A coastal landscape with clear turquoise waters, rocky hills, and a distant mountain range.

Compare and book 5 Star hotels in Samos Prefecture, Samos

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Check availability on Samos Prefecture 5 Star Hotels

Tonight
21 Oct - 22 Oct
Tomorrow
22 Oct - 23 Oct
This weekend
23 Oct - 25 Oct
Next weekend
30 Oct - 1 Nov

Our top choices for Samos Prefecture 5-star hotels

A modern resort with a central pool, lounge areas, and mountain views.
A spa area with two massage tables, a stone floor, and a bamboo partition.
A bar area with a wooden counter and stools.
A beachside lounge area with outdoor seating, a large umbrella, and a view of the sea.

1. Casa Cook Samos

Casa Cook Samos
Samos
United States
ercan
£203
includes taxes & fees
28 Oct - 29 Oct
Casa Cook Samos
A row of wooden beach umbrellas with white cushions on a sandy beach, overlooking the sea.
A covered outdoor seating area with wooden flooring, white cushioned chairs, and tables.
A beach with rows of sunbeds and thatched umbrellas, a clear blue sea, and mountains in the background.
A modern bedroom with a bed, bedside tables, a desk, and a view of the sea.

2. Proteas Blu Resort - Adults Only

Proteas Blu Resort - Adults Only
Samos
Germany
Artsem
Proteas Blu Resort - Adults Only
A beach with rows of beige lounge chairs and umbrellas, a clear sky, and a calm sea with a distant mountain.
A coastal hotel with a swimming pool, surrounded by greenery and overlooking the sea.
A beachside lounge with white umbrellas and beige lounge chairs, a wooden deck, and a view of the sea and a pier in the background.
A modern kitchen with a central island, pendant lighting, and a tiled backsplash.

3. Doryssa Seaside Resort

Doryssa Seaside Resort
Samos
United States
Athanasios
Doryssa Seaside Resort
An infinity pool with lounge chairs and a view of a coastal town.
A modern multi-story building with a landscaped courtyard, featuring a mix of flat and sloped roofs, and a variety of plants and trees.
A bar area with stools, a counter, and bottles.
A modern outdoor seating area with a view of a coastal town and mountains.

4. Nirema Hotel & Spa Samos - MGallery Collection (opening Q3 2026)

Nirema Hotel & Spa Samos - MGallery Collection (opening Q3 2026)
Samos
£141
includes taxes & fees
23 Oct - 24 Oct
Nirema Hotel & Spa Samos - MGallery Collection (opening Q3 2026)
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Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Samos Prefecture.
Hydrele Beach Hotel

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Doryssa Theorem Hotel

Doryssa Theorem Hotel

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Samian Mare Hotel Suites & Spa

Samian Mare Hotel Suites & Spa

Kanari 123 Samos Samos Island
£79
23 Oct - 24 Oct
includes taxes & fees
9.2/10 Wonderful! (37 reviews)
Samian Mare Hotel Suites & Spa
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Samos Prefecture

Explore attractions like Balos Beach and Lemonakia Beach as you discover things to see and do in Samos Prefecture.

See all hotels in Samos Prefecture
A beach with blue chairs and a hammock overlooking the sea.
Photo by Erdem Yücel

Top Samos Prefecture Hotel Reviews

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