Title: Hotels in Effingham, SC - Best Effingham Hotels from £42 - Fully Refundable Options - Expedia.co.uk [Holiday Rentals in Effingham](https://expedia.co.uk/Effingham-Holiday-Rentals.d553248635975849973.Travel-Guide-HolidayRentals)[Effingham Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Effingham.d553248635975849973.Car-Hire-Guide)[Effingham Holidays](https://expedia.co.uk/Effingham.d553248635975849973.Holidays-City-Breaks) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Effingham Pool [](https://www.expedia.co.uk/Hotel-Search?destination=Effingham%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975849973&latLong=34.057571%2C-79.75341&adults=2&startDate=2026-03-23&d1=2026-03-23&endDate=2026-03-25&d2=2026-03-25&amenities=POOL) Apart­ment [](https://www.expedia.co.uk/Hotel-Search?destination=Effingham%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975849973&latLong=34.057571%2C-79.75341&adults=2&startDate=2026-03-23&d1=2026-03-23&endDate=2026-03-25&d2=2026-03-25&lodging=APARTMENT) Family friendly [](https://www.expedia.co.uk/Hotel-Search?destination=Effingham%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975849973&latLong=34.057571%2C-79.75341&adults=2&startDate=2026-03-23&d1=2026-03-23&endDate=2026-03-25&d2=2026-03-25&travelerType=family_friendly) Pet friendly [](https://www.expedia.co.uk/Hotel-Search?destination=Effingham%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975849973&latLong=34.057571%2C-79.75341&adults=2&startDate=2026-03-23&d1=2026-03-23&endDate=2026-03-25&d2=2026-03-25&amenities=PETS) ## Check prices for these dates Tonight [9 Mar - 10 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975849973&startDate=2026-03-09&endDate=2026-03-10&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [10 Mar - 11 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975849973&startDate=2026-03-10&endDate=2026-03-11&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [13 Mar - 15 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975849973&startDate=2026-03-13&endDate=2026-03-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [20 Mar - 22 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975849973&startDate=2026-03-20&endDate=2026-03-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Effingham hotels ![Terrace/patio](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/c8bc9166.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Serves lunch and dinner](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/e2ea309a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout curtains, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/0e00b7af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property – evening/night](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/c29c3321.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Place Florence Downtown [](https://www.expedia.co.uk/Florence-Hotels-Hyatt-Place-Florence-Downtown.h32772870.Hotel-Information) Florence 9.0/10 Wonderful (1,006 reviews) "Great location and well maintained property. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Karen £98 includes taxes & fees 15 Mar - 16 Mar [](https://www.expedia.co.uk/Florence-Hotels-Hyatt-Place-Florence-Downtown.h32772870.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/64840011.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/fefdad76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Non Smoking | Pillow-top beds, desk, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/a63ff680.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillow-top beds, desk, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/6df606aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Florence Center Area [](https://www.expedia.co.uk/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) Florence 9.2/10 Wonderful (1,244 reviews) "Great location, friendly staff. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Defelicio £84 includes taxes & fees 29 Mar - 30 Mar [](https://www.expedia.co.uk/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/22000000/21760000/21758600/21758593/89338f8a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, Tempur-Pedic beds, in-room safe, desk](https://images.trvl-media.com/lodging/22000000/21760000/21758600/21758593/861e9f4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/22000000/21760000/21758600/21758593/1aa3f791.