Title: Mesopotamia Travel Guide: Best of Mesopotamia, Argentina Travel 2025 | Expedia.co.uk [Hotels in Mesopotamia](https://expedia.co.uk/Mesopotamia-Hotels.d6208836.Travel-Guide-Hotels)[Holiday Rentals in Mesopotamia](https://expedia.co.uk/Mesopotamia-Holiday-Rentals.d6208836.Travel-Guide-HolidayRentals)[Flights to Mesopotamia](https://expedia.co.uk/Cheap-Flights-To-Mesopotamia.d6208836.Travel-Guide-Flights)[Mesopotamia Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Mesopotamia.d6208836.Car-Hire-Guide)[Mesopotamia Holidays](https://expedia.co.uk/Mesopotamia.d6208836.Holidays-City-Breaks) # Mesopotamia Travel Guide ## Tourist Guide ![Mesopotamia showing a river or creek and forests](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/196000/196544-Mesopotamia.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Mesopotamia showing forest scenes](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/196000/196542-Mesopotamia.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Mesopotamia](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/71000/71962-Iguazu.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Mesopotamia featuring a river or creek and forests](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/196000/196547-Mesopotamia.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Mesopotamia which includes a river or creek and a cascade](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/196000/196546-Mesopotamia.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ## Visit Mesopotamia Things to do #### The awe-inspiring Iguazú Falls is the centerpiece attraction of this northeastern Argentine region, which also hosts the country’s biggest carnival celebration. A heady mix of ancient history, natural beauty and flamboyant festivals features in Argentina’s hot and humid Mesopotamia region. Be inspired by thundering waterfalls, spot exotic wildlife, experience indigenous traditions and relax at sleepy riverside resorts. Mesopotamia sits sandwiched between two mighty rivers, the Río Paraná and Rió Uruguay, and is covered with subtropical rainforests and wetlands. It includes the provinces of Misiones, Corrientes and Entre Ríos. Straddling the Río Iguazú in Misiones province, and shared between Argentina and Brazil, is the UNESCO-protected Iguazú National Park. Come here to admire the 275 individual waterfalls that make up the Iguazú Falls. Follow trails to panoramic lookouts, ride on a speedboat beneath a cascade and see wildlife such as toucans and monkeys. Access the Brazilian side of the park via a short drive from the town of Puerto Iguazú. Tour the towns of Misiones to appreciate the province’s diversity. Find a gemstone mine in Wanda, flower-filled gardens in Montecarlo and colonial architecture in Oberá. Visit 17th-century Jesuit ruins at San Ignacio. Saltos del Moconá, in Parque Provincial Moconá, is another waterfall worth visiting. Discover a breezy esplanade, graceful architecture and artisan markets, which showcase Guarani culture, in Corrientes city. Spend some time at easy-going river towns, including Itati and Ituzaingó. Be amazed by the craggy, granite ravine of Barrancas del Empedrado and hike amid thick forest in Mburucuya National Park. Go in search of some 350 bird species and the rare maned wolf at Esteros del Iberá wetlands reserve. Hot springs, fishing trips, pristine reserves and boisterous carnival parties await in Entre Ríos province. Gualeguaychú explodes into colour in February with arguably Argentina’s most famous carnival. The powdery, white sand at nearby Ñandubaysal evokes images of a tropical island paradise. Fish for huge dorado in Santa Elena and enjoy the charm of riverfront Colón. Don’t miss the enormous yatay palm trees in El Palmar National Park. The southern area of Mesopotamia is just a short bus ride from Buenos Aires. You can also fly to Corrientes and Puerto Iguazú and then get around the region via public buses and organised tours. - Top hotels in Mesopotamia - Top Holiday Rentals in Mesopotamia ![Marriott Corrientes Hotel](https://images.trvl-media.com/lodging/118000000/117160000/117154200/117154160/45830686_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Marriott Corrientes Hotel Av Costanera Juan Pablo II y Lavalle, Corrientes £100 1 Nov - 2 Nov Stay at this 4.5-star luxury hotel in Corrientes. Popular attractions Costanera de Corrientes and Cumba Cua Park are located nearby. [](https://expedia.co.uk/Hotel-Search?startDate=01%2F11%2F2025&endDate=02%2F11%2F2025&selected=117154160&PinnedHotelID=117154160&HadPinnedHotel=true®ionId=6208836) ![Hotel y Spa Termas del Este](https://images.trvl-media.com/lodging/34000000/33350000/33347000/33346911/459986e2_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hotel y Spa Termas del Este Presidente Raúl alfonsín 877, Federacion Stay at this 3-star spa hotel in Federacion. Enjoy free breakfast, free Wi-Fi and free parking. Popular attractions Termas Federacion Water Park and Termas de ... 