Title: Santa Cruz Travel Guide: Best of Santa Cruz, O'Higgins Region Travel 2026 | Expedia.co.uk [Hotels in Santa Cruz](https://expedia.co.uk/Santa-Cruz-Hotels.d6047957.Travel-Guide-Hotels)[Holiday Rentals in Santa Cruz](https://expedia.co.uk/Santa-Cruz-Holiday-Rentals.d6047957.Travel-Guide-HolidayRentals)[Flights to Santa Cruz](https://expedia.co.uk/Cheap-Flights-To-Santa-Cruz.d6047957.Travel-Guide-Flights)[Santa Cruz Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Santa-Cruz.d6047957.Car-Hire-Guide)[Santa Cruz Holidays](https://expedia.co.uk/Santa-Cruz.d6047957.Holidays-City-Breaks) # Santa Cruz Travel Guide ## Tourist Guide ![Rows of vineyards, Santa Cruz, Chile](https://images.trvl-media.com/place/6047957/e58d3014-ef10-4c60-9e03-08890e2f5494.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Chilean Wine - Vineyards - Chile](https://images.trvl-media.com/place/6047957/cdb9eb51-9321-43be-93a7-cc61dddb971b.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Vineyards in the Colchagua Valley - Chile](https://images.trvl-media.com/place/6047957/a319a664-b489-4d8b-88b2-e380b1fe83ec.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Santa Cruz](https://images.trvl-media.com/place/6047957/3f6f573a-78af-41a2-967b-d9399720ea19.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Santa Cruz](https://images.trvl-media.com/place/6047957/f768a89d-e5dc-49f1-898d-c44500189966.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ## Visit Santa Cruz Things to do - Top hotels in Santa Cruz - Top Holiday Rentals in Santa Cruz ![Santa Cruz Plaza](https://images.trvl-media.com/lodging/2000000/1410000/1406700/1406642/3fe1c8d9_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Santa Cruz Plaza Plaza De Armas 286 Santa Cruz O'Higgins £103 29 Mar - 30 Mar Stay at this spa hotel in Santa Cruz. Enjoy free Wi-Fi, free parking and a full-service spa. Our guests praise the helpful staff in their reviews. Popular attractions ... 8.8/10 Excellent! (349 reviews) Me parecio un lindo hotel, el Desayuno es muy completo tipico chileno. Creo que en el chek in deberian informar de las cosas con que cuenta el hotel y paseos, creo que tener que ir a otra oficina es una perdida de recursos. Nos toco una habitacion con tinaja la que disfrutamos es algo muy bueno, ... Reviewed on 20 Mar 2026 [](https://expedia.co.uk/Hotel-Search?startDate=29%2F03%2F2026&endDate=30%2F03%2F2026&selected=1406642&PinnedHotelID=1406642&HadPinnedHotel=true®ionId=6047957) ![Hotel Cava Colchagua](https://images.trvl-media.com/lodging/10000000/9430000/9423000/9422950/38e10dec_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hotel Cava Colchagua Barreales´s Way Santa Cruz O'Higgins £102 1 Apr - 2 Apr Stay at this spa hotel in Santa Cruz. Enjoy free breakfast, a full-service spa and an on-site winery. Popular attractions Laura Hartwig Winery and Casino Colchagua ... [](https://expedia.co.uk/Hotel-Search?startDate=01%2F04%2F2026&endDate=02%2F04%2F2026&selected=9422950&PinnedHotelID=9422950&HadPinnedHotel=true®ionId=6047957) ![Hotel Vendimia Parador](https://images.trvl-media.com/lodging/23000000/22440000/22438600/22438533/93f91da4_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hotel Vendimia Parador Camino Los Boldos SN Santa Cruz O'Higgins £74 21 Apr - 22 Apr Stay at this hotel in Santa Cruz. Enjoy free Wi-Fi, free parking and free food shopping service. Our guests praise the helpful staff in their reviews. Popular ... 