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/22000000/21760000/21758600/21758593/042032ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Staybridge Suites Florence - Civic Center by IHG [](https://www.expedia.co.uk/Florence-Hotels-Staybridge-Suites-Florence-Civic-Center.h21758593.Hotel-Information) Florence 9.4/10 Exceptional (965 reviews) "Room clean, bed good, breakfast good choices, front desk excellent" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) mona £113 includes taxes & fees 29 Mar - 30 Mar [](https://www.expedia.co.uk/Florence-Hotels-Staybridge-Suites-Florence-Civic-Center.h21758593.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/2000000/1370000/1367300/1367205/ddbd2495.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1370000/1367300/1367205/8b770330.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/2000000/1370000/1367300/1367205/68010423.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool](https://images.trvl-media.com/lodging/2000000/1370000/1367300/1367205/f19c2d4a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Garden Inn Florence [](https://www.expedia.co.uk/Florence-Hotels-Hilton-Garden-Inn-Florence.h1367205.Hotel-Information) Florence 8.6/10 Excellent (287 reviews) "The hotel is very pet friendly. Close to stores and restaurants. Clean, friendly, for is great in the restaurant in the hotel as well. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michelle £95 includes taxes & fees 16 Mar - 17 Mar [](https://www.expedia.co.uk/Florence-Hotels-Hilton-Garden-Inn-Florence.h1367205.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1510000/1509700/1509674/9c0353ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast ](https://images.trvl-media.com/lodging/2000000/1510000/1509700/1509674/fb5956cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1510000/1509700/1509674/6c72c859.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Accessible (Communications, Mobility, Access Tub) | In-room safe, desk, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/2000000/1510000/1509700/1509674/cfd93cd5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG [](https://www.expedia.co.uk/Florence-Hotels-Holiday-Inn-Ex-Hotel-Suites-Florence-I-95-I-20-Civic-Ctr.h1509674.Hotel-Information) Florence 9.2/10 Wonderful (1,009 reviews) "Clean rooms and nice breakfast. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Adam £102 includes taxes & fees 15 Mar - 16 Mar [](https://www.expedia.co.uk/Florence-Hotels-Holiday-Inn-Ex-Hotel-Suites-Florence-I-95-I-20-Civic-Ctr.h1509674.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/10000000/9150000/9142300/9142228/06692e76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/10000000/9150000/9142300/9142228/59da7dea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/10000000/9150000/9142300/9142228/7e5ec8df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/10000000/9150000/9142300/9142228/w6955h4642x8y0-4ae289f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Inn at the Crossroads [](https://www.expedia.co.uk/Florence-Hotels-The-Inn-At-The-Crossroads.h9142228.Hotel-Information) Lake City 9.4/10 Exceptional (860 reviews) "We always enjoy our stay at the Inn. Food at the Bistro never disappoints and the bartender is always friendly and remembers us from past visits. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Barbara £117 includes taxes & fees 15 Mar - 16 Mar [](https://www.expedia.co.uk/Florence-Hotels-The-Inn-At-The-Crossroads.h9142228.Hotel-Information) ![Free buffet breakfast ](https://images.trvl-media.com/lodging/1000000/30000/24900/24816/2dfd6373.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/30000/24900/24816/b51b62f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24900/24816/a6fa48ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool](https://images.trvl-media.com/lodging/1000000/30000/24900/24816/72e5d4f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Mullins - Marion [](https://www.expedia.co.uk/Florence-Hotels-Quality-Inn.h24816.Hotel-Information) Marion 7.8/10 Good (391 reviews) "It was ok clean would stay there again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) jeff £81 includes taxes & fees 27 Mar - 28 Mar [](https://www.expedia.co.uk/Florence-Hotels-Quality-Inn.h24816.Hotel-Information) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/20000/11800/11724/1b5fb4c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11800/11724/bac50e5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/11800/11724/d1f8ba02.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/1000000/20000/11800/11724/1f011cac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Florence Near Civic Center [](https://www.expedia.co.uk/Florence-Hotels-Days-Inn-By-Wyndham-Florence-Near-Civic-Center.h11724.Hotel-Information) Florence 7.0/10 Good (1,011 reviews) "Love this room dearly" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Andre £55 includes taxes & fees 15 Mar - 16 Mar [](https://www.expedia.co.uk/Florence-Hotels-Days-Inn-By-Wyndham-Florence-Near-Civic-Center.h11724.