Title: The 10 Best 4 Star Hotels in Santa Cruz - 2025 Updated Prices | Expedia.co.uk [Santa Cruz Travel Guide](https://expedia.co.uk/Santa-Cruz.dx6047957)[Hotels in Santa Cruz](https://expedia.co.uk/Santa-Cruz-Hotels.d6047957.Travel-Guide-Hotels)[Holiday Rentals in Santa Cruz](https://expedia.co.uk/Santa-Cruz-Holiday-Rentals.d6047957.Travel-Guide-HolidayRentals)[Flights to Santa Cruz](https://expedia.co.uk/Cheap-Flights-To-Santa-Cruz.d6047957.Travel-Guide-Flights)[Things to do in Santa Cruz](https://expedia.co.uk/Things-To-Do-In-Santa-Cruz.d6047957.Travel-Guide-Activities)[Santa Cruz Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Santa-Cruz.d6047957.Car-Hire-Guide)[Santa Cruz Holidays](https://expedia.co.uk/Santa-Cruz.d6047957.Holidays-City-Breaks) ![](https://mediaim.expedia.com/destination/2/cc9d4f6227cc14a14b1c75c0de60343b.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Vivian Rennó # Compare and book 4 Star hotels in Santa Cruz, O'Higgins Region ![price find illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Santa Cruz 4 Star Hotels Tonight [16 Sept - 17 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=6047957&startDate=2025-09-16&endDate=2025-09-17&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [17 Sept - 18 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=6047957&startDate=2025-09-17&endDate=2025-09-18&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [19 Sept - 21 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=6047957&startDate=2025-09-19&endDate=2025-09-21&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [26 Sept - 28 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=6047957&startDate=2025-09-26&endDate=2025-09-28&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Santa Cruz 4 Star Hotels ## Our top choices for Santa Cruz 4-star hotels ![Outdoor pool, pool loungers](https://images.trvl-media.com/lodging/2000000/1410000/1406700/1406642/3fe1c8d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property – evening/night](https://images.trvl-media.com/lodging/2000000/1410000/1406700/1406642/75df94bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Twin Room | 1 bedroom, minibar, in-room safe, desk](https://images.trvl-media.com/lodging/2000000/1410000/1406700/1406642/4b01e3a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/2000000/1410000/1406700/1406642/b6c7442f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Santa Cruz Plaza Santa Cruz 8.6/10 Excellent (324) "the staff were very attentive, would recommend" £90 29 Sept - 30 Sept [](https://www.expedia.co.uk/San-Fernando-Hotels-Santa-Cruz-Plaza.h1406642.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/10000000/9430000/9423000/9422950/47af8d73.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Icono, Habitación en Barrica de Vino | Premium bedding, minibar, in-room safe, bed sheets](https://images.trvl-media.com/lodging/10000000/9430000/9423000/9422950/5682628a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily local cuisine breakfast ](https://images.trvl-media.com/lodging/10000000/9430000/9423000/9422950/f9f5b273.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Gran Reserva, Habitación en Barrica de Vino | Premium bedding, minibar, in-room safe, bed sheets](https://images.trvl-media.com/lodging/10000000/9430000/9423000/9422950/405fcbc1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Cava Colchagua Santa Cruz 8.8/10 Excellent (165) "Interesting and beautiful place to stay. Barrel rooms are comfortable. Staff are very pleasant and accomodating. Food at the restaurant was fantastic. Shower was not the best." [](https://www.expedia.co.uk/San-Fernando-Hotels-Hotel-Cava-Colchagua.h9422950.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/113000000/112250000/112245800/112245785/2c83ee9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/113000000/112250000/112245800/112245785/2875b347.