Title: The Best Hotels Closest to Main Street Hyannis in Hyannis - 2026 Updated Prices | Expedia.co.uk [Hyannis Travel Guide](https://expedia.co.uk/Hyannis.dx1544)[Holiday Rentals in Hyannis](https://expedia.co.uk/Hyannis-Holiday-Rentals.d1544.Travel-Guide-HolidayRentals)[Flights to Hyannis](https://expedia.co.uk/Cheap-Flights-To-Hyannis.d1544.Travel-Guide-Flights)[Things to do in Hyannis](https://expedia.co.uk/Things-To-Do-In-Hyannis.d1544.Travel-Guide-Activities)[Main Street Hyannis Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Main-Street-Hyannis.d6287458.Car-Hire-Guide)[Main Street Hyannis Holidays](https://expedia.co.uk/Main-Street-Hyannis-Hyannis.d6287458.Attraction) ![Main Street Hyannis featuring street scenes as well as a couple](https://images.trvl-media.com/place/6287458/f083813a-eac6-4b18-a763-a901fa1ed4e5.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6287458/f083813a-eac6-4b18-a763-a901fa1ed4e5.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [19 Jan - 20 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6287458&startDate=2026-01-19&endDate=2026-01-20&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [20 Jan - 21 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6287458&startDate=2026-01-20&endDate=2026-01-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [23 Jan - 25 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6287458&startDate=2026-01-23&endDate=2026-01-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [30 Jan - 1 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6287458&startDate=2026-01-30&endDate=2026-02-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Property class ## Our top choices for Main Street Hyannis hotels ![Terrace/patio](https://images.trvl-media.com/lodging/8000000/7650000/7640900/7640889/7438dff7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Marina](https://images.trvl-media.com/lodging/8000000/7650000/7640900/7640889/f27823ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/8000000/7650000/7640900/7640889/87d9418f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Aerial view](https://images.trvl-media.com/lodging/8000000/7650000/7640900/7640889/3fdd0247.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Anchor In Distinctive Waterfront Lodging [](https://www.expedia.co.uk/Hyannis-Hotels-Anchor-In-Distinctive-Waterfront-Lodging.h7640889.Hotel-Information) 0.4 mi from Main Street Hyannis 9.4/10 Exceptional (1,005 reviews) "The Anchor In is a lovely hotel with friendly staff and clean, updated rooms. It is very convenient to the ferry and to various dining options in Hyannis. Great place to stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cynthia £122 includes taxes & fees 20 Jan - 21 Jan [](https://www.expedia.co.uk/Hyannis-Hotels-Anchor-In-Distinctive-Waterfront-Lodging.h7640889.Hotel-Information) ![Indoor pool, seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/10000/4400/4331/ac25d19b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Beach nearby](https://images.trvl-media.com/lodging/1000000/10000/4400/4331/4eacbec7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/10000/4400/4331/6a1047d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lunch and dinner served, American cuisine](https://images.trvl-media.com/lodging/1000000/10000/4400/4331/9771d4ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Cove at Yarmouth by Westgate Resorts [](https://www.expedia.co.uk/West-Yarmouth-Hotels-The-Cove-At-Yarmouth.h4331.Hotel-Information) 1.3 mi from Main Street Hyannis 9.2/10 Wonderful (247 reviews) "The staff are amazing! Love the amenities - the pool, recreation center, activities for the kids such as windchime arts and crafts. The arcade is always a hit. The Loft makes it so easy to not have to stress about a place to go to for dinner. The Cove is a great place for everyone! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lauren £102 includes taxes & fees 20 Jan - 21 Jan [](https://www.expedia.co.uk/West-Yarmouth-Hotels-The-Cove-At-Yarmouth.h4331.Hotel-Information) ![Indoor pool, seasonal outdoor pool, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/3000000/2560000/2558700/2558618/dc2c7156.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 King Studio Whirlpool Non Smoking | Premium bedding, down duvets, in-room safe, blackout curtains](https://images.trvl-media.com/lodging/3000000/2560000/2558700/2558618/040fea3c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2560000/2558700/2558618/b2eb67f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, seasonal outdoor pool, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/3000000/2560000/2558700/2558618/f6ec329c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Cape Cod-West Yarmouth [](https://www.expedia.co.uk/West-Yarmouth-Hotels-Hampton-Inn-Suites-Cape-Cod-West-Yarmouth.h2558618.Hotel-Information) 1 mi from Main Street Hyannis 8.8/10 Excellent (1,002 reviews) "They were excellent. Felt extremely comfortable. Their breakfast was amazing, staff were so friendly!