Title: TOP Luxury Hotels in Mesopotamia for 2025 - Mesopotamia Upscale Hotels | Expedia.co.uk [Mesopotamia Travel Guide](https://expedia.co.uk/Mesopotamia.dx6208836)[Hotels in Mesopotamia](https://expedia.co.uk/Mesopotamia-Hotels.d6208836.Travel-Guide-Hotels)[Holiday Rentals in Mesopotamia](https://expedia.co.uk/Mesopotamia-Holiday-Rentals.d6208836.Travel-Guide-HolidayRentals)[Flights to Mesopotamia](https://expedia.co.uk/Cheap-Flights-To-Mesopotamia.d6208836.Travel-Guide-Flights)[Mesopotamia Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Mesopotamia.d6208836.Car-Hire-Guide)[Mesopotamia Holidays](https://expedia.co.uk/Mesopotamia.d6208836.Holidays-City-Breaks) ![Mesopotamia showing a river or creek and forests](https://images.trvl-media.com/place/6208836/ca0c6990-9932-4f38-bee6-e89ce7080803.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find luxury hotels in Mesopotamia - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Mesopotamia Luxury Hotels Tonight [28 Nov - 29 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6208836&startDate=2025-11-28&endDate=2025-11-29&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [29 Nov - 30 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6208836&startDate=2025-11-29&endDate=2025-11-30&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [28 Nov - 30 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6208836&startDate=2025-11-28&endDate=2025-11-30&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [5 Dec - 7 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6208836&startDate=2025-12-05&endDate=2025-12-07&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Top Mesopotamia Luxury Hotels ![Outdoor pool, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/1000000/60000/53300/53288/7373d519.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Suite (Cataratas) | Hypo-allergenic bedding, free minibar, in-room safe, blackout curtains](https://images.trvl-media.com/lodging/1000000/60000/53300/53288/704bf94d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, Terrace | Hypo-allergenic bedding, free minibar, in-room safe, blackout curtains](https://images.trvl-media.com/lodging/1000000/60000/53300/53288/d7a9171c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, Terrace | Hypo-allergenic bedding, free minibar, in-room safe, blackout curtains](https://images.trvl-media.com/lodging/1000000/60000/53300/53288/56e76a76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel das Cataratas, A Belmond Hotel, Iguassu Falls Foz do Iguaçu 9.8/10 Exceptional (1015) "The staff were friendly, the views of the falls were wonderful, the food was delicious, and the room was comfortable." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Fatimah £667 includes taxes & fees 14 Dec - 15 Dec [](https://www.expedia.co.uk/Foz-Do-Iguacu-Hotels-Hotel-Das-Cataratas.h53288.Hotel-Information) ![Indoor pool, 3 outdoor pools, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/1000000/980000/979400/979370/afaaa032.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/1000000/980000/979400/979370/ecef832c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch, dinner served; international cuisine ](https://images.trvl-media.com/lodging/1000000/980000/979400/979370/7f654841.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/980000/979400/979370/680b507f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Iguazu Grand Resort Spa & Casino Puerto Iguazú 9.0/10 Wonderful (585) "It is an excellent place to stay on vacation. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kelly £182 9 Dec - 10 Dec [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-Iguazu-Grand-Resort-Spa-Casino.h979370.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/460000/454100/454059/596c9ef3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 restaurants, breakfast, lunch, dinner served; international cuisine ](https://images.trvl-media.com/lodging/1000000/460000/454100/454059/bc2da393.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/1000000/460000/454100/454059/176949a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/1000000/460000/454100/454059/78c20d2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Gran Melia Iguazú Puerto Iguazú 9.2/10 Wonderful (1008) "Breakfast was great" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) DONALD £491 14 Dec - 15 Dec [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-Gran-Melia-Iguazu.h454059.Hotel-Information) ![2 outdoor pools, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/3000000/2460000/2450100/2450070/f6b00076.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2460000/2450100/2450070/f319948a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Double Room | Living area | 40-inch LED TV with cable channels, TV, pay films](https://images.trvl-media.com/lodging/3000000/2460000/2450100/2450070/19c30028.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Poolside bar](https://images.trvl-media.com/lodging/3000000/2460000/2450100/2450070/32c235b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Loi Suites Iguazú Hotel Puerto Iguazú 9.2/10 Wonderful (1002) "Rooms were spotless, location excellent, staff friendly." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael £209 2 Dec - 3 Dec [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-Loi-Suites-Iguazu-Hotel.h2450070.Hotel-Information) ![Minibar, in-room safe, desk, blackout curtains](https://images.trvl-media.com/lodging/4000000/3030000/3021000/3020960/82a469cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 outdoor pools](https://images.trvl-media.com/lodging/4000000/3030000/3021000/3020960/w1600h893x0y175-428a2ff8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Villa | Minibar, in-room safe, desk, blackout curtains](https://images.trvl-media.com/lodging/4000000/3030000/3021000/3020960/2e24b1c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/4000000/3030000/3021000/3020960/899bc322.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Reserva Virgin Lodge Puerto Iguazú 8.4/10 Very good (801) "Good breakfast, lots of places to sit and enjoy the day, good pool and attentive staff!