The Best Hotels Closest to Main Street Hyannis in Hyannis - 2026 Updated Prices

A storefront with a sign reading "The Beach Club" and various clothing items displayed in the window.

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Our top choices for Main Street Hyannis hotels

A stone fire pit with four white Adirondack chairs around it, overlooking a marina with boats.

A hotel with a pool area, outdoor seating, and a flag.

A row of wicker chairs with cushions, a map on the wall, and a view of the outside through a window.

A marina with multiple boats docked, surrounded by residential houses and greenery.

1. Anchor In Distinctive Waterfront Lodging

0.4 mi from Main Street Hyannis

kathy

£160

includes taxes & fees

4 Oct - 5 Oct

A hotel room with a large bed, a chair, a table, and a window with curtains.

A house with white siding, a balcony with white railings, and two flower boxes with plants.

A hotel corridor with patterned carpet, a decorative ceiling light, and a view of parked cars outside.

A brick pathway leading to a building with a sign reading "SeaCoast Inn" and the number 33.

2. SeaCoast Inn

< 0.1 mi from Main Street Hyannis

Jacob

£94

includes taxes & fees

6 Oct - 7 Oct

A covered walkway with wooden flooring, planter boxes with plants, and a white exterior wall.

A hallway with a sign reading 'ASCEND COLLECTION,' a wooden planter with plants, and a reflective floor.

A living room with a sofa, coffee table, and patterned chair. There are two wall-mounted ship wheels and a framed picture on the wall.

A spacious, modern restaurant with a long counter and multiple seating areas.

3. Heritage House Inn on Cape Cod, an Ascend Collection Hotel

0.2 mi from Main Street Hyannis

Jessica

£109

includes taxes & fees

18 Oct - 19 Oct

An indoor swimming pool with a wooden ceiling, potted plants, and lounge chairs.

A beachside table with two chairs, a blue umbrella, and a white tablecloth.

A two-story building with a prominent tower, large windows, and a well-lit entrance.

A beach scene with a directional signpost and beach chairs.

4. Bayside Resort Hotel

1.4 mi from Main Street Hyannis

Lester

£111

includes taxes & fees

27 Oct - 28 Oct

A modern conference room with a long table, chairs, a flat-screen TV, and pendant lighting.

A hotel room with a bed, a TV, a sofa, a lamp, and a chair.

A modern reception area with a desk, chairs, a fireplace, and a decorative plant.

A reception area with a wooden reception desk, a digital kiosk, and a fireplace.

5. Fairfield Inn & Suites by Marriott Cape Cod Hyannis

1.4 mi from Main Street Hyannis

Shruti

£131

includes taxes & fees

25 Oct - 26 Oct

A marina with boats docked, a wooden pier, and residential buildings in the background.

A motel with a two-story structure, a covered parking area, and a small adjacent building.

A hotel room with a large bed, two bedside tables, a desk with a chair, a mirror, and two wall lamps.

6. Cape Cod Inn

0.2 mi from Main Street Hyannis

Julianne

£88

includes taxes & fees

6 Oct - 7 Oct

An indoor swimming pool with a high ceiling and large windows.

A modern bar area with a curved wooden counter, multiple stools, and a display case with beverages.

A hotel reception area with a digital display showing today's weather and this week's forecast.

7. Courtyard By Marriott Cape Cod Hyannis

1 mi from Main Street Hyannis

SHREYASI

£118

includes taxes & fees

25 Oct - 26 Oct

An outdoor patio with wicker furniture, a fire pit, and umbrellas.

A breakfast bar with waffle makers, a fruit bowl, and a coffee station.

A reception area with a sign reading "Welcome to the Patriot State" and a counter with a "Hilton" sign.

A snack and drink kiosk with a 'Treats' sign, a chalkboard menu, and shelves stocked with various snacks and beverages.

8. Hampton Inn & Suites Cape Cod-West Yarmouth

1 mi from Main Street Hyannis

Carmen E

£106

includes taxes & fees

13 Oct - 14 Oct

A modern living room with a sofa, coffee table, and kitchen area with appliances.

A building with a covered entrance, a parking lot, and a tree with pink blossoms.

A sign for Hyannis Host Inn with a building in the background.