8.4/10 Very Good! (12 reviews) good for a 1 night stay Reviewed on 16 Aug 2025 [Get rates](https://expedia.co.uk/Hotel-Search?startDate=07%2F11%2F2025&endDate=08%2F11%2F2025&selected=33346911&PinnedHotelID=33346911&HadPinnedHotel=true®ionId=6208836) [](https://expedia.co.uk/Hotel-Search?startDate=07%2F11%2F2025&endDate=08%2F11%2F2025&selected=33346911&PinnedHotelID=33346911&HadPinnedHotel=true®ionId=6208836) ![O2 Hotel Gualeguaychú](https://images.trvl-media.com/lodging/77000000/76460000/76459400/76459363/759ad5d8_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### O2 Hotel Gualeguaychú 115 3 de Febrero, Gualeguaychú, Entre Ríos £22 2 Nov - 3 Nov Stay at this hotel in Gualeguaychú. Enjoy free Wi-Fi, a 24-hour front desk and a business centre. Popular attractions Gualeguaychú Cathedral and San Martin Square ... 7.6/10 Good! (62 reviews) Hotel is very comfortable and clean. There is no breakfast or hotel parking, and the wifi does not work properly in most floors and rooms. Other than that, the staff is very friendly and nice. Reviewed on 2 Jan 2025 [](https://expedia.co.uk/Hotel-Search?startDate=02%2F11%2F2025&endDate=03%2F11%2F2025&selected=76459363&PinnedHotelID=76459363&HadPinnedHotel=true®ionId=6208836) [See all 492 properties in Mesopotamia](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=25%2F10%2F2025&endDate=26%2F10%2F2025®ionId=6208836) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![Donsuites Apart Hotel](https://images.trvl-media.com/lodging/5000000/4950000/4947900/4947848/fb045420_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Donsuites Apart Hotel La Rioja 442, Corrientes, Corrientes Stay at this 3-star aparthotel in Corrientes. Enjoy free breakfast, free Wi-Fi and a rooftop terrace. Popular attractions Museo de Artesanías Tradicionales Folclóricas ... 8.6/10 Excellent! (103 reviews) Loved this place, super clean, and the staff were very nice and helpful😍 Reviewed on 30 Aug 2024 [](https://expedia.co.uk/Corrientes-Hotels-Donsuites-Apart-Hotel.h4947848.Hotel-Information) ![Totoras Apart Federacion](https://images.trvl-media.com/lodging/34000000/33350000/33341500/33341429/13800447_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Totoras Apart Federacion Ñandubay (ex Hermanas Betancourt) 2610, Federacion, Entre Rios Stay at this aparthotel in Federacion. Enjoy free Wi-Fi, free parking and room service. Popular attractions Termas de Federacion and Termas Federacion Water ... Buena estadia para unos dias .todo muy limpio a pesar de que estan aun terminando dptos.tal vez deben cuidar más los horarios de descanso del turista con los ruidos de la obra . Pocos utensilios de cocina si se quiere cocinar ahi mismo.Pero tranquilo y suficiente Reviewed on 8 Mar 2023 [](https://expedia.co.uk/Federacion-Hotels-Totoras-Apart-Federacion.h33341429.Hotel-Information) ![Agustín 1 Apart](https://images.trvl-media.com/lodging/100000000/99270000/99269400/99269311/9cad496d_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Agustín 1 Apart 130 Gral. Pedro Ferré, Parana, Entre Ríos Stay at this 4-star aparthotel in Parana. Enjoy free Wi-Fi, parking (surcharge) and on-site spa services. Popular attractions Plaza de Mayo and Museu De Sitio ... 9/10 Wonderful! (4 reviews) Indico Meu problema foi só a garagem, o apartamento é ótimo, limpeza estava impecável. Reviewed on 25 Jan 2025 [](https://expedia.co.uk/Parana-Hotels-Agustin-1-Apart.h99269311.Hotel-Information) [See all properties in Mesopotamia](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience®ionId=6208836&sort=VACATION_RENTAL) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check Mesopotamia hotel availability [](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=2025-10-24&endDate=2025-10-25) [Tonight](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=2025-10-24&endDate=2025-10-25) [](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=2025-10-24&endDate=2025-10-25) [](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=2025-10-24&endDate=2025-10-25)[24 Oct - 25 Oct](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=2025-10-24&endDate=2025-10-25) [](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=2025-10-25&endDate=2025-10-26) [Tomorrow