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Adrian £90 8 Dec - 9 Dec [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-La-Cantera-Lodge-De-Selva-By-DON.h3020960.Hotel-Information) ![Outdoor pool, open 9:00 AM to 9:00 PM, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/4000000/3290000/3281500/3281425/260f31f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, down duvets, minibar, in-room safe](https://images.trvl-media.com/lodging/4000000/3290000/3281500/3281425/b63c0178.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/4000000/3290000/3281500/3281425/c58f50d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sauna, hot tub, steam room, body treatments, body scrubs, facials](https://images.trvl-media.com/lodging/4000000/3290000/3281500/3281425/660d3f9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Saint George Puerto Iguazú 8.8/10 Excellent (1016) "Location was fantastic for walking to restaurants!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lee £76 1 Dec - 2 Dec [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-Hotel-Saint-George.h3281425.Hotel-Information) ![Couples treatment room(s), sauna, steam room, body treatments](https://images.trvl-media.com/lodging/2000000/1830000/1829100/1829043/6394d862.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee shop](https://images.trvl-media.com/lodging/2000000/1830000/1829100/1829043/2e3f5e26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/2000000/1830000/1829100/1829043/5439a1a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Couples treatment room(s), sauna, steam room, body treatments](https://images.trvl-media.com/lodging/2000000/1830000/1829100/1829043/3e2fe331.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Panoramic Grand Puerto Iguazú 8.6/10 Excellent (631) "Room was spotless and staff was very helpfull." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jaime Ricardo £155 1 Dec - 2 Dec [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-Panoramic-Grand.h1829043.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/5000000/4050000/4041500/4041467/ab7cf242.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/5000000/4050000/4041500/4041467/01e96b7c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/5000000/4050000/4041500/4041467/544e495f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sun deck](https://images.trvl-media.com/lodging/5000000/4050000/4041500/4041467/c8e2d18f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Marcopolo Suites Iguazu Puerto Iguazú 6.6/10 (321) "Clean, and close to the center of the city." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rodolfo [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-Marcopolo-Suites-Iguazu.h4041467.Hotel-Information) ![Outdoor pool, open 9 AM to 7 PM, pool loungers](https://images.trvl-media.com/lodging/4000000/3470000/3469400/3469387/298f1619.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Double Room | View from room](https://images.trvl-media.com/lodging/4000000/3470000/3469400/3469387/06851dcf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dinner served, Argentinean cuisine, pool views ](https://images.trvl-media.com/lodging/4000000/3470000/3469400/3469387/5d6cd34f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor spa tub](https://images.trvl-media.com/lodging/4000000/3470000/3469400/3469387/714d6028.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Boutique Hotel Delafonte Puerto Iguazú 8.6/10 Excellent (364) "Great location, good restaurant, nice pools, very responsive staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jennifer [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-Boutique-Hotel-De-La-Fonte.h3469387.Hotel-Information) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/4000000/3240000/3235000/3234974/1b8fea71.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (Ñande Roga) | 1 bedroom, premium bedding, down duvets, minibar](https://images.trvl-media.com/lodging/4000000/3240000/3235000/3234974/85070960.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/4000000/3240000/3235000/3234974/587c4eb7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/4000000/3240000/3235000/3234974/9d219c15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Aldea de la Selva Lodge Puerto Iguazú 8.8/10 Excellent (501) "Breakfast was mediocre " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gladies £71 14 Dec - 15 Dec [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-La-Aldea-De-La-Selva-Lodge.h3234974.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-12-12&endDate=2025-12-13®ionId=6208836&adults=2&star=50&sort=RECOMMENDED&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2025/11/05/BEX-BF-25_FR-DE-MX-UK_1_Desktop.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## Black Friday Sale Save up to 40% on select hotels. [Book now](https://expedia.co.uk/cheap-deals?rfrr=AFFINITY_BF_PROMO_6208836) ## Find out more about Mesopotamia ### Mesopotamiaand its attractions for luxury travelers Mesopotamia, Argentina, is a hidden gem for luxury travellers seeking both adventure and comfort. A visit to the stunning Ibera Wetlands offers the chance to witness extraordinary biodiversity, where you can arrange private guided tours to spot caimans, capybaras, and an array of exotic birds, all while enjoying a gourmet picnic amidst nature. The cultural richness of the region is evident in the charming town of Mercedes, where you can indulge in exclusive wine tastings at local vineyards known for their exquisite Malbecs, paired perfectly with delicious regional cuisine prepared by renowned chefs. For those interested in history, the archaeological site of San Ignacio Mini showcases the impressive Jesuit ruins, providing a fascinating glimpse into the past, complemented by a luxurious stay at nearby boutique hotels offering personalised service and modern amenities. The lush landscapes and tranquil rivers offer opportunities for private yacht excursions, where you can relax with champagne while soaking in the breathtaking scenery, providing a perfect blend of relaxation and exploration. For an ultimate experience, consider staying in the upscale lodges in the heart of the wetlands, where plush accommodations and attentive staff ensure you are pampered throughout your stay. ## Top Mesopotamia Hotel Reviews ## Explore a world of travel with Expedia - More ways to book - [Book Luxury Hotels in Mesopotamia on Expedia.com.ar](https://www.expedia.com.ar/Mesopotamia-Hoteles-Hotel-De-Lujo.0-0-d6208836-tHoteldelujo.Guia-filtrada-de-Hoteles)