A hotel room with a desk, a television, a microwave, and a window with curtains.

9. Hyannis Host Inn

1 mi from Main Street Hyannis

Caroline

£70

includes taxes & fees

29 Sept - 30 Sept

A gym with various cardio and strength training equipment, including treadmills, elliptical machines, and weight machines.

A swimming pool with a metal ladder, surrounded by lounge chairs and umbrellas, with a building in the background.

A hotel room with two beds, a desk with a computer, a chair, and a window with curtains.

A hotel room with a gray sofa, a television on a stand, a sliding door, a framed picture on the wall, and a lamp on a side table.

10. Holiday Inn Hyannis by IHG

1.8 mi from Main Street Hyannis

Alexander

£116

includes taxes & fees

25 Oct - 26 Oct

A long dining table with chairs, a kitchen area, and a large window.

A hotel room with a bed, a desk with a flat-screen TV, a coffee maker, a microwave, a vacuum cleaner, and a sliding door to a balcony.

A Comfort Inn hotel with a modern facade, large glass windows, and a clear sky.

An indoor swimming pool with clear blue water, tiled walls, and a ceiling painted in blue.

11. Comfort Inn Hyannis - Cape Cod

0.2 mi from Main Street Hyannis

catherine

£93

includes taxes & fees

22 Oct - 23 Oct

A two-story hotel with a curved facade, a balcony, and a sign indicating the lobby.

A resort pool area with multiple lounge chairs and umbrellas, a hot tub, and a large building in the background.

A waterfront hotel with a view of the marina and boats.

An outdoor seating area with wicker furniture, umbrellas, and a stone wall.

12. Hyannis Harbor Hotel

0.4 mi from Main Street Hyannis

Jayne

£117

includes taxes & fees

18 Oct - 19 Oct

An outdoor seating area with wooden furniture and a fire pit, surrounded by trees and a gravel path.

A row of white buildings with balconies, outdoor seating, and flower beds.

A lobby with a wooden floor, a reception desk, a large window, and a ceiling fan.

A decorative shark sculpture with the text "Cape Sands Inn" at a beachside location.

13. Cape Sands Inn

1.2 mi from Main Street Hyannis

Donald

£68

includes taxes & fees

27 Sept - 28 Sept

An indoor swimming pool with a covered area, poolside chairs, and a table.

A hotel room with a large bed, two bedside lamps, a nightstand, a framed picture on the wall, and a curtain.

A spacious living area with a kitchen, a coffee machine, a television, and a magazine rack.

A white building with large windows and a blue sign indicating it is a bank.

14. Americas Best Value Inn & Suites Hyannis Cape Cod

0.3 mi from Main Street Hyannis

Linda

£65

includes taxes & fees

27 Sept - 28 Sept

A house with a brick exterior and a covered patio area.

A four-poster bed with a footboard, a bedside table with a lamp, a wooden bench, and a dresser with a mirror.

A bathroom with a bathtub, a shower, and a toilet. There are towels hanging on the wall.

A two-story building with a sign for Sea Breeze Inn, including contact information and a beach view.

15. Sea Breeze Inn

1.1 mi from Main Street Hyannis

Rita

£104

includes taxes & fees

23 Oct - 24 Oct

A beach with clear skies and gentle waves.

A fire pit with chairs arranged around it, set on sandy ground with a wooden fence and foliage in the background.

A reception area with a wooden counter, a blue accent wall, and striped armchairs.

A swimming pool with clear blue water, surrounded by a tiled deck and a building with a green roof in the background.

16. Sunbird Cape Cod Resort

1.4 mi from Main Street Hyannis

Sherri

£85

includes taxes & fees

27 Sept - 28 Sept

A grassy area with blue Adirondack chairs arranged around a central fire pit. In the background, there are two buildings with a playground structure.

A sand sculpture of a sun with sunglasses and the text "Fun in the Sun" on a beach.

17. Sunbird ANNEX Resort

1.4 mi from Main Street Hyannis

Evroy

£86

includes taxes & fees

27 Oct - 28 Oct

A spacious living area with a checkered floor, a wooden staircase, a sofa set, a television, and a potted plant.

A compact, modern bathroom with a wooden vanity, a mirror, a hairdryer, and a small seating area.

