Title: TOP Central Missouri Spa Hotels for 2026 - Spas in Central Missouri, MO | Expedia.co.uk [Central Missouri Travel Guide](https://expedia.co.uk/Central-Missouri.dx6058776)[Hotels in Central Missouri](https://expedia.co.uk/Central-Missouri-Hotels.d6058776.Travel-Guide-Hotels)[Holiday Rentals in Central Missouri](https://expedia.co.uk/Central-Missouri-Holiday-Rentals.d6058776.Travel-Guide-HolidayRentals)[Flights to Central Missouri](https://expedia.co.uk/Cheap-Flights-To-Central-Missouri.d6058776.Travel-Guide-Flights)[Things to do in Central Missouri](https://expedia.co.uk/Things-To-Do-In-Central-Missouri.d6058776.Travel-Guide-Activities)[Central Missouri Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Central-Missouri.d6058776.Car-Hire-Guide)[Central Missouri Holidays](https://expedia.co.uk/Central-Missouri.d6058776.Holidays-City-Breaks) ![Missouri State Capitol which includes an administrative building, a fountain and heritage architecture](https://images.trvl-media.com/place/6092643/f7036169-7e6d-403b-b3a3-fac711433497.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Spa Hotels in Central Missouri, MO - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Central Missouri Spa Hotels Tonight [26 Dec - 27 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6058776&startDate=2025-12-26&endDate=2025-12-27&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [27 Dec - 28 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6058776&startDate=2025-12-27&endDate=2025-12-28&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [26 Dec - 28 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6058776&startDate=2025-12-26&endDate=2025-12-28&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [2 Jan - 4 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6058776&startDate=2026-01-02&endDate=2026-01-04&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Central Missouri hotels with a spa ![Couples treatment room(s), hot tub, body treatments, hydrotherapy](https://images.trvl-media.com/lodging/1000000/50000/40800/40728/4d290838.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40800/40728/7a41768f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40800/40728/7e36eb59.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/50000/40800/40728/41084352.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lodge Of Four Seasons Golf Resort, Marina & Spa [](https://www.expedia.co.uk/Osage-Beach-Hotels-Lodge-Of-Four-Seasons-Golf-Resort.h40728.Hotel-Information) Lake Ozark 7.4/10 Good (1085) "Great Stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Karen £79 includes taxes & fees 12 Jan - 13 Jan 2026 [](https://www.expedia.co.uk/Osage-Beach-Hotels-Lodge-Of-Four-Seasons-Golf-Resort.h40728.Hotel-Information) ![Couples treatment room(s), steam room, body treatments](https://images.trvl-media.com/lodging/10000000/9790000/9785300/9785264/c54d3975.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Aerial view](https://images.trvl-media.com/lodging/10000000/9790000/9785300/9785264/bfd40943.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges, poolside bar](https://images.trvl-media.com/lodging/10000000/9790000/9785300/9785264/64c8ff64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, coffee/tea maker](https://images.trvl-media.com/lodging/10000000/9790000/9785300/9785264/8d3e409f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Lodge at Old Kinderhook Golf Resort [](https://www.expedia.co.uk/Osage-Beach-Hotels-The-Lodge-At-Old-Kinderhook-Golf-Resort.h9785264.Hotel-Information) Camdenton 9.4/10 Exceptional (746) "Easy access, fast friendly check in and excellent Accommodations." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Richard [](https://www.expedia.co.uk/Osage-Beach-Hotels-The-Lodge-At-Old-Kinderhook-Golf-Resort.h9785264.Hotel-Information) ![Couples treatment room(s), body treatments, hydrotherapy, aromatherapy](https://images.trvl-media.com/lodging/3000000/2020000/2015400/2015357/7d41cdab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Grand Suite (Two Double Beds) | Terrace/patio](https://images.trvl-media.com/lodging/3000000/2020000/2015400/2015357/1773a780.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Ballroom](https://images.trvl-media.com/lodging/3000000/2020000/2015400/2015357/b09c0391.