£376 Cheap Flights from San Diego (SAN) to Santiago (SCL)

View £376 flight on Sat, 6 Feb 2027Opens in a new window

Popular airlines from San Diego Intl. Airport (SAN) to Santiago Intl. Airport (SCL)

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Cheap Flights from San Diego (SAN) to Santiago (SCL)

Prices were available within the past 7 days and start at £376 for one-way flights and £643 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

LATAM Airlines Group
Sat, 6 Feb - Mon, 15 Feb
SAN
San Diego
SCL
Santiago
£643 Return, found 6 days ago
£643
Return
found 6 days ago
Select LATAM Airlines Group flight, departing Sat, 6 Feb from San Diego to Santiago, returning Mon, 15 Feb, priced at £643 found 6 days ago
LATAM Airlines Group
Thu, 4 Feb - Tue, 16 Feb
SAN
San Diego
SCL
Santiago
£648 Return, found 6 days ago
£648
Return
found 6 days ago
Select LATAM Airlines Group flight, departing Thu, 4 Feb from San Diego to Santiago, returning Tue, 16 Feb, priced at £648 found 6 days ago
LATAM Airlines Group
Sat, 6 Feb - Mon, 15 Feb
SAN
San Diego
SCL
Santiago
£725 Return, found 6 days ago
£725
Return
found 6 days ago
Select LATAM Airlines Group flight, departing Sat, 6 Feb from San Diego to Santiago, returning Mon, 15 Feb, priced at £725 found 6 days ago
Air Canada
Sat, 6 Feb - Mon, 15 Feb
SAN
San Diego
SCL
Santiago
£749 Return, found 6 days ago
£749
Return
found 6 days ago
Select Air Canada flight, departing Sat, 6 Feb from San Diego to Santiago, returning Mon, 15 Feb, priced at £749 found 6 days ago
Air Canada
Sat, 6 Feb - Mon, 15 Feb
SAN
San Diego
SCL
Santiago
£761 Return, found 6 days ago
£761
Return
found 6 days ago
Select Air Canada flight, departing Sat, 6 Feb from San Diego to Santiago, returning Mon, 15 Feb, priced at £761 found 6 days ago
LATAM Airlines Group
Thu, 4 Feb - Tue, 16 Feb
SAN
San Diego
SCL
Santiago
£785 Return, found 6 days ago
£785
Return
found 6 days ago
Select LATAM Airlines Group flight, departing Thu, 4 Feb from San Diego to Santiago, returning Tue, 16 Feb, priced at £785 found 6 days ago
LATAM Airlines Group
Thu, 4 Feb - Tue, 16 Feb
SAN
San Diego
SCL
Santiago
£789 Return, found 6 days ago
£789
Return
found 6 days ago
Select LATAM Airlines Group flight, departing Thu, 4 Feb from San Diego to Santiago, returning Tue, 16 Feb, priced at £789 found 6 days ago
LATAM Airlines Group
Sat, 6 Feb - Mon, 15 Feb
SAN
San Diego
SCL
Santiago
£802 Return, found 6 days ago
£802
Return
found 6 days ago
Select LATAM Airlines Group flight, departing Sat, 6 Feb from San Diego to Santiago, returning Mon, 15 Feb, priced at £802 found 6 days ago
JetBlue Airways
Thu, 4 Feb - Tue, 16 Feb
SAN
San Diego
SCL
Santiago
£830 Return, found 6 days ago
£830
Return
found 6 days ago
Select JetBlue Airways flight, departing Thu, 4 Feb from San Diego to Santiago, returning Tue, 16 Feb, priced at £830 found 6 days ago
Alaska Airlines
Thu, 4 Feb - Tue, 16 Feb
SAN
San Diego
SCL
Santiago
£837 Return, found 6 days ago
£837
Return
found 6 days ago
Select Alaska Airlines flight, departing Thu, 4 Feb from San Diego to Santiago, returning Tue, 16 Feb, priced at £837 found 6 days ago

Find the cheapest month to fly from San Diego (SAN) to Santiago (SCL)

November is typically the cheapest month to fly

From £566 - £907 per traveller.