A spa room with a large bathtub, a mirror, and a chandelier.

A modern kitchen with white cabinets, a black countertop, and a blue rug with an anchor design.

18. Hyannis Plaza Hotel

0.5 mi from Main Street Hyannis

Arlinda

£86

includes taxes & fees

27 Sept - 28 Sept

A hotel room with two beige sofas, a glass coffee table, and a flat-screen TV mounted on the wall.

A hotel room with two beds, a desk with a television, a mirror, and a bathroom visible through an open door.

An indoor swimming pool with lounge chairs and a clear view of the outside.

A bathroom with beige tiles, a white sink, and a mirror.

19. Days Inn by Wyndham West Yarmouth/Hyannis Cape Cod Area

1 mi from Main Street Hyannis

Katherine

£67

includes taxes & fees

27 Sept - 28 Sept

A hotel room with a sofa, a dining table with chairs, a desk with a chair, and large windows with curtains.

A two-story motel with a sign reading "RELAXNN Cape Code Inn." It features a covered front porch and a fenced parking area.

A two-story motel with a sign reading "Relax Inn Cape Cod".

A hotel room with two beds, wooden headboards, a desk, and a chair.

20. Relax Inn Cape Cod

0.9 mi from Main Street Hyannis

Chris

£61

includes taxes & fees

27 Sept - 28 Sept

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Compare popular hotels close to Main Street Hyannis

Property	Property class	Guest rating
Anchor In Distinctive Waterfront Lodging	9.4 Exceptional 1,004 reviews	View
SeaCoast Inn	9.0 Wonderful 885 reviews	View
Heritage House Inn on Cape Cod, an Ascend Collection Hotel	9.0 Wonderful 158 reviews	View
Bayside Resort Hotel	8.8 Excellent 1,604 reviews	View
Fairfield Inn & Suites by Marriott Cape Cod Hyannis	8.8 Excellent 751 reviews	View

Top Main Street Hyannis Hotel Reviews

Americas Best Value Inn & Suites Hyannis Cape Cod

10/10 Excellent

"Clean rooms great housekeeping Front desk friendly I would encourage a repave of your parking lot But otherwise I would return Great price!!! Affordable!!! Great location!!! Thanks!"

Courtyard Resort

10/10 Excellent

"Nice place. Staff was lovely."

Heritage House Inn on Cape Cod, an Ascend Collection Hotel

8/10 Good

"Rooms were nice. Beds & pillows great. The outside just needs work."

Cape Cod Inn

10/10 Excellent

"Enjoyed our stay at this inn. Great location. Room was clean and it was nice having a fridge."

Doubletree by Hilton Cape Cod - Hyannis

8/10 Good

"Basic stay. Nothing fancy. Did the job for our overnight stay. Quick in and out. Just wanted a clean comfortable room. Got one"

Cape Cod Harbor House Inn

10/10 Excellent

"A"

Ocean Street Inn on Hyannis Harbor

10/10 Excellent

"Great room and got to use the pool at the main hotel. Great stay."

Other attractions near Main Street Hyannis

A bronze statue of a man in a polo shirt standing in front of a building with a brick facade, white columns, and an American flag.

John F. Kennedy Hyannis Museum

8.8/10 (444 reviews)

Learn about the 35th president of the United States at this revealing museum, which is just a short distance from the Kennedy Compound.

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A model boat with a rope tied around it, displayed in a museum setting.

Cape Cod Maritime Museum

9.0/10 (16 reviews)

You can spend an afternoon studying the exhibits at Cape Cod Maritime Museum during your trip to Hyannis. Stroll along the seaside in this family-friendly area or visit its seafood restaurants.

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A white church with a steeple and a sign for Saint Francis Xavier Sunday masses.

St. Francis Xavier Church

8.6/10 (58 reviews)

After visiting St. Francis Xavier Church, make a plan to see the other sights and activities in Hyannis. Wander through the beautiful beaches and waterfront in this family-friendly area.

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A memorial plaque with a bust of John F. Kennedy surrounded by a stone wall.

John F. Kennedy Memorial

9.0/10 (262 reviews)

Take a moment to reflect on John F. Kennedy’s defining role in American politics, as well as his untimely death, at this poignant memorial.

