Sant' Ambrogio Holidays from £262

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Your Sant Ambrogio Holiday

Make planning your travels stress-free by booking a holiday package to Sant Ambrogio. We'll handle all the details, so you can concentrate on soaking up everything this neighbourhood has to offer. Some nearby attractions to check out during your trip to Sant Ambrogio include Cathedral of Santa Maria del Fiore, Ponte Vecchio and Uffizi Gallery. Stop dreaming and start doing. When it's time to lock in your dream holiday to Sant Ambrogio, Expedia will help you get there.

Price found within the past 48 hours. Click for updated prices.
La Villa di STR

La Villa di STR

3 out of 5
Siena Historical Center
Price was £412, price is now £262 per person
£262
per person
7 Jan - 10 Jan
found 1 day ago
Return direct flight included
Manchester (MAN) to Florence (FLR)
9.2/10 Wonderful! (455 reviews)
We had a great stay at La Villa. We spent 4 days bicycling and our rental company was able to coordinate drop off and pick up without us needing to be involved. They had a storage area for our bikes. Location was away from the crowds but close enough to walk to all of the sites. Breakfast was excellent.

Reviewed on 13 Oct 2026

Hotel Botticelli

Hotel Botticelli

4 out of 5
Historic Centre of Florence
Save 100% on your flight
Price was £832, price is now £582 per person
£582
per person
29 Dec - 5 Jan
found 1 day ago
Return flight included
London (LON) to Florence (FLR)
8.8/10 Excellent! (1,004 reviews)
Location was great! Breakfast was abundant. Staff helpful.

Reviewed on 21 Oct 2026

The Moon Boutique Hotel & Spa

The Moon Boutique Hotel & Spa

4 out of 5
Historic Centre of Florence
Price was £554, price is now £388 per person
£388
per person
1 Dec - 4 Dec
found 2 hours ago
Return flight included
London (LGW) to Florence (FLR)
9.6/10 Exceptional! (605 reviews)
Everything was wonderful about our stay at The Moon Hotel and Spa. The room was beautiful and clean, the staff were friendly and helpful and it was a great location for sightseeing in Florence. We especially appreciated the very generous breakfast that was always served efficiently and with a smile. We would definitely stay again.

Reviewed on 23 Oct 2026

The Hoxton, Florence

The Hoxton, Florence

4 out of 5
Historic Centre of Florence
Price was £460, price is now £324 per person
£324
per person
27 Nov - 30 Nov
found 1 day ago
Return flight included
Edinburgh (EDI) to Florence (FLR)
9.4/10 Exceptional! (370 reviews)

Hotel Ginori al DUOMO

Hotel Ginori al DUOMO

4 out of 5
Historic Centre of Florence
Price was £418, price is now £302 per person
£302
per person
11 Dec - 15 Dec
found 1 day ago
Return flight included
London (LON) to Florence (FLR)
8.8/10 Excellent! (72 reviews)

Where to stay in Sant' Ambrogio

Find the best Sant' Ambrogio areas and neighborhoods for the activities you enjoy most. Learn more about Sant' Ambrogio
A river with buildings on the right bank.

Historic Centre of Florence

10 out of top 10 points of interest in this area

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

Find hotels in Historic Centre of Florence

Top hotels in Sant' Ambrogio

Hotel Bodoni

Hotel Bodoni

2 out of 5
Via Martiri del Popolo, 27 Florence FI
Fully refundableReserve now, pay when you stay
The price is £66 per night from 8 Nov to 9 Nov
£66
8 Nov - 9 Nov
includes taxes & fees
8.2/10 Very good! (889 reviews)
"Excellent hotel! I will definitely visit again! They even allow me to leave my bags at no extra charge since the check out was early and I did not departed until late night Everyone was super respectful and helpful"

Reviewed on 22 Oct 2026

Hotel Bodoni
Hotel Bavaria

Hotel Bavaria

1 out of 5
Borgo Albizi 26 Florence FI
The price is £53 per night from 18 Nov to 19 Nov
£53
18 Nov - 19 Nov
includes taxes & fees
8.2/10 Very good! (473 reviews)
"Recommend this great location, historic 16th century Spanish nobleman’s 5 level mansion. Very quiet guests, three nice bathrooms, nice common room, nice fruit water every day and advanced settings coffee machine, great nearby restaurants (reservation needed for some), historic art frescos, and interactive ..."