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/1000000/50000/42900/42876/88f4ba4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/42900/42876/1e0c4eb4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/50000/42900/42876/e1b59003.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/50000/42900/42876/f287bfc0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Florence Center [](https://www.expedia.co.uk/Florence-Hotels-Hampton-Inn-Suites-Florence-Center.h42876.Hotel-Information) Florence 9.0/10 Wonderful (858 reviews) "Staff was very kind and conscious of our needs" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Robert £92 includes taxes & fees 5 Apr - 6 Apr [](https://www.expedia.co.uk/Florence-Hotels-Hampton-Inn-Suites-Florence-Center.h42876.Hotel-Information) ![Bar (on property)](https://images.trvl-media.com/lodging/7000000/6130000/6129000/6128999/e5aa7c6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/7000000/6130000/6129000/6128999/9a944163.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/7000000/6130000/6129000/6128999/af0558b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/7000000/6130000/6129000/6128999/05b9e041.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Florence, Tapestry Collection by Hilton [](https://www.expedia.co.uk/Florence-Hotels-Hotel-Florence.h6128999.Hotel-Information) Florence 8.8/10 Excellent (620 reviews) "Special place. Great staff with an outstanding restaurant " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) John D £109 includes taxes & fees 5 Apr - 6 Apr [](https://www.expedia.co.uk/Florence-Hotels-Hotel-Florence.h6128999.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/3000000/2480000/2478700/2478624/e08b1bcd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/3000000/2480000/2478700/2478624/c76a36a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2480000/2478700/2478624/4aae214d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2480000/2478700/2478624/de3f1188.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Residence Inn Marriott Florence [](https://www.expedia.co.uk/Florence-Hotels-Residence-Inn-Marriott-Florence.h2478624.Hotel-Information) Florence 8.8/10 Excellent (523 reviews) "Clean room, great location, easy check-in & check-out, friendly service" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Shaun £90 includes taxes & fees 15 Mar - 16 Mar [](https://www.expedia.co.uk/Florence-Hotels-Residence-Inn-Marriott-Florence.h2478624.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/77000000/76030000/76026200/76026194/da6adbe4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/77000000/76030000/76026200/76026194/0724af0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/77000000/76030000/76026200/76026194/831257e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/77000000/76030000/76026200/76026194/f276d90d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Aloft Florence [](https://www.expedia.co.uk/Florence-Hotels-Aloft-Florence.h76026194.Hotel-Information) Florence 8.6/10 Excellent (289 reviews) "Awesome stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cynthia £93 includes taxes & fees 23 Mar - 24 Mar [](https://www.expedia.co.uk/Florence-Hotels-Aloft-Florence.h76026194.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/e4f3361f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down duvets, pillow-top beds, in-room safe](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/0c64863b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/96d5feb4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/0b9239a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Park Inn by Radisson Florence, SC [](https://www.expedia.co.uk/Florence-Hotels-Park-Inn-By-Radisson-Florence.h47086732.Hotel-Information) Florence 9.0/10 Wonderful (2,254 reviews) "Room was clean, staff friendly, and the includes breakfast was great " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Samantha £71 includes taxes & fees 15 Mar - 16 Mar [](https://www.expedia.co.uk/Florence-Hotels-Park-Inn-By-Radisson-Florence.h47086732.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/4000000/3030000/3026100/3026100/c68ab7f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/4000000/3030000/3026100/3026100/434898b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic Area](https://images.trvl-media.com/lodging/4000000/3030000/3026100/3026100/5054dc3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, pillow-top beds, desk, blackout curtains](https://images.trvl-media.com/lodging/4000000/3030000/3026100/3026100/67a43c3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Florence I-95 [](https://www.expedia.co.uk/Florence-Hotels-Comfort-Suites-Florence-I-95.h3026100.Hotel-Information) Florence 8.4/10 Very good (1,007 reviews) "Great accommodations and courteous staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Leslie £89 includes taxes & fees 15 Mar - 16 Mar [](https://www.expedia.co.uk/Florence-Hotels-Comfort-Suites-Florence-I-95.h3026100.