£147 Cheap Flights from St. Louis (STL) to San Diego (SAN)

View £147 flight on Tue, 16 Jun 2026Opens in a new window

Flight 1

Popular airlines from Lambert-St. Louis International Airport (STL) to San Diego Intl. Airport (SAN)

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Cheap Flights from St. Louis (STL) to San Diego (SAN)

Prices were available within the past 7 days and start at £147 for one-way flights and £271 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Alaska Airlines
Wed, 27 May - Wed, 3 Jun
STL
St. Louis
SAN
San Diego
£271 Return, found 19 hours ago
£271
Return
found 19 hours ago
Select Alaska Airlines flight, departing Wed, 27 May from St. Louis to San Diego, returning Wed, 3 Jun, priced at £271 found 19 hours ago
Alaska Airlines
Wed, 27 May - Wed, 3 Jun
STL
St. Louis
SAN
San Diego
£286 Return, found 19 hours ago
£286
Return
found 19 hours ago
Select Alaska Airlines flight, departing Wed, 27 May from St. Louis to San Diego, returning Wed, 3 Jun, priced at £286 found 19 hours ago
Alaska Airlines
Wed, 27 May - Wed, 3 Jun
STL
St. Louis
SAN
San Diego
£289 Return, found 19 hours ago
£289
Return
found 19 hours ago
Select Alaska Airlines flight, departing Wed, 27 May from St. Louis to San Diego, returning Wed, 3 Jun, priced at £289 found 19 hours ago
Alaska Airlines
Fri, 8 May - Sun, 10 May
STL
St. Louis
SAN
San Diego
£301 Return, found 6 days ago
£301
Return
found 6 days ago
Select Alaska Airlines flight, departing Fri, 8 May from St. Louis to San Diego, returning Sun, 10 May, priced at £301 found 6 days ago
Alaska Airlines
Wed, 27 May - Wed, 3 Jun
STL
St. Louis
SAN
San Diego
£304 Return, found 19 hours ago
£304
Return
found 19 hours ago
Select Alaska Airlines flight, departing Wed, 27 May from St. Louis to San Diego, returning Wed, 3 Jun, priced at £304 found 19 hours ago
Alaska Airlines
Wed, 27 May - Wed, 3 Jun
STL
St. Louis
SAN
San Diego
£308 Return, found 19 hours ago
£308
Return
found 19 hours ago
Select Alaska Airlines flight, departing Wed, 27 May from St. Louis to San Diego, returning Wed, 3 Jun, priced at £308 found 19 hours ago
Alaska Airlines
Wed, 27 May - Wed, 3 Jun
STL
St. Louis
SAN
San Diego
£315 Return, found 19 hours ago
£315
Return
found 19 hours ago
Select Alaska Airlines flight, departing Wed, 27 May from St. Louis to San Diego, returning Wed, 3 Jun, priced at £315 found 19 hours ago
Alaska Airlines
Wed, 27 May - Wed, 3 Jun
STL
St. Louis
SAN
San Diego
£323 Return, found 19 hours ago
£323
Return
found 19 hours ago
Select Alaska Airlines flight, departing Wed, 27 May from St. Louis to San Diego, returning Wed, 3 Jun, priced at £323 found 19 hours ago
Alaska Airlines
Wed, 27 May - Wed, 3 Jun
STL
St. Louis
SAN
San Diego
£327 Return, found 19 hours ago
£327
Return
found 19 hours ago
Select Alaska Airlines flight, departing Wed, 27 May from St. Louis to San Diego, returning Wed, 3 Jun, priced at £327 found 19 hours ago
Alaska Airlines
Wed, 27 May - Wed, 3 Jun
STL
St. Louis
SAN
San Diego
£330 Return, found 19 hours ago
£330
Return
found 19 hours ago
Select Alaska Airlines flight, departing Wed, 27 May from St. Louis to San Diego, returning Wed, 3 Jun, priced at £330 found 19 hours ago

