Title: TOP Mesopotamia Spa Hotels for 2026 - Spas in Mesopotamia | Expedia.co.uk [Mesopotamia Travel Guide](https://expedia.co.uk/Mesopotamia.dx6208836)[Hotels in Mesopotamia](https://expedia.co.uk/Mesopotamia-Hotels.d6208836.Travel-Guide-Hotels)[Holiday Rentals in Mesopotamia](https://expedia.co.uk/Mesopotamia-Holiday-Rentals.d6208836.Travel-Guide-HolidayRentals)[Flights to Mesopotamia](https://expedia.co.uk/Cheap-Flights-To-Mesopotamia.d6208836.Travel-Guide-Flights)[Mesopotamia Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Mesopotamia.d6208836.Car-Hire-Guide)[Mesopotamia Holidays](https://expedia.co.uk/Mesopotamia.d6208836.Holidays-City-Breaks) ![Mesopotamia showing a river or creek and forests](https://images.trvl-media.com/place/6208836/ca0c6990-9932-4f38-bee6-e89ce7080803.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Spa Hotels in Mesopotamia - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Mesopotamia Spa Hotels Tonight [1 Dec - 2 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6208836&startDate=2025-12-01&endDate=2025-12-02&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [2 Dec - 3 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6208836&startDate=2025-12-02&endDate=2025-12-03&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [5 Dec - 7 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6208836&startDate=2025-12-05&endDate=2025-12-07&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [12 Dec - 14 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6208836&startDate=2025-12-12&endDate=2025-12-14&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Mesopotamia Spa Hotels ![Indoor pool, 2 outdoor pools, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/112000000/111550000/111541700/111541690/182c3232.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Double Room | In-room safe, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/112000000/111550000/111541700/111541690/e22e8bc7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/112000000/111550000/111541700/111541690/a0871cfa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/112000000/111550000/111541700/111541690/8d2994c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Mayim Hotel Termal & SPA Concordia 8.8/10 Excellent (5) "Muy lindo hotel , lástima q se rompió el aire acondicionado y no hay secador de pelo an la habitación " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Catalina £70 8 Dec - 9 Dec [](https://www.expedia.co.uk/Concordia-Hotels-Mayim-Hotel-Termal-SPA.h111541690.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/12000000/11880000/11876000/11875903/afd7d710.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/12000000/11880000/11876000/11875903/750a674d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV](https://images.trvl-media.com/lodging/12000000/11880000/11876000/11875903/7876fff6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/12000000/11880000/11876000/11875903/f32e7494.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Club Valle Termal Resort Federacion 9.2/10 Wonderful (94) "Lamentablemente el lugar no refleja lo contratado por la plataforma. Cuando llegamos no tenían nuestras reservas, nos enviaron a una habitación con puerta de vidrio que no cerraba, arañas en la habitación, las sábanas viejas y manchadas, colchones vencidos y sin forro. Una experiencia espeluznante. " ![Costa Rica](https://a.travel-assets.com/egds/marks/flags/cr.svg) Pablo £33 19 Dec - 20 Dec [](https://www.expedia.co.uk/Federacion-Hotels-Club-Valle-Termal-Resort.h11875903.Hotel-Information) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/16000000/15370000/15362200/15362145/43c3ae01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/16000000/15370000/15362200/15362145/c45620e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/16000000/15370000/15362200/15362145/a0cc5957.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, free WiFi, bed sheets](https://images.trvl-media.com/lodging/16000000/15370000/15362200/15362145/96c73453.