A calm sea with a small boat and a row of palm trees on the shore.

Compare and book 4 Star hotels in Eastern Panama, Panama

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Check availability on Eastern Panama 4 Star Hotels

Tonight
29 Aug - 30 Aug
Tomorrow
30 Aug - 31 Aug
Next weekend
4 Sept - 6 Sept
In two weeks
11 Sept - 13 Sept

Our top choices for Eastern Panama 4-star hotels

A bedroom with a bed, a TV, and a balcony with a view of the sea.
A coastal property with multiple white buildings, a beach, and a person paddleboarding.
An aerial view of a coastal resort with multiple buildings, a beach, and surrounding forested hills.
A bathtub with water, towels, and flowers on a balcony overlooking the sea.

1. Ordovician Beach Resort

Ordovician Beach Resort
Isla Grande
Canada
Janet
£344
includes taxes & fees
7 Sept - 8 Sept
Ordovician Beach Resort

2. Mandalas Ecolodge

Mandalas Ecolodge
Caimitillo
Mandalas Ecolodge

3. El Otro Lado

El Otro Lado
Portobelo
United States
Jacob
El Otro Lado

4. Portobello Historico

Portobello Historico
Portobelo
Portobello Historico
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Learn more about Eastern Panama

Head to sights like Cayos Holandeses and Isla Diablo as you discover Eastern Panama.

See all hotels in Eastern Panama
A calm sea with a small boat and a row of palm trees on the shore.
Photo by Nico Barner

Top Eastern Panama Hotel Reviews

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Frequently asked questions

How much does it cost to stay in a 4-star hotel in Eastern Panama?
With Expedia's handy filter tool, scoring an awesome deal on a 4-star hotel in Eastern Panama just got simpler. Start by keying in your chosen arrival date and length of your holiday. Then sort the results by price and pick the option that best matches your budget and style.
  • Search for the lowest price from £344
What's the difference between 5-star and 4-star hotels in Eastern Panama?
If you decide to book a stay at a 4-star hotel in Eastern Panama, you'll usually find lots of conveniences to keep you comfortable, such as a pool, restaurant and gym. You can experience top-quality service and upscale accommodation. Go for a 5-star hotel and you'll have access to a few more bells and whistles — think on-site spas, concierge assistance and nightly turndown services. You'll most likely get extra amenities and premium services at a 5-star retreat, but both are terrific options for luxury guests.
Does Eastern Panama have any 4-star all-inclusive resorts?
Use our "All inclusive" filter to find your next getaway in Eastern Panama where just about everything is taken care of, from your meals to your accommodation, activities and entertainment. We can also help you find standard 4-star stays in and around this leading destination.