£191 Cheap Flights from Knoxville (TYS) to Chicago (ORD)

To find a cheap flight from Knoxville, TN (TYS-McGhee Tyson) to Chicago, IL (ORD-O'Hare Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.

The best airline to fly with from Knoxville, TN (TYS-McGhee Tyson) to Chicago, IL (ORD-O'Hare Intl.) will differ from traveller to traveller. If you like to fly early, United Airlines offers early morning flights. If price is the most important factor, American Airlines typically offers the lowest fares. American Airlines offers the most daily flights from Knoxville, TN (TYS-McGhee Tyson) to Chicago, IL (ORD-O'Hare Intl.), which is brilliant if flexibility is what you value most. The best carrier for this journey could also be the one you have a loyalty membership with, as flying with that airline or another airline within the same alliance could help you collect points or enjoy lounge access.

The earliest flight from Knoxville, TN (TYS-McGhee Tyson) to Chicago, IL (ORD-O'Hare Intl.) typically departs at approximately 5:00 AM local time, operated by American Airlines. This is a seasonal service active in March. An early departure like this can help you maximise your time at your destination. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.

You'll typically find the most flights from Knoxville, TN (TYS-McGhee Tyson) to Chicago, IL (ORD-O'Hare Intl.) on a Friday, with around 37 flights available. This gives you plenty of options for your travel plans. Major airlines on this route include American Airlines, Delta Air Lines, and United Airlines. Fridays and Thursdays have notably more flight options compared to other days of the week.

The most popular departure times for flights from Knoxville, TN (TYS-McGhee Tyson) to Chicago, IL (ORD-O'Hare Intl.) are in the early morning, from 6am to 9am. This accounts for around 29% of total traffic. Many major carriers, including American Airlines and Delta, offer flights during this window. This timing works well because it allows you to get an early start on your day in Chicago.

It's easy to earn miles on a Knoxville, TN (TYS-McGhee Tyson) to Chicago, IL (ORD-O'Hare Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.

If you booked your Knoxville, TN (TYS-McGhee Tyson) to Chicago, IL (ORD-O'Hare Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.