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch, dinner served; Caribbean cuisine ](https://images.trvl-media.com/lodging/3000000/2020000/2015400/2015357/926b808f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Camden on the Lake Resort & Spa [](https://www.expedia.co.uk/Osage-Beach-Hotels-Camden-On-The-Lake-Resort-Spa.h2015357.Hotel-Information) Lake Ozark 9.0/10 Wonderful (1001) "Awesome staff, great food and service!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lori [](https://www.expedia.co.uk/Osage-Beach-Hotels-Camden-On-The-Lake-Resort-Spa.h2015357.Hotel-Information) ![Sun deck](https://images.trvl-media.com/lodging/1000000/30000/21300/21228/268207dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Blackout curtains, iron/ironing board, travel cot, free WiFi](https://images.trvl-media.com/lodging/1000000/30000/21300/21228/83344a11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/30000/21300/21228/a7d33a02.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/21300/21228/e7bd5e4e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Margaritaville Lake Resort Lake of the Ozarks [](https://www.expedia.co.uk/Osage-Beach-Hotels-Margaritaville-Lake-Resort-Lake-Of-The-Ozarks.h21228.Hotel-Information) Osage Beach 8.4/10 Very good (1002) "My family and I had a wonderful time staying at this resort. The staff were very welcoming and helpful, and the rooms and facilities were all great. We really enjoyed our stay! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Amos £103 includes taxes & fees 4 Jan - 5 Jan 2026 [](https://www.expedia.co.uk/Osage-Beach-Hotels-Margaritaville-Lake-Resort-Lake-Of-The-Ozarks.h21228.Hotel-Information) ![Couples treatment room(s), body treatments, aromatherapy](https://images.trvl-media.com/lodging/2000000/1550000/1545200/1545110/1a33bfc2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/2000000/1550000/1545200/1545110/f663be7b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/2000000/1550000/1545200/1545110/cfa9b0fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/2000000/1550000/1545200/1545110/c5b42c11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Courtland Hotel and Day Spa [](https://www.expedia.co.uk/Pittsburg-Hotels-The-Courtland-Hotel-And-Day-Spa.h1545110.Hotel-Information) Fort Scott 9.2/10 Wonderful (275) "This is a great place to stay and with easy access to town area!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mark £62 includes taxes & fees 30 Dec - 31 Dec [](https://www.expedia.co.uk/Pittsburg-Hotels-The-Courtland-Hotel-And-Day-Spa.h1545110.Hotel-Information) ![Couples treatment room(s), aromatherapy, hot stone massages](https://images.trvl-media.com/lodging/2000000/1670000/1664700/1664659/f1ee0a61.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Spa Suite | Premium bedding, down duvets, memory-foam beds, in-room safe](https://images.trvl-media.com/lodging/2000000/1670000/1664700/1664659/1f413a42.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Guest Suite | Premium bedding, down duvets, memory-foam beds, in-room safe](https://images.trvl-media.com/lodging/2000000/1670000/1664700/1664659/436e9cc1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Spa Suite | View from room](https://images.trvl-media.com/lodging/2000000/1670000/1664700/1664659/34923626.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hermann Hill [](https://www.expedia.co.uk/Washington-Hotels-Hermann-Hill.h1664659.Hotel-Information) Hermann 9.4/10 Exceptional (110) "Top notch they think of everything. Highly recommend. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kevin £258 includes taxes & fees 5 Jan - 6 Jan 2026 [](https://www.expedia.co.uk/Washington-Hotels-Hermann-Hill.h1664659.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-01-09&endDate=2026-01-10®ionId=6058776&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Find out more about Central Missouri ### Top Central Missouri attractions for a relaxing vacation Central Missouri offers a delightful blend of relaxation and adventure, making it a perfect region for travelers seeking hotels with spas. Begin your journey at the serene Lake of the Ozarks, where stunning views and tranquil waters set the tone for a restful getaway. Enjoy a day of boating or fishing, followed by a rejuvenating spa treatment at one of the lakeside resorts. Next, explore the picturesque Ha Ha Tonka State Park, where you can hike through lush trails that lead to breathtaking vistas and the ruins of a historic stone castle, perfect for a leisurely family outing. For a taste of local history, venture to the Missouri State Capitol in Jefferson City, where