Title: Main Street Hyannis in Hyannis | Expedia.co.uk [Main Street Hyannis Hotels](https://expedia.co.uk/Main-Street-Hyannis-Hotels.0-l6287458-0.Travel-Guide-Filter-Hotels)[Flights to Hyannis](https://expedia.co.uk/Cheap-Flights-To-Hyannis.d1544.Travel-Guide-Flights)[Things to do in Hyannis](https://expedia.co.uk/Things-To-Do-In-Hyannis.d1544.Travel-Guide-Activities)[Main Street Hyannis Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Main-Street-Hyannis.d6287458.Car-Hire-Guide)[Hyannis Holidays](https://expedia.co.uk/Hyannis.d1544.Holidays-City-Breaks) # Main Street Hyannis ![Main Street Hyannis which includes street scenes as well as a couple](https://images.trvl-media.com/place/6287458/3dc1167b-95a0-4295-b537-9961081522cb.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Main Street Hyannis which includes street scenes as well as a couple](https://images.trvl-media.com/place/6287458/3dc1167b-95a0-4295-b537-9961081522cb.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Main Street Hyannis showing signage](https://images.trvl-media.com/place/6287458/6cbd6bcb-75e5-4848-be65-87e11f5c8e91.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Main Street Hyannis featuring street scenes as well as a couple](https://images.trvl-media.com/place/6287458/f083813a-eac6-4b18-a763-a901fa1ed4e5.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Main Street Hyannis](https://images.trvl-media.com/place/6287458/41cb7c4b-31e0-402f-ba25-cc551d995f6c.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ## Visit Main Street Hyannis Activities [Hyannis travel guide](https://expedia.co.uk/Hyannis.dx1544) --- --- ### Popular places to visit ![John F. Kennedy Hyannis Museum showing a statue or sculpture](https://images.trvl-media.com/place/6070185/7e9e6a58-eb55-48ff-bc35-a3283de6db0c.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### John F. Kennedy Hyannis Museum 4.5/5(8 reviews) Learn about the 35th president of the United States at this revealing museum, which is just a short distance from the Kennedy Compound. [](https://expedia.co.uk/John-F-Kennedy-Hyannis-Museum-Hyannis.d6070185.Attraction) ![Hyannis](https://images.trvl-media.com/place/553248635146342095/f4f9f2be-5681-4d82-8f2a-a01d46fc93fc.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Cape Cod Maritime Museum You can spend an afternoon studying the exhibits at Cape Cod Maritime Museum during your trip to Hyannis. Stroll along the beautiful beaches in this family-friendly area or visit its seafood restaurants. [](https://expedia.co.uk/Cape-Cod-Maritime-Museum-Hyannis.d553248635146342095.Attraction) ![Hyannis](https://images.trvl-media.com/place/6286986/68f1113f-193c-4991-a964-5912a97a8e48.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### St. Francis Xavier Church After visiting St. Francis Xavier Church, make a plan to see the other sights and activities in Hyannis. Wander through the beautiful beaches and waterfront in this family-friendly area. [](https://expedia.co.uk/St-Francis-Xavier-Church-Hyannis.d6286986.Attraction) ![Hyannis Harbor featuring a bay or harbour and a sunset as well as a small group of people](https://images.trvl-media.com/place/6127091/1a09cb90-8904-47ba-add1-64a005b0f780.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Hyannis Harbor 4/5(27 reviews) See the Cape Cod peninsula from a different perspective by riding a boat out of this picturesque harbor or wandering along its docks and jetties. [](https://expedia.co.uk/Hyannis-Harbor-Hyannis.d6127091.Attraction) ![John F. Kennedy Memorial](https://images.trvl-media.com/place/6286978/c00333f7-44ea-4627-8dea-9172edb188af.