San Francisco Holidays from £502
Book a Hotel + Flight or Car together to unlock savings
Your San Francisco Holiday
When a fun city break is calling, answer it with a holiday package to San Francisco. The neighbourhood of El Cangrejo, which is good for distilleries and craft breweries, bars and pubs and cafes, makes a fantastic base for your adventures. You'll want to do a little exploring during your trip to San Francisco. Carve out some time for top attractions such as Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama. That dream San Francisco holiday is just a few clicks away. Explore flights, accommodation and more on Expedia for an adventure that's tailored to suit your travel style.
Price found within the past 48 hours. Click for updated prices.
Riande Aeropuerto Hotel & Casino
Tocumen Airport
£515
per person
13 Nov - 17 Nov
found 13 hours ago
Return flight included
Kingston (KIN) to Panama City (PTY)
8.6/10 Excellent! (1,819 reviews)
Nice place for a 1 night stay. Nothing fancy. Rooms and hotel a little outdated but the breakfast was good. So a nice place for a 1 night stay during a layover.
Reviewed on 10 Oct 2026
Where to stay in San Francisco
Find the best San Francisco areas and neighborhoods for the activities you enjoy most. Learn more about San Francisco
Casco Viejo
Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.
Bella Vista
1 out of top 10 points of interest in this area
Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina Station. You might spend time checking out top sights like Via Espana and Iglesia del Carmen.
El Cangrejo
The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.
San Felipe
While visiting San Felipe, you might make a stop by sights like Independence Square and Interoceanic Canal Museum.
Calidonia
2 out of top 10 points of interest in this area
Calidonia is a destination travellers like for its shopping, and you might hop aboard the metro at Lotería Station or Santo Tomás Station to explore sights like Via Espana.
Top hotels in San Francisco
Megapolis Hotel Panamá
Avenida Balboa Panama City
Fully refundableReserve now, pay when you stay
£113
31 Oct - 1 Nov
includes taxes & fees
8.6/10 Excellent! (1,778 reviews)
"Hgghhggghhvhchughugg. Hughhggg"
Reviewed on 10 Oct 2026
Ramada Plaza by Wyndham Panama Punta Pacifica
Via Israel y Calle 71, San Francisco Panama City Panama
£81
10 Nov - 11 Nov
includes taxes & fees
Decapolis Hotel Panama City
Avenida Balboa Con Multicentro Panama City Panama
Fully refundableReserve now, pay when you stay
£72
31 Oct - 1 Nov
includes taxes & fees
8.6/10 Excellent! (1,731 reviews)
"Para el precio no esta mal pero si puedes reservar el megapolis esta en mejores condiciones."
Reviewed on 10 Oct 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Why should I book my San Francisco holiday with Expedia?
Choose Expedia to plan your next big adventure easily and all in the same place. Our top tip for bagging an unbeatable deal on a San Francisco getaway? Bundle your hotel, flights and/or hire car into a package holiday. Then add a couple of exciting tours and activities. Many bookings also have flexible cancellation policies, so there's no need to worry if you have to change your travel plans. Round-the-clock assistance with cancelling and amending your trip is on-hand via our Customer Service Portal link.
When is the best time of year to holiday in San Francisco?
Love sightseeing but don't like huge crowds? Lock in your San Francisco getaway for May, August and October. Typically, it's much quieter than in November, December and January. Organise your visit to San Francisco based on what style of adventure you want. November is the coolest time of year, when average daytime temperatures are 25ºC. In January, the warmest month, expect averages of 26ºC during the day.
What are the top hotels for my holiday in San Francisco?
If you're wanting to stay within easy reach of San Francisco, lock in a room at Home Suite Ocean View or Modern Apartment in a Luxurious Residential Unit in the heart of the city. Both will make you feel at home and are popular options with many travellers.
How do I get a cheap holiday to San Francisco?
Browse and book everything all in one place with our San Francisco holidays. You'll discover deals on hotels, flights, tours and more that'll keep your bank account happy and your adventurous spirit alive. And, with more than 400 partner airlines and 321,000 properties worldwide to choose from, you'll have endless opportunities to mix and match as you want. Learn more about how you can save money on your holiday when you bundle your flight and hotel bookings with Expedia.
