£296 Cheap Flights from Panama City (PTY) to Chicago (ORD)

View £296 flight on Thu, 4 Jun 2026Opens in a new window

Popular airlines from Tocumen Intl. Airport (PTY) to Chicago O'Hare International Airport (ORD)

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Cheap Flights from Panama City (PTY) to Chicago (ORD)

Prices were available within the past 7 days and start at £296 for one-way flights and £533 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Thu, 24 Sept - Mon, 28 Sept
PTY
Panama City
ORD
Chicago
£533 Return, found 13 hours ago
£533
Return
found 13 hours ago
Select American Airlines flight, departing Thu, 24 Sept from Panama City to Chicago, returning Mon, 28 Sept, priced at £533 found 13 hours ago
Delta
Thu, 24 Sept - Mon, 28 Sept
PTY
Panama City
ORD
Chicago
£533 Return, found 13 hours ago
£533
Return
found 13 hours ago
Select Delta flight, departing Thu, 24 Sept from Panama City to Chicago, returning Mon, 28 Sept, priced at £533 found 13 hours ago
avianca
Sun, 17 May - Sun, 24 May
PTY
Panama City
ORD
Chicago
£546 Return, found 1 day ago
£546
Return
found 1 day ago
Select avianca flight, departing Sun, 17 May from Panama City to Chicago, returning Sun, 24 May, priced at £546 found 1 day ago
avianca
Sat, 6 Jun - Sat, 13 Jun
PTY
Panama City
ORD
Chicago
£547 Return, found 4 days ago
£547
Return
found 4 days ago
Select avianca flight, departing Sat, 6 Jun from Panama City to Chicago, returning Sat, 13 Jun, priced at £547 found 4 days ago
avianca
Sat, 6 Jun - Sat, 13 Jun
PTY
Panama City
ORD
Chicago
£548 Return, found 4 days ago
£548
Return
found 4 days ago
Select avianca flight, departing Sat, 6 Jun from Panama City to Chicago, returning Sat, 13 Jun, priced at £548 found 4 days ago
avianca
Thu, 24 Sept - Mon, 28 Sept
PTY
Panama City
ORD
Chicago
£549 Return, found 13 hours ago
£549
Return
found 13 hours ago
Select avianca flight, departing Thu, 24 Sept from Panama City to Chicago, returning Mon, 28 Sept, priced at £549 found 13 hours ago
avianca
Sat, 6 Jun - Sat, 13 Jun
PTY
Panama City
ORD
Chicago
£555 Return, found 4 days ago
£555
Return
found 4 days ago
Select avianca flight, departing Sat, 6 Jun from Panama City to Chicago, returning Sat, 13 Jun, priced at £555 found 4 days ago
avianca
Sun, 17 May - Sun, 24 May
PTY
Panama City
ORD
Chicago
£562 Return, found 1 day ago
£562
Return
found 1 day ago
Select avianca flight, departing Sun, 17 May from Panama City to Chicago, returning Sun, 24 May, priced at £562 found 1 day ago
Copa
Sat, 6 Jun - Sat, 13 Jun
PTY
Panama City
ORD
Chicago
£590 Return, found 4 days ago
£590
Return
found 4 days ago
Select Copa flight, departing Sat, 6 Jun from Panama City to Chicago, returning Sat, 13 Jun, priced at £590 found 4 days ago
United
Thu, 24 Sept - Mon, 28 Sept
PTY
Panama City
ORD
Chicago
£628 Return, found 13 hours ago
£628
Return
found 13 hours ago
Select United flight, departing Thu, 24 Sept from Panama City to Chicago, returning Mon, 28 Sept, priced at £628 found 13 hours ago

Frequently asked questions

How much is a flight from Panama Airport to O'Hare Airport?
Pack your bags, because round-trip journeys from Panama Airport to O'Hare Intl. Airport (ORD) start from £533. That's based on fares advertised within the last 7 days on Expedia for flights departing within the next year. Prices can increase quickly, so book now to get the best deal. Prices and availability are subject to change. Additional terms apply.
Do I need to pay a cancellation fee if I cancel my flight from Panama Airport to ORD?
We get that life can throw the odd curveball, so we've made it as simple as possible for you to cancel your trip online. Just visit the Customer Service Portal and follow the instructions.
How do I find cheap flights from Panama Airport to O'Hare Intl. Airport (ORD) that have flexible change policies?
Many airlines offer the option to reschedule your flight without a change fee. All you pay is the difference between the original flight and the new flight. When you're searching for Panama Airport to O'Hare Airport flights, you'll see a "no change fees" filter for you to select.
How far is the flight from Panama Airport to ORD?
The flying distance between Tocumen Intl. Airport (PTY) and ORD is 3,800 kilometres. Sneak in a nap or bury your nose in a book and the journey will zip on by.
Which airlines fly direct from PTY to O'Hare Intl. Airport (ORD)?
Flying nonstop from Tocumen Intl. Airport (PTY) to O'Hare Airport is easy with Copa Airlines (CM). This top carrier operates 30 flights every month.
Are PTY to ORD flight tickets cheaper when they're purchased at the last minute?
Booking last minute from PTY to ORD can be hit-or-miss. You may be able to score a bargain, but then again, you could miss out altogether! If you'd prefer to start planning your trip early, Expedia compares flight deals up to 12 months in advance. Just remember that not all airlines issue their prices that far in advance. Our advice? Check back often as prices are updated regularly.