9.6/10 Exceptional! (84 reviews) This is a lovely family run establishment in a small traditional building, the interior is delightfully decorated with antique curios. The grounds include a nice pool overlooked by a sun deck which affords views of the surrounding countryside. It also has secure parking. Our room was large and tastefully ... Reviewed on 19 Mar 2026 [](https://expedia.co.uk/Hotel-Search?startDate=21%2F04%2F2026&endDate=22%2F04%2F2026&selected=22438533&PinnedHotelID=22438533&HadPinnedHotel=true®ionId=6047957) [See all 56 properties in Santa Cruz](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=27%2F03%2F2026&endDate=28%2F03%2F2026®ionId=6047957) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![Colchagua Tiny Lodge](https://images.trvl-media.com/lodging/113000000/112020000/112019700/112019659/a6261078_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Colchagua Tiny Lodge I-350 kilometro 4,5 Santa Cruz O'Higgins Stay at this cabin in Santa Cruz. Enjoy free Wi-Fi, free parking and private hot tubs. Popular attractions Lapostolle Clos Apalta Winery and Bodega Viña Viu ... [](https://expedia.co.uk/Santa-Cruz-Hotels-Colchagua-Tiny-Lodge.h112019659.Hotel-Information) ![The ambush. Field and comfort](https://images.trvl-media.com/lodging/39000000/38120000/38118300/38118253/48553e33_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### The ambush. Field and comfort Santa Cruz Región del Libertador Gral. Bernardo O’Higgins Stay at this holiday home in Santa Cruz. Enjoy free breakfast, a garden and patios. Popular attractions Laura Hartwig Winery and Plaza de Armas are located ... [](https://expedia.co.uk/Santa-Cruz-Hotels-The-Ambush-Field-And-Comfort.h38118253.Hotel-Information) ![Intown Apart Santa Cruz](https://images.trvl-media.com/lodging/19000000/18690000/18680300/18680229/317611de_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Intown Apart Santa Cruz Claudio Cancino 92 Santa Cruz O'Higgins Stay at this business-friendly apartment in Santa Cruz. Enjoy free Wi-Fi, parking (surcharge) and an airport shuttle (surcharge). Popular attractions Plaza de ... 10/10 Exceptional! (1 review) Boa experiência A experiência no Check In foi muito boa. Mário, quem nos atendeu, foi muito cordial e como estavamos chegando de Pucon (12h de viagem) cheguei às 9h da manhã. Assim mesmo, ele nos proporcionou a antecipação do apartamento para descansarmos. O prédio é novo e o quarto estava em excelentes condições: ... Reviewed on 26 Sept 2017 [](https://expedia.co.uk/San-Fernando-Hotels-Intown-Apart-Santa-Cruz.h18680229.Hotel-Information) [See all properties in Santa Cruz](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience®ionId=6047957&sort=VACATION_RENTAL) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check Santa Cruz hotel availability [Tonight ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6047957&startDate=2026-03-26&endDate=2026-03-27)[26 Mar - 27 Mar](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6047957&startDate=2026-03-26&endDate=2026-03-27) [Tomorrow night ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6047957&startDate=2026-03-27&endDate=2026-03-28)[27 Mar - 28 Mar](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6047957&startDate=2026-03-27&endDate=2026-03-28) [This weekend ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6047957&startDate=27%2F03%2F2026&endDate=29%2F03%2F2026)[27 Mar - 29 Mar](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6047957&startDate=27%2F03%2F2026&endDate=29%2F03%2F2026) [Next weekend ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6047957&startDate=03%2F04%2F2026&endDate=05%2F04%2F2026)[3 Apr - 5 Apr](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6047957&startDate=03%2F04%2F2026&endDate=05%2F04%2F2026) ### Popular places to visit #### Lapostolle Clos Apalta Winery 4.5/5(3 reviews) You can enjoy a tasting or tour at Lapostolle Clos Apalta Winery during your travels to Santa Cruz. While in this relaxing area, you can savour the wineries and restaurants. [](https://expedia.co.uk/Lapostolle-Clos-Apalta-Winery-San-Fernando.d553248621532463283.Attraction) #### Casino Colchagua Why not roll the dice with a visit to Casino Colchagua during your travels in Santa Cruz? While in this relaxing area, you can savour the