Florida Keys Spa Holidays

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    Save up to £335 when you book a flight and hotel together*
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    With over 300,000 hotels worldwide, it's easy to create a perfect package
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    Packages with flights are ATOL protected

Top flight + Spa hotel deals in Florida Keys

Price found within the past 48 hours. Click for updated prices.
Parrot Key Hotel & Villas
Pier House Resort & Spa
Casa Marina Key West, Curio Collection by Hilton
Southernmost Beach Resort and Guesthouses
Ocean Key Resort - A Noble House Resort
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Top Spa Florida Keys Hotels

Cheeca Lodge & Spa

Cheeca Lodge & Spa

5 out of 5
81801 Overseas Highway, Mile Marker 82, Marker 82, Islamorada, FL
  • 3 hours drive from Duval Street
Stay at this 5-star luxury resort in Islamorada. Enjoy free parking, 3 outdoor pools and a full-service spa. Our guests praise the pool and the helpful staff ...
9/10 Wonderful! (1,149 reviews)

Travellers like: full-service spa, sauna, steam room, massage

Travellers say...
"Great place. Best way to relax and enjoy the keys."

Reviewed on 17 Aug 2025

Cheeca Lodge & Spa
Pier House Resort & Spa

Pier House Resort & Spa

4 out of 5
1 Duval St, Key West, FL
  • 11 min walk from Duval Street
Stay at this 4-star beach resort in Key West. Enjoy a full-service spa, a private beach and 2 bars/lounges. Our guests praise the pool and the bar in their reviews. ...
9/10 Wonderful! (1,005 reviews)

Travellers like: full-service spa, massage, facials, manicures and pedicures

Perfect Hotel for a getaway.
"We stayed at the pier house on the “off” season and just loved it. It was super cute, super clean rooms and grounds. The A/C was cold as was the fridge in our room. if I had to find something to complain about it would have to be the lighting in the bathroom was not the best- hard to do makeup in ..."

Reviewed on 14 Aug 2025

Pier House Resort & Spa
Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

4 out of 5
1319 Duval Street, Key West, FL
  • 11 min walk from Duval Street
Stay at this 4-star beach hotel in Key West. Enjoy free Wi-Fi, 3 outdoor pools and a full-service spa. Our guests praise the pool and the bar in their reviews. ...
8.6/10 Excellent! (2,682 reviews)

Travellers like: full-service spa, massage, facials, couples spa treatments

Travellers say...
"We booked Southernmost Beach Resort for our honeymoon, and WOW! The room was impeccably clean, the shores pool/bar was amazing and a lot of fun each day with DJ’s, activities, etc. The Beach Cafe has a phenomenal dinner and is a great view right on the water. Everything you need is right at the property, ..."

Reviewed on 17 Aug 2025

Southernmost Beach Resort and Guesthouses
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.