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Check prices for these dates

Next weekend
3 Jul - 5 Jul
In two weeks
10 Jul - 12 Jul

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Our top choices for Uptown hotels

Breakfast, dinner and brunch served

The Principal Hotel

The Principal Hotel
3.5 star property
19.1 mi from Uptown
9.6 out of 10, Exceptional, (319 reviews)
"Great hotel and nice staff!"
United States
Michelle
The price is £87
includes taxes & fees
28 Jun - 29 Jun
The Principal Hotel
Lobby

Comfort Inn Alton near I-255

Comfort Inn Alton near I-255
2.5 star property
18.1 mi from Uptown
7.4 out of 10, Good, (571 reviews)
"Beautiful area!!"
United States
Krystyne
The price is £73
includes taxes & fees
5 Jul - 6 Jul
Comfort Inn Alton near I-255
Suite, 1 King Bed, Non Smoking (One-Bedroom, Honeymoon) | Jetted bathtub

Seasons Inn & Suites Highland

Seasons Inn & Suites Highland
2.5 star property
17.7 mi from Uptown
8.0 out of 10, Very good, (664 reviews)
"The staff is very friendly and accommodating they took care of us very well. "
United States
Philip
The price is £88
includes taxes & fees
29 Jun - 30 Jun
Seasons Inn & Suites Highland
5 restaurants; breakfast, lunch, dinner and brunch served

River City Casino & Hotel

River City Casino & Hotel
4.0 star property
17.5 mi from Uptown
9.2 out of 10, Wonderful, (1,636 reviews)
"Would stay again in a heartbeat!"
United States
Austin
The price is £91
includes taxes & fees
29 Jun - 30 Jun
River City Casino & Hotel
Deluxe Studio Suite, 1 King Bed, Non Smoking | Pillow-top beds, in-room safe, desk, laptop workspace

Super 8 by Wyndham O'Fallon

Super 8 by Wyndham O'Fallon
2.0 star property
8.7 mi from Uptown
6.6 out of 10, (1,017 reviews)
"Bed was comfy and shower was hot. No complaints as I was passing through and just looking for a place to lay my head! Would stay here again!"
United States
Rebekah
The price is £51
includes taxes & fees
28 Jun - 29 Jun
Super 8 by Wyndham O'Fallon
Gazebo

Country Hearth Inn & Suites Edwardsville St. Louis

Country Hearth Inn & Suites Edwardsville St. Louis
2.5 star property
8.5 mi from Uptown
8.6 out of 10, Excellent, (718 reviews)
"We had a great stay and the breakfast was really good."
United States
Tonya
The price is £112
includes taxes & fees
1 Jul - 2 Jul
Country Hearth Inn & Suites Edwardsville St. Louis
Exterior

Comfort Inn & Suites Saint Louis Lafayette Square

Comfort Inn & Suites Saint Louis Lafayette Square
2.5 star property
13 mi from Uptown
8.0 out of 10, Very good, (339 reviews)
"Breakfast was good and the motel is located within easy drive to Busch stadium, Union station and Botanical gardens."
United States
Charles
The price is £93
includes taxes & fees
19 Jul - 20 Jul
Comfort Inn & Suites Saint Louis Lafayette Square
Lobby

Drury Inn & Suites St. Louis Collinsville

Drury Inn & Suites St. Louis Collinsville
3.0 star property
Eastport, 1.6 mi from Uptown
9.6 out of 10, Exceptional, (1,004 reviews)
"We returned to this property after staying there last week. It was a great value."
United States
Maryanna
The price is £93
includes taxes & fees
2 Jul - 3 Jul
Drury Inn & Suites St. Louis Collinsville
Free daily buffet breakfast

Best Western St. Louis Fairview Heights

Best Western St. Louis Fairview Heights
2.5 star property
4.6 mi from Uptown
8.0 out of 10, Very good, (16 reviews)
"The room was clean well kept and a good location!!"
United States
Landra
The price is £68
includes taxes & fees
30 Jun - 1 Jul
Best Western St. Louis Fairview Heights
Exterior

Bel Air Motel

Bel Air Motel
3.5 star property
14.6 mi from Uptown
8.6 out of 10, Excellent, (220 reviews)
"Clean rooms, good stay"
United States
Tai
The price is £67
includes taxes & fees
29 Jun - 30 Jun
Bel Air Motel
Free daily buffet breakfast

Best Western Plus MidAmerica Hotel

Best Western Plus MidAmerica Hotel
2.5 star property
12.4 mi from Uptown
9.0 out of 10, Wonderful, (1,001 reviews)
"Super close to mid America airport. Great breakfast and they had complimentary chili in the evening."
United States
Scot
The price is £98
includes taxes & fees
20 Jul - 21 Jul
Best Western Plus MidAmerica Hotel
Free WiFi, bed sheets

Indian Mound Motel

Indian Mound Motel
2.5 star property
6 mi from Uptown
8.0 out of 10, Very good, (199 reviews)
"Friendly staff, not far from the city. I would definitely stay there again!"
United States
Samantha
The price is £52
includes taxes & fees
29 Jun - 30 Jun
Indian Mound Motel
Indoor pool

