Title: TOP Luxury Hotels in Mesopotamia for 2026 - Mesopotamia Upscale Hotels | Expedia.co.uk [Mesopotamia Travel Guide](https://expedia.co.uk/Mesopotamia.dx6208836)[Hotels in Mesopotamia](https://expedia.co.uk/Mesopotamia-Hotels.d6208836.Travel-Guide-Hotels)[Holiday Rentals in Mesopotamia](https://expedia.co.uk/Mesopotamia-Holiday-Rentals.d6208836.Travel-Guide-HolidayRentals)[Flights to Mesopotamia](https://expedia.co.uk/Cheap-Flights-To-Mesopotamia.d6208836.Travel-Guide-Flights)[Mesopotamia Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Mesopotamia.d6208836.Car-Hire-Guide)[Mesopotamia Holidays](https://expedia.co.uk/Mesopotamia.d6208836.Holidays-City-Breaks) ![Mesopotamia showing a river or creek and forests](https://images.trvl-media.com/place/6208836/ca0c6990-9932-4f38-bee6-e89ce7080803.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6208836/ca0c6990-9932-4f38-bee6-e89ce7080803.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Mesopotamia Luxury Hotels Tonight [12 Jan - 13 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6208836&startDate=2026-01-12&endDate=2026-01-13&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [13 Jan - 14 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6208836&startDate=2026-01-13&endDate=2026-01-14&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [16 Jan - 18 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6208836&startDate=2026-01-16&endDate=2026-01-18&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [23 Jan - 25 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6208836&startDate=2026-01-23&endDate=2026-01-25&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Our top choices for Mesopotamia luxury hotels ![Suite, Terrace | Hypo-allergenic bedding, free minibar, in-room safe, blackout curtains](https://images.trvl-media.com/lodging/1000000/60000/53300/53288/3fe012c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, Terrace | Hypo-allergenic bedding, free minibar, in-room safe, blackout curtains](https://images.trvl-media.com/lodging/1000000/60000/53300/53288/56e76a76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Children’s activities](https://images.trvl-media.com/lodging/1000000/60000/53300/53288/11bcbc9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/60000/53300/53288/d9f65657.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel das Cataratas, A Belmond Hotel, Iguassu Falls [](https://www.expedia.co.uk/Foz-Do-Iguacu-Hotels-Hotel-Das-Cataratas.h53288.Hotel-Information) Foz do Iguaçu 9.8/10 Exceptional (1,001 reviews) "Perfect location and very attentive service, espacios and comfortable rooms " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Oslay £657 includes taxes & fees 5 Feb - 6 Feb [](https://www.expedia.co.uk/Foz-Do-Iguacu-Hotels-Hotel-Das-Cataratas.h53288.Hotel-Information) ![Indoor pool, 3 outdoor pools, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/1000000/980000/979400/979370/afaaa032.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Couples treatment room(s), sauna, hot tub, steam room, body treatments](https://images.trvl-media.com/lodging/1000000/980000/979400/979370/3de28959.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor spa tub](https://images.trvl-media.com/lodging/1000000/980000/979400/979370/83cafc92.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch, dinner served; international cuisine ](https://images.trvl-media.com/lodging/1000000/980000/979400/979370/7f654841.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Iguazu Grand Resort Spa & Casino [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-Iguazu-Grand-Resort-Spa-Casino.h979370.Hotel-Information) Puerto Iguazú 9.0/10 Wonderful (599 reviews) "Big rooms Friendly and respectful staff Loved our stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Amin £255 13 Jan - 14 Jan [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-Iguazu-Grand-Resort-Spa-Casino.h979370.Hotel-Information) ![Private pool](https://images.trvl-media.com/lodging/1000000/460000/454100/454059/c43a985d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/1000000/460000/454100/454059/6d489a21.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Aerial view](https://images.trvl-media.com/lodging/1000000/460000/454100/454059/1551ab16.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/1000000/460000/454100/454059/3d04f2c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Gran Melia Iguazú [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-Gran-Melia-Iguazu.h454059.Hotel-Information) Puerto Iguazú 9.2/10 Wonderful (1,003 reviews) "Great hotel, great service, great location. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Adriana £595 5 Feb - 6 Feb [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-Gran-Melia-Iguazu.h454059.Hotel-Information) ![2 outdoor pools, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/3000000/2460000/2450100/2450070/71380e56.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Villa | Bathroom | Separate bathtub and shower, rainfall showerhead, designer toiletries](https://images.trvl-media.com/lodging/3000000/2460000/2450100/2450070/d0267182.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Villa | Balcony](https://images.trvl-media.com/lodging/3000000/2460000/2450100/2450070/bc8a5aa3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/3000000/2460000/2450100/2450070/d73ef262.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Loi Suites Iguazú Hotel [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-Loi-Suites-Iguazu-Hotel.h2450070.Hotel-Information) Puerto Iguazú 9.2/10 Wonderful (1,005 reviews) "The room was spotless. The pools were amazing and the staff was friendly." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kathryn £243 8 Feb - 9 Feb [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-Loi-Suites-Iguazu-Hotel.h2450070.Hotel-Information) ![Minibar, in-room safe, desk, blackout curtains](https://images.trvl-media.com/lodging/4000000/3030000/3021000/3020960/82a469cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Studio Suite | Minibar, in-room safe, desk, blackout curtains](https://images.trvl-media.com/lodging/4000000/3030000/3021000/3020960/cf5dfc79.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/4000000/3030000/3021000/3020960/899bc322.