What should I do on my San Francisco holiday?
Offering leading attractions such as Miraflores Locks and Metropolitan Cathedral of Panama, a holiday in San Francisco is packed with exciting places to visit. Albrook Shopping Mall and Multiplaza Pacific Mall are two other sights worth discovering.
What is the best area to stay in when on holiday in San Francisco?
There's so much to explore in San Francisco, so stay near its top attractions and spend more time sightseeing. Multiplaza Pacific Mall is one place to add to your to-do list.
Do I need a visa for my San Francisco holiday?
Official government websites are the best source of information on visa requirements, application procedures and any supporting documentation. Your nationality and the reason for your visit, whether it be for work or holidays, will determine if you need a visa for San Francisco. Also check that your passport is up to date and has a minimum of six months validity remaining after the date of your return. Do all your travel planning ahead of time to avoid any last-minute surprises.
What should I wear on my San Francisco holiday?
Do some research into the types of clothing people in San Francisco wear, and maybe even check out fashion pages on social media for inspiration. Try to create a versatile wardrobe full of pieces that work for your destination and show off your unique style.
What does an Expedia San Francisco holiday include?
Hotels, flights and hire cars — we've got them all. With Expedia, you can shape your San Francisco package however you want. All you have to do is work out just what you need. Once you've made your booking, why not add extras like activities and experiences? The more you bundle, the bigger the savings! Explore a variety of styles on Expedia and find the right fit for you and your travel companions. From the most popular property types, like apartments and condos, to many other options, there are loads of holiday retreats in San Francisco to select from so you can personalise your stay just the way you like it.
Does Expedia offer Book Now, Pay Later San Francisco holidays?
Your bank balance shouldn't prevent you from escaping on holiday, so Expedia has devised a solution to help. Now that we've joined forces with online lender Klarna, it's easier than ever to book your dream getaway without draining your savings. Klarna offers flexible payment options at checkout that take the worry out of budgeting for your trip. Check out these flexible payment options:
- Pay monthly holidays: Klarna offers convenient monthly payment plans that suit all budgets, so you can have that well-deserved holiday now.
- No-deposit holidays: If no upfront fee for your getaway makes hitting that "book now" button more stress-free, opt for a no-deposit holiday plan with Klarna so that you can Book Now, Pay Later!
Can I choose my airline with a San Francisco Expedia holiday?
With a holiday package, you're always in charge. Whether you're looking to fly to San Francisco in economy or business class, simply pick from the available airline options. Expedia has access to more than 400 partner airlines all over the world.
Stay near popular San Francisco attractions
Multiplaza Pacific Mall
9.0/10 (4,497 reviews)
During your trip to Panama City, you can search for that perfect souvenir at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.
Via Espana
8.4/10 (2,902 reviews)
During your trip to Panama City, you can browse for the perfect souvenirs at Via Espana. Stroll along the seaside or visit the casinos in this vibrant area.
ATLAPA Conventions Center
7.6/10 (31 reviews)
Learn about the events happening in ATLAPA Conventions Center during your trip to Panama City. Stroll along the seaside in this vibrant area or visit its top-notch restaurants.
Multicentro Panama
8.2/10 (274 reviews)
During your trip to Panama City, you can find the perfect gifts to bring home at Multicentro Panama. Stroll along the seaside or visit the casinos in this vibrant area.
Pacific Center
You can browse for the perfect souvenirs at Pacific Center during your visit to Panama City. You can enjoy the restaurants while in the area.
Omar Torrijos Recreational Park
5.6/10 (4 reviews)
Omar Torrijos Recreational Park is just one of the places to see in Panama City, so why not enjoy the other things to explore during your travels? Amble around this vibrant area's seaside and enjoy its lively bars.
Things to do
Panama Canal: The Most Complete Wildlife Experience
£36
per adult
98% of travellers recommend
Panama City: All-Inclusive Catamaran Cruise to Taboga Island
£74
per adult
94% of travellers recommend
Half day of Panama city and canal tour: shared and private
£50
per adult
96% of travellers recommend
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.