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/50000/42700/42602/25cb76ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds | Premium bedding, desk, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/50000/42700/42602/bdaaa724.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/1000000/50000/42700/42602/2132b0fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic Area](https://images.trvl-media.com/lodging/1000000/50000/42700/42602/41091644.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Spark by Hilton Florence North I-95, SC [](https://www.expedia.co.uk/Florence-Hotels-Spark-By-Hilton-Florence-North-I-95.h42602.Hotel-Information) Florence 7.8/10 Good (52 reviews) "Wonderful staff and very clean room and facilities , " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) catherine £91 includes taxes & fees 5 Apr - 6 Apr [](https://www.expedia.co.uk/Florence-Hotels-Spark-By-Hilton-Florence-North-I-95.h42602.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/59000000/58990000/58985600/58985556/2544034c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/59000000/58990000/58985600/58985556/5cc0357e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/59000000/58990000/58985600/58985556/2a6d6c86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, Multiple Beds | Free cots/infant beds, free rollaway beds, bed sheets](https://images.trvl-media.com/lodging/59000000/58990000/58985600/58985556/949b4986.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Latta by IHG [](https://www.expedia.co.uk/Florence-Hotels-Holiday-Inn-Express-Suites-Latta.h58985556.Hotel-Information) Latta 9.4/10 Exceptional (561 reviews) "Front desk is amazing! Rooms are clean and quiet. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kimberly £99 includes taxes & fees 24 Mar - 25 Mar [](https://www.expedia.co.uk/Florence-Hotels-Holiday-Inn-Express-Suites-Latta.h58985556.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11600/11535/8dae8685.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/11600/11535/dc8d999b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/1000000/20000/11600/11535/852cfc33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast ](https://images.trvl-media.com/lodging/1000000/20000/11600/11535/f82666ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn & Suites Florence Civic Center [](https://www.expedia.co.uk/Florence-Hotels-Quality-Inn-And-Suites-Civic.h11535.Hotel-Information) Florence 7.8/10 Good (1,279 reviews) "Quiet clean and many options local for food etc Good for a night or two stay Bed was comfortable " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Louis £75 includes taxes & fees 10 Mar - 11 Mar [](https://www.expedia.co.uk/Florence-Hotels-Quality-Inn-And-Suites-Civic.h11535.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/28000000/27050000/27041900/27041849/a8854f5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/28000000/27050000/27041900/27041849/8339db76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/28000000/27050000/27041900/27041849/5b7b6acc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/28000000/27050000/27041900/27041849/d5b1a48f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru by Hilton Florence I-95 [](https://www.expedia.co.uk/Florence-Hotels-Tru-By-Hilton-Florence-I-95.h27041849.Hotel-Information) Florence 8.4/10 Very good (1,005 reviews) "We enjoyed our stay. Everything stood out Staff, Clean room and Amenities. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marita £84 includes taxes & fees 16 Mar - 17 Mar [](https://www.expedia.co.uk/Florence-Hotels-Tru-By-Hilton-Florence-I-95.h27041849.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/58000000/57720000/57719800/57719723/6ea04fee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Suite | Free WiFi, bed sheets](https://images.trvl-media.com/lodging/58000000/57720000/57719800/57719723/801b8be0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch flat-screen TV with cable channels, TV](https://images.trvl-media.com/lodging/58000000/57720000/57719800/57719723/d32e89e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/58000000/57720000/57719800/57719723/b658ab38.