Title: The 10 Best 5 Star Hotels in Mesopotamia - 2026 Updated Prices | Expedia.co.uk [Mesopotamia Travel Guide](https://expedia.co.uk/Mesopotamia.dx6208836)[Hotels in Mesopotamia](https://expedia.co.uk/Mesopotamia-Hotels.d6208836.Travel-Guide-Hotels)[Holiday Rentals in Mesopotamia](https://expedia.co.uk/Mesopotamia-Holiday-Rentals.d6208836.Travel-Guide-HolidayRentals)[Flights to Mesopotamia](https://expedia.co.uk/Cheap-Flights-To-Mesopotamia.d6208836.Travel-Guide-Flights)[Mesopotamia Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Mesopotamia.d6208836.Car-Hire-Guide)[Mesopotamia Holidays](https://expedia.co.uk/Mesopotamia.d6208836.Holidays-City-Breaks) ![Mesopotamia showing a river or creek and forests](https://images.trvl-media.com/place/6208836/ca0c6990-9932-4f38-bee6-e89ce7080803.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Compare and book 5 Star hotels in Mesopotamia, Argentina - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Mesopotamia 5 Star Hotels Tonight [9 Jan - 10 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6208836&startDate=2026-01-09&endDate=2026-01-10&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [10 Jan - 11 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6208836&startDate=2026-01-10&endDate=2026-01-11&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [9 Jan - 11 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6208836&startDate=2026-01-09&endDate=2026-01-11&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [16 Jan - 18 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6208836&startDate=2026-01-16&endDate=2026-01-18&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Mesopotamia 5-star hotels ![Lobby](https://images.trvl-media.com/lodging/5000000/4390000/4388000/4387932/5e4f0852.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area | 32-inch LCD TV with cable channels, TV, pay films](https://images.trvl-media.com/lodging/5000000/4390000/4388000/4387932/9efdb0ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/5000000/4390000/4388000/4387932/a8b18273.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/bathtub, rainfall showerhead, free toiletries](https://images.trvl-media.com/lodging/5000000/4390000/4388000/4387932/77675c32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Bagú Urbano [](https://www.expedia.co.uk/Posadas-Hotels-Hotel-Urbano-Posadas.h4387932.Hotel-Information) Posadas 8.4/10 Very good (346 reviews) "Excelente " ![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg) SOFIA [](https://www.expedia.co.uk/Posadas-Hotels-Hotel-Urbano-Posadas.h4387932.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Mesopotamia-Hotels.s50-0-d6208836.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Mesopotamia-Hotels.s50-0-d6208836.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Mesopotamia. ![Amérian Hotel Casino Gala](https://images.trvl-media.com/lodging/2000000/1200000/1197100/1197026/a75881f1_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Amérian Hotel Casino Gala Juan Domingo Perón 330 esq. Necochea Resistencia Chaco [Get rates](https://expedia.co.uk/Hotel-Search?startDate=23%2F01%2F2026&endDate=24%2F01%2F2026&selected=1197026&PinnedHotelID=1197026&HadPinnedHotel=true®ionId=6208836) 9/10 Wonderful! (172 reviews) [](https://expedia.co.uk/Resistencia-Hotels-Amerian-Hotel-Casino-Gala.h1197026.Hotel-Information) ![Esplendor by Wyndham Savoy Rosario](https://images.trvl-media.com/lodging/3000000/2810000/2803500/2803473/36b8ac51_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Esplendor by Wyndham Savoy Rosario San Lorenzo 1022 Rosario Santa Fe £71 17 Jan - 18 Jan 8.4/10 Very Good! (449 reviews) [](https://expedia.co.uk/Rosario-Hotels-Esplendor-By-Wyndham-Savoy-Rosario.h2803473.Hotel-Information) ![Marriott Corrientes Hotel](https://images.trvl-media.com/lodging/118000000/117160000/117154200/117154160/45830686_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Marriott Corrientes Hotel Av Costanera Juan Pablo II y Lavalle Corrientes £100 16 Jan - 17 Jan 9.6/10 Exceptional! (12 reviews) [](https://expedia.co.uk/Corrientes-Hotels-Marriott-Corrientes-Hotel.h117154160.Hotel-Information) Still don't see what you're looking for? [See all properties in Mesopotamia.](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F01%2F2026&endDate=11%2F01%2F2026®ionId=6208836&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F01%2F2026&endDate=11%2F01%2F2026®ionId=6208836&star=50&star=50&amenities=POOL)[Spa](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F01%2F2026&endDate=11%2F01%2F2026®ionId=6208836&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F01%2F2026&endDate=11%2F01%2F2026®ionId=6208836&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F01%2F2026&endDate=11%2F01%2F2026®ionId=6208836&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F01%2F2026&endDate=11%2F01%2F2026®ionId=6208836&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Learn more about Mesopotamia The awe-inspiring Iguazú Falls is the centerpiece attraction of this northeastern Argentine region, which also hosts the country’s biggest carnival celebration. [See all hotels in Mesopotamia](https://www.expedia.co.uk/Hotel-Search?startDate=2026-01-23&endDate=2026-01-24&adults=2®ionId=6208836) ![Mesopotamia showing a river or creek and forests](https://images.trvl-media.com/place/6208836/ca0c6990-9932-4f38-bee6-e89ce7080803.jpg?impolicy=fcrop&w=900&h=506&p=1&q=high) ## Top Mesopotamia Hotel Reviews ## Find out more about Mesopotamia ## Explore a world of travel with Expedia - More ways to book - [Book 5 Star Hotels in Mesopotamia on Expedia.com.ar ](https://www.expedia.com.ar/5Estrella-Mesopotamia-Hoteles.s50-0-d6208836.Guia-filtrada-de-Hoteles)