Title: TOP Adults Only Resorts & Hotels in Mesopotamia for 2025 | Expedia.co.uk [Mesopotamia Travel Guide](https://expedia.co.uk/Mesopotamia.dx6208836)[Hotels in Mesopotamia](https://expedia.co.uk/Mesopotamia-Hotels.d6208836.Travel-Guide-Hotels)[Holiday Rentals in Mesopotamia](https://expedia.co.uk/Mesopotamia-Holiday-Rentals.d6208836.Travel-Guide-HolidayRentals)[Flights to Mesopotamia](https://expedia.co.uk/Cheap-Flights-To-Mesopotamia.d6208836.Travel-Guide-Flights)[Mesopotamia Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Mesopotamia.d6208836.Car-Hire-Guide)[Mesopotamia Holidays](https://expedia.co.uk/Mesopotamia.d6208836.Holidays-City-Breaks) ![Mesopotamia showing forest scenes](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/196000/196542-Mesopotamia.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Search Adults Only Resorts & Hotels in Mesopotamia ![price find illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Mesopotamia Adults Only Resorts & Hotels Tonight [25 Sept - 26 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=6208836&startDate=2025-09-25&endDate=2025-09-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [26 Sept - 27 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=6208836&startDate=2025-09-26&endDate=2025-09-27&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [26 Sept - 28 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=6208836&startDate=2025-09-26&endDate=2025-09-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [3 Oct - 5 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6208836&startDate=2025-10-03&endDate=2025-10-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Mesopotamia Adults Only Resorts & Hotels ![Balcony](https://images.trvl-media.com/lodging/9000000/8200000/8195100/8195029/26da2558.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Marina](https://images.trvl-media.com/lodging/9000000/8200000/8195100/8195029/bd5a059b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/9000000/8200000/8195100/8195029/be460183.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/9000000/8200000/8195100/8195029/15b1f4a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Estancia Río de las Aves Ceibas [](https://www.expedia.co.uk/Ceibas-Hotels-Estancia-Rio-De-Las-Aves.h8195029.Hotel-Information) ![Outdoor pool, pool loungers](https://images.trvl-media.com/lodging/17000000/16380000/16373700/16373631/9dda69ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Double Room | Iron/ironing board, rollaway beds, free WiFi, bed sheets](https://images.trvl-media.com/lodging/17000000/16380000/16373700/16373631/3edd55be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/17000000/16380000/16373700/16373631/a099c031.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/17000000/16380000/16373700/16373631/d19f627d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Beer Hotel Iguazu - Hostel Puerto Iguazú 7.6/10 Good (91) " Awesome!! The fusion between hotel and brewery is great. Very comfortable rooms and excellent beers and food. I recommend it!!!!!!" £34 28 Sept - 29 Sept [](https://www.expedia.co.uk/Puerto-Iguazu-Hotels-Beer-Hotel-Iguazu.h16373631.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-10-09&endDate=2025-10-10®ionId=6208836&adults=2&travelerType=adults_only&sort=RECOMMENDED&openPlayBack=true) ## Find out more about Mesopotamia ### Discover top Mesopotamia attractions Mesopotamia, Argentina, offers a rich tapestry of experiences that cater perfectly to the adventurous family. Begin your journey at the stunning Iguazú Falls, where the sheer power of nature is on display; take a boat ride to feel the mist and marvel at the breathtaking views. For a taste of the local wildlife, visit the Iberá Wetlands, a biodiversity hotspot where you can spot capybaras, caimans, and a variety of bird species while enjoying a guided kayak tour through the tranquil waters. Culture enthusiasts will appreciate the charming town of San Ignacio Mini, home to the ruins of a Jesuit mission that provide a fascinating glimpse into Argentina's historic history. Don't miss the chance to explore the lush landscapes of the Yabotí Biosphere Reserve, perfect for hiking and discovering the region's unique flora and fauna. Finally, unwind in the picturesque town of El Soberbio, famous for its scenic views of the Uruguay River and the surrounding hills. This area offers a range of comfortable hotels and lodges, many equipped with attentive service and family-friendly amenities, ensuring you can relax after your daily adventures. With Mesopotamia's blend of natural wonders and cultural experiences, your family will create unforgettable memories together. ## Top Mesopotamia Hotel Reviews