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Affordable Suites Florence [](https://www.expedia.co.uk/Florence-Hotels-Affordable-Suites-Florence.h57719723.Hotel-Information) Florence 9.2/10 Wonderful (142 reviews) "Nice clean room; friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Angelo [](https://www.expedia.co.uk/Florence-Hotels-Affordable-Suites-Florence.h57719723.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/32fd6fc1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee service](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/e7174d53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/7b1066c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Non Smoking | 1 bedroom, desk, blackout curtains, soundproofing](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/8a1b879d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Howard Johnson by Wyndham Florence [](https://www.expedia.co.uk/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information) Florence 8.6/10 Excellent (2,587 reviews) "I nice place to stay, very quiet, good breakfast, nice staff, spotless room. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Timothy £59 includes taxes & fees 15 Mar - 16 Mar [](https://www.expedia.co.uk/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-03-23&endDate=2026-03-24®ionId=553248635975849973&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-uk-fr-de.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Holiday Sale Members save up to 40% on hotels and holiday homes. Plan this year’s big trip and save. [Book now](https://expedia.co.uk/cheap-deals?rfrr=HTG_SPRING_PROMO_553248635975849973) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FEffingham-Hotels.d553248635975849973.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FEffingham-Hotels.d553248635975849973.Travel-Guide-Hotels) ## Top Effingham Hotel Reviews ![Days Inn by Wyndham Florence/I-95 North](https://images.trvl-media.com/lodging/1000000/20000/15500/15497/099eb7f9_y.jpg) ### Days Inn by Wyndham Florence/I-95 North 2/10 Terrible "Front desk person was rude and could barely hear him. Didn’t get the room I paid for. Floor was dirty as soon as I opened the door. " [](https://expedia.co.uk/Florence-Hotels-Days-Inn-By-Wyndham-FlorenceI-95-North.h15497.Hotel-Information) ![Quality Inn & Suites Florence Civic Center](https://images.trvl-media.com/lodging/1000000/20000/11600/11535/8dae8685_y.jpg) ### Quality Inn & Suites Florence Civic Center 10/10 Excellent "Everything was fine" [](https://expedia.co.uk/Florence-Hotels-Quality-Inn-And-Suites-Civic.h11535.Hotel-Information) ![Hilton Garden Inn Florence](https://images.trvl-media.com/lodging/2000000/1370000/1367300/1367205/ddbd2495_y.jpg) ### Hilton Garden Inn Florence 10/10 Excellent "Very nice stay. Very clean hotel" [](https://expedia.co.uk/Florence-Hotels-Hilton-Garden-Inn-Florence.h1367205.Hotel-Information) ![Tru by Hilton Florence I-95](https://images.trvl-media.com/lodging/28000000/27050000/27041900/27041849/a8854f5d_y.jpg) ### Tru by Hilton Florence I-95 8/10 Good "room was small but clean" [](https://expedia.co.uk/Florence-Hotels-Tru-By-Hilton-Florence-I-95.h27041849.Hotel-Information) ![Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG](https://images.trvl-media.com/lodging/1000000/970000/970000/969975/ffaddd2a_y.jpg) ### Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG 10/10 Excellent "Nice room. Clean and restful." [](https://expedia.co.uk/Florence-Hotels-Holiday-Inn-Express-Hotel-Suites-Florence-I-95-At-Hwy-327.h969975.Hotel-Information) ![Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG](https://images.trvl-media.com/lodging/2000000/1510000/1509700/1509674/9c0353ec_y.jpg) ### Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG 8/10 Good "Good location easy accessible parking." [](https://expedia.co.uk/Florence-Hotels-Holiday-Inn-Ex-Hotel-Suites-Florence-I-95-I-20-Civic-Ctr.h1509674.Hotel-Information) ![Park Inn by Radisson Florence, SC](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/e4f3361f_y.jpg) ### Park Inn by Radisson Florence, SC 8/10 Good "Room was comfortable and nice" [](https://expedia.co.uk/Florence-Hotels-Park-Inn-By-Radisson-Florence.h47086732.Hotel-Information) ![Comfort Inn & Suites Florence Center Area](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/64840011_y.jpg) ### Comfort Inn & Suites Florence Center Area 8/10 Good "At 8am breakfast was missing many items. Oatmeal low and no sugar or cinnamon etc. no yogurt. Granted it was a full hotel but planning for capacity seemed amiss. " [](https://expedia.co.uk/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) ![Howard Johnson by Wyndham Florence](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/32fd6fc1_y.jpg) ### Howard