Cheap Flights from Knoxville (TYS) to San Diego (SAN)

Flight 1

Popular airlines from Alcoa - Knoxville Airport (TYS) to San Diego Intl. Airport (SAN)

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Cheap Flights from Knoxville (TYS) to San Diego (SAN)

Prices were available within the past 7 days and start at for one-way flights and £488 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Alaska Airlines
Wed, 13 May - Sun, 17 May
TYS
Knoxville
SAN
San Diego
£488 Return, found 5 days ago
£488
Return
found 5 days ago
Select Alaska Airlines flight, departing Wed, 13 May from Knoxville to San Diego, returning Sun, 17 May, priced at £488 found 5 days ago
Alaska Airlines
Thu, 14 May - Sun, 17 May
TYS
Knoxville
SAN
San Diego
£552 Return, found 5 days ago
£552
Return
found 5 days ago
Select Alaska Airlines flight, departing Thu, 14 May from Knoxville to San Diego, returning Sun, 17 May, priced at £552 found 5 days ago

Frequently asked questions

How do I find cheap flights from Knoxville, TN (TYS-McGhee Tyson) to San Diego, CA (SAN-San Diego Intl.)?
To find a cheap flight from Knoxville, TN (TYS-McGhee Tyson) to San Diego, CA (SAN-San Diego Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Knoxville, TN (TYS-McGhee Tyson) to San Diego, CA (SAN-San Diego Intl.)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
How many flights per day from Knoxville, TN (TYS-McGhee Tyson) to San Diego, CA (SAN-San Diego Intl.)?
There are approximately 59 connecting flights per day from Knoxville, TN (TYS-McGhee Tyson) to San Diego, CA (SAN-San Diego Intl.). Some common connection points include Nashville Intl. (BNA), O'Hare Intl. (ORD), and Dallas-Fort Worth Intl. (DFW).
What is the earliest flight from Knoxville, TN (TYS-McGhee Tyson) to San Diego, CA (SAN-San Diego Intl.)?
The earliest flight from Knoxville, TN (TYS-McGhee Tyson) (TYS) to San Diego, CA (SAN-San Diego Intl.) (SAN) typically departs at approximately 5:00 AM local time, operated by American Airlines. This is a seasonal service active in March. An early departure like this can help you maximize your time at your destination. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What day of the week has the most flights from Knoxville, TN (TYS-McGhee Tyson) to San Diego, CA (SAN-San Diego Intl.)?
You'll typically find the most flights from Knoxville, TN (TYS-McGhee Tyson) to San Diego, CA (SAN-San Diego Intl.) on a Wednesday, with around 45 flights available. This gives you a good selection of options for your travel plans. Major airlines on this route include American Airlines, United Airlines, and Delta Air Lines. Flight schedules are consistent throughout the week, so you'll find similar options on other days.
What are the most popular departure times for flights from Knoxville, TN (TYS-McGhee Tyson) to San Diego, CA (SAN-San Diego Intl.)?
The most popular departure times for flights from Knoxville, TN (TYS-McGhee Tyson) to San Diego, CA (SAN-San Diego Intl.) are in the early morning, from 6am to 9am. About 29% of passengers prefer this time window. Many major carriers, including American Airlines, United Airlines and Delta Air Lines, offer flights during this window. This timing works well because it allows you to arrive at your destination with plenty of time to settle in and start your day.
How long does it take to fly from Knoxville, TN (TYS-McGhee Tyson) to San Diego, CA (SAN-San Diego Intl.)?
Flights from TYS to SAN with one stop typically take around 8 hours, covering approximately 1,899 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Knoxville, TN (TYS-McGhee Tyson) to San Diego, CA (SAN-San Diego Intl.)?
Select the "Business class" and "First class" filters when looking for TYS to SAN flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip.
How do I earn miles on a Knoxville, TN (TYS-McGhee Tyson) to San Diego, CA (SAN-San Diego Intl.) flight with Expedia?
It's easy to earn miles on a Knoxville, TN (TYS-McGhee Tyson) to San Diego, CA (SAN-San Diego Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for San Diego from McGhee Tyson (TYS)?
From McGhee Tyson (TYS), you can fly into San Diego Intl. (SAN) to reach San Diego. Some flights may connect through major hubs like Dallas-Fort Worth Intl. (DFW), O'Hare Intl. (ORD), Charlotte-Douglas Intl. (CLT) before reaching San Diego. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Knoxville, TN (TYS-McGhee Tyson) to San Diego, CA (SAN-San Diego Intl.) at the last minute?
Typically, booking a last minute flight from Knoxville, TN (TYS-McGhee Tyson) to San Diego, CA (SAN-San Diego Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Knoxville, TN (TYS-McGhee Tyson) to San Diego, CA (SAN-San Diego Intl.) flight and hotel package?
Securing a Knoxville, TN (TYS-McGhee Tyson) to San Diego, CA (SAN-San Diego Intl.) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Knoxville, TN (TYS-McGhee Tyson) to San Diego, CA (SAN-San Diego Intl.)?
If you booked your Knoxville, TN (TYS-McGhee Tyson) to San Diego, CA (SAN-San Diego Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
McGhee Tyson
Destination airport
San Diego Intl.
Return price
£487
Distance
3038 km
Average flight time
6 hours 15 mins

Book with confidence

Compare flights from Knoxville to San Diego easily and book with confidence

For travelling on business or for pleasure, Expedia makes it easy to book your flights from Knoxville to San Diego. Operating between them flights per day, 2 airlines cover the route. And fly direct, getting you to San Diego Intl. in just hours. If you have a preferred carrier, use our advanced search tool to find the right flight from McGhee Tyson to San Diego Intl..  

To make things even better, in the advanced search, you can also choose to fly economy, premium economy, business or first class, select your maximum number of stops, and pick your preferred departure and arrival time. You can also opt for refundable and direct flights. 

Grab a great deal on your flight from McGhee Tyson (TYS) to San Diego Intl. (SAN)

The easiest way to view the best deals on flights from Knoxville to San Diego today is to enter your travel dates and hit search. From here, you can sort your results by price to see the cheapest flights first. Right now, return flights from McGhee Tyson to San Diego Intl. start at just £488 and range up to £552.  

To find an even better deal, try  

  • being flexible on your dates – midweek flights can be cheaper
  • looking for other airports near Knoxville and San Diego
  • booking your flight during May, the cheapest month on this route
  • varying your flight times – early morning and late at night are sometimes cheaper 

Why you should book your Knoxville to San Diego flight with Expedia!

We cater for all flight types, cabin classes and airlines. So whether you’re booking flights from McGhee Tyson to San Diego Intl. for a budget break or a business trip with a bit of pleasure thrown in, we make it easy to secure the seat that’s right for you.  

Thanks to our supersized inventory that offers great choice all in one place, you know you’ll get a great deal with Expedia. Especially if you bundle your flight together with your hotel, you will unlock amazing savings. For added peace of mind, you can choose flexible bookings or filter to find refundable options, so you won’t pay a fee to change your flight.  

Compare flights from Knoxville to San Diego easily and book with confidence

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