Best Western Troy Hotel

Best Western Troy Hotel
2.5 star property
6.3 mi from Uptown
8.0 out of 10, Very good, (992 reviews)
"We stayed at the best western in May 2026. The room was very clean, staff was helpful, we had all that we needed. The breakfast was also great. We would definitely stay here again."
United States
Joyce
The price is £67
includes taxes & fees
29 Jun - 30 Jun
Best Western Troy Hotel
Room, 1 Queen Bed, Jetted Tub | Blackout curtains, free WiFi, bed sheets

Red Lion Inn & Suites Pontoon Beach

Red Lion Inn & Suites Pontoon Beach
2.5 star property
7.6 mi from Uptown
7.8 out of 10, Good, (682 reviews)
"My room was clean with a comfortable bed at a reasonable price. A better option than other similar hotels in the vicinity."
United States
Jim
The price is £62
includes taxes & fees
28 Jun - 29 Jun
Red Lion Inn & Suites Pontoon Beach
Indoor pool

Super 8 by Wyndham Troy IL/St. Louis Area

Super 8 by Wyndham Troy IL/St. Louis Area
2.0 star property
6.2 mi from Uptown
8.0 out of 10, Very good, (1,003 reviews)
"Good customer service well put together hotel"
United States
Donta
The price is £61
includes taxes & fees
28 Jun - 29 Jun
Super 8 by Wyndham Troy IL/St. Louis Area
Bar (on property)

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
4.0 star property
11.1 mi from Uptown
8.8 out of 10, Excellent, (1,308 reviews)
"The staff is wonderful, helpful, and friendly. Great bar and great location. I would definitely stay here again."
United States
Marlynn
The price is £100
includes taxes & fees
12 Jul - 13 Jul
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
Rooftop terrace

Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch
3.0 star property
11.1 mi from Uptown
9.6 out of 10, Exceptional, (3,521 reviews)
"Wonderful place to stay in St Louis! Great location, great staff, wonderful breakfast buffet, and reasonably priced!"
United States
Christopher
The price is £151
includes taxes & fees
28 Jun - 29 Jun
Drury Plaza Hotel St. Louis at the Arch
Lobby

Drury Inn & Suites St. Louis Fairview Heights

Drury Inn & Suites St. Louis Fairview Heights
3.0 star property
4.5 mi from Uptown
9.2 out of 10, Wonderful, (1,007 reviews)
"Great place to stay"
United States
Brad
The price is £87
includes taxes & fees
1 Jul - 2 Jul
Drury Inn & Suites St. Louis Fairview Heights
Exterior

Holiday Inn Express Troy by IHG

Holiday Inn Express Troy by IHG
2.5 star property
6.2 mi from Uptown
9.2 out of 10, Wonderful, (791 reviews)
"Hotel was clean and staff were all very friendly."
United States
Brook
The price is £103
includes taxes & fees
5 Jul - 6 Jul
Holiday Inn Express Troy by IHG
Lobby

Comfort Inn Edwardsville - St. Louis

Comfort Inn Edwardsville - St. Louis
2.5 star property
6.8 mi from Uptown
8.4 out of 10, Very good, (879 reviews)
"Enjoyed my stay! Hotel was nice and convenient"
United States
Renita M.
The price is £85
includes taxes & fees
8 Jul - 9 Jul
Comfort Inn Edwardsville - St. Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Uptown

Find the best Uptown areas for the activities you enjoy most.
An aerial view of a city with a prominent river, a large bridge, and surrounding buildings.

Eastport

While visiting Eastport, you might make a stop by sights like Splash City Family Waterpark and Gateway Conference Center.

Mulberry Hills

Though Mulberry Hills may not have many top sights, you can venture to the surrounding area to see attractions like World's Largest Catsup Bottle and Gateway Conference Center.

A large, historic building with arched windows and a prominent corner entrance.

Historic Downtown Collinsville

Though Historic Downtown Collinsville may not have many top sights, you can venture to the surrounding area to see attractions like World's Largest Catsup Bottle and Gateway Conference Center.

Top Uptown Hotel Reviews

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

8/10 Good
"Historic building in good location. It is next to the convention center and near the metro rail. Several nice restaurants are nearby."
Curtis V VIDDELL 4-night trip
Posted 3 hours ago
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Frequently asked questions

When is the best time to go to Uptown?
The best time to go to Uptown is from late spring (May) to early autumn (September), when the weather is most pleasant for exploring the area.

During these months, you'll find comfortable temperatures, typically ranging from 18°C to 28°C, which is ideal for walking around and enjoying outdoor attractions. The longer daylight hours also mean more time for sightseeing and relaxing by the lakefront. This period also sees various outdoor events and festivals, adding to the local experience.

Couples looking for a romantic getaway will appreciate the warmer months when they can take leisurely strolls along the lakefront or enjoy an evening meal at one of the many alfresco dining spots. The mild evenings are superb for catching a show at the historic venues in the district.

Solo travellers will find late spring and early autumn convenient for exploring Uptown's diverse offerings without the extreme heat or cold.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Uptown.
How can I save on a Uptown hotel booking with Expedia?
Members always get our best prices. Find our best Uptown hotel deals by joining Expedia's free travel rewards program today. As a member, you can unlock instant savings and member perks when you're logged in to your account. Another tip is to book your hotel and flights together on Expedia, where bundling can result in significant savings.
How much is the nightly rate at a Uptown hotel?
Hotel prices in Uptown often vary, but you can find a great deal on Expedia. Different factors affect nightly hotel rates, such as the time of year or the days of the week you want to book. To find the best deals for your stay, be flexible with your dates, and sort search results by "Price: low to high" for our cheapest rates.