A large suspension bridge, industrial cranes, and a calm river.

Compare and book 5 Star hotels in Panama Canal Zone, Panama

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Save instantly and earn perks with One Key
    Learn about One Key

  • Be picky

    Search almost a million properties worldwide

Check availability on Panama Canal Zone 5 Star Hotels

Tonight
13 Oct - 14 Oct
Tomorrow
14 Oct - 15 Oct
This weekend
16 Oct - 18 Oct
Next weekend
23 Oct - 25 Oct

Our top choices for Panama Canal Zone 5-star hotels

A rooftop pool with sun loungers and umbrellas, surrounded by palm trees and modern buildings.
A modern hotel room with a dining area, a TV, and a city view.
A hotel room with a bed, a TV, a desk, and a view of the cityscape through a window.
A modern living room with a sofa set, a coffee table, and a dining area with chairs and a table.

1. Hotel Riu Plaza Panama

Hotel Riu Plaza Panama
Bella Vista
United States
Yullando Abbigale
£110
includes taxes & fees
28 Oct - 29 Oct
Hotel Riu Plaza Panama
A person seated at a bar with a drink, in a room with a teal accent wall and hanging lights.
A modern interior with a decorative ceiling, a person in a white dress, and a blue-lit wall.
A tall, modern building with a prominent logo at the top, surrounded by other high-rise buildings in a cityscape.
An outdoor seating area with wicker chairs and tables, large windows offering a city view at dusk.

2. Waldorf Astoria Panama

Waldorf Astoria Panama
Bella Vista
United States
Aysha
£219
includes taxes & fees
31 Oct - 1 Nov
Waldorf Astoria Panama
A balcony with a table, chairs, and a view of a city skyline across a body of water.
A spacious lobby with high ceilings, modern furniture, and decorative lighting fixtures.
A spacious living room with a high ceiling, large windows, and a decorative ceiling fan.
A spacious lobby with a round coffee table, seating areas, and a large wall clock.

3. Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City
Casco Viejo
United States
Jose
£292
includes taxes & fees
3 Nov - 4 Nov
Sofitel Legend Casco Viejo, Panama City
A modern hotel room with a sofa, a coffee table, a TV mounted on the wall, and a dining area with a table and chairs.
An indoor swimming pool with lounge chairs and red chairs, surrounded by lush greenery and a modern interior design.
A modern hotel entrance with a prominent 'Renaissance Hotel' sign, a well-lit outdoor area with a wooden structure, and a staircase leading to the upper floors.
The exterior of the Renaissance Hotel with a modern design, featuring a prominent 'R' logo, a geometric ceiling design, and a well-lit entrance area.

4. Renaissance Panama City Hotel

Renaissance Panama City Hotel
Bella Vista
United States
Carlos
£112
includes taxes & fees
6 Nov - 7 Nov
Renaissance Panama City Hotel
A poolside area with lounge chairs and a view of the ocean.
A modern building with a symmetrical facade, multiple balconies, and a central atrium with lighting.
A modern hotel room with a large bed, a chair, a nightstand with a lamp, and a view of the cityscape at dusk.
A terrace with seating and a view of the ocean.

5. JW Marriott Panama

JW Marriott Panama
San Francisco
United States
Alberto
£233
includes taxes & fees
7 Nov - 8 Nov
JW Marriott Panama
A pool area with lounge chairs and umbrellas, surrounded by greenery and a multi-story building in the background.
A modern interior with a central seating area, potted plants, and a staircase.
A spacious hotel lobby with modern furniture, large windows, and a city view.
A modern building with a sign reading 'HYATT REGENCY.'

6. Hyatt Regency Panama City

Hyatt Regency Panama City
Bella Vista
United States
Mariah
£155
includes taxes & fees
7 Nov - 8 Nov
Hyatt Regency Panama City
A hotel entrance with a central water feature, seating areas, and potted plants.
A spacious lobby with a wooden ceiling, a central wooden table surrounded by potted plants, and a marble wall with a large window in the background.
The entrance of The Santa Maria with a covered walkway and a view of the interior.
An outdoor dining area with wicker chairs and tables, a bar with bottles, and a pool in the background.

7. The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Juan Diaz
United States
Carmen
£230
includes taxes & fees
1 Nov - 2 Nov
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
A modern restaurant with large windows offering a city view, warm lighting, and contemporary furniture.
A modern living room with a city view, featuring a purple accent wall, a white sofa, and a glass table.
A high-rise building with a rooftop pool area, surrounded by other buildings.
A modern high-rise building with a prominent 'W' logo, surrounded by other buildings and a busy street at night.