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Hyannis Armory

Learn about the local history of Hyannis with a stop at Hyannis Armory. Wander the waterfront and beautiful beaches in the area.

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Hyannis Youth & Community Center

8.2/10 (22 reviews)

You can take time to visit Hyannis Youth & Community Center during your travels to Hyannis. Stroll along the beautiful beaches or visit the shops in the area.

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Zion Union Heritage Museum

6.0/10 (1 review)

You can spend an afternoon exploring the galleries in Zion Union Heritage Museum during your trip to Hyannis. Make time to visit the area's shops or simply enjoy its seafood restaurants.

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Commotion Charters

6.0/10 (3 reviews)

Enjoy an outing to Commotion Charters during your stay in Hyannis. Attend a sporting event or simply enjoy the seafood restaurants while you're in the area.

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Frequently asked questions

What's the area like around Main Street Hyannis?

Main Street Hyannis is located in a walkable area of Hyannis known for its top seafood restaurants and major shopping area. If you're looking for a convenient place to stay, take a look at the 197 hotels and other accommodation options you'll find within a mile.

Where is the best place to stay near Main Street Hyannis?

Adjacent to Main Street Hyannis, Hyannis Travel Inn is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and an outdoor pool. Other good options within a short distance include Hyannis Harbor Hotel and Ocean Street Inn on Hyannis Harbor.

How many hotels can I expect to find near Main Street Hyannis?

Expedia has 197 hotels and other accommodation options within a mile from Main Street Hyannis.

If I need to cancel the hotel reservation for my stay near Main Street Hyannis, will I receive a refund?

Yes! Most hotel reservations are fully refundable if cancelled prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If your reservation is non-refundable, you might be able to still cancel and get a refund within 24 hours of your booking. Add dates, click "Search", then filter by "fully refundable" to review the top deals on offer near Main Street Hyannis.

What can I see and do near Main Street Hyannis?

John F. Kennedy Hyannis Museum, Centerville Historical Museum and Edward Gorey House feature captivating exhibits. Hyannis Harbor, Sandy Neck Lighthouse and West Parish Meetinghouse are landmarks that you won't want to miss. Local parks like Lewis Bay, Veterans Memorial Park and Dennis Pond Conservation Area are peaceful spots to stop and take in some fresh air.

Search Hotels Near Main Street Hyannis, Hyannis

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Treat yourself

Be picky

Check prices for these dates

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Our top choices for Main Street Hyannis hotels

1. Anchor In Distinctive Waterfront Lodging

2. SeaCoast Inn

3. Heritage House Inn on Cape Cod, an Ascend Collection Hotel

4. Bayside Resort Hotel

5. Fairfield Inn & Suites by Marriott Cape Cod Hyannis

6. Cape Cod Inn

7. Courtyard By Marriott Cape Cod Hyannis

8. Hampton Inn & Suites Cape Cod-West Yarmouth

9. Hyannis Host Inn

10. Holiday Inn Hyannis by IHG

11. Comfort Inn Hyannis - Cape Cod

12. Hyannis Harbor Hotel

13. Cape Sands Inn

14. Americas Best Value Inn & Suites Hyannis Cape Cod

15. Sea Breeze Inn

16. Sunbird Cape Cod Resort

17. Sunbird ANNEX Resort

18. Hyannis Plaza Hotel

19. Days Inn by Wyndham West Yarmouth/Hyannis Cape Cod Area

20. Relax Inn Cape Cod

Compare popular hotels close to Main Street Hyannis

Top Main Street Hyannis Hotel Reviews

Americas Best Value Inn & Suites Hyannis Cape Cod

Courtyard Resort

Heritage House Inn on Cape Cod, an Ascend Collection Hotel

Cape Cod Inn

Doubletree by Hilton Cape Cod - Hyannis

Cape Cod Harbor House Inn

Ocean Street Inn on Hyannis Harbor

Other attractions near Main Street Hyannis

John F. Kennedy Hyannis Museum

Cape Cod Maritime Museum

St. Francis Xavier Church

John F. Kennedy Memorial

Hyannis Armory

Hyannis Youth & Community Center

Zion Union Heritage Museum

Commotion Charters

Frequently asked questions