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£295 Cheap Flights from Panama City (PTY) to Chicago (ORD)

View £295 flight on Sun, 1 Nov 2026Opens in a new window

Popular airlines from Tocumen Intl. Airport (PTY) to Chicago O'Hare International Airport (ORD)

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Cheap Flights from Panama City (PTY) to Chicago (ORD)

Prices were available within the past 7 days and start at £295 for one-way flights and £547 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

avianca
Sun, 1 Nov - Fri, 6 Nov
PTY
Panama City
ORD
Chicago
£547 Return, found 6 days ago
£547
Return
found 6 days ago
Select avianca flight, departing Sun, 1 Nov from Panama City to Chicago, returning Fri, 6 Nov, priced at £547 found 6 days ago
avianca
Wed, 19 Aug - Wed, 26 Aug
PTY
Panama City
ORD
Chicago
£552 Return, found 1 day ago
£552
Return
found 1 day ago
Select avianca flight, departing Wed, 19 Aug from Panama City to Chicago, returning Wed, 26 Aug, priced at £552 found 1 day ago
avianca
Sat, 29 Aug - Wed, 9 Sept
PTY
Panama City
ORD
Chicago
£576 Return, found 4 days ago
£576
Return
found 4 days ago
Select avianca flight, departing Sat, 29 Aug from Panama City to Chicago, returning Wed, 9 Sept, priced at £576 found 4 days ago
avianca
Mon, 17 Aug - Mon, 24 Aug
PTY
Panama City
ORD
Chicago
£578 Return, found 1 day ago
£578
Return
found 1 day ago
Select avianca flight, departing Mon, 17 Aug from Panama City to Chicago, returning Mon, 24 Aug, priced at £578 found 1 day ago
avianca
Wed, 19 Aug - Wed, 26 Aug
PTY
Panama City
ORD
Chicago
£582 Return, found 1 day ago
£582
Return
found 1 day ago
Select avianca flight, departing Wed, 19 Aug from Panama City to Chicago, returning Wed, 26 Aug, priced at £582 found 1 day ago
avianca
Mon, 3 Aug - Thu, 20 Aug
PTY
Panama City
ORD
Chicago
£601 Return, found 2 days ago
£601
Return
found 2 days ago
Select avianca flight, departing Mon, 3 Aug from Panama City to Chicago, returning Thu, 20 Aug, priced at £601 found 2 days ago
avianca
Mon, 3 Aug - Thu, 20 Aug
PTY
Panama City
ORD
Chicago
£610 Return, found 2 days ago
£610
Return
found 2 days ago
Select avianca flight, departing Mon, 3 Aug from Panama City to Chicago, returning Thu, 20 Aug, priced at £610 found 2 days ago
Copa
Sun, 1 Nov - Fri, 6 Nov
PTY
Panama City
ORD
Chicago
£615 Return, found 6 days ago
£615
Return
found 6 days ago
Select Copa flight, departing Sun, 1 Nov from Panama City to Chicago, returning Fri, 6 Nov, priced at £615 found 6 days ago
avianca
Mon, 3 Aug - Thu, 20 Aug
PTY
Panama City
ORD
Chicago
£617 Return, found 2 days ago
£617
Return
found 2 days ago
Select avianca flight, departing Mon, 3 Aug from Panama City to Chicago, returning Thu, 20 Aug, priced at £617 found 2 days ago
avianca
Mon, 3 Aug - Thu, 20 Aug
PTY
Panama City
ORD
Chicago
£629 Return, found 2 days ago
£629
Return
found 2 days ago
Select avianca flight, departing Mon, 3 Aug from Panama City to Chicago, returning Thu, 20 Aug, priced at £629 found 2 days ago

Find the cheapest month to fly from Panama City (PTY) to Chicago (ORD)

April is typically the cheapest month to fly

From £249 - £502 per traveller.