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, minibar, laptop workspace, free WiFi](https://images.trvl-media.com/lodging/113000000/112250000/112245800/112245785/b4d8c5ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Separate bathtub and shower, bathrobes, towels, soap](https://images.trvl-media.com/lodging/113000000/112250000/112245800/112245785/ef606481.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vibo Wine Lodge Santa Cruz [](https://www.expedia.co.uk/Santa-Cruz-Hotels-Vibo-Wine-Lodge.h112245785.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Santa-Cruz-Hotels.s40-0-d6047957.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Santa-Cruz-Hotels.s40-0-d6047957.Travel-Guide-Filter-Hotels) ## Explore similar 5-star hotels Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Santa Cruz. ![Vik Chile](https://images.trvl-media.com/lodging/9000000/8730000/8726600/8726594/7cfca4ac_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Vik Chile Valle de Millahue, San Vicente, O'Higgins £485 21 Sept - 22 Sept 9/10 Wonderful! (146 reviews) [](https://expedia.co.uk/San-Fernando-Hotels-Vik-Chile.h8726594.Hotel-Information) ![Barrica Lodge](https://images.trvl-media.com/lodging/119000000/118210000/118203700/118203695/f232fc98_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Barrica Lodge Ruta I-706, Santa Cruz £97 21 Sept - 22 Sept [](https://expedia.co.uk/Santa-Cruz-Hotels-Barrica-Lodge.h118203695.Hotel-Information) Still don't see what you're looking for? [See all properties in Santa Cruz.](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=17%2F09%2F2025&endDate=18%2F09%2F2025®ionId=6047957&star=40) You can also use these popular filters to refine your search. [Pool](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=17%2F09%2F2025&endDate=18%2F09%2F2025®ionId=6047957&star=40&star=40&amenities=POOL)[Spa](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=17%2F09%2F2025&endDate=18%2F09%2F2025®ionId=6047957&star=40&star=40&amenities=SPA_ON_SITE)[Hot tub](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=17%2F09%2F2025&endDate=18%2F09%2F2025®ionId=6047957&star=40&star=40&amenities=HOT_TUB)[Breakfast included](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=17%2F09%2F2025&endDate=18%2F09%2F2025®ionId=6047957&star=40&star=40&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=17%2F09%2F2025&endDate=18%2F09%2F2025®ionId=6047957&star=40&star=40&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Learn more about Santa Cruz Nestled in the heart of wine country, Santa Cruz invites visitors to taste world-class Colchagua Valley wines at family-owned vineyards. Museum of Colchagua showcases impressive pre-Columbian artefacts while the Plaza de Armas offers local crafts and regional foods on weekends. [See all hotels in Santa Cruz](https://www.expedia.co.uk/Hotel-Search?startDate=2025-09-30&endDate=2025-10-01&adults=2®ionId=6047957) ![](https://mediaim.expedia.com/destination/2/cc9d4f6227cc14a14b1c75c0de60343b.jpg?impolicy=fcrop&w=900&h=675&p=1&q=high) Photo by Vivian Rennó ## Top Santa Cruz Hotel Reviews ![Santa Cruz Plaza](//images.trvl-media.com/lodging/2000000/1410000/1406700/1406642/3fe1c8d9_y.jpg) ### Santa Cruz Plaza 10/10 Excellent "The hotel truly shines with its exceptional cleanliness and a refined design that takes inspiration from the Chilean countryside" [](https://expedia.co.uk/San-Fernando-Hotels-Santa-Cruz-Plaza.h1406642.Hotel-Information) ![Hotel Cava Colchagua](//images.trvl-media.com/lodging/10000000/9430000/9423000/9422950/47af8d73_y.jpg) ### Hotel Cava Colchagua 10/10 Excellent "Fun, interesting, pools ice cold, dogs barking all night. Still you don’t want to miss this opportunity." [](https://expedia.co.uk/San-Fernando-Hotels-Hotel-Cava-Colchagua.h9422950.Hotel-Information) ## Find out more about Santa Cruz ## Frequently asked questions ### What are the best 4-star hotels in Santa Cruz? > Expedia travellers enjoy staying at [Santa Cruz Plaza](https://www.expedia.co.uk/San-Fernando-Hotels-Santa-Cruz-Plaza.h1406642.Hotel-Information). From its handy amenities