Title: The 10 Best 5 Star Hotels in Pythagorio - 2026 Updated Prices | Expedia.co.uk [Pythagorio Travel Guide](https://expedia.co.uk/Pythagorio.dx6143006)[Hotels in Pythagorio](https://expedia.co.uk/Pythagorio-Hotels.d6143006.Travel-Guide-Hotels)[Holiday Rentals in Pythagorio](https://expedia.co.uk/Pythagorio-Holiday-Rentals.d6143006.Travel-Guide-HolidayRentals)[Flights to Pythagorio](https://expedia.co.uk/Cheap-Flights-To-Pythagorio.d6143006.Travel-Guide-Flights)[Things to do in Pythagorio](https://expedia.co.uk/Things-To-Do-In-Pythagorio.d6143006.Travel-Guide-Activities)[Pythagorio Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Pythagorio.d6143006.Car-Hire-Guide)[Pythagorio Holidays](https://expedia.co.uk/Pythagorio.d6143006.Holidays-City-Breaks) ![Energy limonate😋👌](https://images.trvl-media.com/place/3216/dca468b8-7b0b-4772-ac6e-b0c76bc61818.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Erdem Yücel # Compare and book 5 Star hotels in Pythagorio, Samos - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Pythagorio 5 Star Hotels Tonight [23 Dec - 24 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6143006&startDate=2025-12-23&endDate=2025-12-24&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [24 Dec - 25 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6143006&startDate=2025-12-24&endDate=2025-12-25&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [26 Dec - 28 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6143006&startDate=2025-12-26&endDate=2025-12-28&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [2 Jan - 4 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6143006&startDate=2026-01-02&endDate=2026-01-04&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Pythagorio-Hotels.s50-0-d6143006.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Pythagorio-Hotels.s50-0-d6143006.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Pythagorio. ![Samian Mare Hotel Suites & Spa](https://images.trvl-media.com/lodging/92000000/91940000/91937000/91936993/2a23cbc6_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Samian Mare Hotel Suites & Spa Kanari 123 Samos Samos Island [Get rates](https://expedia.co.uk/Hotel-Search?startDate=06%2F01%2F2026&endDate=07%2F01%2F2026&selected=91936993&PinnedHotelID=91936993&HadPinnedHotel=true®ionId=6143006) 9.2/10 Wonderful! (23 reviews) [](https://expedia.co.uk/Samos-Hotels-Samian-Mare-Hotel-Suites-Spa.h91936993.Hotel-Information) ![Doryssa Theorem Hotel](https://images.trvl-media.com/lodging/91000000/90870000/90861800/90861756/fb6ac4e4_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Doryssa Theorem Hotel Pythagoreio Samos Samos Island [Get rates](https://expedia.co.uk/Hotel-Search?startDate=06%2F01%2F2026&endDate=07%2F01%2F2026&selected=90861756&PinnedHotelID=90861756&HadPinnedHotel=true®ionId=6143006) 9.4/10 Exceptional! (81 reviews) [](https://expedia.co.uk/Samos-Hotels-Doryssa-Theorem-Hotel.h90861756.Hotel-Information) ![Erato by Samian Mare](https://images.trvl-media.com/lodging/93000000/92010000/92000300/92000281/1b337338_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Erato by Samian Mare 115 Kon/nou Kanari Samos [Get rates](https://expedia.co.uk/Hotel-Search?startDate=06%2F01%2F2026&endDate=07%2F01%2F2026&selected=92000281&PinnedHotelID=92000281&HadPinnedHotel=true®ionId=6143006) 9.2/10 Wonderful! (18 reviews) [](https://expedia.co.uk/Samos-Hotels-Erato-Seaside-Hotel-By-Samian-Mare.h92000281.Hotel-Information) Still don't see what you're looking for? [See all properties in Pythagorio.](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=24%2F12%2F2025&endDate=25%2F12%2F2025®ionId=6143006&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=24%2F12%2F2025&endDate=25%2F12%2F2025®ionId=6143006&star=50&star=50&amenities=POOL)[Spa](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=24%2F12%2F2025&endDate=25%2F12%2F2025®ionId=6143006&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=24%2F12%2F2025&endDate=25%2F12%2F2025®ionId=6143006&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=24%2F12%2F2025&endDate=25%2F12%2F2025®ionId=6143006&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=24%2F12%2F2025&endDate=25%2F12%2F2025®ionId=6143006&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Learn more about Pythagorio The ancient harbour town showcases Pythagoras' legacy at its archaeological museum and the impressive remains of Tunnel of Eupalinos. Waterfront tavernas serve fresh seafood beside bobbing fishing boats, while nearby beaches offer perfect swimming spots. [See all hotels in Pythagorio](https://www.expedia.co.uk/Hotel-Search?startDate=2026-01-06&endDate=2026-01-07&adults=2®ionId=6143006) ![Energy limonate😋👌](https://images.trvl-media.com/place/3216/dca468b8-7b0b-4772-ac6e-b0c76bc61818.jpg?impolicy=fcrop&w=320&h=400&p=1&q=high) Photo by Erdem Yücel ## Top Pythagorio Hotel Reviews ![Casa Cook Samos](https://images.trvl-media.com/lodging/73000000/72990000/72988800/72988785/d2773c4f_y.jpg) ### Casa Cook Samos 10/10 Excellent "Clean and modernly decorated rooms with all the facilities" [](https://expedia.co.uk/Samos-Hotels-Casa-Cook-Samos.h72988785.Hotel-Information) ![Proteas Blu Resort - Adults Only](https://images.trvl-media.com/lodging/4000000/3580000/3579900/3579852/7a59d23e_y.jpg) ### Proteas Blu Resort - Adults Only 10/10 Excellent "Perfect" [](https://expedia.co.uk/Samos-Hotels-Proteas-Blu-Resort.h3579852.Hotel-Information) ![Doryssa Seaside Resort](https://images.trvl-media.com/lodging/1000000/590000/583300/583244/97c98bf6_y.jpg) ### Doryssa Seaside Resort 10/10 Excellent "nice and relaxing hotel very close to Pythagoreio center. " [](https://expedia.co.uk/Samos-Hotels-Doryssa-Seaside-Resort.h583244.Hotel-Information) ## Find out more about Pythagorio ## Frequently asked questions ### How much does it cost to stay in a 5-star hotel in Pythagorio? > - Search for the lowest price per night ### What makes a hotel 5 stars in Pythagorio? ### Are there any 5-star all-inclusive resorts in Pythagorio? ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - [4 Star Hotels in Samos ](https://www.expedia.co.uk/4Star-Samos-Hotels.s40-0-d3216.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Kokkari ](https://www.expedia.co.uk/5Star-Kokkari-Hotels.s50-0-d6052055.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Samos ](https://www.expedia.co.uk/5Star-Samos-Hotels.s50-0-d3216.Travel-Guide-Filter-Hotels) - [Potokaki Hotels ](https://www.expedia.co.uk/Potokaki-Hotels.d3000377660.Travel-Guide-Hotels) - [Hotels near Samos Intl. ](https://www.expedia.co.uk/Samos-Intl-Airport-Hotels.0-aSMI-0.Travel-Guide-Filter-Hotels) - 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