Title: TOP Adults Only Resorts & Hotels in Mesilla, NM for 2025 | Expedia.co.uk [Hotels in Mesilla](https://expedia.co.uk/Mesilla-Hotels.d132684.Travel-Guide-Hotels)[Holiday Rentals in Mesilla](https://expedia.co.uk/Mesilla-Holiday-Rentals.d132684.Travel-Guide-HolidayRentals)[Mesilla Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Mesilla.d132684.Car-Hire-Guide)[Mesilla Holidays](https://expedia.co.uk/Mesilla.d132684.Holidays-City-Breaks) ![](https://mediaim.expedia.com/destination/2/249a9bad94be11a6d3feebf081ee28b9.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Lane # Search Adults Only Resorts & Hotels in Mesilla ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Mesilla Adults Only Resorts & Hotels Tonight [14 Oct - 15 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=132684&startDate=2025-10-14&endDate=2025-10-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [15 Oct - 16 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=132684&startDate=2025-10-15&endDate=2025-10-16&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [17 Oct - 19 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=132684&startDate=2025-10-17&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [24 Oct - 26 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=132684&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Mesilla Adults Only Resorts & Hotels We don't have any properties that match your exact search [See all properties in Mesilla](https://expedia.co.uk/Hotel-Search?startDate=2025-10-28&endDate=2025-10-29®ionId=132684&adults=2) ## Recommended hotels in Mesilla ![Outdoor dining](https://images.trvl-media.com/lodging/34000000/33740000/33734400/33734305/6c9ad3e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/34000000/33740000/33734400/33734305/1aae16a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/34000000/33740000/33734400/33734305/68dfdf11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/34000000/33740000/33734400/33734305/3d1fb213.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Charming Casita in historic Town of Mesilla, NM 2392 Calle de Parian Mesilla 10/10 Exceptional (81) "Clean and as advertised, would stay again " £173 includes taxes & fees 19 Oct - 20 Oct [](https://www.expedia.co.uk/Mesilla-Hotels-Charming-Casita-In-Historic-Town-Of-Mesilla.h33734305.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/108000000/107490000/107488900/107488849/122cbe77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/108000000/107490000/107488900/107488849/d45d0acb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/108000000/107490000/107488900/107488849/dca76153.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/108000000/107490000/107488900/107488849/w1091h818x0y38-4b795423.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Josefina's King Suite in Historic Old Mesilla Plaza. Mesilla 9.8/10 Exceptional (19) "My husband and I love staying at Josephina’s! It’s comfy, close to shopping and dining. " £128 includes taxes & fees 2 Nov - 3 Nov [](https://www.expedia.co.uk/Mesilla-Hotels-Josefinas-King-Suite-In-Historic-Old-Mesilla-Plaza.h107488849.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/80000/75400/75365/62ae9c45.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free continental breakfast ](https://images.trvl-media.com/lodging/1000000/80000/75400/75365/74e32868.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed, Non Smoking (Executive, Mountain/Pool View) | Premium bedding, desk, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/80000/75400/75365/5579b7c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/80000/75400/75365/8d313d50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain Las Cruces 8.2/10 Very good (2280) "Good place to stay with plenty of food and market options with in walking distances." £52 includes taxes & fees 22 Oct - 23 Oct [](https://www.expedia.co.uk/Las-Cruces-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Las-Cruces-Organ-Mountain.h75365.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15100/15035/4e26c2df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/15100/15035/89306788.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/20000/15100/15035/dc33242f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic Area](https://images.trvl-media.com/lodging/1000000/20000/15100/15035/b4a415ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Las Cruces Las Cruces 8.2/10 Very good (1238) "Clean rooms convenient location and welcomes.pets!" £44 includes taxes & fees 29 Oct - 30 Oct [](https://www.expedia.co.uk/Las-Cruces-Hotels-Days-Inn-By-Wyndham-Las-Cruces.h15035.Hotel-Information) ![Business centre](https://images.trvl-media.com/lodging/1000000/30000/20600/20506/90d9a325.