to its dedicated staff, everything about this 4-star hotel in Santa Cruz is designed to offer a memorable holiday experience. ### How much does it cost to stay in a 4-star hotel in Santa Cruz? > With Expedia's handy filter tool, scoring a superb deal on a 4-star hotel in Santa Cruz just got simpler. Start by keying in your chosen arrival date and length of your break. Then sort the results by price and pick a hotel that best matches your budget and style. > > > > - Search for the lowest price from £97 ### What's the difference between 5-star and 4-star hotels in Santa Cruz? > Treat yourself to luxury living during your Santa Cruz getaway by staying at a 4-star hotel. As well as featuring upscale accommodation, these properties are usually packed with amenities, including large beds, complimentary bathrobes and plenty more. A 5-star hotel will go above and beyond to make your stay an even more indulgent and special one. 24-hour concierge assistance, elegant décor and world-class dining are only the start of the exclusive services and conveniences you'll likely get access to. ## Explore a world of travel with Expedia - Explore a world of travel with Expedia ### Choose Your Santa Cruz Hotel Style - [Winery Hotels in Santa Cruz](https://expedia.co.uk/Santa-Cruz-Hotels-Winery-Hotels.0-0-d6047957-tWineryHotels.Travel-Guide-Filter-Hotels) ### Recommended cities for you - [Hotels in Sao Paulo](https://expedia.co.uk/Sao-Paulo-Hotels.d180023.Travel-Guide-Hotels) - [Hotels in Cartagena](https://expedia.co.uk/Cartagena-Hotels.d926.Travel-Guide-Hotels) - [Hotels in Buenos Aires](https://expedia.co.uk/Buenos-Aires-Hotels.d178242.Travel-Guide-Hotels) - [Hotels in Itajai](https://expedia.co.uk/Itajai-Hotels.d6053365.Travel-Guide-Hotels) - [Hotels in Lima](https://expedia.co.uk/Lima-Hotels.d178277.Travel-Guide-Hotels) - [Hotels in Florianópolis](https://expedia.co.uk/Florianopolis-Hotels.d6053360.Travel-Guide-Hotels) - [Hotels in Bogotá](https://expedia.co.uk/Bogota-Hotels.d178238.Travel-Guide-Hotels) - [Hotels in Santiago](https://expedia.co.uk/Santiago-Hotels.d178306.Travel-Guide-Hotels) - [Hotels in San Andrés](https://expedia.co.uk/San-Andres-Hotels.d6024028.Travel-Guide-Hotels) - [Hotels in Medellin](https://expedia.co.uk/Medellin-Hotels.d2246.Travel-Guide-Hotels) - [Hotels in Quito](https://expedia.co.uk/Quito-Hotels.d6053672.Travel-Guide-Hotels) ### Explore more hotels - [Vibo Wine Lodge](https://expedia.co.uk/Santa-Cruz-Hotels-Vibo-Wine-Lodge.h112245785.Hotel-Information) - [Barrica Lodge](https://expedia.co.uk/Santa-Cruz-Hotels-Barrica-Lodge.h118203695.Hotel-Information) - [Callihue de Colchagua Lodge](https://expedia.co.uk/San-Fernando-Hotels-Callihue-De-Colchagua-Lodge.h44039063.Hotel-Information) - [Hostal Gomero](https://expedia.co.uk/Santa-Cruz-Hotels-Hostal-Gomero.h100701612.Hotel-Information) - [Parcela con tranque, sala de juegos, terraza,](https://expedia.co.uk/Santa-Cruz-Hotels-Parcela-Con-Tranque.h78503070.Hotel-Information) - [Weekend & Wine B&B](https://expedia.co.uk/Santa-Cruz-Hotels-Weekend-Wine-BB.h15362096.Hotel-Information) - [Hotel Hoja de Parra](https://expedia.co.uk/San-Fernando-Hotels-Hotel-Hoja-De-Parra.h19125826.Hotel-Information) - [El Refugio de Santa Cruz](https://expedia.co.uk/Santa-Cruz-Hotels-El-Refugio-De-Santa-Cruz.h107131185.Hotel-Information) - [Tierra y Vino](https://expedia.co.uk/San-Fernando-Hotels-Tierra-Y-Vino.h45739627.Hotel-Information) - [Apalta Lofts, enjoy the vineyards in front of the vineyards](https://expedia.co.uk/Santa-Cruz-Hotels-Vrbo-Property.h119995983.Hotel-Information) - [Hotel Casa de Campo](https://expedia.co.uk/San-Fernando-Hotels-Hotel-Casa-De-Campo.h15462567.Hotel-Information) [See a list of all hotels in Santa Cruz](https://expedia.co.uk/All-Santa-Cruz-Hotels.d6047957.Travel-Guide-City-All-Hotels) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app ![QR code to download the app](data:image/png;base64,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)