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Linda £94 includes taxes & fees 25 Jan - 26 Jan [](https://www.expedia.co.uk/West-Yarmouth-Hotels-Hampton-Inn-Suites-Cape-Cod-West-Yarmouth.h2558618.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/10000/1600/1517/3168dc41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/1600/1517/5cb65d15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/10000/1600/1517/1a19fbd4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/10000/1600/1517/85e7753a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard By Marriott Cape Cod Hyannis [](https://www.expedia.co.uk/Hyannis-Hotels-Courtyard-By-Marriott-Cape-Cod-Hyannis.h1517.Hotel-Information) 1 mi from Main Street Hyannis 8.8/10 Excellent (490 reviews) "Parking was free and easy, room was very clean and housekeeping service was top notch. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Maureen £109 includes taxes & fees 25 Jan - 26 Jan [](https://www.expedia.co.uk/Hyannis-Hotels-Courtyard-By-Marriott-Cape-Cod-Hyannis.h1517.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/116000000/115250000/115243800/115243739/5d7ebe6e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/116000000/115250000/115243800/115243739/e9405833.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/116000000/115250000/115243800/115243739/9d421872.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/116000000/115250000/115243800/115243739/0a9fa15c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard Resort [](https://www.expedia.co.uk/Hyannis-Hotels-Courtyard-Resort.h115243739.Hotel-Information) 0.2 mi from Main Street Hyannis 8.4/10 Very good (53 reviews) "It was ok. Best part was it was near everything. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kimberly £91 includes taxes & fees 20 Jan - 21 Jan [](https://www.expedia.co.uk/Hyannis-Hotels-Courtyard-Resort.h115243739.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/40500/40461/9f940314.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/40500/40461/e8d49199.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40500/40461/dbd19b42.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, seasonal outdoor pool, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/1000000/50000/40500/40461/3e4f4967.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Doubletree by Hilton Cape Cod - Hyannis [](https://www.expedia.co.uk/Hyannis-Hotels-Doubletree-By-Hilton-Cape-Cod-Hyannis.h40461.Hotel-Information) 0.6 mi from Main Street Hyannis 8.4/10 Very good (885 reviews) "It was a decent stay I can’t complain " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rony £100 includes taxes & fees 25 Jan - 26 Jan [](https://www.expedia.co.uk/Hyannis-Hotels-Doubletree-By-Hilton-Cape-Cod-Hyannis.h40461.Hotel-Information) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/2000000/1250000/1240500/1240460/b37d6e5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1250000/1240500/1240460/015bb1aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout curtains, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/2000000/1250000/1240500/1240460/0874e47d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/2000000/1250000/1240500/1240460/d4c5b048.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn Hyannis - Cape Cod [](https://www.expedia.co.uk/Hyannis-Hotels-Comfort-Inn.h1240460.Hotel-Information) 0.2 mi from Main Street Hyannis 8.0/10 Very good (1,002 reviews) "Nice hotel had a perfect stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) David £84 includes taxes & fees 19 Feb - 20 Feb [](https://www.expedia.co.uk/Hyannis-Hotels-Comfort-Inn.h1240460.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1340000/1330200/1330174/3bffd99c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed | Internet, bed sheets, alarm clocks](https://images.trvl-media.com/lodging/2000000/1340000/1330200/1330174/bbed7ace.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/2000000/1340000/1330200/1330174/6cc9c6b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/2000000/1340000/1330200/1330174/906db676.