Santa Cruz Holidays from £1,074

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to £750 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Packages with flights are ATOL protected

Your Santa Cruz Holiday

There's no better way to get away than with one of our holiday packages to Santa Cruz. The lively atmosphere and beaches are two of the countless reasons to spend some time in this awesome city. A trip to Santa Cruz is an ideal opportunity to do some sightseeing. Be sure to stop by renowned attractions like Lapostolle Clos Apalta Winery, Laura Hartwig Winery and Casino Colchagua. Your perfect Santa Cruz holiday is a couple of clicks away. Browse airfares, hotels and more on Expedia for an adventure that's tailored just for you.

Top Santa Cruz Flight + Hotel Deals

Price found within the past 48 hours. Click for updated prices.
ICON Hotel

ICON Hotel

4 out of 5
Las Condes
Price was £1,398, price is now £1,074 per person
£1,074
per person
6 Oct - 12 Oct
found 1 day ago
Return direct flight included
London (LON) to Santiago (SCL)
8.6/10 Excellent! (1,004 reviews)
My room was not done for 3 days even requesting it at the front desk personally. They receive packages but didn’t call you or message to let you know that they arrived, I still have one missing. Infrastructure is good but service is poor. Non functional for businesses purposes.

Reviewed on 29 Jun 2026

Moderno depto. en Stgo. cerca del metro

Moderno depto. en Stgo. cerca del metro

2 out of 5
Downtown Santiago
Save 100% on your flight
Price was £894,658, price is now £700,778 per person
£700,778
per person
6 Oct - 12 Oct
found 1 day ago
Return direct flight included
London (LON) to Santiago (SCL)
No reviews

Casa Bueras Boutique Hotel

Casa Bueras Boutique Hotel

4.5 out of 5
Downtown Santiago
Price was £1,425, price is now £1,139 per person
£1,139
per person
6 Oct - 12 Oct
found 1 day ago
Return direct flight included
London (LON) to Santiago (SCL)
9.2/10 Wonderful! (548 reviews)

AT HOME Alonso

AT HOME Alonso

4 out of 5
Vitacura
Price was £1,590, price is now £1,333 per person
£1,333
per person
6 Oct - 12 Oct
found 1 day ago
Return direct flight included
London (LON) to Santiago (SCL)
10/10 Exceptional! (2 reviews)
Excelente apart-hotel! A localização é ótima, o apartamento é muito limpo, confortável e bem equipado. O check-in foi fácil e a comunicação com o anfitrião foi rápida e eficiente. Tudo estava exatamente como anunciado, proporcionando uma estadia tranquila e agradável. Recomendo com certeza e voltaria a me hospedar aqui em uma próxima viagem.

Reviewed on 21 Jul 2026

Luciano K Hotel

Luciano K Hotel

4.5 out of 5
Downtown Santiago
Price was £1,298, price is now £1,099 per person
£1,099
per person
6 Oct - 12 Oct
found 1 day ago
Return direct flight included
London (LON) to Santiago (SCL)
9/10 Wonderful! (760 reviews)
I had a very pleasant stay at Luciano K Hotel in Santiago. The staff were truly outstanding — warm, attentive, and consistently helpful from check-in to check-out, making the whole experience feel smooth and personal. As an Expedia Platinum member, I also received a nice room upgrade, which was much appreciated and added extra comfort to the stay. I also liked the room itself — it had a number of small designer touches and interesting details that made it feel a bit more unique than a standard hotel room, without being over the top. Overall, a very positive experience, with excellent service at the heart of it.

Reviewed on 4 Jul 2026

Santa Cruz Essential Information

Language
Spanish
Currency
Chilean pesos
Local Welcome
¡Hola!
Local Goodbye
Adiós
Population
33,300
Max Temp Winter
16ºC
Max Temp Summer
32ºC
Top Sights
Lapostolle Clos Apalta Winery, Museo de Colchagua and MontGras Winery

Top hotels in Santa Cruz

Santa Cruz Plaza

Santa Cruz Plaza

4 out of 5
Plaza De Armas 286 Santa Cruz O'Higgins
The price is £91 per night from 12 Aug to 13 Aug
£91
12 Aug - 13 Aug
Santa Cruz Plaza
Hotel Vendimia Parador

Hotel Vendimia Parador

3 out of 5
Camino Los Boldos SN Santa Cruz O'Higgins
Fully refundableReserve now, pay when you stay
The price is £62 per night from 22 Aug to 23 Aug
£62
22 Aug - 23 Aug
9.6/10 Exceptional! (85 reviews)
""I had a wonderful experience at this hotel. The location is fantastic—central and convenient to everything I wanted to see. The room was spotless and well-maintained, which I really appreciated. But what truly sets this place apart is the staff. From the front desk to the housekeeping team, everyone ..."