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Villa | Bathroom | Free toiletries, hair dryer, bidet, towels](https://images.trvl-media.com/lodging/4000000/3030000/3021000/3020960/3ac32bd1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Reserva Virgin Lodge [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-La-Cantera-Lodge-De-Selva-By-DON.h3020960.Hotel-Information) Puerto Iguazú 8.4/10 Very good (809 reviews) "The hotel is in great shape in the middle of the jungle, the staff was very helpful. We booked their new years dinner, it was great food! We really enjoyed our stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ivan £147 14 Jan - 15 Jan [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-La-Cantera-Lodge-De-Selva-By-DON.h3020960.Hotel-Information) ![Outdoor pool, open 9:00 AM to 9:00 PM, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/4000000/3290000/3281500/3281425/260f31f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/4000000/3290000/3281500/3281425/7644a18e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/4000000/3290000/3281500/3281425/71461004.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/4000000/3290000/3281500/3281425/a8f544ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Saint George [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-Hotel-Saint-George.h3281425.Hotel-Information) Puerto Iguazú 8.8/10 Excellent (1,006 reviews) "The breakfast was really good!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Shinji £96 18 Jan - 19 Jan [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-Hotel-Saint-George.h3281425.Hotel-Information) ![Couples treatment room(s), sauna, steam room, body treatments](https://images.trvl-media.com/lodging/2000000/1830000/1829100/1829043/6394d862.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/2000000/1830000/1829100/1829043/1cddc3b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1830000/1829100/1829043/21b8d40a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Couples treatment room(s), sauna, steam room, body treatments](https://images.trvl-media.com/lodging/2000000/1830000/1829100/1829043/3e2fe331.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Panoramic Grand [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-Panoramic-Grand.h1829043.Hotel-Information) Puerto Iguazú 8.8/10 Excellent (634 reviews) "Friendly staff great breakfast amazing views, location near town " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Stefania [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-Panoramic-Grand.h1829043.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/5000000/4050000/4041500/4041467/ab97ae19.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Triple Room | In-room safe, bed sheets](https://images.trvl-media.com/lodging/5000000/4050000/4041500/4041467/f17b57e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/5000000/4050000/4041500/4041467/9788b105.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/5000000/4050000/4041500/4041467/544e495f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Marcopolo Suites Iguazu [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-Marcopolo-Suites-Iguazu.h4041467.Hotel-Information) Puerto Iguazú 6.6/10 (324 reviews) "Clean, and close to the center of the city." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rodolfo [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-Marcopolo-Suites-Iguazu.h4041467.Hotel-Information) ![Outdoor pool, open 9 AM to 7 PM, pool loungers](https://images.trvl-media.com/lodging/4000000/3470000/3469400/3469387/ca10ddeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Double Room | Minibar, in-room safe, blackout curtains, free WiFi](https://images.trvl-media.com/lodging/4000000/3470000/3469400/3469387/d7c44803.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite | Minibar, in-room safe, blackout curtains, free WiFi](https://images.trvl-media.com/lodging/4000000/3470000/3469400/3469387/678479c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dinner served, Argentinean cuisine, pool views ](https://images.trvl-media.com/lodging/4000000/3470000/3469400/3469387/5d6cd34f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Boutique Hotel Delafonte [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-Boutique-Hotel-De-La-Fonte.h3469387.Hotel-Information) Puerto Iguazú 8.6/10 Excellent (364 reviews) "Great location, good restaurant, nice pools, very responsive staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jennifer [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-Boutique-Hotel-De-La-Fonte.h3469387.Hotel-Information) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/4000000/3240000/3235000/3234974/7e00f6e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/4000000/3240000/3235000/3234974/w701h880x0y1-5fc078d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/4000000/3240000/3235000/3234974/787572d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/4000000/3240000/3235000/3234974/024260d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Aldea de la Selva Lodge [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-La-Aldea-De-La-Selva-Lodge.h3234974.Hotel-Information) Puerto Iguazú 8.8/10 Excellent (521 reviews) "Authentic jungle stay with well maintained facilities and beautiful scenery. Rooms are ample and in great working condition. Best price-quality ratio in the area!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Maximo £100 13 Jan - 14 Jan [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-La-Aldea-De-La-Selva-Lodge.h3234974.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-01-26&endDate=2026-01-27®ionId=6208836&adults=2&star=50&sort=RECOMMENDED&openPlayBack=true) ## Find out more about Mesopotamia ### Mesopotamiaand its attractions for luxury travelers Mesopotamia, Argentina, is a hidden gem for luxury travellers seeking both adventure and comfort. A visit to the stunning Ibera Wetlands offers the chance to witness extraordinary biodiversity, where you can arrange private guided tours to spot caimans, capybaras, and an array of exotic birds, all while enjoying a gourmet picnic amidst nature. The cultural richness of the region is evident in the charming town of Mercedes, where you can indulge in exclusive wine tastings at local vineyards known for their exquisite Malbecs, paired perfectly with delicious regional cuisine prepared by renowned chefs. For those interested in history, the archaeological site of San Ignacio Mini showcases the impressive Jesuit ruins, providing a fascinating glimpse into the past, complemented by a luxurious stay at nearby boutique hotels offering personalised service and modern amenities. The lush landscapes and tranquil rivers offer opportunities for private yacht excursions, where you can relax with champagne while soaking in the breathtaking scenery, providing a perfect blend of relaxation and exploration. For an ultimate experience, consider staying in the upscale lodges in the heart of the wetlands, where plush accommodations and attentive staff ensure you are pampered throughout your stay. ## Top Mesopotamia Hotel Reviews ## Explore a world of travel with Expedia - More ways to book - [Book Luxury Hotels in Mesopotamia on Expedia.com.ar ](https://www.expedia.com.ar/Mesopotamia-Hoteles-Hotel-De-Lujo.0-0-d6208836-tHoteldelujo.Guia-filtrada-de-Hoteles)