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### John F. Kennedy Memorial 5/5(1 review) Take a moment to reflect on John F. Kennedy’s defining role in American politics, as well as his untimely death, at this poignant memorial. [](https://expedia.co.uk/John-F-Kennedy-Memorial-Hyannis.d6286978.Attraction) #### Hyannis Armory Learn about the local history of Hyannis with a stop at Hyannis Armory. Wander the waterfront and beautiful beaches in the area. [](https://expedia.co.uk/Hyannis-Armory-Hyannis.d950930054190297088.Attraction) --- ## Top Hotel Deals ## Check availability on hotels close to Main Street Hyannis [Tonight ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=6287458&startDate=2026-02-08&endDate=2026-02-09)[8 Feb - 9 Feb](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=6287458&startDate=2026-02-08&endDate=2026-02-09) [Tomorrow night ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=6287458&startDate=2026-02-09&endDate=2026-02-10)[9 Feb - 10 Feb](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=6287458&startDate=2026-02-09&endDate=2026-02-10) [Next weekend ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=6287458&startDate=13%2F02%2F2026&endDate=15%2F02%2F2026)[13 Feb - 15 Feb](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=6287458&startDate=13%2F02%2F2026&endDate=15%2F02%2F2026) ![Courtyard Resort](https://images.trvl-media.com/lodging/116000000/115250000/115243800/115243739/5d7ebe6e_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Courtyard Resort 125 North St Hyannis MA [](https://expedia.co.uk/Hyannis-Hotels-Courtyard-Resort.h115243739.Hotel-Information) ![Hyannis Travel Inn](https://images.trvl-media.com/lodging/2000000/1380000/1379200/1379109/fe11d49f_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hyannis Travel Inn 18 North St Hyannis MA [](https://expedia.co.uk/Hyannis-Hotels-Hyannis-Travel-Inn.h1379109.Hotel-Information) ![Comfort Inn Hyannis - Cape Cod](https://images.trvl-media.com/lodging/2000000/1250000/1240500/1240460/f7a87ca8_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Comfort Inn Hyannis - Cape Cod 259 Main Street Hyannis MA [](https://expedia.co.uk/Hyannis-Hotels-Comfort-Inn.h1240460.Hotel-Information) ![Margaritaville Resort Cape Cod](https://images.trvl-media.com/lodging/1000000/20000/12900/12897/b57e0b1f_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Margaritaville Resort Cape Cod 1225 Iyannough Rd Hyannis MA [](https://expedia.co.uk/Hyannis-Hotels-Cape-Codder-Resort-And-Spa.h12897.Hotel-Information) ![Hyannis Plaza Hotel](https://images.trvl-media.com/lodging/2000000/1120000/1119300/1119277/f7fc1d07_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hyannis Plaza Hotel 662 Main Street Hyannis MA [](https://expedia.co.uk/Hyannis-Hotels-Hyannis-Plaza-Hotel.h1119277.Hotel-Information) ![Anchor In Distinctive Waterfront Lodging](https://images.trvl-media.com/lodging/8000000/7650000/7640900/7640889/7438dff7_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Anchor In Distinctive Waterfront Lodging 1 South Street Hyannis MA [](https://expedia.co.uk/Hyannis-Hotels-Anchor-In-Distinctive-Waterfront-Lodging.h7640889.Hotel-Information) ![Hyannis Harbor Hotel](https://images.trvl-media.com/lodging/1000000/60000/55000/54945/741b5772_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hyannis Harbor Hotel 213 Ocean St Hyannis MA [](https://expedia.co.uk/Hyannis-Hotels-Hyannis-Harbor-Hotel.h54945.Hotel-Information) ![SeaCoast Inn](https://images.trvl-media.com/lodging/10000000/9410000/9400300/9400206/90-92aafafd_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### SeaCoast Inn 33 Ocean Street Hyannis MA [](https://expedia.co.uk/Hyannis-Hotels-SeaCoast-Inn.h9400206.Hotel-Information) ![Bayside Resort Hotel](https://images.trvl-media.com/lodging/1000000/900000/896700/896697/85f07916_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Bayside Resort Hotel 225 Route 28 West Yarmouth MA [](https://expedia.co.uk/West-Yarmouth-Hotels-Bayside-Resort-Hotel.h896697.Hotel-Information) [See all 3,523 properties in Main Street Hyannis](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Package®ionId=6287458) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. 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