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cape Sands Inn [](https://www.expedia.co.uk/West-Yarmouth-Hotels-Cape-Sands-Inn.h1330174.Hotel-Information) 1.2 mi from Main Street Hyannis 8.2/10 Very good (1,020 reviews) "Room was nice and spacious, very clean. Upstairs people was a little loud but other than that the stay was good. Would definitely stay again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Celestina £64 includes taxes & fees 20 Jan - 21 Jan [](https://www.expedia.co.uk/West-Yarmouth-Hotels-Cape-Sands-Inn.h1330174.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/1000000/60000/55000/54945/741b5772.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/60000/55000/54945/3225f1fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/60000/55000/54945/03465c0c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/60000/55000/54945/0271fbcb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyannis Harbor Hotel [](https://www.expedia.co.uk/Hyannis-Hotels-Hyannis-Harbor-Hotel.h54945.Hotel-Information) 0.4 mi from Main Street Hyannis 8.0/10 Very good (1,001 reviews) "Lovely stay! One of the best hotels to stay in Hyannis. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mary £126 includes taxes & fees 25 Jan - 26 Jan [](https://www.expedia.co.uk/Hyannis-Hotels-Hyannis-Harbor-Hotel.h54945.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/12500/12477/6128ed99.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/20000/12500/12477/0fe4f63e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/12500/12477/c18bcef6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, outdoor pool, pool loungers](https://images.trvl-media.com/lodging/1000000/20000/12500/12477/12aa0105.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Hyannis by IHG [](https://www.expedia.co.uk/Hyannis-Hotels-Holiday-Inn-Hyannis-By-IHG.h12477.Hotel-Information) 1.8 mi from Main Street Hyannis 8.2/10 Very good (985 reviews) "Nice place" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Linda £98 includes taxes & fees 25 Jan - 26 Jan [](https://www.expedia.co.uk/Hyannis-Hotels-Holiday-Inn-Hyannis-By-IHG.h12477.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1560000/1556000/1555968/5ba979da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 Queen Bed | Bathroom | Towels](https://images.trvl-media.com/lodging/2000000/1560000/1556000/1555968/4269b11c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Room | Iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/2000000/1560000/1556000/1555968/b3929abf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1560000/1556000/1555968/719ceca4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sea Breeze Inn [](https://www.expedia.co.uk/Hyannis-Hotels-Sea-Breeze-Inn.h1555968.Hotel-Information) 1.1 mi from Main Street Hyannis 7.8/10 Good (193 reviews) "Nice place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kevin £68 includes taxes & fees 20 Jan - 21 Jan [](https://www.expedia.co.uk/Hyannis-Hotels-Sea-Breeze-Inn.h1555968.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1120000/1119300/1119277/f7fc1d07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1120000/1119300/1119277/ef69e045.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed | Premium bedding, down duvets, in-room safe, individually decorated](https://images.trvl-media.com/lodging/2000000/1120000/1119300/1119277/4dfa52ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Plaza Suite | Premium bedding, down duvets, in-room safe, individually decorated](https://images.trvl-media.com/lodging/2000000/1120000/1119300/1119277/34fe26da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyannis Plaza Hotel [](https://www.expedia.co.uk/Hyannis-Hotels-Hyannis-Plaza-Hotel.h1119277.Hotel-Information) 0.5 mi from Main Street Hyannis 7.0/10 Good (990 reviews) "The best staff abd it was clean and beautiful " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Heather £71 includes taxes & fees 19 Feb - 20 Feb [](https://www.expedia.co.uk/Hyannis-Hotels-Hyannis-Plaza-Hotel.h1119277.Hotel-Information) ![Family House, Private Bathroom, Pool View | Lounge](https://images.trvl-media.com/lodging/120000000/119380000/119374000/119373964/d6ef30c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family House, Private Bathroom, Pool View | Terrace/patio](https://images.trvl-media.com/lodging/120000000/119380000/119374000/119373964/67634136.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family House, Private Bathroom, Pool View | Lounge](https://images.trvl-media.com/lodging/120000000/119380000/119374000/119373964/f2591e0d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family House, Private Bathroom, Pool View | Garden](https://images.trvl-media.com/lodging/120000000/119380000/119374000/119373964/9bd5f506.