Title: The 10 Best 4 Star Hotels in Eastern Panama - 2025 Updated Prices | Expedia.co.uk

  

[Eastern Panama Travel Guide](https://expedia.co.uk/Eastern-Panama.dx6246114)[Hotels in Eastern Panama](https://expedia.co.uk/Eastern-Panama-Hotels.d6246114.Travel-Guide-Hotels)[Holiday Rentals in Eastern Panama](https://expedia.co.uk/Eastern-Panama-Holiday-Rentals.d6246114.Travel-Guide-HolidayRentals)[Flights to Eastern Panama](https://expedia.co.uk/Cheap-Flights-To-Eastern-Panama.d6246114.Travel-Guide-Flights)[Things to do in Eastern Panama](https://expedia.co.uk/Things-To-Do-In-Eastern-Panama.d6246114.Travel-Guide-Activities)[Eastern Panama Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Eastern-Panama.d6246114.Car-Hire-Guide)[Eastern Panama Holidays](https://expedia.co.uk/Eastern-Panama.d6246114.Holidays-City-Breaks)

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# Compare and book 4 Star hotels in Eastern Panama, Panama

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## Check availability on Eastern Panama 4 Star Hotels

Tonight

[11 Oct - 12 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6246114&startDate=2025-10-11&endDate=2025-10-12&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[12 Oct - 13 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6246114&startDate=2025-10-12&endDate=2025-10-13&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[17 Oct - 19 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6246114&startDate=2025-10-17&endDate=2025-10-19&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two weeks

[24 Oct - 26 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6246114&startDate=2025-10-24&endDate=2025-10-26&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Top Eastern Panama 4 Star Hotels

![Luxury Suite | 1 bedroom, Egyptian cotton sheets, premium bedding, pillow-top beds](https://images.trvl-media.com/lodging/104000000/103770000/103761600/103761591/20f9a672.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, Ocean View | Terrace/patio](https://images.trvl-media.com/lodging/104000000/103770000/103761600/103761591/4275f8e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/104000000/103770000/103761600/103761591/cd5c460a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/104000000/103770000/103761600/103761591/ece402e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Ordovician Beach Resort

Isla Grande

10/10

Exceptional

(3)

"Amazing piece of Caribbean paradise! The staff went above and beyond to make us feel special."

[](https://www.expedia.co.uk/Ordovician-Beach-Resort.h103761591.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/108000000/107720000/107714100/107714077/956c2c4f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/108000000/107720000/107714100/107714077/cc15fa52.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Basic Suite, Mountain View | 1 bedroom, free WiFi](https://images.trvl-media.com/lodging/108000000/107720000/107714100/107714077/14e84dc7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Basic Suite, Mountain View | Private kitchen](https://images.trvl-media.com/lodging/108000000/107720000/107714100/107714077/beb3d81a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Mandalas Ecolodge

Caimitillo

[](https://www.expedia.co.uk/Caimitillo-Hotels-Mandalas-Ecolodge.h107714077.Hotel-Information)

![Outdoor pool](https://images.trvl-media.com/lodging/5000000/4320000/4313000/4312945/a37c3663.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/5000000/4320000/4313000/4312945/a31596fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/5000000/4320000/4313000/4312945/849612f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Manicures and pedicures](https://images.trvl-media.com/lodging/5000000/4320000/4313000/4312945/58db5c1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### El Otro Lado

Portobelo

9.8/10

Exceptional

(8)

"Amazing.. Amazing. You need extra words, We loved it. We loved it.Amazing.. Amazing. You need extra words, We loved it. We loved it. Amazing.. Amazing. You need extra words, We loved it. We loved it. "

[](https://www.expedia.co.uk/Portobelo-Hotels-El-Otro-Lado.h4312945.Hotel-Information)

![Premium bedding, down duvets, individually decorated](https://images.trvl-media.com/lodging/38000000/37040000/37032000/37031981/94721000.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, down duvets, individually decorated](https://images.trvl-media.com/lodging/38000000/37040000/37032000/37031981/94981263.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![30-inch TV with premium TV channels, DVD player](https://images.trvl-media.com/lodging/38000000/37040000/37032000/37031981/5edecc13.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premier Apartment, Bay View | Bathroom | Shower, designer toiletries, towels, soap](https://images.trvl-media.com/lodging/38000000/37040000/37032000/37031981/838e9b19.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Portobello Historico

Portobelo

[](https://www.expedia.co.uk/Portobelo-Hotels-Portobello-Historico.h37031981.Hotel-Information)

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## Learn more about Eastern Panama

Head to sights like Cayos Holandeses and Chagres National Park as you discover Eastern Panama.

[See all hotels in Eastern Panama](https://www.expedia.co.uk/Hotel-Search?startDate=2025-10-25&endDate=2025-10-26&adults=2&regionId=6246114)

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## Top Eastern Panama Hotel Reviews

## Find out more about Eastern Panama

## Frequently asked questions

### How much does it cost to stay in a 4-star hotel in Eastern Panama?

> With Expedia's handy filter tool, scoring an awesome deal on a 4-star hotel in Eastern Panama just got simpler. Start by keying in your chosen arrival date and length of your holiday. Then sort the results by price and pick the option that best matches your budget and style.
> 
>   
> 
> -   Search for the lowest price

### What's the difference between 5-star and 4-star hotels in Eastern Panama?

> If you decide to book a stay at a 4-star hotel in Eastern Panama, you'll usually find lots of conveniences to keep you comfortable, such as a pool, restaurant and gym. You can experience top-quality service and upscale accommodation. Go for a 5-star hotel and you'll have access to a few more bells and whistles — think on-site spas, concierge assistance and nightly turndown services. You'll most likely get extra amenities and premium services at a 5-star retreat, but both are terrific options for luxury guests.

### Does Eastern Panama have any 4-star all-inclusive resorts?

> Use our "All inclusive" filter to find your next getaway in Eastern Panama where just about everything is taken care of, from your meals to your accommodation, activities and entertainment. We can also help you find standard 4-star stays in and around this leading destination.