Florida Keys adults only hotels from £89

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Top Adults only hotels in Florida Keys

 Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly
3.5 out of 5
1118 Fleming St, Key West, FL
The price is £118 per night from 26 Aug to 27 Aug
£118
per night
26 Aug - 27 Aug
9.8/10 Exceptional! (109 reviews)
"It was a wonderful stay, from beginning to end."

Reviewed on 19 Aug 2025

Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly
Duval House
3 out of 5
815 Duval St, Key West, FL
The price is £89 per night from 26 Aug to 27 Aug
£89
per night
26 Aug - 27 Aug
9.4/10 Exceptional! (1,011 reviews)
"Awesome stay"

Reviewed on 19 Aug 2025

Duval House
Southernmost House
4 out of 5
1400 Duval Street, Key West, FL
The price is £221 per night from 4 Sept to 5 Sept
£221
per night
4 Sept - 5 Sept
9.2/10 Wonderful! (1,002 reviews)
"This hotel is beautiful, love the history Bed comfortable Would definitely come and stay here again"

Reviewed on 15 Aug 2025

Southernmost House
Casa Morada
3.5 out of 5
136 Madeira Road, Islamorada, FL
9.2/10 Wonderful! (405 reviews)
"The marina was clean and convenient."

Reviewed on 3 Aug 2025

Casa Morada
Ridley House - Key West Historic Inns
3.5 out of 5
601 Caroline St, Key West, FL
The price is £224 per night from 26 Aug to 27 Aug
£224
per night
26 Aug - 27 Aug
9.2/10 Wonderful! (810 reviews)
Well located- super cute
"Well located walkable in Key West. The staff is excellent just know that the amenities are good. Breakfast is chef- provided and very good. Theres no elevator - just know before you go . Also it is Not Quiet - roosters crowing and buses going by. Take a sound machine or ear plugs. Nothing you can ..."

Reviewed on 18 Aug 2025

Ridley House - Key West Historic Inns
Paradise Inn Key West - Adults Only
3.5 out of 5
819 Simonton Street, Key West, FL
9/10 Wonderful! (1,002 reviews)
"Beautiful grounds"

Reviewed on 17 Aug 2025

Paradise Inn Key West - Adults Only
Heron House - Adult Only
3.5 out of 5
512 Simonton St, Key West, FL
The price is £118 per night from 21 Aug to 22 Aug
£118
per night
21 Aug - 22 Aug
9/10 Wonderful! (1,137 reviews)
"Beautiful and quaint little place to stay. Just a couple blocks from the main Street, so we walked the whole time. The staff was super friendly, the room was clean, and the breakfast was good. Will def stay again!"

Reviewed on 17 Aug 2025

Heron House - Adult Only
Heron House Court - Adult Only
3 out of 5
412 Frances St, Key West, FL
The price is £110 per night from 26 Aug to 27 Aug
£110
per night
26 Aug - 27 Aug
8.8/10 Excellent! (1,003 reviews)
"Was a quint little place that was quiet and close to the water Very friendly and accommodating."

Reviewed on 11 Aug 2025

Heron House Court - Adult Only
The Cabana Inn Key West - Adults Only
3 out of 5
413 Applerouth Lane, Key West, FL
8.8/10 Excellent! (1,010 reviews)
"I enjoyed the cocktails and appetizers in the evening. The place was centrally located. Parking was awesome. I enjoyed our huge room."

Reviewed on 18 Aug 2025

The Cabana Inn Key West - Adults Only
The Southernmost Inn - Adults Only
3 out of 5
525 United Street, Key West, FL
The price is £116 per night from 21 Aug to 22 Aug
£116
per night
21 Aug - 22 Aug
8.2/10 Very Good! (1,162 reviews)
"Ok"

Reviewed on 16 Aug 2025

The Southernmost Inn - Adults Only
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Frequently Asked Questions

How can I find the best adults only resorts in Florida Keys?

The best adults only resort for you is deeply personal. First off, decide what you want from your dream holiday, then use our filters to bring it to life. Find resorts with hot tubs, spas and incredible views, then check out the reviews to see how other guests enjoyed their stay.

How much does a Florida Keys adults-only hotel cost?

With Expedia, you can find adults only hotels from £89 to per night. Prices and availability are subject to change. Additional terms may apply.

How can I find an adults only all-inclusive holiday in Florida Keys?

It’s simple. Just select the all-inclusive filter to find the best resorts where you can eat, drink and holiday to your heart’s content.

What can I expect from Florida Keys 5-star all-inclusive adults only hotels?

Luxury comes as standard in the 5-star resorts of Florida Keys. Step into spotless surroundings, stellar service and all the amenities your heart desires, from spas and pools to casinos and cocktail bars.

Why should I book a Florida Keys adults only hotel with entertainment?

When you book an adult only hotel with entertainment, pack your bags to get dolled up for the very best of comedy, cabaret, music, magic and much more – all just steps from your room.

How can I find the best deals on adults only resorts in Florida Keys?

To find amazing deals in Florida Keys and for a quieter experience, book your holiday in . The more flexible you can be with your dates, the better your chances are of getting a fantastic wallet-friendly deal. You can always check out our latest cheap deals for a little inspiration.

Do adults only hotels in Florida Keys offer free cancellation?

Some adults only hotels here offer free cancellation. Some don’t. It’s always best to check before you book. You can filter by free cancellation and pay later options to find resorts with that extra flexibility you want.

Why should I book my adults only resort in Florida Keys with Expedia?

At Expedia, we put everything you need to book your dream trip in one place. With a vast selection of incredible adult only accommodation at your fingertips, all that’s left to do is set your sights on what’s right for you.