8. W Panama

W Panama
Bella Vista
United States
Naomi
£192
includes taxes & fees
1 Nov - 2 Nov
W Panama
A modern hotel pool area with lounge chairs and a clear view of the ocean.
A modern interior with a spiral staircase, a large window, and a seating area.
A modern bar area with seating and a view of the city.
A marina with boats docked, a city skyline with illuminated buildings, and a visible moon in the sky.

9. Hilton Panama

Hilton Panama
Bella Vista
United States
Simon
£212
includes taxes & fees
7 Nov - 8 Nov
Hilton Panama
A hotel with a pool, beach, and palm trees.
A spacious lobby with a large seating area, a reception desk, and large windows offering a view of the ocean and palm trees.
A spacious lobby with a modern design, featuring a central seating area with sofas and ottomans, surrounded by large, open spaces and natural light.
A large hotel with multiple towers, a central courtyard with a swimming pool, and surrounding landscaped areas.

10. The Westin Playa Bonita Panama

The Westin Playa Bonita Panama
Veracruz
United States
Lyman
£171
includes taxes & fees
29 Oct - 30 Oct
The Westin Playa Bonita Panama
A modern living room with a sofa, round black ottomans, and a vase of flowers. A cityscape is visible through the window.
A bar area with a long counter, multiple bar stools, and a television screen. There are large windows providing natural light and a view of the outdoors.
A rooftop swimming pool with a cityscape view, glass railings, and a modern architectural design.
A person performing a yoga pose in a living room with a large window and a sofa.

11. Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel
Bella Vista
United States
Juliet
£176
includes taxes & fees
14 Nov - 15 Nov
Bristol Panama, a Registry Collection Hotel
Lobby
Banquet hall
Bar (on property)
Breakfast area

12. Waymore Hotel Spa and Casino

Waymore Hotel Spa and Casino
Bella Vista
United States
Aldo
£85
includes taxes & fees
7 Nov - 8 Nov
Waymore Hotel Spa and Casino
Terrace/patio
Casino
Outdoor pool
Outdoor spa tub

13. Megapolis Hotel Panamá

Megapolis Hotel Panamá
San Francisco
United States
MARVIN
£217
includes taxes & fees
12 Nov - 13 Nov
Megapolis Hotel Panamá
Save an average of 15% on thousands of hotels when you're signed in

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Panama Canal Zone.
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

Ave. Domingo Diaz Tocumen Panama
£118
9 Nov - 10 Nov
includes taxes & fees
8.6/10 Excellent! (2,762 reviews)
Crowne Plaza Panama Airport by IHG
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

Plaza de la Independencia Casco Viejo Panama City Panama
£186
9 Nov - 10 Nov
includes taxes & fees
9/10 Wonderful! (1,000 reviews)
Central Hotel Panama Casco Viejo
Megapolis Hotel Panamá

Megapolis Hotel Panamá

Avenida Balboa Panama City
£111
31 Oct - 1 Nov
includes taxes & fees
Megapolis Hotel Panamá
Still don't see what you're looking for?
See all properties in Panama Canal Zone.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Panama Canal Zone

Explore the relaxing area of Panama Canal Zone—rainforests, golf courses and popular sights like Albrook Shopping Mall.

See all hotels in Panama Canal Zone
A large suspension bridge, industrial cranes, and a calm river.

Top Panama Canal Zone Hotel Reviews

Find out more about Panama Canal Zone

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Panama Canal Zone?
The amount you pay for a 5-star hotel in Panama Canal Zone depends on factors such as when you want to go and the length of your trip. A top tip for scoring the best deal? Use our pricing filters to compare all of the available accommodation for your chosen dates.
  • Search for the lowest price per night from £111
What makes a hotel 5 stars in Panama Canal Zone?
Faultless guest service is integral to every 5-star hotel in Panama Canal Zone. From the moment you enter the lobby, staff ensure your every need is met, whether arranging valet parking or providing in-room massage treatments. Additionally, hotels have to offer upscale conveniences to obtain a 5-star rating. These can include deluxe baths, an on-site spa, pools, fine dining kitchens and knowledgeable concierge.
Are there any 5-star all-inclusive resorts in Panama Canal Zone?
Our filter tool is the best way to narrow down what you want. Select "5-star" and "All inclusive" to see the most upscale hotels in Panama Canal Zone where your meals, accommodation, activities and entertainment are included in the price. At these getaways, your trip is pure indulgence from the moment you step foot in the lobby.