Reviewed on 1 Apr 2026

Hotel Vendimia Parador
La Perla Hotel

La Perla Hotel

3.5 out of 5
El Rosal, Parcela 4, Lote A, Capellanía Santa Cruz O'Higgins
The price is £64 per night from 17 Aug to 18 Aug
£64
17 Aug - 18 Aug
La Perla Hotel
See all 57 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Stay near popular Santa Cruz attractions

Lapostolle Clos Apalta Winery

9.4/10 (21 reviews)
Carved into the hillside, Clos Apalta Winery produces award-winning Bordeaux-style wines using a gravitational system. Reserve a private tour to taste premium vintages overlooking the stunning Colchagua Valley.
See properties

What to do in Santa Cruz

Customers

Moment Premium Tasting Tour

£29
per adult
Moment Premium Tasting Tour
Make Your Own Wine & Guided Vineyard Tour

Make Your Own Wine & Guided Vineyard Tour

£35
per adult
Make Your Own Wine & Guided Vineyard Tour
Viu Manent tour

Viu Manent and Montes Winery, Colchagua Valley from semi-private

£211
per adult
Viu Manent and Montes Winery, Colchagua Valley from semi-private
See all activities in Santa Cruz

Frequently asked questions

How much does a Santa Cruz travel package cost?
The most affordable Santa Cruz travel package is £1,074, so your dream holiday can become a reality — without a hefty price tag. Bundle flights, hotels and car rentals to customize a package that matches your travel style.
If I'm not able to travel, can I cancel my Santa Cruz travel package?
We totally understand — the universe can throw the odd curveball. If you've booked a Santa Cruz travel package and have to cancel or change it, we can help. We recommend looking up our Customer Service Portal first for information. But in general, if you've booked your package within 24 hours, you may be able to cancel or amend your itinerary free of charge. If it's been longer than 24 hours, your hotel, airline or car rental company may impose a fee.
How do I get a cheap travel package to Santa Cruz?
Track down flights that fit your schedule, add a hotel room to your booking and watch the savings grow with a Santa Cruz travel package. It's that easy! From flights and hotels to rental cars and activities, Expedia is your gateway to cheap travel. And with over 550 partner airlines and 1,000,000 hotel options globally to choose from, you won't be short of choice.
Does Expedia offer Book Now, Pay Later Santa Cruz holidays?
Expedia has partnered with online lender Klarna to make booking your next getaway a bit easier on the wallet. Paying in instalments means you can spread the costs of your next big adventure, leaving you with more money to play with while you're travelling. Klarna has several payment plans to pick from, so you're sure to find something that suits your budget. Browse these flexible payment options:

  • Pay monthly holidays: If paying bite-sized amounts each month works for you, Klarna offers just that! Paying in convenient monthly instalments will make that dream getaway possible.
  • Pay in instalments holidays: With this Book Now, Pay Later option, Klarna allows you to pay off your trip over multiple transactions.
  • Low deposit holidays: If paying a small percentage of your trip (rather than the total upfront) makes it easier to hit that "book now" button, choose a low deposit holiday payment plan from Klarna.

Where should I stay in Santa Cruz?
A getaway to Santa Cruz isn't complete without visiting Museo de Colchagua, Lapostolle Clos Apalta Winery and Laura Hartwig Winery. Spend your evenings close to these popular sights and make sightseeing a breeze.
What are the top hotels in Santa Cruz?
Make a reservation at TerraViña. It's one of this neighbourhood's most popular hotels. Another well-known option in Santa Cruz is Noi Blend Colchagua.
How far in advance should I book my Santa Cruz holiday?
While not all air carriers advertise tickets early, customers are usually able to start comparing international airfares on Expedia up to 12 months in advance. This is when you'll bag some fantastic bargains. If you've left everything to the last minute, you might still get lucky. Sometimes the lowest prices become available only weeks prior to departure.
What does an Expedia Santa Cruz travel package include?
Choose from any combination of hotels, flights and rental cars. Once you've made your booking, you can also add on activities and experiences. Want to pick your airfare class? That's easily done too. The choice is yours when it comes to organising your perfect Santa Cruz trip.
What should I know before booking a Santa Cruz travel package?
Whether it's adventure or relaxation you're craving, a Santa Cruz travel package lets you organise your escape your way. Plus, you'll score great discounts when you combine your accommodation with your rental car and flights. The more you bundle, the bigger the savings!
Can I choose my airline with a Santa Cruz Expedia travel package?
With a travel package, you're in charge. Whether you're eager to fly to Santa Cruz in business or coach, simply choose from the available airline options. Expedia has access to more than 550 partner airlines across the world.

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.