrounding area. Find out more about Santa Fe.

What is there to see in Santa Fe?

Places to visit in the wider area include Turkey Creek Golf Course, O'Leno State Park and San Felasco Hammock Preserve State Park. You'll also find Devil's Milhopper Geological State Park and Gainesville Raceway in the area. Take a look at what more there is to see and do in Expedia's Santa Fe guide.

What's the weather like in Santa Fe?

The hottest months are usually July and August, with an average temperature of 27°C, while the coldest months are January and February, with an average of 15°C. The rainiest months in Santa Fe are August, June, July and September, with each month seeing an average of 177 mm of rainfall.

Explore a world of travel with Expedia

Car hire Gainesville

Gainesville Holiday Rentals

Book Hotels in Santa Fe on Expedia.com

Find hotels in Santa Fe, FL from £49

Go beyond your typical stay in Santa Fe

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Santa Fe hotels

1. Hampton Inn & Suites Alachua I-75

2. Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

3. La Quinta by Wyndham Gainesville

4. Best Western Gateway Grand

5. Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

6. Quality Inn Alachua - Gainesville Area

7. Clarion Pointe Alachua - Gainesville Area

8. BlueGem Motel

9. TownePlace Suites by Marriott Gainesville Northwest

10. Hotel Indigo Gainesville-Celebration Pointe by IHG

11. Palms Garden Inn

12. Aloft by Marriott Gainesville University Area

13. Hyatt Place Gainesville Downtown

14. Best Western Waldo Inn and Suites

15. Drury Inn & Suites Gainesville

16. Baymont By Wyndham Gainesville I-75

17. Holiday Inn Gainesville - University Center by IHG

18. The Reitz Union Hotel

19. Holiday Inn Express & Suites Gainesville I-75 by IHG

20. Fairfield Inn & Suites by Marriott Gainesville I-75

Top Santa Fe Hotel Reviews

Drury Inn & Suites Gainesville

HOM Hotel Gainesville, SureStay Collection by Best Western

Country Inn & Suites by Radisson, Gainesville, FL

Sleep Inn & Suites University/Shands

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Comfort Suites Gainesville near University

Hotel Indigo Gainesville-Celebration Pointe by IHG

Gainesville Lodge

Red Roof Inn PLUS+ Gainesville

More cheap stays in Santa Fe

Red Roof Inn PLUS+ Gainesville

Quality Inn Gainesville near University

Days Inn by Wyndham Gainesville University I-75

HOM Hotel Gainesville, SureStay Collection by Best Western

Sleep Inn & Suites University/Shands

Comfort Suites Gainesville near University

Frequently asked questions

Explore a world of travel with Expedia