Title: TOP Luxury Hotels in Mesopotamia for 2025 - Mesopotamia Upscale Hotels | Expedia.co.uk [Mesopotamia Travel Guide](https://expedia.co.uk/Mesopotamia.dx6208836)[Hotels in Mesopotamia](https://expedia.co.uk/Mesopotamia-Hotels.d6208836.Travel-Guide-Hotels)[Holiday Rentals in Mesopotamia](https://expedia.co.uk/Mesopotamia-Holiday-Rentals.d6208836.Travel-Guide-HolidayRentals)[Flights to Mesopotamia](https://expedia.co.uk/Cheap-Flights-To-Mesopotamia.d6208836.Travel-Guide-Flights)[Mesopotamia Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Mesopotamia.d6208836.Car-Hire-Guide)[Mesopotamia Holidays](https://expedia.co.uk/Mesopotamia.d6208836.Holidays-City-Breaks) ![Mesopotamia showing forest scenes](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/196000/196542-Mesopotamia.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find luxury hotels in Mesopotamia ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Mesopotamia Luxury Hotels Tonight [12 Oct - 13 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6208836&startDate=2025-10-12&endDate=2025-10-13&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [13 Oct - 14 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6208836&startDate=2025-10-13&endDate=2025-10-14&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [17 Oct - 19 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6208836&startDate=2025-10-17&endDate=2025-10-19&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [24 Oct - 26 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6208836&startDate=2025-10-24&endDate=2025-10-26&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Mesopotamia Luxury Hotels ![Outdoor pool, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/1000000/60000/53300/53288/7373d519.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, Terrace | Hypo-allergenic bedding, free minibar, in-room safe, blackout curtains](https://images.trvl-media.com/lodging/1000000/60000/53300/53288/56e76a76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, Terrace | Hypo-allergenic bedding, free minibar, in-room safe, blackout curtains](https://images.trvl-media.com/lodging/1000000/60000/53300/53288/d7a9171c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Suite (Cataratas) | Hypo-allergenic bedding, free minibar, in-room safe, blackout curtains](https://images.trvl-media.com/lodging/1000000/60000/53300/53288/704bf94d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel das Cataratas, A Belmond Hotel, Iguassu Falls Foz do Iguaçu 9.8/10 Exceptional (1007) "great breakfast and pool area" £639 includes taxes & fees 15 Oct - 16 Oct [](https://www.expedia.co.uk/Foz-Do-Iguacu-Hotels-Hotel-Das-Cataratas.h53288.Hotel-Information) ![Indoor pool, 3 outdoor pools, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/1000000/980000/979400/979370/afaaa032.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/1000000/980000/979400/979370/ecef832c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/980000/979400/979370/680b507f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch, dinner served; international cuisine ](https://images.trvl-media.com/lodging/1000000/980000/979400/979370/7f654841.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Iguazu Grand Resort Spa & Casino Puerto Iguazú 9.0/10 Wonderful (566) "Excellent place , will come back." £281 13 Oct - 14 Oct [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-Iguazu-Grand-Resort-Spa-Casino.h979370.Hotel-Information) ![2 outdoor pools, open 9:00 AM to 8:00 PM, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/1000000/460000/454100/454059/2ab2ddf5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Snack bar](https://images.trvl-media.com/lodging/1000000/460000/454100/454059/d4717a4a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 2 Single Beds (Waterfal View) | 1 bedroom, Egyptian cotton sheets, premium bedding, down duvets](https://images.trvl-media.com/lodging/1000000/460000/454100/454059/a8a3224c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/460000/454100/454059/756174db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Gran Melia Iguazú Puerto Iguazú 9.2/10 Wonderful (1005) "views are beautiful, staff were very nice and attentive. wonderful stay" £432 17 Oct - 18 Oct [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-Gran-Melia-Iguazu.h454059.Hotel-Information) ![2 outdoor pools, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/3000000/2460000/2450100/2450070/f6b00076.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/3000000/2460000/2450100/2450070/434e4bbb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Poolside bar](https://images.trvl-media.com/lodging/3000000/2460000/2450100/2450070/32c235b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Double Room | Living area | 40-inch LED TV with cable channels, TV, pay films](https://images.trvl-media.com/lodging/3000000/2460000/2450100/2450070/19c30028.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Loi Suites Iguazú Hotel Puerto Iguazú 9.2/10 Wonderful (1002) "We liked the jungle surroundings and the swimming pools" £206 28 Oct - 29 Oct [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-Loi-Suites-Iguazu-Hotel.h2450070.Hotel-Information) ![1 bedroom, minibar, in-room safe, desk](https://images.trvl-media.com/lodging/4000000/3030000/3021000/3020960/82a469cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Villa | 1 bedroom, minibar, in-room safe, desk](https://images.trvl-media.com/lodging/4000000/3030000/3021000/3020960/2e24b1c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, minibar, in-room safe, desk](https://images.trvl-media.com/lodging/4000000/3030000/3021000/3020960/3fdaf0a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 outdoor pools](https://images.trvl-media.com/lodging/4000000/3030000/3021000/3020960/w1600h893x0y175-428a2ff8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Reserva Virgin Lodge Puerto Iguazú 8.4/10 Very good (794) "Great place to stay " [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-La-Cantera-Lodge-De-Selva-By-DON.h3020960.Hotel-Information) ![Outdoor pool, open 9:00 AM to 9:00 PM, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/4000000/3290000/3281500/3281425/260f31f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, down duvets, minibar, in-room safe](https://images.trvl-media.com/lodging/4000000/3290000/3281500/3281425/b63c0178.