Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the price guarantee available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Florida Keys Business Hotels

See all 357 Hotels in Florida Keys

Get 200 Nectar points when you book your hotel
Simply enter your Nectar card number when prompted. Your points will be credited 30 days after you return from your trip.

Hyatt Place Marathon Florida Keys

Hyatt Place Marathon Florida Keys

1996 Overseas Highway, Marathon
3.0 out of 5.0
4.5 out of 5 (420 reviews)
Lovely , large, clean hotel with great amenities.Friendly helpful staff. Lovely breakfast. 2 great swimming pools. lovely poolside restaurant bar overlooking harbour great visiting wildlife
  15 Sep 2017

£117

£117
Fairfield Inn & Suites by Marriott Key West, Keys Collection

Fairfield Inn & Suites by Marriott Key West, Keys Collection

3852 North Roosevelt Boulevard, Key West
3.0 out of 5.0
4.1 out of 5 (152 reviews)
Great hotelQuick getaway to key West,hotel was great and Anibal was awesome. Due to Irma we cut it short but will definitely return.
  7 Sep 2017

£148

£148
The Gates Hotel Key West

The Gates Hotel Key West

3824 N Roosevelt Blvd, Key West
4.0 out of 5.0
4.3 out of 5 (315 reviews)
Hurricane Irmaour stay was less than 24 hours instead of 6 nights due to being evacuated because of hurricane Irma. The staff was helpful on getting us out before the hurricane hit.
  11 Sep 2017

£94

£94
Hawks Cay Resort

Hawks Cay Resort

61 Hawks Cay Blvd, Duck Key
4.0 out of 5.0
4.1 out of 5 (1,140 reviews)
Nice resort with its own beach and 2 pools We love staying at Hawk's Cay. I love that they have heir own little private beach/lagoon area. Main pool is beautiful, but when you want to get away from other people's kids, there is an adult pool as well. It's a little older but still really nice. My only complaint is that is that the menus have ...
  17 Sep 2017

£164

£164
Bayside Inn Key Largo

Bayside Inn Key Largo

99490 Overseas Hwy, Key Largo
2.5 out of 5.0
2.9 out of 5 (647 reviews)
Nice hotel close to the beach We had a wonderful time and I would stay again. They have there own beach and you can sit and see the sunsets which my wife really enjoyed. There is a sushi bar. They also have a continental breakfast
  10 Sep 2017

£65

£65
Ibis Bay Beach Resort

Ibis Bay Beach Resort

3101 N. Roosevelt Blvd, Key West
2.5 out of 5.0
3.6 out of 5 (537 reviews)
We spent more money for the hotel because our friends had already book it and we wanted to joing them. We paid more than the value for money we got. The rooms were small but just enough. Breakfast was very bad. They had nothing but some bread, bagel and butter, cream cheese. We had the beach front ...
  19 Sep 2017

£112

£112
Coconut Cay Resort & Marina

Coconut Cay Resort & Marina

7196 Overseas Highway, Marathon
2.0 out of 5.0
3.3 out of 5 (170 reviews)
Great hotelLoved the hotels newly built unit. Beautiful furniture and the bed was extremely comfortable. Staff was very friendly and knowledgeable of area. Will definitely stay here again.
  9 Jul 2017

£72

£72
Cheeca Lodge & Spa

Cheeca Lodge & Spa

81801 Overseas Highway, Mile Marker 82, Islamorada
4.0 out of 5.0
4.4 out of 5 (657 reviews)
Daughter got married here on the beach at sunset. Beautiful hotel and spa facilities. Close enough to Miami in terms of travel, but you feel like you're away in the Caribbean.
  11 Sep 2017

£111

£111
Glunz Ocean Beach Hotel & Resort

Glunz Ocean Beach Hotel & Resort

351 East Ocean Drive, Key Colony Beach
3.0 out of 5.0
4.4 out of 5 (175 reviews)
Nice hotel by the beach First time staying in this hotel. The room and the hotel is kept well. The beach area is great and the pools are great as well. Only complain is that we overpaid for this room for being on labor day weekend. But we had a nice time here so will be back again.
  5 Sep 2017

£105

£105
Islander Resort, a Guy Harvey Outpost

Islander Resort, a Guy Harvey Outpost

82100 Overseas Highway, Islamorada
3.0 out of 5.0
4.2 out of 5 (673 reviews)
No clean towels for the second day, internet not good. No paper towel either.
  9 Sep 2017

£117

£117
Map

Recently booked Florida Keys hotels

Lime Tree Bay Resort
3.5 out of 5.0
Last booking: 4 minutes ago
Key West Marriott Beachside Hotel
3.5 out of 5.0
Last booking: 27 minutes ago
Pier House Resort & Spa
4.0 out of 5.0
Last booking: 32 minutes ago
Playa Largo Resort & Spa, Autograph Collection
3.5 out of 5.0
Last booking: 46 minutes ago
Amy Slate's Amoray Dive Resort
2.0 out of 5.0
Last booking: 48 minutes ago
Duval Inn
3.0 out of 5.0
Last booking: 1 hour ago
NYAH Key West - Adult Exclusive
2.5 out of 5.0
Last booking: 1 hour ago
The Cabana Inn Key West - Adult Exclusive
3.0 out of 5.0
Last booking: 2 hours ago
Paradise Inn Key West - Adult Exclusive
3.5 out of 5.0
Last booking: 2 hours ago

Pocket Guide: Business Hotelss in Florida Keys

Where to Find Conference-Centre Hotels in Florida Keys

Where better to host your conference than in the scenic visitor-ready region of Florida Keys? Hotels all along the string of islands offer excellent conference facilities surrounded by the Florida Key’s spectacular coastline.

As the main city in the region, Key West naturally offers the most conference-centre hotels, while hotels in Key Largo will place you near mainland Florida and the fantastic domestic and international transport links of Miami.

Conference-Centre Facilities in Florida Keys

The efficient tourist infrastructure here means that customer service is a top priority, which makes travelling to Florida Keys for conferences a breeze. Arrange pick-up services from the airport in a cab or limo. At your hotel, make use of 24-hour front desks, room service and hotel-wide WiFi.

Many Florida Keys hotels offer flexible conference facilities, including expansive rooms complete with projectors, screens and complimentary refreshments. You can make use of air-conditioned exhibition halls and lecture halls to host big events, while breakout rooms can accommodate seminars and talks for different sized groups.

Total Relaxation during Your Conference

Choose a conference-centre hotel in Florida Keys that comes with an on-site spa and gym so you can unwind after the day’s lectures and presentations. Work up a sweat on treadmills and exercise bikes before cooling off in the outdoor pool. Treat yourself to massages and beauty treatment during your down time.

Poolside bars are ideal places to mingle with fellow delegates while enjoying a cocktail as the sun sets over the ocean. Find accommodation with a private beach and your conference or work trip can also double as a relaxing bonding experience in the south of Florida.

Luxurious Rooms with Extensive Amenities

At the end of the day, retreat to a hotel room that comes with a private balcony and ocean views. Minibars, laundry and room service ensure that your every need is met during your conference stay in Florida Keys.

A conference in Florida Keys is more than just talks and presentations, it’s a way to experience one of the most scenic parts of Florida, even when you are visiting for work-related reasons.