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/20600/20506/269dd61d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/20600/20506/b11dfff8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Non Smoking, Refrigerator & Microwave | In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/30000/20600/20506/c6ba58b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Mission Inn Las Cruces 8.8/10 Excellent (1214) "Good location between downtown Las Cruces and Mesilla. " £70 includes taxes & fees 16 Oct - 17 Oct [](https://www.expedia.co.uk/Las-Cruces-Hotels-Best-Western-Mission-Inn.h20506.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/2000000/1730000/1723300/1723204/0bffe062.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1730000/1723300/1723204/affa980e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/2000000/1730000/1723300/1723204/68a7ba44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed with Sofa bed, Refrigerator & Microwave (2 Rooms, Terrace) | 1 bedroom, desk, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/2000000/1730000/1723300/1723204/1cbb8d60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Las Cruces Las Cruces 9.4/10 Exceptional (1004) "Always like staying here." £82 includes taxes & fees 2 Nov - 3 Nov [](https://www.expedia.co.uk/Las-Cruces-Hotels-Drury-Inn-Suites-Las-Cruces.h1723204.Hotel-Information) ![Outdoor pool, open 8:00 AM to 10:00 PM, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/1000000/30000/21300/21267/5b5c1a96.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21300/21267/7f7a0786.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor wedding area](https://images.trvl-media.com/lodging/1000000/30000/21300/21267/3f2542a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property – evening/night](https://images.trvl-media.com/lodging/1000000/30000/21300/21267/679005c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Encanto de Las Cruces Las Cruces 9.0/10 Wonderful (1537) "Hotel is beautiful. " £126 includes taxes & fees 8 Nov - 9 Nov [](https://www.expedia.co.uk/Las-Cruces-Hotels-Hotel-Encanto-De-Las-Cruces.h21267.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1200000/1197200/1197199/fb7bdbda.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Vending machine](https://images.trvl-media.com/lodging/2000000/1200000/1197200/1197199/76ee5740.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool](https://images.trvl-media.com/lodging/2000000/1200000/1197200/1197199/3be181be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1200000/1197200/1197199/448dd132.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Las Cruces, NM - Telshor Las Cruces 7.4/10 Good (1005) "Great place to stay with dogs!" £51 includes taxes & fees 16 Oct - 17 Oct [](https://www.expedia.co.uk/Las-Cruces-Hotels-Motel-6-Las-Cruces.h1197199.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/13000000/12820000/12817800/12817768/a6b6426a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/13000000/12820000/12817800/12817768/2816db98.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Children’s theme room](https://images.trvl-media.com/lodging/13000000/12820000/12817800/12817768/e9e5804d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/13000000/12820000/12817800/12817768/f6627f8c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Las Cruces I-10 Las Cruces 8.8/10 Excellent (1007) "clean room ; nice staff; good parking" £92 includes taxes & fees 2 Nov - 3 Nov [](https://www.expedia.co.uk/Las-Cruces-Hotels-Hampton-Inn-Suites-Las-Cruces-I-10.h12817768.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/2000000/1670000/1665200/1665185/b0473335.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![One king studio suite non smoking | 1 bedroom, hypo-allergenic bedding, down duvets, blackout curtains](https://images.trvl-media.com/lodging/2000000/1670000/1665200/1665185/ba02988e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/2000000/1670000/1665200/1665185/a680ade8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/2000000/1670000/1665200/1665185/e8134107.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Las Cruces I-25 Las Cruces 8.6/10 Excellent (1009) "Good place to stay we where there for one night overall good." £85 includes taxes & fees 29 Oct - 30 Oct [](https://www.expedia.co.uk/Las-Cruces-Hotels-Hampton-Inn-Suites-Las-Cruces-I-25.h1665185.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-10-28&endDate=2025-10-29®ionId=132684&adults=2&travelerType=adults_only&sort=RECOMMENDED&openPlayBack=true) ## Top Mesilla Hotel Reviews ## Frequently asked questions ### How much do adults-only hotels in Mesilla cost? > Adults-only properties in Mesilla can be found in a range of prices depending on the amenities provided and the type of room you book. Whatever you decide on, you can have all the youngster-free tranquility you want at a price that doesn't break the bank. ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - Other - More ways to book - [Gay-Friendly Hotels in Alamogordo](https://www.expedia.co.uk/Alamogordo-Hotels-Gay-Friendly-Hotel.0-0-d6054974-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - [Anthony Hotels](https://www.expedia.co.uk/Anthony-Hotels.d6140995.Travel-Guide-Hotels) - [Caballo Hotels](https://www.expedia.co.uk/Caballo-Hotels.d3000447695.Travel-Guide-Hotels) - [Chaparral Hotels](https://www.expedia.co.uk/Chaparral-Hotels.d3000350231.Travel-Guide-Hotels) - [Hotels near Chile Pepper Institute](https://www.expedia.co.uk/Chile-Pepper-Institute-Hotels.0-l553248621533114173-0.Travel-Guide-Filter-Hotels) - [Columbus Hotels](https://www.expedia.co.uk/Columbus-Hotels.d91634.Travel-Guide-Hotels) - [Deming Hotels](https://www.expedia.co.uk/Deming-Hotels.d6833.Travel-Guide-Hotels) - 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[Flights to Las Cruces](https://www.expedia.co.uk/Cheap-Flights-To-Las-Cruces.d2137.Travel-Guide-Flights) - [Flights to Sunland Park](https://www.expedia.co.uk/Cheap-Flights-To-Sunland-Park.d6354940.Travel-Guide-Flights) - [Flights to Truth or Consequences](https://www.expedia.co.uk/Cheap-Flights-To-Truth-Or-Consequences.d10038.Travel-Guide-Flights) - [Flights to White Sands](https://www.expedia.co.uk/Cheap-Flights-To-White-Sands.d6208412.Travel-Guide-Flights) - [Flights from White Sands Regional](https://www.expedia.co.uk/lp/airports/alm/flights-from-white-sands-regional-airport) - [Flights from Las Cruces Intl.](https://www.expedia.co.uk/lp/airports/lru/flights-from-las-cruces-intl-airport) - [Flights from Vado](https://www.expedia.co.uk/lp/flights/3000447949/flights-from-vado) - [Flights from Anthony](https://www.expedia.co.uk/lp/flights/6140995/flights-from-anthony) - [Flights from White Sands](https://www.expedia.co.uk/lp/flights/6208412/flights-from-white-sands) - [Flights from Sunland Park](https://www.expedia.co.uk/lp/flights/6354940/flights-from-sunland-park) - 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[Flights from Manchester (MAN) to Las Cruces (LRU)](https://www.expedia.co.uk/lp/flights/man/lru/manchester-to-las-cruces) - [Flights from San Diego (SAN) to Las Cruces (LRU)](https://www.expedia.co.uk/lp/flights/san/lru/san-diego-to-las-cruces) - [Flights from San Antonio (SAT) to Alamogordo (ALM)](https://www.expedia.co.uk/lp/flights/sat/alm/san-antonio-to-alamogordo) - [Flights from Sacramento (SMF) to Las Cruces (LRU)](https://www.expedia.co.uk/lp/flights/smf/lru/sacramento-to-las-cruces) - [Flights from Vancouver (YVR) to Las Cruces (LRU)](https://www.expedia.co.uk/lp/flights/yvr/lru/vancouver-to-las-cruces) - [Dripping Springs Natural Area](https://www.expedia.co.uk/Dripping-Springs-Natural-Area-Las-Cruces.d553248621532643104.Attraction) - [La Union Holidays](https://www.expedia.co.uk/La-Union.d6049127.Holidays-City-Breaks) - [Las Cruces Holidays](https://www.expedia.co.uk/Las-Cruces.d2137.Holidays-City-Breaks) - [Visit Las Cruces](https://www.expedia.co.uk/Las-Cruces.dx2137) - [Red Hawk Golf Club](https://www.expedia.co.uk/Red-Hawk-Golf-Club-Las-Cruces.d553248621532643121.Attraction) - [Visit Sunland Park](https://www.expedia.co.uk/Sunland-Park.dx6354940) - [Truth or Consequences Holidays](https://www.expedia.co.uk/Truth-Or-Consequences.d10038.Holidays-City-Breaks) - [Visit Truth or Consequences](https://www.expedia.co.uk/Truth-Or-Consequences.dx10038) - [White Sands National Park](https://www.expedia.co.uk/White-Sands-National-Park-New-Mexico.d6093661.Attraction) - [Alamo Rent A Car Rental Cars in Santa Teresa](https://www.expedia.co.uk/Alamo-Rent-A-Car-Car-Rentals-In-Santa-Teresa.d6337326-c6.Car-Rental-Guide-Suppliers) - [Rental cars Las Cruces Intl. airport](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Las-Cruces-Intl.d5591628.Car-Hire-Guide) - [Car hire Las Cruces](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Las-Cruces.d2137.Car-Hire-Guide) - [Car hire Truth or Consequences](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Truth-Or-Consequences.d10038.Car-Hire-Guide) - [Essence Car Rental Rental Cars in Organ Mountains Desert Peaks National Monument](https://www.expedia.co.uk/Essence-Car-Rental-Car-Rentals-In-Organ-Mountains-Desert-Peaks-National-Monument.d553248635998039563-c1085.Car-Rental-Guide-Suppliers) - [Hertz Rental Cars in Truth or Consequences](https://www.expedia.co.uk/Hertz-Car-Rentals-In-Truth-Or-Consequences.d10038-c40.Car-Rental-Guide-Suppliers) - [Minivan Car Hire near White Sands National Park](https://www.expedia.co.uk/Minivan-Car-Rentals-In-White-Sands-National-Park.d6093661-tMinivan.Car-Rental-Guide-Class) - [People Carrier Car Hire near White Sands National Park](https://www.expedia.co.uk/Van-Car-Rentals-In-White-Sands-National-Park.d6093661-tVan.Car-Rental-Guide-Class) - [Las Cruces Holiday Rentals](https://www.expedia.co.uk/Las-Cruces-Holiday-Rentals.d2137.Travel-Guide-HolidayRentals) - [Truth or Consequences Holiday Rentals](https://www.expedia.co.uk/Truth-Or-Consequences-Holiday-Rentals.d10038.Travel-Guide-HolidayRentals) - [Things to do in Las Cruces](https://www.expedia.co.uk/Things-To-Do-In-Las-Cruces.d2137.Travel-Guide-Activities) - [Book Adults Only Resorts & Hotels in Mesilla on Expedia.com](https://www.expedia.com/Mesilla-Hotels-Adults-Only-Resorts.0-0-d132684-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels)