£173 Cheap Flights from Myrtle Beach (MYR) to San Diego (SAN)

View £173 flight on Mon, 14 Sept 2026Opens in a new window

Flight 1

Popular airlines from Myrtle Beach Intl. Airport (MYR) to San Diego Intl. Airport (SAN)

  • Be in the know

    Get alerts if flight prices drop or rise*

  • Book smarter

    Save up to 25% on select hotels after you book a flight*

  • Earn twice

    Earn your airline miles on top of our rewards
    Sign in

Cheap Flights from Myrtle Beach (MYR) to San Diego (SAN)

Prices were available within the past 7 days and start at £173 for one-way flights and £314 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Fri, 11 Sept - Tue, 15 Sept
MYR
Myrtle Beach
SAN
San Diego
£314 Return, found 1 day ago
£314
Return
found 1 day ago
Select Delta flight, departing Fri, 11 Sept from Myrtle Beach to San Diego, returning Tue, 15 Sept, priced at £314 found 1 day ago
Delta
Tue, 8 Sept - Tue, 29 Sept
MYR
Myrtle Beach
SAN
San Diego
£326 Return, found 1 day ago
£326
Return
found 1 day ago
Select Delta flight, departing Tue, 8 Sept from Myrtle Beach to San Diego, returning Tue, 29 Sept, priced at £326 found 1 day ago
Delta
Mon, 14 Sept - Fri, 18 Sept
MYR
Myrtle Beach
SAN
San Diego
£345 Return, found 1 day ago
£345
Return
found 1 day ago
Select Delta flight, departing Mon, 14 Sept from Myrtle Beach to San Diego, returning Fri, 18 Sept, priced at £345 found 1 day ago
Delta
Tue, 8 Sept - Fri, 25 Sept
MYR
Myrtle Beach
SAN
San Diego
£357 Return, found 1 day ago
£357
Return
found 1 day ago
Select Delta flight, departing Tue, 8 Sept from Myrtle Beach to San Diego, returning Fri, 25 Sept, priced at £357 found 1 day ago
Delta
Sun, 1 Nov - Fri, 13 Nov
MYR
Myrtle Beach
SAN
San Diego
£364 Return, found 1 day ago
£364
Return
found 1 day ago
Select Delta flight, departing Sun, 1 Nov from Myrtle Beach to San Diego, returning Fri, 13 Nov, priced at £364 found 1 day ago
Delta
Mon, 14 Sept - Fri, 18 Sept
MYR
Myrtle Beach
SAN
San Diego
£372 Return, found 1 day ago
£372
Return
found 1 day ago
Select Delta flight, departing Mon, 14 Sept from Myrtle Beach to San Diego, returning Fri, 18 Sept, priced at £372 found 1 day ago
American Airlines
Mon, 14 Sept - Fri, 18 Sept
MYR
Myrtle Beach
SAN
San Diego
£378 Return, found 1 day ago
£378
Return
found 1 day ago
Select American Airlines flight, departing Mon, 14 Sept from Myrtle Beach to San Diego, returning Fri, 18 Sept, priced at £378 found 1 day ago
American Airlines
Mon, 14 Sept - Fri, 18 Sept
MYR
Myrtle Beach
SAN
San Diego
£384 Return, found 1 day ago
£384
Return
found 1 day ago
Select American Airlines flight, departing Mon, 14 Sept from Myrtle Beach to San Diego, returning Fri, 18 Sept, priced at £384 found 1 day ago
American Airlines
Mon, 14 Sept - Fri, 18 Sept
MYR
Myrtle Beach
SAN
San Diego
£385 Return, found 1 day ago
£385
Return
found 1 day ago
Select American Airlines flight, departing Mon, 14 Sept from Myrtle Beach to San Diego, returning Fri, 18 Sept, priced at £385 found 1 day ago
United
Mon, 14 Sept - Fri, 18 Sept
MYR
Myrtle Beach
SAN
San Diego
£430 Return, found 1 day ago
£430
Return
found 1 day ago
Select United flight, departing Mon, 14 Sept from Myrtle Beach to San Diego, returning Fri, 18 Sept, priced at £430 found 1 day ago

Frequently asked questions

How do I find cheap flights from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to San Diego, CA (SAN-San Diego Intl.)?
To find a cheap flight from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to San Diego, CA (SAN-San Diego Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to San Diego, CA (SAN-San Diego Intl.)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
How many flights per day from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to San Diego, CA (SAN-San Diego Intl.)?
There are approximately 27 connecting flights per day from Myrtle Beach Intl. (MYR) to San Diego Intl. (SAN). Some common connection points include O'Hare Intl. (ORD), Hartsfield-Jackson Atlanta Intl. (ATL), and Baltimore Washington Intl. Thurgood Marshall (BWI).
What is the earliest flight from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to San Diego, CA (SAN-San Diego Intl.)?
The earliest flight from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) (MYR) to San Diego, CA (SAN-San Diego Intl.) (SAN) typically departs at approximately 5:00 AM local time, operated by American Airlines. This is a seasonal service active in December. An early departure like this can help you maximise your time at your destination. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What day of the week has the most flights from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to San Diego, CA (SAN-San Diego Intl.)?
If you're flying from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to San Diego, CA (SAN-San Diego Intl.), you'll generally find the most flights on a Friday, with around 19 flights available. This gives you plenty of options to choose from for your travel plans. Major airlines on this route include American Airlines, Delta Air Lines, and Southwest Airlines. Flight schedules are consistent throughout the week, so you'll have a good selection of flights no matter which day you choose.
What are the most popular departure times for flights from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to San Diego, CA (SAN-San Diego Intl.)?
The most popular departure times for flights from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to San Diego, CA (SAN-San Diego Intl.) are in the early morning, from 6am to 9am. About 28% of passengers prefer this time. Many major carriers, including American Airlines, Delta Air Lines and Southwest Airlines, offer flights during this window. This timing works well if you like to get an early start to your travel day and arrive at your destination with plenty of time left.
How long does it take to fly from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to San Diego, CA (SAN-San Diego Intl.)?
Flying from MYR to SAN with a connection usually takes about 9 hours 20 minutes, traveling roughly 2,201 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to San Diego, CA (SAN-San Diego Intl.)?
Select the "Business class" and "First class" filters when looking for MYR to SAN flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip.
How do I earn miles on a Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to San Diego, CA (SAN-San Diego Intl.) flight with Expedia?
It's easy to earn miles on a Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to San Diego, CA (SAN-San Diego Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia. *Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for San Diego from MYR (MYR)?
From MYR (MYR), you can fly directly into San Diego Intl. (SAN) to reach San Diego. Some flights may connect through major hubs like Liberty Intl. (EWR), Baltimore Washington Intl. Thurgood Marshall (BWI), Nashville Intl. (BNA) before reaching San Diego. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to San Diego, CA (SAN-San Diego Intl.) at the last minute?
Typically, booking a last minute flight from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to San Diego, CA (SAN-San Diego Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to San Diego, CA (SAN-San Diego Intl.) flight and hotel package?
Securing a Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to San Diego, CA (SAN-San Diego Intl.) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to San Diego, CA (SAN-San Diego Intl.)?
If you booked your Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to San Diego, CA (SAN-San Diego Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Myrtle Beach Intl.
Destination airport
San Diego Intl.
Airlines serving
American Airlines, Delta, United
Return price
£282
Distance
3521 km

Book with confidence

Compare flights from Myrtle Beach to San Diego easily and book with confidence

For travelling on business or for pleasure, Expedia makes it easy to book your flights from Myrtle Beach to San Diego. Operating between them flights per day, 20 airlines cover the route. And fly direct, getting you to San Diego Intl. in just hours. If you have a preferred carrier, use our advanced search tool to find the right flight from Myrtle Beach Intl. to San Diego Intl..  

To make things even better, in the advanced search, you can also choose to fly economy, premium economy, business or first class, select your maximum number of stops, and pick your preferred departure and arrival time. You can also opt for refundable and direct flights. 

Grab a great deal on your flight from Myrtle Beach Intl. (MYR) to San Diego Intl. (SAN)

The easiest way to view the best deals on flights from Myrtle Beach to San Diego today is to enter your travel dates and hit search. From here, you can sort your results by price to see the cheapest flights first. Right now, return flights from Myrtle Beach Intl. to San Diego Intl. start at just £314 and range up to £430.  

To find an even better deal, try  

  • being flexible on your dates – midweek flights can be cheaper
  • looking for other airports near Myrtle Beach and San Diego
  • booking your flight during September, the cheapest month on this route
  • varying your flight times – early morning and late at night are sometimes cheaper 

Why you should book your Myrtle Beach to San Diego flight with Expedia!

We cater for all flight types, cabin classes and airlines. So whether you’re booking flights from Myrtle Beach Intl. to San Diego Intl. for a budget break or a business trip with a bit of pleasure thrown in, we make it easy to secure the seat that’s right for you.  

Thanks to our supersized inventory that offers great choice all in one place, you know you’ll get a great deal with Expedia. Especially if you bundle your flight together with your hotel, you will unlock amazing savings. For added peace of mind, you can choose flexible bookings or filter to find refundable options, so you won’t pay a fee to change your flight.  

Compare flights from Myrtle Beach to San Diego easily and book with confidence

Explore a world of travel with Expedia

*Available to Expedia members.