Frequently asked questions

How much does a flight from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.) cost?
You can find one-way and return flights from PTY to ORD with Expedia. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see our cheapest fares first, and use the Price Tracking tool to receive alerts when PTY to ORD ticket fares go up or down.
What is the cheapest month to fly from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.)?
September is typically the cheapest month to fly from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.), with average return fares around £402. September often sees lower prices as the peak summer travel season winds down, leading to reduced demand. March and June are also good months to find deals on this route.
Which airlines fly direct from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.)?
Only one airline offers direct flights from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.). Copa operates 16 direct flights from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.) every week.
What is the cheapest airline that flies from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.)?
For connecting flights, Avianca is one of the cheapest airlines, with return tickets starting from around £247 typically with a layover in El Salvador Intl. (SAL). Copa is one of the cheapest airlines offering nonstop return flights from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.), with tickets starting from around £425 for flights that can be booked for departure within the next year. Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.
How do I find cheap flights from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.)?
To find a cheap flight from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best airline to fly with from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.)?
The best airline to fly with from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.) will differ from traveler to traveler. If you like to fly early, Copa offers early morning flights. If price is the most important factor, Copa typically offers the lowest fares. Copa offers the most daily flights from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.), which is great if flexibility is what you value most. The best carrier for this journey could also be the one you have a loyalty membership with, as flying with that airline or another airline within the same alliance could help you collect points or enjoy lounge access.
What is the best time to fly from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.)?
The cheapest months to fly from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.) are typically September and June, with average return flights costing around £402. These months can offer a good balance, as September often brings pleasant autumn weather to Chicago, and June is the start of summer, both popular times for travel. If you're flexible, aiming for these months could help you find more affordable fares.
How many flights per day from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.)?
You'll find approximately 2 nonstop flights per day from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.). For even more choices, look at flights that include layovers, as there are around 40 connecting flights per day. Some common connection points include El Dorado Intl. (BOG), George Bush Intercontinental (IAH), and El Salvador Intl. (SAL).
What is the earliest flight from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.)?
The earliest flight from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.) typically departs around 2:55 AM local time, operated by Avianca. This is a seasonal service, active in January, February, March, October, November, and December. An early departure like this can help you make the most of your time at your destination. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What day of the week has the most flights from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.)?
You'll typically find the most flights from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.) on a Tuesday, with around 33 flights available. This gives you a good selection of options for your journey. Major airlines on this route include Copa, United, and Avianca. Flight schedules are quite consistent throughout the week, so you'll have plenty of options no matter which day you choose to fly.
What are the most popular departure times for flights from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.)?
The most popular departure times for flights from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.) are in the morning, from 6am to 9am. Many major carriers, including Copa, United and Delta, offer flights during this window. Many travellers prefer these early morning flights as they allow you to arrive at your destination with plenty of time to settle in or start your day.
How long does it take to fly from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.)?
A non-stop flight from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.) typically takes around 5 hours 44 minutes. This route covers a distance of approximately 3,753 kilometers. If you opt for a one-stop flight, the journey will take longer, usually around 9 hours 18 minutes. Keep in mind that these are average times, and actual flight durations can vary due to factors like wind patterns and air traffic.
Can you fly business or first class from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.)?
Yes, you can fly business class between PTY and ORD. Airlines that offer business class service on this route include:
  • Avianca
  • Copa
  • Aeromexico
  • American Airlines
How do I earn miles on a Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.) flight with Expedia?
It's easy to earn miles on a Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Chicago, IL (ORD) from Panama City (PTY)?
If you're planning to travel to Chicago from Tocumen Intl. (PTY), you can fly directly into O'Hare Intl. (ORD). Some flights may connect through major hubs like Miami Intl. (MIA), El Salvador Intl. (SAL), or El Dorado Intl. (BOG) before reaching Chicago. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.) at the last minute?
Typically, booking a last minute flight from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.) flight and hotel package?
Securing a Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.)?
If you booked your Panama City (PTY-Tocumen Intl.) to Chicago, IL (ORD-O'Hare Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Tocumen Intl.
Destination airport
O'Hare Intl.
Return price
£546
Distance
3731 km
Average flight time
5 hours 42 mins

Book with confidence

Compare flights from Panama City to Chicago easily and book with confidence

For travelling on business or for pleasure, Expedia makes it easy to book your flights from Panama City to Chicago. Operating between them flights per day, 20 airlines cover the route. And fly direct, getting you to O'Hare Intl. in just hours. If you have a preferred carrier, use our advanced search tool to find the right flight from Tocumen Intl. to O'Hare Intl..  

To make things even better, in the advanced search, you can also choose to fly economy, premium economy, business or first class, select your maximum number of stops, and pick your preferred departure and arrival time. You can also opt for refundable and direct flights. 

Grab a great deal on your flight from Tocumen Intl. (PTY) to O'Hare Intl. (ORD)

The easiest way to view the best deals on flights from Panama City to Chicago today is to enter your travel dates and hit search. From here, you can sort your results by price to see the cheapest flights first. Right now, return flights from Tocumen Intl. to O'Hare Intl. start at just £547 and range up to £636.  

To find an even better deal, try  

  • being flexible on your dates – midweek flights can be cheaper
  • looking for other airports near Panama City and Chicago
  • booking your flight during November, the cheapest month on this route
  • varying your flight times – early morning and late at night are sometimes cheaper 

Why you should book your Panama City to Chicago flight with Expedia!

We cater for all flight types, cabin classes and airlines. So whether you’re booking flights from Tocumen Intl. to O'Hare Intl. for a budget break or a business trip with a bit of pleasure thrown in, we make it easy to secure the seat that’s right for you.  

Thanks to our supersized inventory that offers great choice all in one place, you know you’ll get a great deal with Expedia. Especially if you bundle your flight together with your hotel, you will unlock amazing savings. For added peace of mind, you can choose flexible bookings or filter to find refundable options, so you won’t pay a fee to change your flight.  

Compare flights from Panama City to Chicago easily and book with confidence

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*Available to Expedia members.