The best area to stay in Boca Do Acre is the town centre, particularly around the main square, Praça da Matriz.
This central area is the heart of Boca Do Acre, where you'll find the most amenities and local life. It's characterised by its proximity to the Acre River, the main church, and the municipal market. The streets directly surrounding Praça da Matriz offer the most convenience for visitors.
For any traveller, especially those visiting Boca Do Acre for the first time, staying in the town centre is the most practical choice.