Frequently asked questions

How do I find cheap flights from San Diego, CA (SAN-San Diego Intl.) to Santiago (SCL-Arturo Merino Benitez)?
To find a cheap flight from San Diego, CA (SAN-San Diego Intl.) to Santiago (SCL-Arturo Merino Benitez), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from San Diego, CA (SAN-San Diego Intl.) to Santiago (SCL-Arturo Merino Benitez)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
How many flights per day from San Diego, CA (SAN-San Diego Intl.) to Santiago (SCL-Arturo Merino Benitez)?
There are approximately 38 connecting flights per day from San Diego Intl. (SAN) to Arturo Merino Benitez (SCL). Some common connection points include John F. Kennedy Intl. (JFK), George Bush Intercontinental (IAH), and Hartsfield-Jackson Atlanta Intl. (ATL).
What is the earliest flight from San Diego, CA (SAN-San Diego Intl.) to Santiago (SCL-Arturo Merino Benitez)?
The earliest flight from San Diego, CA (SAN-San Diego Intl.) to Santiago (SCL-Arturo Merino Benitez) typically departs at approximately 6:00 AM local time, operated by American Airlines. This is a seasonal service active in March. An early departure like this can help you maximise your time at your destination. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What day of the week has the most flights from San Diego, CA (SAN-San Diego Intl.) to Santiago (SCL-Arturo Merino Benitez)?
You'll typically find the most flights from San Diego Intl. (SAN) to Arturo Merino Benitez (SCL) on a Sunday, with around 45 flights available. This gives you plenty of options for your travel plans. Major airlines on this route include United Airlines, Delta Air Lines, and American Airlines.
What are the most popular departure times for flights from San Diego, CA (SAN-San Diego Intl.) to Santiago (SCL-Arturo Merino Benitez)?
The most popular departure times for flights from San Diego, CA (SAN-San Diego Intl.) to Santiago (SCL-Arturo Merino Benitez) are between 12pm and 3pm. About 34% of passengers prefer this time. Many major carriers, including American Airlines, United Airlines and Air Canada, offer flights during this window. This timing works well because it allows you to have a productive morning before heading to the airport, and you'll arrive at your destination in the evening.
How long does it take to fly from San Diego, CA (SAN-San Diego Intl.) to Santiago (SCL-Arturo Merino Benitez)?
Flights from SAN to SCL with one stop typically take around 20 hours 20 minutes, covering approximately 5,475 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from San Diego, CA (SAN-San Diego Intl.) to Santiago (SCL-Arturo Merino Benitez)?
Select the "Business class" and "First class" filters when looking for SAN to SCL flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip.
How do I earn miles on a San Diego, CA (SAN-San Diego Intl.) to Santiago (SCL-Arturo Merino Benitez) flight with Expedia?
It's easy to earn miles on a San Diego, CA (SAN-San Diego Intl.) to Santiago (SCL-Arturo Merino Benitez) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia. *Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Santiago from San Diego Intl. (SAN)?
When traveling from San Diego Intl. (SAN) to Santiago, you can fly into Cibao Intl. (STI) and Arturo Merino Benitez (SCL). Some flights may connect through major hubs like Charlotte-Douglas Intl. (CLT), Sky Harbor Intl. (PHX), Dallas-Fort Worth Intl. (DFW) before reaching Santiago. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from San Diego, CA (SAN-San Diego Intl.) to Santiago (SCL-Arturo Merino Benitez) at the last minute?
Typically, booking a last minute flight from San Diego, CA (SAN-San Diego Intl.) to Santiago (SCL-Arturo Merino Benitez) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a San Diego, CA (SAN-San Diego Intl.) to Santiago (SCL-Arturo Merino Benitez) flight and hotel package?
Securing a San Diego, CA (SAN-San Diego Intl.) to Santiago (SCL-Arturo Merino Benitez) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from San Diego, CA (SAN-San Diego Intl.) to Santiago (SCL-Arturo Merino Benitez)?
If you booked your San Diego, CA (SAN-San Diego Intl.) to Santiago (SCL-Arturo Merino Benitez) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
San Diego Intl.
Destination airport
Arturo Merino Benitez
Airlines serving
Copa, LATAM Airlines Group
Return price
£643
Distance
8759 km

Book with confidence

Compare flights from San Diego to Santiago easily and book with confidence

For travelling on business or for pleasure, Expedia makes it easy to book your flights from San Diego to Santiago. Operating between them flights per day, 20 airlines cover the route. And fly direct, getting you to Arturo Merino Benitez in just hours. If you have a preferred carrier, use our advanced search tool to find the right flight from San Diego Intl. to Arturo Merino Benitez.  

To make things even better, in the advanced search, you can also choose to fly economy, premium economy, business or first class, select your maximum number of stops, and pick your preferred departure and arrival time. You can also opt for refundable and direct flights. 

Grab a great deal on your flight from San Diego Intl. (SAN) to Arturo Merino Benitez (SCL)

The easiest way to view the best deals on flights from San Diego to Santiago today is to enter your travel dates and hit search. From here, you can sort your results by price to see the cheapest flights first. Right now, return flights from San Diego Intl. to Arturo Merino Benitez start at just £643 and range up to £837.  

To find an even better deal, try  

  • being flexible on your dates – midweek flights can be cheaper
  • looking for other airports near San Diego and Santiago
  • booking your flight during February, the cheapest month on this route
  • varying your flight times – early morning and late at night are sometimes cheaper 

Why you should book your San Diego to Santiago flight with Expedia!

We cater for all flight types, cabin classes and airlines. So whether you’re booking flights from San Diego Intl. to Arturo Merino Benitez for a budget break or a business trip with a bit of pleasure thrown in, we make it easy to secure the seat that’s right for you.  

Thanks to our supersized inventory that offers great choice all in one place, you know you’ll get a great deal with Expedia. Especially if you bundle your flight together with your hotel, you will unlock amazing savings. For added peace of mind, you can choose flexible bookings or filter to find refundable options, so you won’t pay a fee to change your flight.  

Compare flights from San Diego to Santiago easily and book with confidence

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*Available to Expedia members.