Frequently asked questions

What is the cheapest month to fly from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.)?
September is typically the cheapest month to fly from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.), with average return fares of approximately £402. This is about 16% lower than the average price throughout the year. September often sees lower prices as the summer travel rush ends and before the holiday season begins, leading to reduced demand. Other cheap months to fly from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.) include March and June.
Which airlines fly direct from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.)?
Enter PTY to ORD and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
How do I find cheap flights from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.)?
To find a cheap flight from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best airline to fly with from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.)?
The best airline to fly with from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.) will differ from traveller to traveller. If you like to fly early, CM offers early morning flights. If price is the most important factor, CM typically offers the lowest fares. CM offers the most daily flights from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.), which is great if flexibility is what you value most. The best carrier for this journey could also be the one you have a loyalty membership with, as flying with that airline or another airline within the same alliance could help you collect points or enjoy lounge access.
What is the best time to fly from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.)?
The best time to fly from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.) is typically September or June. These months offer the most budget-friendly options, with average return flights around £402. While we don't have specific popularity data for these months, choosing a time with lower prices often means you'll find good availability and potentially more flexible schedules. This information is based on booking data from the past year.
How many flights per day from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.)?
There are approximately 2 nonstop flights per day from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.). For even more choice, look at flights that include layovers, as there are around 39 connecting flights per day. Some common connection points include El Dorado Intl. (BOG), George Bush Intercontinental (IAH), and Miami Intl. (MIA).
What is the earliest flight from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.)?
The earliest flight from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.) typically departs at approximately 2:55 AM local time, operated by Avianca. This is a seasonal service active in January, February, March, October, November, and December. An early departure like this can help you maximise your time at your destination. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What day of the week has the most flights from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.)?
You'll typically find the most flights from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.) on a Tuesday, with around 34 flights available. This gives you a good selection of options for your travel plans. Major airlines on this route include Copa Airlines, United Airlines, and Avianca.
What are the most popular departure times for flights from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.)?
The most popular departure times for flights from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.) are in the early morning, from 6am to 9am. About 28% of passengers prefer this time. Copa Airlines and United Airlines offer flights during this window. Many travelers prefer these early flights as they allow you to arrive at your destination with plenty of time to start your day.
How long does it take to fly from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.)?
A nonstop flight from PTY to ORD typically takes around 5 hours 50 minutes, covering approximately 2,332 miles. Connecting flights on this route usually add 3 hours 30 minutes to your travel time. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.)?
Select the "Business class" and "First class" filters when looking for PTY to ORD flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip.
How do I earn miles on a Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.) flight with Expedia?
It's easy to earn miles on a Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia. *Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Chicago from Tocumen Intl. (PTY)?
When traveling from Tocumen Intl. (PTY) to Chicago, you can fly into Midway Intl. (MDW) and O'Hare Intl. (ORD). Some flights may connect through major hubs like Mexico City Intl. (MEX), General Mariano Escobedo Intl. (MTY) before reaching Chicago. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.) at the last minute?
Typically, booking a last minute flight from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.) flight and hotel package?
Securing a Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.)?
If you booked your Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Tocumen Intl.
Destination airport
O'Hare Intl.
Airlines serving
Aeromexico, American Airlines, Copa, Delta, United, avianca
Return price
£533
Distance
3731 km
Average flight time
5 hours 48 mins

Book with confidence

Compare flights from Panama City to Chicago easily and book with confidence

For travelling on business or for pleasure, Expedia makes it easy to book your flights from Panama City to Chicago. Operating between them flights per day, 20 airlines cover the route. And fly direct, getting you to O'Hare Intl. in just hours. If you have a preferred carrier, use our advanced search tool to find the right flight from Tocumen Intl. to O'Hare Intl..  

To make things even better, in the advanced search, you can also choose to fly economy, premium economy, business or first class, select your maximum number of stops, and pick your preferred departure and arrival time. You can also opt for refundable and direct flights. 

Grab a great deal on your flight from Tocumen Intl. (PTY) to O'Hare Intl. (ORD)

The easiest way to view the best deals on flights from Panama City to Chicago today is to enter your travel dates and hit search. From here, you can sort your results by price to see the cheapest flights first. Right now, return flights from Tocumen Intl. to O'Hare Intl. start at just £533 and range up to £628.  

To find an even better deal, try  

  • being flexible on your dates – midweek flights can be cheaper
  • looking for other airports near Panama City and Chicago
  • booking your flight during September, the cheapest month on this route
  • varying your flight times – early morning and late at night are sometimes cheaper 

Why you should book your Panama City to Chicago flight with Expedia!

We cater for all flight types, cabin classes and airlines. So whether you’re booking flights from Tocumen Intl. to O'Hare Intl. for a budget break or a business trip with a bit of pleasure thrown in, we make it easy to secure the seat that’s right for you.  

Thanks to our supersized inventory that offers great choice all in one place, you know you’ll get a great deal with Expedia. Especially if you bundle your flight together with your hotel, you will unlock amazing savings. For added peace of mind, you can choose flexible bookings or filter to find refundable options, so you won’t pay a fee to change your flight.  

Compare flights from Panama City to Chicago easily and book with confidence

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