Title: The 10 Best 4 Star Hotels in Eastern Panama - 2026 Updated Prices | Expedia.co.uk

[Eastern Panama Travel Guide](https://expedia.co.uk/Eastern-Panama.dx6246114)[Hotels in Eastern Panama](https://expedia.co.uk/Eastern-Panama-Hotels.d6246114.Travel-Guide-Hotels)[Holiday Rentals in Eastern Panama](https://expedia.co.uk/Eastern-Panama-Holiday-Rentals.d6246114.Travel-Guide-HolidayRentals)[Flights to Eastern Panama](https://expedia.co.uk/Cheap-Flights-To-Eastern-Panama.d6246114.Travel-Guide-Flights)[Things to do in Eastern Panama](https://expedia.co.uk/Things-To-Do-In-Eastern-Panama.d6246114.Travel-Guide-Activities)[Eastern Panama Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Eastern-Panama.d6246114.Car-Hire-Guide)[Eastern Panama Holidays](https://expedia.co.uk/Eastern-Panama.d6246114.Holidays-City-Breaks)

![50 Shades of blue. Sailing through the San Blas Islands in Panama lets you experience  a pure paradise and crystal clear water. You can buy fresh fish and other seefood drirectly from local fishermen. If you want you can also play Robinson Crusoe on islands with literally only one palm tree. 
#BVSBlue](https://images.trvl-media.com/place/6246376/42fe0cae-c805-47d5-a705-ee119c68d58c.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

Photo by Nico Barner

![](https://images.trvl-media.com/place/6246376/42fe0cae-c805-47d5-a705-ee119c68d58c.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check availability on Eastern Panama 4 Star Hotels

Tonight

[13 Jan - 14 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6246114&startDate=2026-01-13&endDate=2026-01-14&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[14 Jan - 15 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6246114&startDate=2026-01-14&endDate=2026-01-15&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[16 Jan - 18 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6246114&startDate=2026-01-16&endDate=2026-01-18&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[23 Jan - 25 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6246114&startDate=2026-01-23&endDate=2026-01-25&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Eastern Panama 4-star hotels

![Luxury Suite | 1 bedroom, Egyptian cotton sheets, premium bedding, pillow-top beds](https://images.trvl-media.com/lodging/104000000/103770000/103761600/103761591/9a39b281.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Room, Ocean View | 1 bedroom, Egyptian cotton sheets, premium bedding, pillow-top beds](https://images.trvl-media.com/lodging/104000000/103770000/103761600/103761591/81e41030.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool](https://images.trvl-media.com/lodging/104000000/103770000/103761600/103761591/4a052041.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Luxury Suite | 1 bedroom, Egyptian cotton sheets, premium bedding, pillow-top beds](https://images.trvl-media.com/lodging/104000000/103770000/103761600/103761591/013d70fa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Ordovician Beach Resort

[](https://www.expedia.co.uk/Ordovician-Beach-Resort.h103761591.Hotel-Information)

Isla Grande

10/10

Exceptional

(4 reviews)

"Amazing piece of Caribbean paradise! The staff went above and beyond to make us feel special."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Francisco

[](https://www.expedia.co.uk/Ordovician-Beach-Resort.h103761591.Hotel-Information)

![Room, Mountain View, Mountainside | Free WiFi](https://images.trvl-media.com/lodging/108000000/107720000/107714100/107714077/79f935fa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, Mountain View, Mountainside | Bathroom](https://images.trvl-media.com/lodging/108000000/107720000/107714100/107714077/005def76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/108000000/107720000/107714100/107714077/956c2c4f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/108000000/107720000/107714100/107714077/65c1a6f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Mandalas Ecolodge

[](https://www.expedia.co.uk/Caimitillo-Hotels-Mandalas-Ecolodge.h107714077.Hotel-Information)

Caimitillo

[](https://www.expedia.co.uk/Caimitillo-Hotels-Mandalas-Ecolodge.h107714077.Hotel-Information)

![Outdoor pool](https://images.trvl-media.com/lodging/5000000/4320000/4313000/4312945/0ba8adcb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/5000000/4320000/4313000/4312945/a31596fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House, Kitchenette | In-room safe, desk, blackout curtains, free WiFi](https://images.trvl-media.com/lodging/5000000/4320000/4313000/4312945/ab831841.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House, Kitchenette | In-room safe, desk, blackout curtains, free WiFi](https://images.trvl-media.com/lodging/5000000/4320000/4313000/4312945/fe077cb2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### El Otro Lado

[](https://www.expedia.co.uk/Portobelo-Hotels-El-Otro-Lado.h4312945.Hotel-Information)

Portobelo

9.8/10

Exceptional

(8 reviews)

"Amazing.. Amazing. You need extra words, We loved it. We loved it.Amazing.. Amazing. You need extra words, We loved it. We loved it. Amazing.. Amazing. You need extra words, We loved it. We loved it. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jacob

[](https://www.expedia.co.uk/Portobelo-Hotels-El-Otro-Lado.h4312945.Hotel-Information)

![Premier Apartment, Bay View | Premium bedding, down duvets, individually decorated](https://images.trvl-media.com/lodging/38000000/37040000/37032000/37031981/b7c60962.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![30-inch TV with premium TV channels, DVD player](https://images.trvl-media.com/lodging/38000000/37040000/37032000/37031981/5edecc13.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/38000000/37040000/37032000/37031981/576244d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, down duvets, individually decorated](https://images.trvl-media.com/lodging/38000000/37040000/37032000/37031981/94981263.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Portobello Historico

[](https://www.expedia.co.uk/Portobelo-Hotels-Portobello-Historico.h37031981.Hotel-Information)

Portobelo

[](https://www.expedia.co.uk/Portobelo-Hotels-Portobello-Historico.h37031981.Hotel-Information)

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## Learn more about Eastern Panama

Head to sights like Cayos Holandeses and Isla Diablo as you discover Eastern Panama. 

[See all hotels in Eastern Panama](https://www.expedia.co.uk/Hotel-Search?startDate=2026-01-27&endDate=2026-01-28&adults=2&regionId=6246114)

![50 Shades of blue. Sailing through the San Blas Islands in Panama lets you experience  a pure paradise and crystal clear water. You can buy fresh fish and other seefood drirectly from local fishermen. If you want you can also play Robinson Crusoe on islands with literally only one palm tree. 
#BVSBlue](https://images.trvl-media.com/place/6246376/42fe0cae-c805-47d5-a705-ee119c68d58c.jpg?impolicy=fcrop&w=899&h=602&p=1&q=high)

Photo by Nico Barner

## Top Eastern Panama Hotel Reviews

## Find out more about Eastern Panama

## Frequently asked questions

### How much does it cost to stay in a 4-star hotel in Eastern Panama?

> - Search for the lowest price

### What's the difference between 5-star and 4-star hotels in Eastern Panama?

### Does Eastern Panama have any 4-star all-inclusive resorts?