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sal's Place [](https://www.expedia.co.uk/Hyannis-Hotels-Sals-Place.h119373964.Hotel-Information) 1.6 mi from Main Street Hyannis £432 includes taxes & fees 20 Jan - 21 Jan [](https://www.expedia.co.uk/Hyannis-Hotels-Sals-Place.h119373964.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/13000000/12430000/12426900/12426891/ae47522f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch flat-screen TV with cable channels, TV](https://images.trvl-media.com/lodging/13000000/12430000/12426900/12426891/2b1f0d40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/13000000/12430000/12426900/12426891/023eb077.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, Multiple Beds | 1 bedroom, premium bedding, down duvets, individually decorated](https://images.trvl-media.com/lodging/13000000/12430000/12426900/12426891/19b90fe2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Village Inn Cape Cod [](https://www.expedia.co.uk/Yarmouth-Port-Hotels-The-Village-Inn-Cape-Cod.h12426891.Hotel-Information) 3.8 mi from Main Street Hyannis 10/10 Exceptional (224 reviews) "It was so charming, would definitely stay there again! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kyle £133 includes taxes & fees 21 Jan - 22 Jan [](https://www.expedia.co.uk/Yarmouth-Port-Hotels-The-Village-Inn-Cape-Cod.h12426891.Hotel-Information) ![Outdoor pool, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/1000000/20000/12900/12897/30f6a06a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/20000/12900/12897/0ad12b76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/20000/12900/12897/20b53391.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/12900/12897/b82acf26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Margaritaville Resort Cape Cod [](https://www.expedia.co.uk/Hyannis-Hotels-Cape-Codder-Resort-And-Spa.h12897.Hotel-Information) 2 mi from Main Street Hyannis 8.8/10 Excellent (430 reviews) "We are very happy with all the people at margaritaville, they are awesome 💝" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ewerton £273 includes taxes & fees 13 Feb - 14 Feb [](https://www.expedia.co.uk/Hyannis-Hotels-Cape-Codder-Resort-And-Spa.h12897.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/7000000/6700000/6697800/6697712/366fdd27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/7000000/6700000/6697800/6697712/32aabc06.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/7000000/6700000/6697800/6697712/5e533d50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/7000000/6700000/6697800/6697712/5bdfdac3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Escape Inn [](https://www.expedia.co.uk/South-Yarmouth-Hotels-The-Escape-Inn.h6697712.Hotel-Information) 4.7 mi from Main Street Hyannis 9.4/10 Exceptional (663 reviews) "Great place" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Karim £69 includes taxes & fees 20 Jan - 21 Jan [](https://www.expedia.co.uk/South-Yarmouth-Hotels-The-Escape-Inn.h6697712.Hotel-Information) ![Deluxe Suite, Oceanfront, 2 Bedrooms | Terrace/patio](https://images.trvl-media.com/lodging/1000000/800000/792100/792097/b4418ecf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/800000/792100/792097/208189d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Studio, Oceanfront, 1 Bedroom | Terrace/patio](https://images.trvl-media.com/lodging/1000000/800000/792100/792097/adb3fb01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Suite, Oceanfront, 2 Bedrooms | Living area | Flat-screen TV, fireplace, DVD player](https://images.trvl-media.com/lodging/1000000/800000/792100/792097/ca36b200.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ocean Club on Smuggler's Beach [](https://www.expedia.co.uk/South-Yarmouth-Hotels-Ocean-Club-On-Smugglers-Beach.h792097.Hotel-Information) 4.3 mi from Main Street Hyannis 9.2/10 Wonderful (1,001 reviews) "beautiful view. my daughter lives in the area nice to stay off season at your lovely place. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) TONYA £135 includes taxes & fees 2 Feb - 3 Feb [](https://www.expedia.co.uk/South-Yarmouth-Hotels-Ocean-Club-On-Smugglers-Beach.h792097.