Hotels in O Brien, FL - Best O Brien Hotels from £47 - Fully Refundable Options

A calm river with clear water, surrounded by dense trees and rocky banks.

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Our top choices for O Brien hotels

A hotel room with a gray sofa, a bed with white linens, a desk with a chair, and a window with blinds.

A modern hotel lobby with a central island table, seating area with chairs, a fireplace, and a bar area.

A modern hotel lobby with a fireplace, seating areas, and a bar.

A modern living room with a sectional sofa, a round coffee table, a hanging chair, and a flat-screen TV on a glass stand.

1. Comfort Suites Lake City

Lake City

Carma

£75

includes taxes & fees

21 Oct - 22 Oct

A La Quinta hotel with a modern facade, multiple windows, and a well-lit entrance.

A modern lobby with a large map mural, a wooden column, and a seating area with a yellow cushion.

A modern restaurant with a long counter, multiple seating options including red and yellow chairs, and a large window providing a view.

A hotel room with a large bed, a sofa, a desk, and a wall with a geometric pattern.

2. La Quinta Inn & Suite by Wyndham Lake City

Lake City

Steven

£84

includes taxes & fees

15 Oct - 16 Oct

A picnic table with a potted plant, located in a grassy area with a tree and a road in the background.

A hotel room with two beds, a nightstand with a phone and remote, and a patterned curtain.

A hotel lobby with a reception desk, a clock, a plant, a water dispenser, and a coffee station.

A living room with a black leather sofa, a wooden coffee table with a plant, and framed pictures on the wall.

3. Americas Best Value Inn Lake City

Lake City

Sara

£57

includes taxes & fees

18 Oct - 19 Oct

A spacious living area with a grey sofa, a coffee table, and a TV stand.

A hotel room with two beds, a desk, a TV, and a large window with curtains.

A hotel room with a sofa, a small table, a lamp, and artwork on the wall.

A hotel entrance with a covered walkway, palm trees, and a clear sky.

4. Best Western Plus Lake City

Lake City

Melissa

£68

includes taxes & fees

1 Nov - 2 Nov

A self-service beverage station with a variety of drinks, snacks, and a refrigerated section.

A modern hotel with a flat roof, multiple windows, and a covered entrance.

A modern interior with two red chairs and a small table, large windows, and hanging pendant lights.

A modern hotel lobby with a central counter displaying snacks and beverages, two digital screens above the counter, and a seating area with a view of the lobby.

5. Tru by Hilton Lake City

Lake City

Carlos

£83

includes taxes & fees

25 Oct - 26 Oct

An outdoor patio area with tables and chairs, surrounded by palm trees and a building with large windows.

A hotel room with a sofa, a desk with a computer, a TV, a mirror, and framed pictures on the wall.

6. Hampton Inn & Suites Lake City

Lake City

James

£89

includes taxes & fees

25 Oct - 26 Oct

An outdoor patio with a stone fire pit, grey cushioned seating, and wicker ottomans.

A modern kitchen with stainless steel appliances, a dishwasher, and a built-in oven.

A modern hotel with a two-story structure, a covered outdoor seating area, and a parking lot with marked spaces.

A modern hotel lobby with a reception desk, seating areas, and a large screen.

7. Home2 Suites by Hilton Lake City

Lake City

William

£93

includes taxes & fees

18 Oct - 19 Oct

An indoor swimming pool with clear water, surrounded by glass doors and windows, and a wooden deck area.

A modern lounge area with a fireplace, comfortable seating, a dining table, and a large window offering a view.

A modern dining area with multiple tables and chairs, a kitchen in the background, and a 'Hello Fall' sign on the wall.

An outdoor patio area with a sectional sofa, chairs, a coffee table, and a fire pit.

8. Fairfield Inn & Suites Lake City

Lake City

Pedro

£80

includes taxes & fees

25 Oct - 26 Oct

A hotel room with a large bed, a desk with a computer, a television, and a window with curtains.

An aerial view of a hotel with a swimming pool, parking lot, and surrounding greenery.

A restaurant with a yellow accent wall, white tiled floor, and black and blue chairs.

9. Super 8 by Wyndham Lake City

Lake City

Scott

£56

includes taxes & fees

22 Oct - 23 Oct

A covered outdoor area with a paved walkway, benches, and potted plants.

A bedroom with a bed, a desk, a chair, and a ceiling fan.

A compact kitchen with a blue refrigerator, a black coffee maker, a microwave, and a small black refrigerator.

A grassy area with a picnic table, a car parked in front of a building with a sloped roof, and trees with hanging moss.

10. Cindys Motel

Mayo

Diane

£72

includes taxes & fees

15 Oct - 16 Oct

A hotel room with a teal accent wall, a sofa, a desk with a chair, a small table, and two framed artworks.

A hotel room with a beige sofa, a small table with a book, a TV on a wooden cabinet, and a window with blinds.

A hotel room with two beds, a TV, a desk with a lamp, and a window with blinds.

A gym with treadmills, weight machines, and dumbbells.

11. Holiday Inn & Suites Lake City by IHG

Lake City

C.jeffery

£86

includes taxes & fees

18 Oct - 19 Oct

A multi-story hotel with a modern design, featuring a prominent entrance and a parking area.

A modern restaurant with round tables and yellow chairs, a bar area with a TV, and a menu display.

A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.

12. Courtyard By Marriott Lake City

Lake City

Angel

£99

includes taxes & fees

1 Nov - 2 Nov

A reception area with a stone wall, a blue accent wall, a clock, and a window with a view of the parking lot.

A bathroom with a towel rack, a shower curtain, and a toilet.

Two doors, one blue and one green, with numbers 105 and 103 respectively, against a brick wall.

A modern bedroom with a wooden headboard, two bedside lamps, a patterned bedspread, and a blue door.

13. Regal Inn

Lake City

Samuel

£47

includes taxes & fees

17 Oct - 18 Oct

A kitchen counter with a coffee maker, a 'Welcome' sign, and a vase of flowers.

A motel named Driftwood Inn with a clear blue sky, palm trees, and a parking lot.

A covered parking area with a Walmart store in the background.

A modern kitchen with a granite countertop, a built-in stove, and a large window with six panels.

14. Driftwood Inn

Lake City

Tammy

£54

includes taxes & fees

15 Oct - 16 Oct

A spacious lobby with a high ceiling, a large window, a dining area with green chairs, and a black door leading outside.

A hotel dining area with tables and chairs, a reception desk, and a kitchen in the background.

A hotel room with two beds, a desk, a chair, a painting on the wall, and a patterned carpet.

A white building with multiple windows and a sign that reads 'Quality Inn.'

15. Quality Inn Lake City

Lake City

Justin

£66

includes taxes & fees

2 Nov - 3 Nov

An aerial view of a campground with RVs, a swimming pool, and tennis courts.

A serene lakeside campsite with picnic tables and chairs.

A covered outdoor dining area with a table and chairs, large windows, and a view of greenery.

A wooden cabin with a kitchen, a bathroom, and a loft bedroom.

16. Suwannee River Rendezvous

Mayo

Beth

£91

includes taxes & fees

15 Oct - 16 Oct

A modern kitchen with a large window, a flat-screen TV, and a coffee machine.

A hotel with a swimming pool, white lounge chairs, and a fenced area.

A reception area with a tiled counter, a computer, a sign reading 'Quality,' and two decorative vases.

A hotel lobby with a dining area, a reception desk, and a view of the outside.

17. Quality Inn White Springs Suwanee

White Springs

Pennee

£56

includes taxes & fees

11 Nov - 12 Nov

A reception area with a Baymont Inn & Suites sign, a reception desk, a glass-top table, and a door.

A bridge over a pond with a fountain, surrounded by palm trees and a building with a red roof.

A breakfast bar with a coffee machine, a microwave, and a sign reading "Breakfast Corner." There are several wooden tables and chairs arranged around the bar.

A hotel room with a patterned carpet, a sofa, a TV, a desk, and a bed with a patterned bedspread.

18. Baymont by Wyndham Lake City I-75

Lake City

Steve

£49

includes taxes & fees

18 Oct - 19 Oct

A hotel room with two beds, a TV, a desk, and a painting of a sunset.

A hotel room with a large bed, a bedside table, a nightstand, a window, and a bathroom with a toilet and sink.

A swimming pool with lounge chairs, a small pool house, and a yellow multi-story building with balconies.

A kitchen with a black refrigerator and a microwave on a wooden shelf.

19. Days Inn by Wyndham Lake City I-75

Lake City

Danny

£61

includes taxes & fees

18 Oct - 19 Oct

A building entrance with a blue door, a security warning sign, and a window overlooking a parking area.

A hotel room with a large bed, two bedside tables, and a headboard.

A two-story building with a parking lot, a white car, and a potted plant.

A bathroom with a toilet, bathtub, and shower curtain.

20. Royal Inn

Live Oak

Roscoe

£52

includes taxes & fees

15 Oct - 16 Oct

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Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien

A calm river surrounded by trees reflecting in the water.

Top O Brien Hotel Reviews

Quality Inn Lake City

10/10 Excellent

"Woman checking us in was great... property was clean, convenient, and quiet. Breakfast was good too.... Would stay here again."

Best Western Plus Lake City

10/10 Excellent

"Property us always just what we need when in the area. Staff is always courteous and helpful. We are at this property a few times a year and never have an issue other than the pool. Its indoor but the area could be maintained better and the water is always freezing. We opt not to use thos amenity"

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

10/10 Excellent

"Great place to stay for checking out the springs in the area"

Baymont by Wyndham Lake City I-75

8/10 Good

"Hotel is in need of major remodeling"

Courtyard By Marriott Lake City

10/10 Excellent

"Great experience, clean , pleasant decor. Quiet and comfortable!"

Tru by Hilton Lake City

8/10 Good

"Room was clean- shampoo and conditioner were included. Beds were comfortable. Breakfast was also good. Better than most breakfast buffets I have been too. Friendly and helpful staff."

La Quinta Inn & Suite by Wyndham Lake City

10/10 Excellent

"Everything was great. Definitely going back"

Hampton Inn & Suites Lake City

10/10 Excellent

"Very clean and the staff was very helpful . My children loved it here. The waffles were amazing."

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

10/10 Excellent

"Staff was friendly and helpful. Breakfast was good."

More cheap stays in O Brien