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sauna, hot tub, steam room, body treatments, body scrubs, facials](https://images.trvl-media.com/lodging/4000000/3290000/3281500/3281425/660d3f9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, down duvets, minibar, in-room safe](https://images.trvl-media.com/lodging/4000000/3290000/3281500/3281425/acc4e956.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Saint George Puerto Iguazú 8.8/10 Excellent (1001) "I appreciated that they held my luggage after I checked out and provided me a place to change clothes after my day at the Falls. They were also very nice about arranging a taxi to the airport." £102 17 Oct - 18 Oct [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-Hotel-Saint-George.h3281425.Hotel-Information) ![Couples treatment room(s), sauna, steam room, body treatments](https://images.trvl-media.com/lodging/2000000/1830000/1829100/1829043/6394d862.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Couples treatment room(s), sauna, steam room, body treatments](https://images.trvl-media.com/lodging/2000000/1830000/1829100/1829043/3e2fe331.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee shop](https://images.trvl-media.com/lodging/2000000/1830000/1829100/1829043/2e3f5e26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/2000000/1830000/1829100/1829043/5439a1a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Panoramic Grand Puerto Iguazú 8.6/10 Excellent (624) "AWESOME EXPERIENCE!!" £227 13 Oct - 14 Oct [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-Panoramic-Grand.h1829043.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/5000000/4050000/4041500/4041467/ab7cf242.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/5000000/4050000/4041500/4041467/544e495f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sun deck](https://images.trvl-media.com/lodging/5000000/4050000/4041500/4041467/c8e2d18f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/5000000/4050000/4041500/4041467/c0543df1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Marcopolo Suites Iguazu Puerto Iguazú 6.6/10 (321) "Clean, and close to the center of the city." [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-Marcopolo-Suites-Iguazu.h4041467.Hotel-Information) ![Outdoor pool, open 9 AM to 7 PM, pool loungers](https://images.trvl-media.com/lodging/4000000/3470000/3469400/3469387/298f1619.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dinner served, Argentinean cuisine, pool views ](https://images.trvl-media.com/lodging/4000000/3470000/3469400/3469387/5d6cd34f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor spa tub](https://images.trvl-media.com/lodging/4000000/3470000/3469400/3469387/714d6028.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fountain](https://images.trvl-media.com/lodging/4000000/3470000/3469400/3469387/863c7686.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Boutique Hotel Delafonte Puerto Iguazú 8.6/10 Excellent (364) "Great location, good restaurant, nice pools, very responsive staff." [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-Boutique-Hotel-De-La-Fonte.h3469387.Hotel-Information) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/4000000/3240000/3235000/3234974/1b8fea71.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/4000000/3240000/3235000/3234974/587c4eb7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (Ñande Roga) | 1 bedroom, premium bedding, down duvets, minibar](https://images.trvl-media.com/lodging/4000000/3240000/3235000/3234974/85070960.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/4000000/3240000/3235000/3234974/12e6da34.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Aldea de la Selva Lodge Puerto Iguazú 8.8/10 Excellent (490) "We loved our stay. The Aldea went beyond our expectations! We highly recommend!" £96 28 Oct - 29 Oct [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-La-Aldea-De-La-Selva-Lodge.h3234974.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-10-26&endDate=2025-10-27®ionId=6208836&adults=2&star=50&sort=RECOMMENDED&openPlayBack=true) ## Find out more about Mesopotamia ### Mesopotamiaand its attractions for luxury travelers Mesopotamia, Argentina, is a hidden gem for luxury travellers seeking both adventure and comfort. A visit to the stunning Ibera Wetlands offers the chance to witness extraordinary biodiversity, where you can arrange private guided tours to spot caimans, capybaras, and an array of exotic birds, all while enjoying a gourmet picnic amidst nature. The cultural richness of the region is evident in the charming town of Mercedes, where you can indulge in exclusive wine tastings at local vineyards known for their exquisite Malbecs, paired perfectly with delicious regional cuisine prepared by renowned chefs. For those interested in history, the archaeological site of San Ignacio Mini showcases the impressive Jesuit ruins, providing a fascinating glimpse into the past, complemented by a luxurious stay at nearby boutique hotels offering personalised service and modern amenities. The lush landscapes and tranquil rivers offer opportunities for private yacht excursions, where you can relax with champagne while soaking in the breathtaking scenery, providing a perfect blend of relaxation and exploration. For an ultimate experience, consider staying in the upscale lodges in the heart of the wetlands, where plush accommodations and attentive staff ensure you are pampered throughout your stay. ## Top Mesopotamia Hotel Reviews ## Explore a world of travel with Expedia - More ways to book - [Book Luxury Hotels in Mesopotamia on Expedia.com.ar](https://www.expedia.com.ar/Mesopotamia-Hoteles-Hotel-De-Lujo.0-0-d6208836-tHoteldelujo.Guia-filtrada-de-Hoteles)