Reviewed on 21 Oct 2026

Hotel Bavaria
Hotel Regency

Hotel Regency

5 out of 5
Piazza M. D'Azeglio, 3 Florence FI
Fully refundableReserve now, pay when you stay
The price is £283 per night from 16 Nov to 17 Nov
£283
16 Nov - 17 Nov
includes taxes & fees
Hotel Regency
See all 552 properties in Sant' Ambrogio
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Frequently asked questions

How much does a Sant Ambrogio travel package cost?
From as little as £262, you can handcraft your own Sant Ambrogio package. Simply bundle hotels, flights and rental cars and we'll reward you with discounts.
If I'm not able to travel, can I cancel my Sant Ambrogio travel package?
Yes, you can. We totally understand that things don't always go to plan, so we're here to help if you need to make changes to your Sant Ambrogio travel package. You may be able to cancel or change your itinerary at no cost if you've booked within 24 hours. Your airline, hotel or car rental company may impose a fee if you booked more than 24 hours ago. Head to our Customer Service Portal for more information. Also, be sure to check your itinerary for the finer details on change fees.
How do I get a cheap travel package to Sant' Ambrogio?
Combining your flight and hotel with Expedia won't just save valuable time — it'll save you dollars too. A Sant' Ambrogio travel package makes it a breeze to arrange your ideal trip. With more than 550 airlines around the world to pick from, finding flights that fit your schedule won't be hard. In addition to that, we have over 1,000,000 hotel options globally to take your pick of. Now that's what we call choice. Whatever your budget, Expedia can show you the world.
Does Expedia offer Book Now, Pay Later Sant' Ambrogio holidays?
Expedia has teamed up with online lender Klarna to make booking your next break easier on the purse strings. Paying by instalment means you can spread the costs of your next dream escape, leaving you with more cash to splash while you're away. Klarna has several payment plans to pick from, so you're sure to find one that works with your budget. Consider these flexible payment options:

  • Pay monthly holidays: Make your holiday dreams come true sooner with Klarna's monthly instalment plans. If making small repayments each month sounds right for you, choose this option at checkout.
  • Pay in instalments holidays: With this Book Now, Pay Later option, Klarna makes it possible to pay for your holiday over multiple transactions.
  • Low deposit holidays: If paying a small percentage of your getaway (rather than the full total upfront) makes it easier to hit that "book now" button, opt for a low deposit holiday payment plan from Klarna.

Where should I stay in Sant Ambrogio?
Make sightseeing easy by staying close to Sant Ambrogio's fantastic attractions. Ponte Vecchio and Cathedral of Santa Maria del Fiore are two which top many visitors' bucket lists.
What are the top hotels in Sant Ambrogio?
Get your trip off to a fantastic start by reserving a room at Hotel LOrologio. It's one of most sought-after hotels in Sant Ambrogio. Another top option is Palazzo Graziani.
How far in advance should I book my Sant Ambrogio holiday?
Travellers are normally able to look up international flights on Expedia within 12 months of departure. Booking at the last minute? With a little bit of luck, it's still possible to purchase a cheap ticket only weeks before your journey.
What does an Expedia Sant Ambrogio travel package include?
It all depends on what type of getaway you're contemplating. Sant Ambrogio travel deals can include car rentals, flights and hotels. You can mix and match to find the bundle that suits your budget and style. You can also add on experiences and activities after you've booked to score even bigger discounts.
What should I know before booking a Sant Ambrogio travel package?
Whether it's relaxation or adventure you're seeking, a Sant Ambrogio travel package lets you plan your escape your way. Plus, you'll get access to great discounts when you combine your hotel with your flights and rental car. The more you bundle, the more you'll save!
Can I choose my airline with a Sant Ambrogio Expedia travel package?
Yes, you sure can. Expedia has access to more than 550 partner airlines globally, so choose the carrier that's a good fit for your budget and travelling style.

Stay near popular Sant' Ambrogio attractions

Great Synagogue of Florence

9.0/10 (6 reviews)
Great Synagogue of Florence is just one of the places to see in Florence, so why not enjoy the other things to explore during your travels? Experience the fascinating museums and acclaimed art galleries in this vibrant area.
See properties

Things to do

Picture 1 for Activity Florence: Pasta & Tiramisu Cooking Class with Unlimited Wine

Florence: Pasta & Tiramisu Cooking Class with Unlimited Wine

£15
per adult
94% of travellers recommend
Florence: Pasta & Tiramisu Cooking Class with Unlimited Wine
Florence: Pasta Cooking Class with Unlimited Wine

Florence: Pasta Cooking Class with Unlimited Wine

£15
per adult
94% of travellers recommend
Florence: Pasta Cooking Class with Unlimited Wine
Michaelangelo's David

Accademia timed-entry Ticket with App Guide

£33
per adult
90% of travellers recommend
Accademia timed-entry Ticket with App Guide
See all activities in Florence

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.