Frequently asked questions

What is the cheapest month to fly from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.)?
April is typically the cheapest month to fly from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.), with average return fares of approximately £487. This is about 12% lower than the average price throughout the year. April often sees lower prices as it's before the peak summer travel season, when demand tends to increase. Other cheap months to fly from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.) include February and May.
Which airlines fly direct from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.)?
Enter STL to SAN and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
How do I find cheap flights from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.)?
To find a cheap flight from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best airline to fly with from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.)?
The best airline to fly with from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.) will differ from traveller to traveller. If you like to fly early, WN offers early morning flights. If price is the most important factor, WN typically offers the lowest fares. WN offers the most daily flights from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.), which is brilliant if flexibility is what you value most. The best carrier for this journey could also be the one you have a loyalty membership with, as flying with that airline or another airline within the same alliance could help you collect points or enjoy lounge access.
What is the best time to fly from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.)?
If you're looking for the best time to fly from St. Louis, MO (STL-Lambert-St. Louis Intl.) (STL) to San Diego, CA (SAN-San Diego Intl.) (SAN), consider travelling in April or May. Based on booking data from the past year, these months typically offer the cheapest return flights, with an average price of around £487. This can be a great time to visit San Diego as the weather is usually pleasant before the peak summer crowds arrive.
How many flights per day from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.)?
There is approximately 1 nonstop flight per day from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.). For even more choice, look at flights that include layovers, as there are around 129 connecting flights per day. Some common connection points include Seattle - Tacoma Intl. (SEA), O'Hare Intl. (ORD), and Dallas-Fort Worth Intl. (DFW).
What is the earliest flight from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.)?
The earliest flight from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.) typically departs at approximately 5:00 AM local time, operated by American Airlines. This is a seasonal service active in January, November, and December. An early departure like this can help maximise your time at your destination. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What day of the week has the most flights from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.)?
You'll typically find the most flights from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.) on a Thursday, with around 89 flights available. This gives you plenty of options for your travel plans. Major airlines on this route include Southwest Airlines, American Airlines, and United Airlines. Flight schedules are consistent throughout the week, with Thursday offering only slightly more options.
What are the most popular departure times for flights from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.)?
The most popular departure times for flights from Lambert-St. Louis Intl. (STL) to San Diego Intl. (SAN) are in the early morning, from 6am to 9am. Approximately 32% of passengers prefer this time window. Many major carriers, including Southwest Airlines, American Airlines and United Airlines, offer flights during this window. These times work well because you can get an early start to your travel day and arrive in San Diego with plenty of time to enjoy your destination.
How long does it take to fly from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.)?
Direct flights from STL to SAN usually take about 4 hours, traveling roughly 1,555 miles. If you opt for a connecting flight, expect to add around 3 hours 50 minutes to your journey. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.)?
Select the "Business class" and "First class" filters when looking for STL to SAN flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip.
How do I earn miles on a St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.) flight with Expedia?
It's easy to earn miles on a St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia. *Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for San Diego from Lambert-St. Louis Intl. (STL)?
If you're planning to travel to San Diego from Lambert-St. Louis Intl. (STL), you can fly directly into San Diego Intl. (SAN) Some flights may connect through major hubs like Seattle - Tacoma Intl. (SEA), Denver Intl. (DEN), Wichita Dwight D. Eisenhower National (ICT) before reaching San Diego. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.) at the last minute?
Typically, booking a last minute flight from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.) flight and hotel package?
Securing a St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.)?
If you booked your St. Louis, MO (STL-Lambert-St. Louis Intl.) to San Diego, CA (SAN-San Diego Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Lambert-St. Louis Intl.
Destination airport
San Diego Intl.
Return price
£270
Distance
2487 km
Average flight time
3 hours 24 mins

Book with confidence

Compare flights from St. Louis to San Diego easily and book with confidence

For travelling on business or for pleasure, Expedia makes it easy to book your flights from St. Louis to San Diego. Operating between them flights per day, 20 airlines cover the route. And fly direct, getting you to San Diego Intl. in just hours. If you have a preferred carrier, use our advanced search tool to find the right flight from Lambert-St. Louis Intl. to San Diego Intl..  

To make things even better, in the advanced search, you can also choose to fly economy, premium economy, business or first class, select your maximum number of stops, and pick your preferred departure and arrival time. You can also opt for refundable and direct flights. 

Grab a great deal on your flight from Lambert-St. Louis Intl. (STL) to San Diego Intl. (SAN)

The easiest way to view the best deals on flights from St. Louis to San Diego today is to enter your travel dates and hit search. From here, you can sort your results by price to see the cheapest flights first. Right now, return flights from Lambert-St. Louis Intl. to San Diego Intl. start at just £271 and range up to £330.  

To find an even better deal, try  

  • being flexible on your dates – midweek flights can be cheaper
  • looking for other airports near St. Louis and San Diego
  • booking your flight during May, the cheapest month on this route
  • varying your flight times – early morning and late at night are sometimes cheaper 

Why you should book your St. Louis to San Diego flight with Expedia!

We cater for all flight types, cabin classes and airlines. So whether you’re booking flights from Lambert-St. Louis Intl. to San Diego Intl. for a budget break or a business trip with a bit of pleasure thrown in, we make it easy to secure the seat that’s right for you.  

Thanks to our supersized inventory that offers great choice all in one place, you know you’ll get a great deal with Expedia. Especially if you bundle your flight together with your hotel, you will unlock amazing savings. For added peace of mind, you can choose flexible bookings or filter to find refundable options, so you won’t pay a fee to change your flight.  

Compare flights from St. Louis to San Diego easily and book with confidence

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*Available to Expedia members.