Sant' Ambrogio Holidays from £474

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

    • payments icon

    Better together

    Save up to £335 when you book a flight and hotel together*
    lob hotels icon

    Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
    lob packages icon

    Rest easy

    Packages with flights are ATOL protected

Your Sant Ambrogio Holiday

Make planning your travels stress-free by booking a holiday package to Sant Ambrogio. We'll handle all the details, so you can concentrate on soaking up everything this neighbourhood has to offer. Some nearby attractions to check out during your trip to Sant Ambrogio include Cathedral of Santa Maria del Fiore, Ponte Vecchio and Uffizi Gallery. Stop dreaming and start doing. When it's time to lock in your dream holiday to Sant Ambrogio, Expedia will help you get there.

Price found within the past 48 hours. Click for updated prices.
LHP River Club

LHP River Club

5 out of 5
Santa Croce
per person
11 Oct - 16 Oct
found 1 day ago
Return flight included
London (LGW) to Florence (FLR)
No reviews
Palazzo Firenze by Baglioni Hotels & Resorts

Palazzo Firenze by Baglioni Hotels & Resorts

5 out of 5
Historic Centre of Florence
per person
10 Sept - 17 Sept
found 1 day ago
Return flight included
London (LON) to Florence (FLR)
9.4/10 Exceptional! (228 reviews)
I VERY MUCH ENJOYED THE STAY

Reviewed on 18 Jul 2025

Aurum Firenze

Aurum Firenze

4 out of 5
Historic Centre of Florence
per person
5 Sept - 12 Sept
found 1 day ago
Return direct flight included
Birmingham (BHX) to Florence (FLR)
7.6/10 Good! (1,012 reviews)
The property is very centrally located—just a short walk from the Duomo and the central train station, with easy access to the tram as well. I was pleasantly surprised by how convenient the location was. The staff were friendly, and the included breakfast was a nice way to start the day with a quick bite. The only suggestion I’d make is to provide a thicker blanket for added comfort.

Reviewed on 29 Jul 2025

The Moon Boutique Hotel & Spa

The Moon Boutique Hotel & Spa

4 out of 5
Historic Centre of Florence
per person
11 Oct - 17 Oct
found 1 day ago
Return direct flight included
Birmingham (BHX) to Florence (FLR)
9.6/10 Exceptional! (462 reviews)
Hands down the best place we have stayed. They accommodated to go breakfasts for our tours, arranged taxis, made cappuccino when we were heading out the door. Wonderful experience

Reviewed on 6 Jun 2025

Precise Tale Poggio Alla Sala

Precise Tale Poggio Alla Sala

5 out of 5
per person
13 Sept - 18 Sept
found 1 day ago
Return flight included
London (LON) to Florence (FLR)
9.4/10 Exceptional! (98 reviews)
The staff were incredibly kind and helpful. I got a flat tire the day I was leaving the hotel and the staff went above and beyond to help me get the tire fixed so I could be on my way. The hotel is beautiful and the food was excellent. I also requested a more private room and the staff changed the room for me right away. Highly recommended for beauty, serene peace and quiet

Reviewed on 19 Jul 2025

Where to stay in Sant' Ambrogio

Find the best Sant' Ambrogio areas and neighborhoods for the activities you enjoy most. Learn more about Sant' Ambrogio
Default Image

Historic Centre of Florence

10 out of top 10 points of interest in this area

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

Find hotels in Historic Centre of Florence

Top hotels in Sant' Ambrogio

Hotel Regency

Hotel Regency

5 out of 5
Piazza M. D'Azeglio, 3, Florence, FI
Fully refundableReserve now, pay when you stay
The price is £316 per night from 16 Aug to 17 Aug
£316
16 Aug - 17 Aug
includes taxes & fees
9.2/10 Wonderful! (433 reviews)
"Loved it! Great place and very convenient"

Reviewed on 4 Jul 2025

Hotel Regency
Hotel Bodoni

Hotel Bodoni

2 out of 5
Via Martiri del Popolo, 27, Florence, FI
Fully refundableReserve now, pay when you stay
The price is £72 per night from 27 Aug to 28 Aug
£72
27 Aug - 28 Aug
includes taxes & fees
8/10 Very Good! (730 reviews)
"Location is great for the price. The hotel itself is odd. Breakfast is good. The paid parking service worked well"

Reviewed on 4 Jul 2025

Hotel Bodoni
Hotel Rita Major

Hotel Rita Major

2 out of 5
Via della Mattonaia, 43, Florence, FI
9.2/10 Wonderful! (138 reviews)
"Wonderful, spacious room which was clean and comfortable. Staff were lovely and breakfast was great. Location was good for walking and catching transport. Highly recommend."