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/39000000/38360000/38357900/38357891/03e2a40a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/39000000/38360000/38357900/38357891/b38fce29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/39000000/38360000/38357900/38357891/bc568ce7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/39000000/38360000/38357900/38357891/1f21d7a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Aiden by Best Western Cape Cod - West Yarmouth [](https://www.expedia.co.uk/West-Yarmouth-Hotels-Aiden-By-Best-Western-Cape-Point.h38357891.Hotel-Information) 2.3 mi from Main Street Hyannis 8.0/10 Very good (1,003 reviews) "Clean room | Breakfast | Bar | Staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Daniel £83 includes taxes & fees 25 Jan - 26 Jan [](https://www.expedia.co.uk/West-Yarmouth-Hotels-Aiden-By-Best-Western-Cape-Point.h38357891.Hotel-Information) ![Indoor pool, open 8:00 AM to 10:00 PM, pool loungers](https://images.trvl-media.com/lodging/2000000/1150000/1143500/1143483/a8ec165b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1150000/1143500/1143483/442db5c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/2000000/1150000/1143500/1143483/b2b8a98b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/2000000/1150000/1143500/1143483/2595be6a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Mariner Resort Cape Cod by The Red Collection [](https://www.expedia.co.uk/West-Yarmouth-Hotels-The-Mariner-Resort.h1143483.Hotel-Information) 2.7 mi from Main Street Hyannis 8.0/10 Very good (445 reviews) "yes, clean room, staff are great, amenities are fine." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) James and Lisa £70 includes taxes & fees 22 Jan - 23 Jan [](https://www.expedia.co.uk/West-Yarmouth-Hotels-The-Mariner-Resort.h1143483.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/2000000/1090000/1084000/1083973/abb817d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, seasonal outdoor pool, pool loungers](https://images.trvl-media.com/lodging/2000000/1090000/1084000/1083973/205ecfd2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Room, 1 King Bed, Non Smoking | Premium bedding, in-room safe, blackout curtains, soundproofing](https://images.trvl-media.com/lodging/2000000/1090000/1084000/1083973/a8904b3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1090000/1084000/1083973/8858149e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ambassador Inn & Suites [](https://www.expedia.co.uk/South-Yarmouth-Hotels-Ambassador-Inn-Suites.h1083973.Hotel-Information) 5.1 mi from Main Street Hyannis 8.6/10 Excellent (633 reviews) "Staff was courteous and helpful." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Valerie [](https://www.expedia.co.uk/South-Yarmouth-Hotels-Ambassador-Inn-Suites.h1083973.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-02-02&endDate=2026-02-03®ionId=6287458&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Top Main Street Hyannis Hotel Reviews ![Hyannis Plaza Hotel](https://images.trvl-media.com/lodging/2000000/1120000/1119300/1119277/f7fc1d07_y.jpg) ### Hyannis Plaza Hotel 10/10 Excellent "The room was a spotless. Everything was clean. Very nice service. I love it. I would definitely stay again." [](https://expedia.co.uk/Hyannis-Hotels-Hyannis-Plaza-Hotel.h1119277.Hotel-Information) ![Bayside Resort Hotel](https://images.trvl-media.com/lodging/1000000/900000/896700/896697/85f07916_y.jpg) ### Bayside Resort Hotel 10/10 Excellent "Yes really good everything sarissha the one clean room she did good job " [](https://expedia.co.uk/West-Yarmouth-Hotels-Bayside-Resort-Hotel.h896697.Hotel-Information) ![Anchor In Distinctive Waterfront Lodging](https://images.trvl-media.com/lodging/8000000/7650000/7640900/7640889/7438dff7_y.jpg) ### Anchor In Distinctive Waterfront Lodging 10/10 Excellent "The Anchor In is a lovely hotel with friendly staff and clean, updated rooms. It is very convenient to the ferry and to various dining options in Hyannis. Great place to stay!" [](https://expedia.co.uk/Hyannis-Hotels-Anchor-In-Distinctive-Waterfront-Lodging.h7640889.Hotel-Information) ![Margaritaville Resort Cape Cod](https://images.trvl-media.com/lodging/1000000/20000/12900/12897/b57e0b1f_y.jpg) ### Margaritaville Resort Cape Cod 10/10 Excellent "Evrything is so clean! We love staying here with our family with small children. The kids love it and so do we! We go back every year. It's become a tradition! " [](https://expedia.co.uk/Hyannis-Hotels-Cape-Codder-Resort-And-Spa.h12897.Hotel-Information) ![Hyannis Harbor Hotel](https://images.trvl-media.com/lodging/1000000/60000/55000/54945/741b5772_y.jpg) ### Hyannis Harbor Hotel 10/10 Excellent "Very friendly staff, The room was very clean and welcoming it felt very comfortable like I was back in Paris." [](https://expedia.co.uk/Hyannis-Hotels-Hyannis-Harbor-Hotel.h54945.Hotel-Information) ![Cape Sands Inn](https://images.trvl-media.com/lodging/2000000/1340000/1330200/1330174/aa954682_y.jpg) ### Cape Sands Inn 10/10 Excellent "We went 12/30 till 1/2\. 