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Costarenas Hotel & Spa Colon 8.6/10 Excellent (58) "spectacular since we arrived the tstaff was wonderful and kind to us very helpful and nice answering all our questions, the hotel very comfortable!! the river view stunning" ![Argentina](https://a.travel-assets.com/egds/marks/flags/ar.svg) Lisette £88 6 Dec - 7 Dec [](https://www.expedia.co.uk/Colon-Hotels-Costarenas-Hotel-Spa.h15362145.Hotel-Information) ![Couples treatment room(s), body treatments, aromatherapy, body scrubs](https://images.trvl-media.com/lodging/37000000/36810000/36801000/36800965/96c06c0b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/37000000/36810000/36801000/36800965/6a6d02f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Couples treatment room(s), body treatments, aromatherapy, body scrubs](https://images.trvl-media.com/lodging/37000000/36810000/36801000/36800965/2f9d647c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/37000000/36810000/36801000/36800965/77b70130.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Maran Suites & Towers - Hotel & Spa Parana 9.0/10 Wonderful (30) "Great location and friendly, accommodating staff. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael £72 10 Dec - 11 Dec [](https://www.expedia.co.uk/Parana-Hotels-Maran-Suites-Towers-Hotel-Spa.h36800965.Hotel-Information) ![Seasonal outdoor pool, open noon to 11:00 PM, pool loungers](https://images.trvl-media.com/lodging/5000000/4420000/4411700/4411601/456e237c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/5000000/4420000/4411700/4411601/98196436.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily buffet breakfast (USD 3 per person)](https://images.trvl-media.com/lodging/5000000/4420000/4411700/4411601/01834db8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/5000000/4420000/4411700/4411601/d89014ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Casona de Susana Colon 7.4/10 Good (25) "La propietaria respeta el precio acordado. En verano si usás más de 8 horas por día el aire acondicionado te cobran un plus." ![Argentina](https://a.travel-assets.com/egds/marks/flags/ar.svg) Marlene Ruth £36 2 Dec - 3 Dec [](https://www.expedia.co.uk/Colon-Hotels-La-Casona-De-Susana.h4411601.Hotel-Information) ![Premium bedding, pillow-top beds, individually decorated](https://images.trvl-media.com/lodging/100000000/99270000/99269400/99269311/9cad496d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/100000000/99270000/99269400/99269311/5f45ac2e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Duplex | Living area | 40-inch LED TV with cable channels, Netflix, streaming services](https://images.trvl-media.com/lodging/100000000/99270000/99269400/99269311/1eee7dc9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business Apartment | Private kitchen | Full-sized fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/100000000/99270000/99269400/99269311/3ee5dbf3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Agustín 1 Apart Parana 9.0/10 Wonderful (4) "Meu problema foi só a garagem, o apartamento é ótimo, limpeza estava impecável." ![Brazil](https://a.travel-assets.com/egds/marks/flags/br.svg) Jose rodrigo kallas £41 8 Dec - 9 Dec [](https://www.expedia.co.uk/Parana-Hotels-Agustin-1-Apart.h99269311.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/115000000/114110000/114109800/114109755/cb01ff56.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/115000000/114110000/114109800/114109755/a2d4eb00.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/115000000/114110000/114109800/114109755/0f7006fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/115000000/114110000/114109800/114109755/c1286a77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Intersur Colon Colón 10/10 Exceptional (2) "Letti molto comodi, belle piscine, personale gentile, pulizia buona, colazione buona. Ottimo rapporto qualità prezzo. " ![Italy](https://a.travel-assets.com/egds/marks/flags/it.svg) Francesco £67 9 Dec - 10 Dec [](https://www.expedia.co.uk/Colon-Hotels-Intersur-Colon.h114109755.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/34000000/33350000/33347000/33346911/ee9ad702.