night](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=2025-10-25&endDate=2025-10-26) [](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=2025-10-25&endDate=2025-10-26) [](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=2025-10-25&endDate=2025-10-26)[25 Oct - 26 Oct](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=2025-10-25&endDate=2025-10-26) [](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=24%2F10%2F2025&endDate=26%2F10%2F2025) [This weekend](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=24%2F10%2F2025&endDate=26%2F10%2F2025) [](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=24%2F10%2F2025&endDate=26%2F10%2F2025) [](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=24%2F10%2F2025&endDate=26%2F10%2F2025)[24 Oct - 26 Oct](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=24%2F10%2F2025&endDate=26%2F10%2F2025) ### Popular places to visit ![El Palmar National Park](https://mediaim.expedia.com/destination/2/04a7d2876dc5e0ece83e6d60439d3e42.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### El Palmar National Park Explore the great outdoors at El Palmar National Park, a lovely green space in Ubajay. [](https://expedia.co.uk/El-Palmar-National-Park-Ubajay.d6096826.Attraction) ![San José Palace](https://mediaim.expedia.com/destination/2/d1f7ef40d5e0538d8a5a460f8d569c5e.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### San José Palace You can spend an afternoon browsing the exhibits at San José Palace during your trip to Caseros. [](https://expedia.co.uk/San-Jose-Palace-Caseros.d553248635974793605.Attraction) #### Termas de Federacion Bring the children to Termas de Federacion and enjoy this exciting theme park in Federacion. Stroll along the beaches or discover the area's waterfalls. [](https://expedia.co.uk/Termas-De-Federacion-Federacion.d553248621532463682.Attraction) #### Termas De Colón Enjoy an outing to Termas De Colón during your stay in Colon. Discover the area's theatre scene and spas. [](https://expedia.co.uk/Termas-De-Colon-Colon.d553248635939591385.Attraction) #### Termas Concepcion Entrerios Bring your family to Termas Concepcion Entrerios and enjoy the excitement of this theme park in Concepción del Uruguay. Experience the area's art scene and museums. [](https://expedia.co.uk/Termas-Concepcion-Entrerios-Concepcion-del-Uruguay.d553248621532463656.Attraction) #### Basilica Nuestra Senora De Itati Learn about the local history of Municipo de Itatí when you take a trip to Basilica Nuestra Senora De Itati. [](https://expedia.co.uk/Basilica-Nuestra-Senora-De-Itati-Municipo-de-Itati.d553248621532463967.Attraction) ## Cities near Mesopotamia ![Misiones which includes views as well as a couple](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/80000/80252-Misiones-Province.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Posadas [](https://expedia.co.uk/Posadas.dx2887) ![Rosario](https://mediaim.expedia.com/destination/1/15c19af6d32f4bdb8f5f454dedd0554e.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Rosario [](https://expedia.co.uk/Rosario.dx3026) ![Photo by Staci Travels](https://mediaim.expedia.com/destination/2/a93c7abbc3040bd02450f8d8d4c93094.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Carmelo [](https://expedia.co.uk/Carmelo.dx602813) ![Photo by Alejandro Ferrari](https://mediaim.expedia.com/destination/2/11375876ba96a0f4d6b62442f228c109.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Corrientes [](https://expedia.co.uk/Corrientes.dx6054203) - Cities near Mesopotamia [Concordia](https://expedia.co.uk/Concordia.dx892)[Posadas](https://expedia.co.uk/Posadas.dx2887)[Rosario](https://expedia.co.uk/Rosario.dx3026)[Salto](https://expedia.co.uk/Salto.dx3293)[Carmelo](https://expedia.co.uk/Carmelo.dx602813)[Esquina](https://expedia.co.uk/Esquina.dx6049079)[Corrientes](https://expedia.co.uk/Corrientes.dx6054203)[Fray Bentos](https://expedia.co.uk/Fray-Bentos.dx6085046)[Colon](https://expedia.co.uk/Colon.dx6144191)[Gualeguaychú](https://expedia.co.uk/Gualeguaychu.dx6201387)[Arenitas Blancas](https://expedia.co.uk/Arenitas-Blancas.dx6287721)[Nueva Palmira](https://expedia.co.uk/Nueva-Palmira.dx6287949)[Nuevo Berlin](https://expedia.co.uk/Nuevo-Berlin.dx6287950)[Colonia Carlos Pellegrini](https://expedia.co.uk/Colonia-Carlos-Pellegrini.dx6343234)[Itaqui](https://expedia.co.uk/Itaqui.dx6352005)[São Borja](https://expedia.co.uk/Sao-Borja.dx6352007)[Monte Caseros](https://expedia.co.uk/Monte-Caseros.dx6354755)[San Lorenzo](https://expedia.co.uk/San-Lorenzo.dx6358759)[Uguay](https://expedia.co.uk/Uguay.dx3000007149) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app ![QR code to download the app](data:image/png;base64,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)