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A rustic building with a wooden door, a hanging red chili, and a cactus plant.

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    Check prices for these dates, 14 – 15 December 2026

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    Our top choices for Mesilla holiday rentals

    1. Charming Casita in historic Town of Mesilla, NM 2392 Calle de Parian

    A building entrance with a wooden door, a brick pathway, and a decorative wreath.

    2. 2 bed, yard, pet friendly in Historic Mesilla.

    A door with a purple frame and a decorative floral pattern above it.

    3. Charming 2-bedroom Casita In Mesilla Park Casita Conway #5

    A hallway with a white console table, a mirror, decorative wall art, and potted plants.

    4. Centrally located Cozy RV with all the essentials in spacious secure gated area!

    A compact room with a wooden table and bench, a television, and a ceiling fan.

    5. Unique 1-bedroom casita in Mesilla Park with hot tub

    A dining area with a table set for two, blue upholstered chairs, a yellow chair, and a floral centerpiece.

    6. 3 bed 2 bath Hacienda near Downtown and NMSU.

    A living room with a sofa, coffee table, and a fireplace.

    7. Charming 1-bedroom house with WiFi, AC Mesilla Park Las Cruces Casita Conway 2

    A kitchen with wooden cabinets, a stainless steel sink, a microwave, and a stove.

    8. Historical 1920s Bungalow Near NMSU & Mesilla

    A hallway with a wooden floor, white walls, and an arched ceiling. There is a dining area with a table and chairs in the distance.

    9. 1 bedroom near NMSU. W/D in unit/pets welcome.

    A kitchen with light green cabinets, a stainless steel oven, a microwave, and a sink.

    10. Modern New Mexico Loft in the heart of Las Cruces.

    A kitchen with granite countertops, a stove, and a dining area with a table and chairs.

    11. 2 bd/2bth near NMSU and Memorial Medical Center

    A living room with a fireplace, a sofa, a coffee table, and a ceiling fan.

    12. Cozy Southwest Casita Minutes to NMSU & I-10

    A single-story building with a brick exterior, a small window, and a door. There is a tree to the right and a parked car in the background.

    13. Mexi-Boho Suite with Clawfoot Tub

    A table with a patterned tablecloth, two red chairs, a potted plant, and a hanging lantern.

    14. 3/2 near University and Memorial Hospital

    A spacious living room with striped sofas, a wooden coffee table, and a ceiling fan.

    15. Downtown Midcentury Studio+ 3 mins to Farmer`s Mkt

    A modern kitchen with white cabinets, a central island, and a microwave above the sink.

    16. 3 bd/Full kitchen/fenced yard near Field of Dreams

    A living room with a sofa, armchair, and coffee table, a fireplace, and a kitchen in the background.

    17. 2 bed with W/D, pets ok, 5 min to Farmers Market

    A dining area with a table and chairs, a hanging light fixture, a microwave, and a dishwasher.

    18. 1 bed W/D in unit, soaker tub near Field of Dreams

    A living room with a sofa, two armchairs, a coffee table, and a lamp.

    19. Studio w/queen bed, pets ok, 3 min to Farmer's mkt

    A bedroom with a bed, a desk, and a chair. There are windows with curtains, a ceiling fan, and a rug.

    20. Cozy SW Retreat Walk to Downtown Las Cruces

    A bedroom with a large bed, two bedside lamps, a colorful abstract painting on the wall, and a wooden door.

    Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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    Top Mesilla Hotel Reviews

    Hampton Inn & Suites Las Cruces I-10

    A spacious lobby with a central dining area, multiple seating options, and a modern chandelier.

    Comfort Inn & Suites Las Cruces Mesilla

    A swimming pool with clear blue water, surrounded by lounge chairs and a tiled wall.

    Best Western Mission Inn

    A buffet area with a variety of baked goods, a coffee station, and a decorative plant.

    Days Inn by Wyndham Las Cruces

    An outdoor patio with wooden benches and a grill area.

    La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain

    A hotel room with two beds, a desk with a TV, a chair, and two lamps.

    Hotel Encanto de Las Cruces

    A courtyard with a central fountain, surrounded by palm trees and well-lit by ambient lighting.

    Springhill Suites By Marriott Las Cruces

    A hotel room with a bed, a TV mounted on the wall, a desk, and a sofa.

    Home2 Suites by Hilton Las Cruces

    An outdoor seating area with a fire pit, sofas, and chairs.

    Holiday Inn Express & Suites Las Cruces North by IHG

    A buffet with various food items, including omelets and other dishes, served in metal containers.

    Staybridge Suites Las Cruces by IHG

    A multi-story building with a stone facade, a central entrance with a wooden archway, and a blue car parked in front.

    Find out more about Mesilla

    Everything you need to know about Mesilla holiday rentals

    Whether you’re excited for the perfect family holiday, a romantic getaway for two, or the ultimate city break, we’ve got the Mesilla holiday rental for you. At Expedia, you can take your pick from private holiday homes, apartments, cottages, apart-hotels, cabins, villas... The list goes on, and on… and on!

    There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Mesilla holiday rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

    Mesilla holiday rentals: An excellent choice for every season

    Whenever you want to travel, a warm welcome awaits you in Mesilla. If you’re looking for a little peace, consider booking during the quieter months, such as . For more hustle and bustle, you may prefer to visit in .

    Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Mesilla holiday rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a holiday rental with multiple bedrooms and shared living spaces to kick back in. The selection of Mesilla holiday rentals we have selected for you start as low as £64 per night. Entering your travel dates in the search wizard you might find even better deals!

    How to find incredible deals on Mesilla rentals

    At Expedia, we put the best Mesilla holiday rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

    To find some top Mesilla rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Mesilla holiday.

    If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Mesilla. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

    Frequently Asked Questions

    Can I find a holiday rental in Mesilla?

    Yes, there are holiday rentals close to the most popular sights in Mesilla, or you can select a more secluded option if you're looking for a relaxing stay. Mesilla is known for its restaurants and shopping. Make sure you have time to check out the theatres while you're in the area.

    What are some of the best holiday rentals that Mesilla has to offer?

    Cheerful desert oasis home with a privacy hot tub! 1 minute to new hospital! : This holiday home rental outside of Mesilla offers a fireplace, a patio and a BBQ to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. You can relax into your holiday with a selection of games and 1 hot tub.

    How many holiday rentals will I find in Mesilla?

    With 8 Expedia holiday rentals, you're guaranteed to find just the right place for your Mesilla stay.

    What’s there to see and do in Mesilla?

    Cultural attractions include Fountain Theatre and Fountain Theater, whereas Rio Grande is one spot to enjoy nature. Other places in town to visit include Mesillia Plaza and San Albino Basilica.

    What’s a holiday rental in Mesilla like?

    Holiday rentals are private properties where you can stay for a few weeks, or just a few days, in Mesilla. Holiday rentals provide amenities like laundry facilities and kitchens so you'll have all the comforts of home. If you're concerned about cleanliness, a holiday rental can provide a sense of seclusion away from public hotel lifts and busy concierge desks while still allowing you to travel. You'll also find more space in a holiday rental than in a hotel, which is another reason why a holiday rental is a popular option for a family getaway.