A calm river with clear water, surrounded by dense trees and rocky banks.

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Check prices for these dates

Tonight
11 Oct - 12 Oct
Tomorrow
12 Oct - 13 Oct
Next weekend
16 Oct - 18 Oct
In two weeks
23 Oct - 25 Oct

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Our top choices for O Brien hotels

A hotel room with a gray sofa, a bed with white linens, a desk with a chair, and a window with blinds.
A modern hotel lobby with a central island table, seating area with chairs, a fireplace, and a bar area.
A modern hotel lobby with a fireplace, seating areas, and a bar.
Exterior

1. Comfort Suites Lake City

Comfort Suites Lake City
Lake City
United States
Carma
£75
includes taxes & fees
21 Oct - 22 Oct
Comfort Suites Lake City
A La Quinta hotel with a modern facade, multiple windows, and a well-lit entrance.
A hotel room with a large bed, a sofa, a desk, and a wall with a geometric pattern.
A modern restaurant with a long counter, multiple seating options including red and yellow chairs, and a large window providing a view.
A modern lobby with a large map mural, a wooden column, and a seating area with a yellow cushion.

2. La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City
Lake City
United States
Steven
£84
includes taxes & fees
13 Oct - 14 Oct
La Quinta Inn & Suite by Wyndham Lake City
A spacious living area with a grey sofa, a coffee table, and a TV stand.
A hotel room with two beds, a desk, a TV, and a large window with curtains.
A modern kitchen with light wood cabinets, granite countertops, and stainless steel appliances. There are signs on the wall advertising different coffee brands.
A hotel entrance with a covered walkway, palm trees, and a clear sky.

3. Best Western Plus Lake City

Best Western Plus Lake City
Lake City
United States
marta
£68
includes taxes & fees
1 Nov - 2 Nov
Best Western Plus Lake City
A picnic table with a potted plant, located in a grassy area with a tree and a road in the background.
A hotel lobby with a reception desk, a clock, a plant, a water dispenser, and a coffee station.
A living room with a black leather sofa, a wooden coffee table with a plant, and framed pictures on the wall.
A hotel lobby with a view of the street, a reception desk, and a large map on the wall.

4. Americas Best Value Inn Lake City

Americas Best Value Inn Lake City
Lake City
United States
Sara
£57
includes taxes & fees
13 Oct - 14 Oct
Americas Best Value Inn Lake City
An indoor swimming pool with clear water, surrounded by glass doors and windows, and a wooden deck area.
A modern lounge area with a fireplace, comfortable seating, a dining table, and a large window offering a view.
An outdoor patio area with a sectional sofa, chairs, a coffee table, and a fire pit.
A modern living room with two green sofas, a white coffee table, and a flat-screen TV mounted on the wall.

5. Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City
Lake City
United States
Pedro
£75
includes taxes & fees
25 Oct - 26 Oct
Fairfield Inn & Suites Lake City
A self-service beverage station with a variety of drinks, snacks, and a refrigerated section.
A modern hotel lobby with a central counter displaying snacks and beverages, two digital screens above the counter, and a seating area with a view of the lobby.
A modern interior with two red chairs and a small table, large windows, and hanging pendant lights.
A modern hotel with a flat roof, multiple windows, and a covered entrance.

6. Tru by Hilton Lake City

Tru by Hilton Lake City
Lake City
United States
Carlos
£84
includes taxes & fees
25 Oct - 26 Oct
Tru by Hilton Lake City
A multi-story hotel with a modern design, featuring a prominent entrance and a parking area.
A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.
A reception area with two wooden reception desks, a wall-mounted decorative piece, and a refrigerator stocked with beverages.
A modern restaurant with round tables and yellow chairs, a bar area with a TV, and a menu display.

7. Courtyard By Marriott Lake City

Courtyard By Marriott Lake City
Lake City
United States
Angel
£93
includes taxes & fees
18 Oct - 19 Oct
Courtyard By Marriott Lake City
An outdoor patio area with tables and chairs, surrounded by palm trees and a building with large windows.
A hotel room with a sofa, a desk with a computer, a TV, a mirror, and framed pictures on the wall.
Pool
Fitness facility

8. Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City
Lake City
United States
James
£89
includes taxes & fees
18 Oct - 19 Oct
Hampton Inn & Suites Lake City
A covered outdoor area with a paved walkway, benches, and potted plants.
A bedroom with a bed, a desk, a chair, and a ceiling fan.
A compact RV kitchen with wooden cabinets, a microwave, a stove, and a sink.
A compact kitchen with a blue refrigerator, a black coffee maker, a microwave, and a small black refrigerator.

9. Cindys Motel

Cindys Motel
Mayo
United States
Diane
£67
includes taxes & fees
11 Nov - 12 Nov
Cindys Motel
An outdoor patio with a stone fire pit, grey cushioned seating, and wicker ottomans.
A modern hotel with a two-story structure, a covered outdoor seating area, and a parking lot with marked spaces.
A modern kitchen with stainless steel appliances, a dishwasher, and a built-in oven.
A modern hotel room with a bed, a desk with a computer, a TV, and a lamp.

10. Home2 Suites by Hilton Lake City

Home2 Suites by Hilton Lake City
Lake City
United States
William
£97
includes taxes & fees
18 Oct - 19 Oct
Home2 Suites by Hilton Lake City
A hotel room with a teal accent wall, a sofa, a desk with a chair, a small table, and two framed artworks.
A reception desk with a Holiday Inn sign, two computer monitors, and a security camera.
A hotel lobby with multiple seating areas, a bar, and an elevator.
A hotel room with a beige sofa, a small table with a book, a TV on a wooden cabinet, and a window with blinds.

11. Holiday Inn & Suites Lake City by IHG

Holiday Inn & Suites Lake City by IHG
Lake City
United States
C.jeffery
£86
includes taxes & fees
18 Oct - 19 Oct
Holiday Inn & Suites Lake City by IHG
A spacious lobby with a high ceiling, a large window, a dining area with green chairs, and a black door leading outside.
A reception area with a counter, a coffee machine, and a potted plant.
A hotel room with two beds, a desk, a chair, a painting on the wall, and a patterned carpet.
A white building with multiple windows and a sign that reads 'Quality Inn.'

12. Quality Inn Lake City

Quality Inn Lake City
Lake City
United States
Brianna
£66
includes taxes & fees
2 Nov - 3 Nov
Quality Inn Lake City
A reception area with a stone wall, a blue accent wall, a clock, and a window with a view of the parking lot.
A modern bedroom with a wooden headboard, two bedside lamps, a patterned bedspread, and a blue door.
A bathroom with a bathtub, a shower, and a toilet.
A bathroom with a towel rack, a shower curtain, and a toilet.

13. Regal Inn

Regal Inn
Lake City
United States
Samuel
£47
includes taxes & fees
13 Oct - 14 Oct
Regal Inn
A hotel room with two beds, a desk, a chair, a sink, and a painting of a pier and sunset.
A restaurant with a counter, chairs, and a tiled floor.
A reception area with a black counter, a desk, a chair, a potted plant, and a door.
A bathroom with a sink, mirror, towel rack, and a microwave.

14. Days Inn by Wyndham Lake City I-10

Days Inn by Wyndham Lake City I-10
Lake City
United States
Pennee
£51
includes taxes & fees
13 Oct - 14 Oct
Days Inn by Wyndham Lake City I-10
A hotel room with a large bed, a desk with a computer, a television, and a window with curtains.
A restaurant with a yellow accent wall, white tiled floor, and black and blue chairs.
A swimming pool with lounge chairs and umbrellas, surrounded by a brick building with balconies and palm trees.
Lobby

15. Super 8 by Wyndham Lake City

Super 8 by Wyndham Lake City
Lake City
United States
Scott
£60
includes taxes & fees
11 Nov - 12 Nov
Super 8 by Wyndham Lake City
A kitchen counter with a coffee maker, a 'Welcome' sign, and a vase of flowers.
A hotel room with two beds, a TV, a desk, and a lamp.
A covered parking area with a Walmart store in the background.
A modern kitchen with a granite countertop, a built-in stove, and a large window with six panels.

