Title: The 10 Best 5 Star Hotels in Northeast Missouri - 2025 Updated Prices | Expedia.co.uk [Northeast Missouri Travel Guide](https://expedia.co.uk/Northeast-Missouri.dx6058818)[Hotels in Northeast Missouri](https://expedia.co.uk/Northeast-Missouri-Hotels.d6058818.Travel-Guide-Hotels)[Holiday Rentals in Northeast Missouri](https://expedia.co.uk/Northeast-Missouri-Holiday-Rentals.d6058818.Travel-Guide-HolidayRentals)[Flights to Northeast Missouri](https://expedia.co.uk/Cheap-Flights-To-Northeast-Missouri.d6058818.Travel-Guide-Flights)[Things to do in Northeast Missouri](https://expedia.co.uk/Things-To-Do-In-Northeast-Missouri.d6058818.Travel-Guide-Activities)[Northeast Missouri Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Northeast-Missouri.d6058818.Car-Hire-Guide)[Northeast Missouri Holidays](https://expedia.co.uk/Northeast-Missouri.d6058818.Holidays-City-Breaks) ![](https://mediaim.expedia.com/destination/9/d8d6f7646f4405d28bd9fb5c66d9ba0c.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Compare and book 5 Star hotels in Northeast Missouri, Missouri ![price find illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Northeast Missouri 5 Star Hotels Tonight [20 Sept - 21 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=6058818&startDate=2025-09-20&endDate=2025-09-21&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [21 Sept - 22 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=6058818&startDate=2025-09-21&endDate=2025-09-22&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [26 Sept - 28 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=6058818&startDate=2025-09-26&endDate=2025-09-28&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [3 Oct - 5 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6058818&startDate=2025-10-03&endDate=2025-10-05&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Northeast Missouri 5 Star Hotels ## Our top choices for Northeast Missouri 5-star hotels ![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/6200/6132/9a597e77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Banquet hall](https://images.trvl-media.com/lodging/1000000/10000/6200/6132/8fec4778.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, premium bedding, minibar, in-room safe](https://images.trvl-media.com/lodging/1000000/10000/6200/6132/dbe99670.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/6200/6132/a54897ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Ritz-Carlton, St. Louis Clayton 9.2/10 Wonderful (548) "Service is exceptional!!!" £449 includes taxes & fees 21 Sept - 22 Sept [](https://www.expedia.co.uk/St-Louis-Hotels-The-Ritz-Carlton.h6132.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Northeast-Missouri-Hotels.s50-0-d6058818.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Northeast-Missouri-Hotels.s50-0-d6058818.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Northeast Missouri. ![Renaissance St. Louis Airport Hotel](https://images.trvl-media.com/lodging/1000000/10000/4700/4672/879431a1_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Renaissance St. Louis Airport Hotel 9801 Natural Bridge Road, St. Louis, MO £107 per night 3 Oct - 4 Oct 8.4/10 Very Good! (1,007 reviews) [](https://expedia.co.uk/St-Louis-Hotels-Renaissance-St-Louis-Airport-Hotel.h4672.Hotel-Information) ![21C Museum Hotel St Louis ](https://images.trvl-media.com/lodging/90000000/89170000/89164600/89164592/bb460692_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### 21C Museum Hotel St Louis 1528 Locust street, St. Louis, MO £120 per night 28 Sept - 29 Sept 9/10 Wonderful! (1,376 reviews) [](https://expedia.co.uk/St-Louis-Hotels-21C-Museum-Hotel-St-Louis.h89164592.Hotel-Information) ![St. Louis Union Station Hotel, Curio Collection by Hilton](https://images.trvl-media.com/lodging/1000000/10000/8800/8738/171d52f3_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### St. Louis Union Station Hotel, Curio Collection by Hilton 1820 Market Street, St. Louis, MO £168 per night 28 Sept - 29 Sept 8.4/10 Very Good! (1,014 reviews) [](https://expedia.co.uk/St-Louis-Hotels-St-Louis-Union-Station-Hotel.h8738.Hotel-Information) Still don't see what you're looking for? [See all properties in Northeast Missouri.](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=21%2F09%2F2025&endDate=22%2F09%2F2025®ionId=6058818&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=21%2F09%2F2025&endDate=22%2F09%2F2025®ionId=6058818&star=50&star=50&amenities=POOL)[Spa](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=21%2F09%2F2025&endDate=22%2F09%2F2025®ionId=6058818&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=21%2F09%2F2025&endDate=22%2F09%2F2025®ionId=6058818&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=21%2F09%2F2025&endDate=22%2F09%2F2025®ionId=6058818&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=21%2F09%2F2025&endDate=22%2F09%2F2025®ionId=6058818&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Learn more about Northeast Missouri Great live music, sports teams and popular sights from St. Louis Union Station to Busch Stadium—explore Northeast Missouri, a family-friendly destination also known for its theatres. [See all hotels in Northeast Missouri](https://www.expedia.co.uk/Hotel-Search?startDate=2025-10-04&endDate=2025-10-05&adults=2®ionId=6058818) ![St. Louis showing interior views](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/21000/21573-Saint-Louis.jpg?impolicy=fcrop&w=900&h=506&p=1&q=high) ## Top Northeast Missouri Hotel Reviews ## Find out more about Northeast Missouri ## Frequently asked questions ### How much does it cost to stay in a 5-star hotel in Northeast Missouri? > The amount you pay for a 5-star hotel in Northeast Missouri can vary depending on the time of year you travel and how long you plan to stay, among a range of factors. Use our price per night filter and other search tools to find the best rate on a high-end stay. > > > > - Search for the lowest price per night from £107 ### What makes a hotel 5 stars in Northeast Missouri? > In Northeast Missouri, a hotel must offer a certain level of top-notch amenities to be designated 5 stars. These can include saunas and spas, on-site gyms, gourmet restaurants, luxury bathroom products, premium bedding and more. What also sets 5-star hotels apart is their guest-focused service. You can expect things like concierge services, nightly turn-down services and in-room massage. Some may even offer thoughtful touches such as a welcome gift. ### Are there any 5-star all-inclusive resorts in Northeast Missouri? > Our convenient filters are the quickest way to narrow down what you're looking for. Select "All inclusive" and "5-star" to show the most luxurious properties in Northeast Missouri where your meals, room, entertainment and activities are included in the upfront price. 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