Reviewed on 18 Jul 2025

Get rates
Hotel Rita Major
See all 495 properties in Sant' Ambrogio
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Frequently asked questions

How much does a Sant Ambrogio travel package cost?
From as little as £474, you can handcraft your own Sant Ambrogio package. Simply bundle hotels, flights and rental cars and we'll reward you with discounts.
If I'm not able to travel, can I cancel my Sant Ambrogio travel package?
Yes, you can. We totally understand that things don't always go to plan, so we're here to help if you need to make changes to your Sant Ambrogio travel package. You may be able to cancel or change your itinerary at no cost if you've booked within 24 hours. Your airline, hotel or car rental company may impose a fee if you booked more than 24 hours ago. Head to our Customer Service Portal for more information. Also, be sure to check your itinerary for the finer details on change fees.
How do I get a cheap travel package to Sant' Ambrogio?
Combining your flight and hotel with Expedia won't just save valuable time — it'll save you dollars too. A Sant' Ambrogio travel package makes it a breeze to arrange your ideal trip. With more than 550 airlines around the world to pick from, finding flights that fit your schedule won't be hard. In addition to that, we have over 1,000,000 hotel options globally to take your pick of. Now that's what we call choice. Whatever your budget, Expedia can show you the world.
Does Expedia offer Book Now, Pay Later Sant' Ambrogio holidays?
Expedia has teamed up with online lender Klarna to make booking your next break easier on the purse strings. Paying by instalment means you can spread the costs of your next dream escape, leaving you with more cash to splash while you're away. Klarna has several payment plans to pick from, so you're sure to find one that works with your budget. Consider these flexible payment options:

  • Pay monthly holidays: Make your holiday dreams come true sooner with Klarna's monthly instalment plans. If making small repayments each month sounds right for you, choose this option at checkout.
  • Pay in instalments holidays: With this Book Now, Pay Later option, Klarna makes it possible to pay for your holiday over multiple transactions.
  • Low deposit holidays: If paying a small percentage of your getaway (rather than the full total upfront) makes it easier to hit that "book now" button, opt for a low deposit holiday payment plan from Klarna.

Where should I stay in Sant Ambrogio?
Make sightseeing easy by staying close to Sant Ambrogio's fantastic attractions. Ponte Vecchio and Cathedral of Santa Maria del Fiore are two which top many visitors' bucket lists.
What are the top hotels in Sant Ambrogio?
Get your trip off to a fantastic start by reserving a room at Hotel LOrologio. It's one of most sought-after hotels in Sant Ambrogio. Another top option is Palazzo Graziani.
How far in advance should I book my Sant Ambrogio holiday?
Travellers are normally able to look up international flights on Expedia within 12 months of departure. Booking at the last minute? With a little bit of luck, it's still possible to purchase a cheap ticket only weeks before your journey.
What does an Expedia Sant Ambrogio travel package include?
It all depends on what type of getaway you're contemplating. Sant Ambrogio travel deals can include car rentals, flights and hotels. You can mix and match to find the bundle that suits your budget and style. You can also add on experiences and activities after you've booked to score even bigger discounts.
What should I know before booking a Sant Ambrogio travel package?
Whether it's relaxation or adventure you're seeking, a Sant Ambrogio travel package lets you plan your escape your way. Plus, you'll get access to great discounts when you combine your hotel with your flights and rental car. The more you bundle, the more you'll save!
Can I choose my airline with a Sant Ambrogio Expedia travel package?
Yes, you sure can. Expedia has access to more than 550 partner airlines globally, so choose the carrier that's a good fit for your budget and travelling style.

Popular places to visit

Piazza Massimo D'Azeglio

Find out about the history of Florence when you take a trip to Piazza Massimo D'Azeglio. Stroll along the riverfront or visit the stunning cathedral in this vibrant area.

Piazza Massimo D'Azeglio

Things to do

Florence: Pasta Cooking Class with Unlimited Wine

Florence: Pasta Cooking Class with Unlimited Wine

£25
per adult
90% of travellers recommend
Florence: Pasta Cooking Class with Unlimited Wine
Pasta Lovers cooking class: learn to cook tagliatelle ravioli and tiramisù

Pasta Lovers cooking class: learn to cook tagliatelle ravioli and tiramisù

£30
per adult
Pasta Lovers cooking class: learn to cook tagliatelle ravioli and tiramisù
See all activities in Florence

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.