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£52 Cheap Flights from St. Louis (STL) to San Diego (SAN)

View £52 flight on Sat, 31 Oct 2026Opens in a new window

Popular airlines from Lambert-St. Louis International Airport (STL) to San Diego Intl. Airport (SAN)

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Cheap Flights from St. Louis (STL) to San Diego (SAN)

Prices were available within the past 7 days and start at £52 for one-way flights and £212 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Alaska Airlines
Thu, 27 Aug - Sat, 29 Aug
STL
St. Louis
SAN
San Diego
£212 Return, found 2 days ago
£212
Return
found 2 days ago
Select Alaska Airlines flight, departing Thu, 27 Aug from St. Louis to San Diego, returning Sat, 29 Aug, priced at £212 found 2 days ago
Alaska Airlines
Mon, 17 Aug - Tue, 25 Aug
STL
St. Louis
SAN
San Diego
£228 Return, found 6 days ago
£228
Return
found 6 days ago
Select Alaska Airlines flight, departing Mon, 17 Aug from St. Louis to San Diego, returning Tue, 25 Aug, priced at £228 found 6 days ago
Alaska Airlines
Mon, 17 Aug - Tue, 25 Aug
STL
St. Louis
SAN
San Diego
£243 Return, found 6 days ago
£243
Return
found 6 days ago
Select Alaska Airlines flight, departing Mon, 17 Aug from St. Louis to San Diego, returning Tue, 25 Aug, priced at £243 found 6 days ago
Alaska Airlines
Thu, 27 Aug - Sat, 29 Aug
STL
St. Louis
SAN
San Diego
£246 Return, found 2 days ago
£246
Return
found 2 days ago
Select Alaska Airlines flight, departing Thu, 27 Aug from St. Louis to San Diego, returning Sat, 29 Aug, priced at £246 found 2 days ago
Alaska Airlines
Mon, 24 Aug - Sat, 29 Aug
STL
St. Louis
SAN
San Diego
£248 Return, found 2 days ago
£248
Return
found 2 days ago
Select Alaska Airlines flight, departing Mon, 24 Aug from St. Louis to San Diego, returning Sat, 29 Aug, priced at £248 found 2 days ago
Alaska Airlines
Mon, 24 Aug - Sat, 29 Aug
STL
St. Louis
SAN
San Diego
£290 Return, found 2 days ago
£290
Return
found 2 days ago
Select Alaska Airlines flight, departing Mon, 24 Aug from St. Louis to San Diego, returning Sat, 29 Aug, priced at £290 found 2 days ago
Alaska Airlines
Mon, 17 Aug - Thu, 20 Aug
STL
St. Louis
SAN
San Diego
£295 Return, found 6 days ago
£295
Return
found 6 days ago
Select Alaska Airlines flight, departing Mon, 17 Aug from St. Louis to San Diego, returning Thu, 20 Aug, priced at £295 found 6 days ago
Alaska Airlines
Mon, 17 Aug - Tue, 25 Aug
STL
St. Louis
SAN
San Diego
£299 Return, found 6 days ago
£299
Return
found 6 days ago
Select Alaska Airlines flight, departing Mon, 17 Aug from St. Louis to San Diego, returning Tue, 25 Aug, priced at £299 found 6 days ago
Alaska Airlines
Mon, 17 Aug - Thu, 20 Aug
STL
St. Louis
SAN
San Diego
£310 Return, found 6 days ago
£310
Return
found 6 days ago
Select Alaska Airlines flight, departing Mon, 17 Aug from St. Louis to San Diego, returning Thu, 20 Aug, priced at £310 found 6 days ago
Alaska Airlines
Thu, 27 Aug - Sat, 29 Aug
STL
St. Louis
SAN
San Diego
£311 Return, found 2 days ago
£311
Return
found 2 days ago
Select Alaska Airlines flight, departing Thu, 27 Aug from St. Louis to San Diego, returning Sat, 29 Aug, priced at £311 found 2 days ago

Find the cheapest month to fly from St. Louis (STL) to San Diego (SAN)

May is typically the cheapest month to fly

From £121 - £225 per traveller.