16. Driftwood Inn

Driftwood Inn
Lake City
United States
Tammy
£55
includes taxes & fees
26 Oct - 27 Oct
Driftwood Inn
A modern kitchen with a large window, a flat-screen TV, and a coffee machine.
A hotel with a swimming pool, white lounge chairs, and a fenced area.
A reception area with a tiled counter, a computer, a sign reading 'Quality,' and two decorative vases.
A hotel lobby with a dining area, a reception desk, and a view of the outside.

17. Quality Inn White Springs Suwanee

Quality Inn White Springs Suwanee
White Springs
United States
Pennee
£54
includes taxes & fees
2 Nov - 3 Nov
Quality Inn White Springs Suwanee
An aerial view of a campground with RVs, a swimming pool, and tennis courts.
A wooden cabin with a porch, a front door, and a small window.
A covered outdoor dining area with a table and chairs, large windows, and a view of greenery.
A serene lakeside campsite with picnic tables and chairs.

18. Suwannee River Rendezvous

Suwannee River Rendezvous
Mayo
United States
Beth
£91
includes taxes & fees
13 Oct - 14 Oct
Suwannee River Rendezvous
A reception area with a Baymont Inn & Suites sign, a reception desk, a glass-top table, and a door.
A hotel room with a patterned carpet, a sofa, a TV, a desk, and a bed with a patterned bedspread.
A hotel room with a large bed, two bedside tables with lamps, a desk with a chair, a television, and a bathroom visible in the background.
A bridge over a pond with a fountain, surrounded by palm trees and a building with a red roof.

19. Baymont by Wyndham Lake City I-75

Baymont by Wyndham Lake City I-75
Lake City
United States
Steve
£49
includes taxes & fees
19 Oct - 20 Oct
Baymont by Wyndham Lake City I-75
An outdoor patio area with wicker chairs, a round table, and a fire pit.
A modern interior with a sofa, round tables, and chairs, a TV mounted on the wall, and a patterned wall.
A modern interior with a dark wood desk, a blue chair, a sofa, and a patterned rug.
A hotel room with a bed, a sofa, a small table, a wardrobe, and a kitchenette.

20. TownePlace Suites by Marriott Lake City

TownePlace Suites by Marriott Lake City
Lake City
United States
Jennifer
£110
includes taxes & fees
18 Oct - 19 Oct
TownePlace Suites by Marriott Lake City
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Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien
A calm river surrounded by trees reflecting in the water.

Top O Brien Hotel Reviews

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

10/10 Excellent
"Staff was friendly and helpful. Breakfast was good."
Chenetta 2-night trip
Posted 1 day ago
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Quality Inn Lake City

Quality Inn Lake City

10/10 Excellent
"Very nice! Was clean, comfortable, friendly and helpful staff, nicely landscaped! Our only drawback was we had to park at restaurant next door as you are only allowed to 1 space and we had our 12x7 cargo trailer. But overall this was amazing! Wanted to book for another night but was sold out as hurricane Iseasia’s presence."
Denise 1-night trip
Posted 2 days ago
Quality Inn Lake City
Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City

10/10 Excellent
"The rooms, clean bathrooms, water pressure. the staff member very nice and polite informative of the location. the area have plenty restaurants in the local history."
Pedro 4-night trip
Posted 3 days ago
Fairfield Inn & Suites Lake City
Holiday Inn Express & Suites Live Oak by IHG