Johnson by Wyndham Florence 8/10 Good "A" [](https://expedia.co.uk/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information) ## More cheap stays in Effingham ![Microtel Inn & Suites by Wyndham Florence](https://images.trvl-media.com/lodging/1000000/200000/200000/199996/4d56e96c_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Microtel Inn & Suites by Wyndham Florence 1912 Enterprise Dr Florence SC £52 15 Mar - 16 Mar includes taxes & fees 6.8/10 (1,005 reviews) [](https://expedia.co.uk/Florence-Hotels-Microtel-Inn-Suites-By-Wyndham-Florence.h199996.Hotel-Information) ![Howard Johnson by Wyndham Florence](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/32fd6fc1_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Howard Johnson by Wyndham Florence 2038 W Lucas Street Florence SC £59 15 Mar - 16 Mar includes taxes & fees 8.6/10 Excellent! (2,587 reviews) [](https://expedia.co.uk/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information) ![Park Inn by Radisson Florence, SC](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/e4f3361f_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Park Inn by Radisson Florence, SC 1729 Mandeville Road Florence SC £71 15 Mar - 16 Mar includes taxes & fees 9/10 Wonderful! (2,254 reviews) [](https://expedia.co.uk/Florence-Hotels-Park-Inn-By-Radisson-Florence.h47086732.Hotel-Information) ![Best Western Inn](https://images.trvl-media.com/lodging/1000000/10000/500/455/ef1db617_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Best Western Inn 1808 W Lucas Street Florence SC £83 10 Mar - 11 Mar includes taxes & fees 7.8/10 Good! (1,003 reviews) [](https://expedia.co.uk/Florence-Hotels-Best-Western-Inn.h455.Hotel-Information) ![Comfort Inn & Suites Florence Center Area](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/64840011_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Comfort Inn & Suites Florence Center Area 527 Woody Jones Blvd Florence SC £84 29 Mar - 30 Mar includes taxes & fees 9.2/10 Wonderful! (1,244 reviews) [](https://expedia.co.uk/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) ![Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG](https://images.trvl-media.com/lodging/1000000/970000/970000/969975/ffaddd2a_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG 2101 Florence Harllee Blvd Florence SC £109 29 Mar - 30 Mar includes taxes & fees 8.6/10 Excellent! (1,009 reviews) [](https://expedia.co.uk/Florence-Hotels-Holiday-Inn-Express-Hotel-Suites-Florence-I-95-At-Hwy-327.h969975.Hotel-Information) ## Frequently asked questions ### What is the best area to stay in Effingham? > This area, often referred to as the Florence-Effingham commercial corridor, is characterised by a concentration of hotels, restaurants, and petrol stations just off the main highways. It's designed for convenience, especially for those travelling through or using Effingham as a base for exploring the wider region. You'll find most services clustered along these two major roads. > > > For solo travellers or couples on a road trip, this area is ideal. Its primary benefit is the ease of getting on and off the highways, simplifying onward journeys. There are also several dining options ranging from casual eateries to sit-down restaurants, making it easy to grab a meal after a day of driving. ### When is the best time to go to Effingham? > During these periods, the weather is pleasantly mild, with comfortable temperatures and lower humidity compared to the peak summer months. This makes it ideal for enjoying outdoor activities and exploring the local area without the intense heat. You'll find it's a great time for leisurely drives through the countryside or visiting nearby attractions. > > > For those planning to attend local events or simply enjoy the comfortable weather, these seasons offer the best conditions. ### Can I cancel my hotel reservation on Expedia? ### How can I save on a Effingham hotel booking with Expedia? ### How much is the nightly rate at a Effingham hotel? ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - More ways to book - [Bishopville Hotels ](https://www.expedia.co.uk/Bishopville-Hotels.d6938.Travel-Guide-Hotels) - [Hilton Hotels in Blenheim ](https://www.expedia.co.uk/Blenheim-Hotels-Hilton-Hotels.0-0-d3000353092--bHiltonHotels.Travel-Guide-Filter-Hotels) - [Blenheim Hotels ](https://www.expedia.co.uk/Blenheim-Hotels.d3000353092.Travel-Guide-Hotels) - [Cades Hotels ](https://www.expedia.co.uk/Cades-Hotels.d3000353095.Travel-Guide-Hotels) - [Centenary Hotels ](https://www.expedia.co.uk/Centenary-Hotels.d3000353100.Travel-Guide-Hotels) - 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