Frequently asked questions

How much does a flight from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.) cost?
You can find one-way and return flights from STL to SAN with Expedia. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see our cheapest fares first, and use the Price Tracking tool to receive alerts when STL to SAN ticket fares go up or down.
What is the cheapest month to fly from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.)?
If you're looking for the cheapest time to fly from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.), April is typically your best bet. You can expect average return fares around £262 during this month. Other budget-friendly months to consider for this route include February and May.
Which airlines fly direct from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.)?
Only one airline offers direct flights from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.). Southwest Airlines operates 8 direct flights from STL to SAN every week.
How do I find cheap flights from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.)?
To find a cheap flight from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best airline to fly with from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.)?
The best airline to fly with from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.) will differ from traveller to traveller. If you like to fly early, Southwest Airlines offers early morning flights. If price is the most important factor, Southwest Airlines typically offers the lowest fares. Southwest Airlines offers the most daily flights from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.), which is great if flexibility is what you value most. The best carrier for this journey could also be the one you have a loyalty membership with, as flying with that airline or another airline within the same alliance could help you collect points or enjoy lounge access.
What is the best time to fly from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.)?
The cheapest months to fly from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.) are typically April and May, with average return flights costing around £262. These months are a great time to visit San Diego as the weather is usually pleasant before the peak summer heat, offering a good balance of affordable fares and an enjoyable travel experience.
How many flights per day from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.)?
There is 1 nonstop flight per day from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.). For even more choices, look at flights that include layovers, as there are around 134 connecting flights per day. Some common connection points include Seattle - Tacoma Intl. (SEA), O'Hare Intl. (ORD), and Dallas-Fort Worth Intl. (DFW).
What is the earliest flight from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.)?
The earliest flight from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.) typically departs around 5:00 AM. This flight is operated by American Airlines. This is a seasonal service, active in January, November, and December. An early departure like this can help you make the most of your time at your destination. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What day of the week has the most flights from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.)?
You'll find the most flights from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.) on a Friday, with around 94 flights available. This gives you plenty of options for your travel plans. Major airlines on this route include Southwest Airlines, American Airlines, and United. Friday offers notably more flight options compared to other days of the week, making it a great day to consider for your journey.
What are the most popular departure times for flights from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.)?
The most popular departure times for flights from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.) are in the early morning, from 6am to 9am. Many major carriers, including Southwest Airlines, American Airlines and United, offer flights during this window. Many travellers prefer these times as it allows for an early start to their day in San Diego.
How long does it take to fly from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.)?
A direct flight from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.) typically takes around 3 hours 48 minutes, covering a distance of about 2,503 kilometers. If you opt for a one-stop flight, your journey will usually be longer, averaging around 6 hours 48 minutes. Flights with two or more stops will take even longer, typically around 11 hours 30 minutes. Keep in mind that actual flight times can vary due to factors like wind patterns and air traffic, so it's always a good idea to allow for some extra time when planning your trip.
Can you fly business or first class from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.)?
Yes, you can fly business class or first class between STL and SAN. You can fly business class with Frontier Airlines and Delta.First class cabins are available on Alaska Airlines, United, Delta, and American Airlines.
How do I earn miles on a St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.) flight with Expedia?
It's easy to earn miles on a St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for San Diego, CA (SAN) from St. Louis, MO (STL)?
If you're planning to travel to San Diego from Lambert-St. Louis Intl. (STL), you can fly directly into San Diego Intl. (SAN). Some flights may connect through major hubs like Seattle - Tacoma Intl. (SEA), Denver Intl. (DEN), or Wichita Dwight D. Eisenhower National (ICT) before reaching San Diego. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.) at the last minute?
Typically, booking a last minute flight from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.) flight and hotel package?
Securing a St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.)?
If you booked your St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Lambert-St. Louis Intl.
Destination airport
San Diego Intl.
Return price
£211
Distance
2487 km
Average flight time
3 hours 17 mins

Book with confidence

Compare flights from St. Louis to San Diego easily and book with confidence

For travelling on business or for pleasure, Expedia makes it easy to book your flights from St. Louis to San Diego. Operating between them flights per day, 20 airlines cover the route. And fly direct, getting you to San Diego Intl. in just hours. If you have a preferred carrier, use our advanced search tool to find the right flight from Lambert-St. Louis Intl. to San Diego Intl..  

To make things even better, in the advanced search, you can also choose to fly economy, premium economy, business or first class, select your maximum number of stops, and pick your preferred departure and arrival time. You can also opt for refundable and direct flights. 

Grab a great deal on your flight from Lambert-St. Louis Intl. (STL) to San Diego Intl. (SAN)

The easiest way to view the best deals on flights from St. Louis to San Diego today is to enter your travel dates and hit search. From here, you can sort your results by price to see the cheapest flights first. Right now, return flights from Lambert-St. Louis Intl. to San Diego Intl. start at just £212 and range up to £311.  

To find an even better deal, try  

  • being flexible on your dates – midweek flights can be cheaper
  • looking for other airports near St. Louis and San Diego
  • booking your flight during August, the cheapest month on this route
  • varying your flight times – early morning and late at night are sometimes cheaper 

Why you should book your St. Louis to San Diego flight with Expedia!

We cater for all flight types, cabin classes and airlines. So whether you’re booking flights from Lambert-St. Louis Intl. to San Diego Intl. for a budget break or a business trip with a bit of pleasure thrown in, we make it easy to secure the seat that’s right for you.  

Thanks to our supersized inventory that offers great choice all in one place, you know you’ll get a great deal with Expedia. Especially if you bundle your flight together with your hotel, you will unlock amazing savings. For added peace of mind, you can choose flexible bookings or filter to find refundable options, so you won’t pay a fee to change your flight.  

Compare flights from St. Louis to San Diego easily and book with confidence

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*Available to Expedia members.