guided tours showcase the impressive architecture and rich stories of the state's past. Don't miss the charming town of Columbia, home to vibrant arts and culture, where you can indulge in local cuisine before unwinding at a boutique hotel that features a pampering spa. By choosing to stay in this area, you’ll enjoy not only luxurious accommodations but also the convenience of nearby attractions, ensuring a well-rounded and fulfilling escape. ## Top Central Missouri Hotel Reviews ![Country Inn & Suites by Radisson, Columbia, MO](https://images.trvl-media.com/lodging/2000000/1660000/1658500/1658463/c8809092_y.jpg) ### Country Inn & Suites by Radisson, Columbia, MO 10/10 Excellent "We were on the way to Kentucky and needed a place to stay. We picked Country Inn & Suites by Radisson for its 9.0 rating and reasonable rate. Our expectations were exceeded with a very clean hotel, very pleasant staff, great room with a clean and spacious bathroom with great lighting, a great shower, quiet HVAC, great sound isolation, great light exclusion to extend and improve sleep, and a good breakfast. The only things that could have made it ideal would have been bananas at breakfast and keycards that would work the entire stay. Honestly, if we need a place to stay in Columbia, MO, this is likely our choice on future trips. Thanks!" [](https://expedia.co.uk/Columbia-Hotels-Country-Inn-Suites-By-Radisson.h1658463.Hotel-Information) ![Holiday Inn Express Hotel & Suites Columbia Univ Area-Hwy 63 by IHG](https://images.trvl-media.com/lodging/8000000/7680000/7678000/7677926/8a05cd33_y.jpg) ### Holiday Inn Express Hotel & Suites Columbia Univ Area-Hwy 63 by IHG 10/10 Excellent "Very clean hotel with friendly staff" [](https://expedia.co.uk/Columbia-Hotels-Holiday-Inn-Express-Hotel-Suites-Columbia-Univ-Area-Hwy-63.h7677926.Hotel-Information) ![Lodge Of Four Seasons Golf Resort, Marina & Spa](https://images.trvl-media.com/lodging/1000000/50000/40800/40728/7e36eb59_y.jpg) ### Lodge Of Four Seasons Golf Resort, Marina & Spa 10/10 Excellent "Loved the warm pool! The Santa workshop treat was amazing! " [](https://expedia.co.uk/Osage-Beach-Hotels-Lodge-Of-Four-Seasons-Golf-Resort.h40728.Hotel-Information) ![Camden on the Lake Resort & Spa](https://images.trvl-media.com/lodging/3000000/2020000/2015400/2015357/21eb378b_y.jpg) ### Camden on the Lake Resort & Spa 10/10 Excellent "It was fancy. " [](https://expedia.co.uk/Osage-Beach-Hotels-Camden-On-The-Lake-Resort-Spa.h2015357.Hotel-Information) ![Wingate by Wyndham - Columbia](https://images.trvl-media.com/lodging/1000000/990000/986100/986086/a16387a6_y.jpg) ### Wingate by Wyndham - Columbia 10/10 Excellent "I loved my stay. The room was clean and very nice. For a continental breakfast, it was really good." [](https://expedia.co.uk/Columbia-Hotels-Wingate-By-Wyndham-Columbia.h986086.Hotel-Information) ![Stoney Creek Hotel Columbia](https://images.trvl-media.com/lodging/2000000/1060000/1052400/1052330/5398551a_y.jpg) ### Stoney Creek Hotel Columbia 10/10 Excellent "noce atmosphere" [](https://expedia.co.uk/Columbia-Hotels-Stoney-Creek-Hotel-Columbia.h1052330.Hotel-Information) ![The Lodge at Old Kinderhook Golf Resort](https://images.trvl-media.com/lodging/10000000/9790000/9785300/9785264/5bef6d22_y.jpg) ### The Lodge at Old Kinderhook Golf Resort 10/10 Excellent "Housekeeping did a great job, the room was impeccable." [](https://expedia.co.uk/Osage-Beach-Hotels-The-Lodge-At-Old-Kinderhook-Golf-Resort.h9785264.Hotel-Information) ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - Other - More ways to book - [Apache Flats Hotels ](https://www.expedia.co.uk/Apache-Flats-Hotels.d553248635975850469.Travel-Guide-Hotels) - [Hotels near California Country Club ](https://www.expedia.co.uk/California-Country-Club-Hotels.0-l553248621594455013-0.Travel-Guide-Filter-Hotels) - [California Hotels ](https://www.expedia.co.uk/California-Hotels.d6351831.Travel-Guide-Hotels) - [Adults Only Resorts & in Missouri ](https://www.expedia.co.uk/Destinations-In-Missouri-Adults-Only-Resorts.0-0-d227-tAdultsOnlyResorts.Hotel-Filter-Destinations) - [All-Inclusive Hotels in Missouri ](https://www.expedia.co.uk/Destinations-In-Missouri-All-Inclusive-Hotel.0-0-d227-tAllInclusiveHotel.Hotel-Filter-Destinations) - [Beach Resorts & in Missouri ](https://www.expedia.co.uk/Destinations-In-Missouri-Beach-Hotels.0-0-d227-tBeachHotels.Hotel-Filter-Destinations) - 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