wineries and restaurants. [](https://expedia.co.uk/Casino-Colchagua-San-Fernando.d553248621532463282.Attraction) #### Colchagua Campo y Vino Enjoy an outing to Colchagua Campo y Vino during your stay in Santa Cruz. While in this relaxing area, you can savour the wineries and restaurants. [](https://expedia.co.uk/Colchagua-Campo-Y-Vino-San-Fernando.d553248621532463281.Attraction) #### Laura Hartwig Winery 5/5(1 review) You can enjoy a tasting or tour at Laura Hartwig Winery during your travels to Santa Cruz. While in this relaxing area, you can savour the wineries and restaurants. [](https://expedia.co.uk/Laura-Hartwig-Winery-San-Fernando.d553248621532463280.Attraction) #### Bodega Viña Viu Manent You can enjoy a tasting or tour at Bodega Viña Viu Manent during your travels to Santa Cruz. While in this relaxing area, you can savour the wineries and restaurants. [](https://expedia.co.uk/Bodega-Vina-Viu-Manent-Santa-Cruz.d873855731647115264.Attraction) #### Museo de Colchagua 5/5(1 review) You can spend time browsing the exhibits at Museo de Colchagua during your trip to Santa Cruz. While in this relaxing area, you can savour the wineries and restaurants. [](https://expedia.co.uk/Museo-De-Colchagua-Santa-Cruz.d6099456.Attraction) ### Things to do ![Peralillo Chapel](https://mediaim.expedia.com/localexpert/45717765/f00a01c2-cae4-419c-98f7-0c1d94b893a8.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Moment Tour Tasting £16 per adult [](https://expedia.co.uk/things-to-do/moment-tour-tasting.a45717765.activity-details) ![Customers](https://mediaim.expedia.com/localexpert/45705412/49ec69fb-197e-4efb-a2f3-02236449f694.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Moment Premium Tasting Tour £29 per adult [](https://expedia.co.uk/things-to-do/moment-premium-tasting-tour.a45705412.activity-details) ![Make Your Own Wine & Guided Vineyard Tour ](https://mediaim.expedia.com/localexpert/46200977/2edfdc20-7979-4beb-b97e-2ba00246939c.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Make Your Own Wine & Guided Vineyard Tour £34 per adult [](https://expedia.co.uk/things-to-do/make-your-own-wine-guided-vineyard-tour.a46200977.activity-details) ![Biking Colchagua Wine Valley](https://mediaim.expedia.com/localexpert/48848543/dffd567d-ddc5-4d49-b668-cbc0314a6200.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Biking Colchagua Wine Valley (4 DAYS) £2,512 per adult [](https://expedia.co.uk/things-to-do/biking-colchagua-wine-valley-4-days.a48848543.activity-details) ![Viu Manent tour](https://mediaim.expedia.com/localexpert/46790586/8281bde6-a8fc-407d-ba24-3d5b37d230c6.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Viu Manent and Montes Winery, Colchagua Valley from semi-private £207 per adult [](https://expedia.co.uk/things-to-do/viu-manent-and-montes-winery.a46790586.activity-details) ![Viu Manet vineyard](https://mediaim.expedia.com/localexpert/2681376/c4fc5f62-e4b2-4f25-b1c1-59373d0b0b80.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Colchagua Valley Viñas Viu Manet and Montes Alfha £282 per adult **100%** of travellers recommend [](https://expedia.co.uk/things-to-do/colchagua-valley-vinas-viu-manet-and-montes-alfha.a2681376.activity-details) [See all activities in Santa Cruz](https://expedia.co.uk/Things-To-Do-In-Santa-Cruz.d6047957.Travel-Guide-Activities) ## Cities near Santa Cruz ![Lolol](https://images.trvl-media.com/place/3000006362/d1f31aae-7d9f-4840-923c-a5919fefcb2b.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Lolol - Cities near Santa Cruz - Places of interest [Nancagua](https://expedia.co.uk/Nancagua.dx3000006338)[Lolol](https://expedia.co.uk/Lolol.dx3000006362) - [Hacienda El Huique ](https://expedia.co.uk/Hacienda-El-Huique-Palmilla.d6099458.Attraction) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. 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