Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5
Nectar
Collect Nectar points
Nectar
Collect Nectar points
Nectar
Collect Nectar points

Search 590,000 properties worldwide.

Search over a million flights, hotels, packages, and more

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Santa Cruz 4 Star Hotels

See all 26 Hotels in Santa Cruz
Santa Cruz Plaza

Santa Cruz Plaza

Plaza De Armas 286, Santa Cruz
    4.0 out of 5.0
     
     
    4.2 out of 5 (110 reviews)
    Excellent hotel in Chilean wine country.We stayed at the Plaza on our way south from Santiago, Chile, headed toward the lakes country, based on a recommendation of a family friend. We went out of our way to stay there on our way back to Santiago to fly home because of the quality of the hotel property, its staff, grounds and amenities. ...
    30 Mar 2018
    Vik Chile

    Vik Chile

    Valle de Millahue, San Vicente
      4.5 out of 5.0
       
       
      4.5 out of 5 (6 reviews)
      6 star estanciaWe have been in the most of the best wineyards hotels in the world there is nothing comparable to this: fantastic art, english speaking professional staff...like private retreat. Utopia in Chille for people looking for the best
      15 Dec 2017
      Map

      Pocket Guide: 4 Star Hotels in Santa Cruz

      Search for hotels in Santa Cruz on Expedia.co.uk. You can easily find your hotels in Santa Cruz using one of the methods below:

      • View our selection of featured hotels in Santa Cruz
      • Use the map to find hotels in the Santa Cruz neighborhood you prefer
      • Use the filters to see hotels in a specific area of Santa Cruz, select a specific theme, brand, or hotel class from basic (1 Star) to luxury hotels (5 Stars) in Santa Cruz
      • Enter your travel dates to view the best deals on hotels in Santa Cruz - while they last