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Check prices for these dates

Next weekend
13 Nov - 15 Nov
In two weeks
20 Nov - 22 Nov
In one month
4 Dec - 6 Dec
In two months
1 Jan - 3 Jan

Our top choices for La Mesa aparthotels

A spacious lounge area with a sofa, a coffee table, and a bar with stools.

1. Marriott Vacation Club®, San Diego

Marriott Vacation Club®, San Diego
3.5 star property
Downtown San Diego
9.4 out of 10, Exceptional, (1,260 reviews)
"Amazing stay! Would definitely come back!"
United States
Dirosia
The price is £124
includes taxes & fees
19 Nov - 20 Nov
Marriott Vacation Club®, San Diego
A narrow, enclosed walkway with wooden railings and a metal grid barrier, leading to a building entrance.

2. City24 Hotel Little Italy Mission Hills

City24 Hotel Little Italy Mission Hills
4.5 star property
Middletown
9.6 out of 10, Exceptional, (241 reviews)
"Friendly staff!"
United States
Donavin
The price is £123
includes taxes & fees
2 Dec - 3 Dec
City24 Hotel Little Italy Mission Hills
A spacious lobby with a sofa, chairs, a bookshelf, and a large window with a view of greenery.

3. Uptown Inn by Vantaggio - Limited Service Apart-Hotel

Uptown Inn by Vantaggio - Limited Service Apart-Hotel
2.5 star property
Hillcrest
8.4 out of 10, Very good, (512 reviews)
"Front desk service was amazing and love the central location to all the LGBTQ bars and restaurants."
United States
Victor
The price is £78
includes taxes & fees
8 Nov - 9 Nov
Uptown Inn by Vantaggio - Limited Service Apart-Hotel
A modern lobby with a green sofa, a wooden accent wall, and a large plant.

4. Little Italy Inn - Limited Service Apart Hotel

Little Italy Inn - Limited Service Apart Hotel
2.5 star property
Downtown San Diego
8.4 out of 10, Very good, (403 reviews)
"Great stay nice staff"
United States
Olivia
The price is £84
includes taxes & fees
9 Nov - 10 Nov
Little Italy Inn - Limited Service Apart Hotel
A neatly made bed with white and gold bedding, two bedside tables with lamps, and three wall-mounted mirrors.

5. Kasa Gaslamp Quarter San Diego

Kasa Gaslamp Quarter San Diego
3.5 star property
Downtown San Diego
7.8 out of 10, Good, (240 reviews)
"Wonderful place!"
Canada
Eric
The price is £94
includes taxes & fees
8 Nov - 9 Nov
Kasa Gaslamp Quarter San Diego
🛋️ Seamless flow between living, dining, and sleeping areas — ideal for entertaining or staying connected during an extended stay.

6. The Penn Hotel - Queen Bed, AC & Walk to Gaslamp!!

The Penn Hotel - Queen Bed, AC & Walk to Gaslamp!!
Downtown San Diego
The price is £174
includes taxes & fees
8 Nov - 9 Nov
The Penn Hotel - Queen Bed, AC & Walk to Gaslamp!!
A dining table set with white bowls, wine glasses, and a vase with flowers.

7. The Penn Hotel - Smart TV, AC & Walk to Gaslamp!!!

The Penn Hotel - Smart TV, AC & Walk to Gaslamp!!!
Downtown San Diego
The price is £249
includes taxes & fees
9 Nov - 10 Nov
The Penn Hotel - Smart TV, AC & Walk to Gaslamp!!!
A rooftop pool with lounge chairs and a city skyline in the background.

8. Kasa Little Italy San Diego

Kasa Little Italy San Diego
4.5 star property
Downtown San Diego
9.6 out of 10, Exceptional, (560 reviews)
"Super nice amenities - would stay again. Great location"
United States
Nirmeen
The price is £226
includes taxes & fees
10 Nov - 11 Nov
Kasa Little Italy San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about La Mesa

Nestled between rolling hills, this charming suburb offers hiking trails through Mission Trails Park and Lake Murray's scenic waterfront paths. Visit the vibrant farmers market on Fridays, then explore the antique shops and local breweries along La Mesa Boulevard's historic district.

See all hotels in La Mesa
A sunset over a mountainous landscape with scattered clouds.

Top reviews in La Mesa

A narrow, enclosed walkway with wooden railings and a metal grid barrier, leading to a building entrance.
City24 Hotel Little Italy Mission Hills

City24 Hotel Little Italy Mission Hills

City24 Hotel Little Italy Mission Hills
Middletown

10/10 Excellent

The Family Room was beautifully decorated. It is clean with loads of space and a very thoughtful layout. It is more than enough for 2 adults and 4 children (3 teens and 1 x 8 year old). It is equipped with quality high tech appliances and loads of USB / USBC sockets and therefore not requiring plugs and adapters. Some can find it a bit out of the way, but given we were driving, it is a very easy and convenient location. Close to the airport and within walking distance to Little...
United Kingdom
Suzanne
Reviewed February 26, 2026
City24 Hotel Little Italy Mission Hills

Frequently Asked Questions

What can I look forward to during my La Mesa aparthotel stay?

When you choose an aparthotel or serviced apartment in La Mesa, you'll probably be more centrally situated. While in this family-friendly area, you can visit the shops and seek out the entertainment venues. La Mesa is also known for its restaurants and zoo.

What are visitors' favourite aparthotels for my stay in La Mesa?

Located 8.5 mi (13.7 km) from La Mesa, Marriott Vacation Club®, San Diego is a favourite aparthotel featuring 264 apartments with free WiFi and comfy beds as well as hotel amenities like a restaurant. In the area, a couple of other top aparthotels to consider are Little Italy Inn - Limited Service Apart Hotel and Uptown Inn by Vantaggio - Limited Service Apart-Hotel.

How many aparthotels will I find in La Mesa?

You'll find a lot of options for your stay in La Mesa with 175 hotels and other accommodation options. Although there aren't many apartments, we can help you search for accommodation that is similar.

What should I see in La Mesa?

Discover some favourite places in the wider area such as San Diego Zoo and Mission Bay. Explore the area and family-friendly sights such as San Diego Natural History Museum, or get out into nature at a spot like Balboa Park. While in the area, you can also visit popular places such as Petco Park and Port of San Diego.

What is an aparthotel?

An aparthotel is both a hotel and an apartment, with the amenities of a traditional hotel, and the privacy and space found in an apartment. Feel like a local in apartment-style accommodation, often situated in the centre of La Mesa. Enjoy making home-cooked meals in the private kitchen and having more space to spread out while you're in town.