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/34000000/33350000/33347000/33346911/e70d9e85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property – evening/night](https://images.trvl-media.com/lodging/34000000/33350000/33347000/33346911/dd41bc20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free self-parking](https://images.trvl-media.com/lodging/34000000/33350000/33347000/33346911/00b851ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel y Spa Termas del Este Federacion 8.4/10 Very good (12) "good for a 1 night stay" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Chase [](https://www.expedia.co.uk/Federacion-Hotels-Hotel-Y-Spa-Termas-Del-Este.h33346911.Hotel-Information) ![Massages](https://images.trvl-media.com/lodging/97000000/96450000/96446000/96445971/bd533bb1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/97000000/96450000/96446000/96445971/433c57ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/97000000/96450000/96446000/96445971/1950856d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/97000000/96450000/96446000/96445971/d08855c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Howard Johnson Plaza La Ribera Resistencia 9.2/10 Wonderful (114) "Very good service. Spacious room. Excellent breakfast." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alberto [](https://www.expedia.co.uk/Resistencia-Hotels-Howard-Johnson-Plaza-La-Ribera.h96445971.Hotel-Information) ![Sauna, steam room, body treatments, hot stone massages, facials](https://images.trvl-media.com/lodging/4000000/3030000/3023900/3023891/891a8cb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Aerial view](https://images.trvl-media.com/lodging/4000000/3030000/3023900/3023891/3b6899cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Casino](https://images.trvl-media.com/lodging/4000000/3030000/3023900/3023891/6fa88a7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/4000000/3030000/3023900/3023891/4349e1ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pullman Rosario City Center Hotel Rosario 8.6/10 Excellent (272) "Nice" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) juan [](https://www.expedia.co.uk/Rosario-Hotels-Pullman-Rosario-City-Center-Hotel.h3023891.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-12-15&endDate=2025-12-16®ionId=6208836&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2025/11/05/BEX-BF-25_FR-DE-MX-UK_1_Desktop.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## Black Friday Sale Save up to 40% on select hotels. [Book now](https://expedia.co.uk/cheap-deals?rfrr=AFFINITY_BF_PROMO_6208836) ## Top Mesopotamia Hotel Reviews ![Club Valle Termal Resort](https://images.trvl-media.com/lodging/12000000/11880000/11876000/11875903/afd7d710_y.jpg) ### Club Valle Termal Resort 10/10 Excellent "La habitación estaba impecable, la limpieza de todo el complejo fue excelente, pero quiero destacar la atención de todo su personal, la disponibilidad constante para atender todas nuestras necesidades. Lo recomiendo y espero poder volver pronto." [](https://expedia.co.uk/Federacion-Hotels-Club-Valle-Termal-Resort.h11875903.Hotel-Information) ![Holiday Inn Express Rosario by IHG](https://images.trvl-media.com/lodging/4000000/3250000/3243000/3242923/502819d5_y.jpg) ### Holiday Inn Express Rosario by IHG 10/10 Excellent "This was really a wonderful place to stay. I highly recommend it." [](https://expedia.co.uk/Rosario-Hotels-Holiday-Inn-Express-Rosario.h3242923.Hotel-Information) ![Amérian Hotel Casino Gala](https://images.trvl-media.com/lodging/2000000/1200000/1197100/1197026/a75881f1_y.jpg) ### Amérian Hotel Casino Gala 10/10 Excellent "Great service and attention!. I highly recommend this hotel . " [](https://expedia.co.uk/Resistencia-Hotels-Amerian-Hotel-Casino-Gala.h1197026.Hotel-Information) ![Holiday Inn Rosario by IHG](https://images.trvl-media.com/lodging/1000000/580000/570400/570357/61653463_y.jpg) ### Holiday Inn Rosario by IHG 10/10 Excellent "Todo perfecto " [](https://expedia.co.uk/Rosario-Hotels-Holiday-Inn-Rosario.h570357.Hotel-Information) ![Wyndham Garden Campana](https://images.trvl-media.com/lodging/1000000/990000/983700/983698/1521535a_y.jpg) ### Wyndham Garden Campana 6/10 Okay "Televisor con problemas de funcionamiento. Ducha que baña todo el baño en lugar de ti. Ventana expuesta al paso de todo el público. " [](https://expedia.co.uk/Pilar-Hotels-Australis-Campana.h983698.Hotel-Information) ![Hathor Concordia](https://images.trvl-media.com/lodging/5000000/4670000/4668300/4668235/cc821f0d_y.jpg) ### Hathor Concordia 10/10 Excellent "Very clean room at affordable price. The dinning is of excellent quality at very reasonable price. The staff are quite friendly and helpful." [](https://expedia.co.uk/Concordia-Hotels-Hathor-Concordia.h4668235.Hotel-Information) ## Explore a world of travel with Expedia - More ways to book - [Book Spa Hotels in Mesopotamia on Expedia.com.ar](https://www.expedia.com.ar/Mesopotamia-Hoteles-Hotel-Con-Spa.0-0-d6208836-tHotelconspa.Guia-filtrada-de-Hoteles)