Holiday Inn Express & Suites Live Oak by IHG

10/10 Excellent
"Angela was wonderful, smooth check in. Room was clean and the bed was so comfortable. All staff was very friendly and helpful. Breakfast was good."
Phyllis 1-night trip
Posted 7 days ago
Holiday Inn Express & Suites Live Oak by IHG
Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

10/10 Excellent
"Great for my sons and grandsons to play for a long weekend. Lots of room and games inside and huge yard to play in. Ideal if you have a boat to enjoy the river."
Richard H. 2-night trip
Posted 3 weeks ago
Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

More cheap stays in O Brien

Baymont by Wyndham Lake City I-75

Baymont by Wyndham Lake City I-75

3598 W Us Highway 90 Lake City FL
£49
19 Oct - 20 Oct
includes taxes & fees
5/10 (1,003 reviews)
Baymont by Wyndham Lake City I-75
Quality Inn Lake City

Quality Inn Lake City

285 Sw Commerce Dr Lake City FL
£66
2 Nov - 3 Nov
includes taxes & fees
8.2/10 Very good! (1,002 reviews)
Quality Inn Lake City
Best Western Plus Lake City

Best Western Plus Lake City

350 SW Florida Gateway Dr Lake City FL
£68
1 Nov - 2 Nov
includes taxes & fees
Best Western Plus Lake City
Comfort Suites Lake City

Comfort Suites Lake City

3690 W Us Highway 90 Lake City FL
£75
21 Oct - 22 Oct
includes taxes & fees
Comfort Suites Lake City
Tru by Hilton Lake City

Tru by Hilton Lake City

284 NW Centurion Court Lake City FL
£84
25 Oct - 26 Oct
includes taxes & fees
Tru by Hilton Lake City
Holiday Inn Express & Suites Live Oak by IHG

Holiday Inn Express & Suites Live Oak by IHG

6694 Us Highway 129 Live Oak FL
£95
8 Nov - 9 Nov
includes taxes & fees
8.4/10 Very good! (888 reviews)
Holiday Inn Express & Suites Live Oak by IHG

Frequently asked questions

What is the best area to stay in O Brien?
The best area to stay in O'Brien, Florida, is along the Suwannee River, particularly around the public boat ramps and access points.This area is the main draw for visitors to O'Brien, as it provides direct access to the natural beauty and recreational opportunities of the Suwannee River. You'll find a scattering of accommodations, from holiday rentals to small, independent motels, often with direct riverfront access or just a short drive away. This allows for convenient enjoyment of activities like fishing, kayaking, and boating.Families will find this area particularly appealing due to the easy access to water-based activities. Many properties offer amenities like barbecue areas and space for children to play, making it simple to enjoy the outdoors together. The nearby Spirit of the Suwannee Music Park also hosts various events throughout the year, which can be a fun addition to a family holiday.For couples looking for a relaxed escape, staying by the river offers a peaceful setting. You can enjoy quiet evenings by the water, explore the river's springs, or simply unwind away from city life.
When is the best time to go to O Brien?
The best time to visit O'Brien, Florida, is typically during the spring (March to May) and autumn (September to November) months.During these periods, the weather is generally mild and pleasant, with comfortable temperatures, making it ideal for enjoying outdoor activities like swimming, fishing, and exploring the natural springs without the intense heat and humidity of summer or the cooler temperatures of winter. The spring also brings blooming wildflowers, adding to the area's natural beauty.For couples looking for a relaxing escape, these shoulder seasons offer a good balance of agreeable weather and fewer crowds compared to peak summer. You'll find it easier to enjoy the tranquility of the Ichetucknee Springs State Park or the Suwannee River without feeling overwhelmed by other visitors.Families travelling with children might also find these times more comfortable for outdoor adventures.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in O Brien.
How much is the nightly rate at a O Brien hotel?
Prices for hotels in O Brien often vary, but you can find a great deal from £47 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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