1st floor was excellent. Had replaced knee it was easy to get around. Room's were clean. Office staffed was very friendly. " [](https://expedia.co.uk/West-Yarmouth-Hotels-Cape-Sands-Inn.h1330174.Hotel-Information) ![Doubletree by Hilton Cape Cod - Hyannis](https://images.trvl-media.com/lodging/1000000/50000/40500/40461/9f940314_y.jpg) ### Doubletree by Hilton Cape Cod - Hyannis 10/10 Excellent "Clean hotel, kind staff, the kids loved the warm indoor pool since it’s winter. All was good. " [](https://expedia.co.uk/Hyannis-Hotels-Doubletree-By-Hilton-Cape-Cod-Hyannis.h40461.Hotel-Information) ![Comfort Inn Hyannis - Cape Cod](https://images.trvl-media.com/lodging/2000000/1250000/1240500/1240460/f7a87ca8_y.jpg) ### Comfort Inn Hyannis - Cape Cod 10/10 Excellent "Very clean, and very helpful and friendly staff" [](https://expedia.co.uk/Hyannis-Hotels-Comfort-Inn.h1240460.Hotel-Information) ![Courtyard Resort](https://images.trvl-media.com/lodging/116000000/115250000/115243800/115243739/5d7ebe6e_y.jpg) ### Courtyard Resort 10/10 Excellent "Room what nice very easy check in.. The only thing is the toilet flooded our room but they moved us to another unit no problem! I always enjoy my stay at courtyard resort" [](https://expedia.co.uk/Hyannis-Hotels-Courtyard-Resort.h115243739.Hotel-Information) ## Hotels near other Main Street Hyannis attractions ![John F. Kennedy Hyannis Museum showcases bronze statue and historic architecture in Hyannis Massachusetts](https://images.trvl-media.com/place/6070185/b92268d1-27eb-4055-a07b-800040c40061.jpg) ### John F. Kennedy Hyannis Museum 4.4/5 (259 reviews) Learn about the 35th president of the United States at this revealing museum, which is just a short distance from the Kennedy Compound. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6070185) ![Cape Cod Maritime Museum which includes a bay or harbor and signage](https://images.trvl-media.com/place/553248635146342095/6c8cea24-96a8-41da-86a8-64397b473956.jpg) ### Cape Cod Maritime Museum You can spend an afternoon studying the exhibits at Cape Cod Maritime Museum during your trip to Hyannis. Stroll along the beautiful beaches in this family-friendly area or visit its seafood restaurants. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248635146342095) ![St. Francis Xavier Church featuring signage and a church or cathedral](https://images.trvl-media.com/place/6286986/d75d0252-a6d7-4bb9-9dd9-82f6c06a49ac.jpg) ### St. Francis Xavier Church 4.4/5 (45 reviews) After visiting St. Francis Xavier Church, make a plan to see the other sights and activities in Hyannis. Wander through the beautiful beaches and waterfront in this family-friendly area. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6286986) ![John F. Kennedy Memorial which includes flowers](https://images.trvl-media.com/place/6286978/9b85082f-75c6-4ae3-ac16-7a3f1c71a2a9.jpg) ### John F. Kennedy Memorial 4.5/5 (110 reviews) Take a moment to reflect on John F. Kennedy’s defining role in American politics, as well as his untimely death, at this poignant memorial. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6286978) ### Hyannis Armory Learn about the local history of Hyannis with a stop at Hyannis Armory. Wander the waterfront and beautiful beaches in the area. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=950930054190297088) ### Hyannis Youth & Community Center You can take time to visit Hyannis Youth & Community Center during your travels to Hyannis. Stroll along the waterfront or visit the shops in the area. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248635976357139) ### Zion Union Heritage Museum You can spend an afternoon exploring the galleries in Zion Union Heritage Museum during your trip to Hyannis. Make time to visit the area's shops or simply enjoy its top-notch restaurants. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=724958852913086464) ### Commotion Charters Enjoy an outing to Commotion Charters during your stay in Hyannis. Attend a sporting event or simply enjoy the seafood restaurants while you're in the area. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532666521) ## Frequently asked questions ### What's the area like around Main Street Hyannis? ### Where is the best place to stay near Main Street Hyannis? ### How many hotels can I expect to find near Main Street Hyannis? ### If I need to cancel the hotel reservation for my stay near Main Street Hyannis, will I receive a refund? ### What can I see and do near Main Street Hyannis?