Title: The 10 Best 5 Star Hotels in Mesopotamia - 2025 Updated Prices | Expedia.co.uk [Mesopotamia Travel Guide](https://expedia.co.uk/Mesopotamia.dx6208836)[Hotels in Mesopotamia](https://expedia.co.uk/Mesopotamia-Hotels.d6208836.Travel-Guide-Hotels)[Holiday Rentals in Mesopotamia](https://expedia.co.uk/Mesopotamia-Holiday-Rentals.d6208836.Travel-Guide-HolidayRentals)[Flights to Mesopotamia](https://expedia.co.uk/Cheap-Flights-To-Mesopotamia.d6208836.Travel-Guide-Flights)[Mesopotamia Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Mesopotamia.d6208836.Car-Hire-Guide)[Mesopotamia Holidays](https://expedia.co.uk/Mesopotamia.d6208836.Holidays-City-Breaks) ![Mesopotamia showing a river or creek and forests](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/196000/196544-Mesopotamia.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Compare and book 5 Star hotels in Mesopotamia, Argentina ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Mesopotamia 5 Star Hotels Tonight [9 Oct - 10 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6208836&startDate=2025-10-09&endDate=2025-10-10&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [10 Oct - 11 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6208836&startDate=2025-10-10&endDate=2025-10-11&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [10 Oct - 12 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6208836&startDate=2025-10-10&endDate=2025-10-12&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [17 Oct - 19 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6208836&startDate=2025-10-17&endDate=2025-10-19&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Mesopotamia 5 Star Hotels ![Lobby](https://images.trvl-media.com/lodging/5000000/4390000/4388000/4387932/5e4f0852.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/bathtub, rainfall showerhead, free toiletries](https://images.trvl-media.com/lodging/5000000/4390000/4388000/4387932/77675c32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area | 32-inch LCD TV with cable channels, TV, pay films](https://images.trvl-media.com/lodging/5000000/4390000/4388000/4387932/9efdb0ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/5000000/4390000/4388000/4387932/39aab7b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Bagú Urbano Posadas 8.4/10 Very good (341) "Nice hotel in deplorable maintenance conditions. Dirtiest carpets and couches I've ever seen. Carpets in the hallways and within the bedrooms had deep stains all throughout. Our mattress and bedsheets had stains on them as well. It's really a pity because the property has potential, but evidently the decision has been made to not invest a dime in maintaining it." [](https://www.expedia.co.uk/Posadas-Hotels-Hotel-Urbano-Posadas.h4387932.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Mesopotamia-Hotels.s50-0-d6208836.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Mesopotamia-Hotels.s50-0-d6208836.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Mesopotamia. ![Esplendor by Wyndham Savoy Rosario](https://images.trvl-media.com/lodging/3000000/2810000/2803500/2803473/36b8ac51_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Esplendor by Wyndham Savoy Rosario San Lorenzo 1022, Between Sarmiento and San Martín, Rosario, Santa Fe £58 13 Oct - 14 Oct 8.4/10 Very Good! (439 reviews) [](https://expedia.co.uk/Rosario-Hotels-Esplendor-By-Wyndham-Savoy-Rosario.h2803473.Hotel-Information) ![Dazzler by Wyndham Rosario](https://images.trvl-media.com/lodging/21000000/20270000/20265400/20265319/65a9aa22_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Dazzler by Wyndham Rosario Junin 187, Rosario, Santa Fe £57 2 Nov - 3 Nov 8.6/10 Excellent! (181 reviews) [](https://expedia.co.uk/Rosario-Hotels-Dazzler-By-Wyndham-Rosario.h20265319.Hotel-Information) ![InterTower Hotel](https://images.trvl-media.com/lodging/10000000/9850000/9845300/9845278/13fc6ccf_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### InterTower Hotel San Jeronimo 2779, Santa Fe, Santa Fe £68 12 Oct - 13 Oct 8.8/10 Excellent! (204 reviews) [](https://expedia.co.uk/Santa-Fe-Hotels-InterTower-Hotel.h9845278.Hotel-Information) Still don't see what you're looking for? [See all properties in Mesopotamia.](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F10%2F2025&endDate=11%2F10%2F2025®ionId=6208836&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F10%2F2025&endDate=11%2F10%2F2025®ionId=6208836&star=50&star=50&amenities=POOL)[Spa](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F10%2F2025&endDate=11%2F10%2F2025®ionId=6208836&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F10%2F2025&endDate=11%2F10%2F2025®ionId=6208836&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F10%2F2025&endDate=11%2F10%2F2025®ionId=6208836&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F10%2F2025&endDate=11%2F10%2F2025®ionId=6208836&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Learn more about Mesopotamia The awe-inspiring Iguazú Falls is the centerpiece attraction of this northeastern Argentine region, which also hosts the country’s biggest carnival celebration. [See all hotels in Mesopotamia](https://www.expedia.co.uk/Hotel-Search?startDate=2025-10-23&endDate=2025-10-24&adults=2®ionId=6208836) ![Mesopotamia showing a river or creek and forests](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/196000/196544-Mesopotamia.jpg?impolicy=fcrop&w=900&h=506&p=1&q=high) ## Top Mesopotamia Hotel Reviews ## Find out more about Mesopotamia ## Explore a world of travel with Expedia - More ways to book - [Book 5 Star Hotels in Mesopotamia on Expedia.com.ar](https://www.expedia.com.ar/5Estrella-Mesopotamia-Hoteles.s50-0-d6208836.Guia-filtrada-de-Hoteles)