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Check prices for these dates

This weekend
14 Aug - 16 Aug
Next weekend
21 Aug - 23 Aug

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Our top choices for Uptown hotels

Lobby

1. Drury Inn & Suites St. Louis Collinsville

Drury Inn & Suites St. Louis Collinsville
3.0 star property
Eastport, 1.6 mi from Uptown
9.6 out of 10, Exceptional, (1,000 reviews)
"Excellent stay everytime !"
United States
Cheryl
The price is £95
includes taxes & fees
20 Aug - 21 Aug
Drury Inn & Suites St. Louis Collinsville
Free daily buffet breakfast

2. Comfort Inn Collinsville near St. Louis

Comfort Inn Collinsville near St. Louis
2.5 star property
Eastport, 1.7 mi from Uptown
8.6 out of 10, Excellent, (1,000 reviews)
"It was a three night stay the property was clean nice buffet breakfast a bit noisy overall but otherwise a good stay"
United States
tina
The price is £80
includes taxes & fees
30 Aug - 31 Aug
Comfort Inn Collinsville near St. Louis
Deluxe Suite, 1 King Bed, Non Smoking | Premium bedding, in-room safe, desk, iron/ironing board

3. Days Inn by Wyndham Collinsville/St. Louis

Days Inn by Wyndham Collinsville/St. Louis
2.5 star property
Eastport, 1.7 mi from Uptown
7.4 out of 10, Good, (1,000 reviews)
"No frills, affordable, convenient location."
United States
Michael
The price is £54
includes taxes & fees
18 Aug - 19 Aug
Days Inn by Wyndham Collinsville/St. Louis
Desk, laptop workspace, blackout curtains, iron/ironing board

4. Super 8 by Wyndham Collinsville St. Louis

Super 8 by Wyndham Collinsville St. Louis
2.0 star property
Eastport, 1.7 mi from Uptown
7.0 out of 10, Good, (1,001 reviews)
"Clean room and friendly staff."
United States
Annett
The price is £45
includes taxes & fees
17 Aug - 18 Aug
Super 8 by Wyndham Collinsville St. Louis
Exterior

5. La Quinta Inn & Suites by Wyndham Collinsville - St. Louis

La Quinta Inn & Suites by Wyndham Collinsville - St. Louis
3.0 star property
Eastport, 1.8 mi from Uptown
7.4 out of 10, Good, (1,013 reviews)
"Great stay. Staff was friendly and hotel was very clean! Would stay again and recommend to others."
United States
Taylor
The price is £77
includes taxes & fees
14 Sept - 15 Sept
La Quinta Inn & Suites by Wyndham Collinsville - St. Louis
Two double bed non smoking | In-room safe, blackout curtains, free cots/infant beds, free WiFi

6. Hampton Inn Collinsville

Hampton Inn Collinsville
2.5 star property
Eastport, 1.7 mi from Uptown
8.4 out of 10, Very good, (732 reviews)
"Very clean and helpful staff."
United States
Ria
The price is £86
includes taxes & fees
30 Aug - 31 Aug
Hampton Inn Collinsville
Lobby

7. DoubleTree by Hilton Collinsville - St. Louis

DoubleTree by Hilton Collinsville - St. Louis
4.0 star property
Eastport, 1.6 mi from Uptown
8.2 out of 10, Very good, (1,000 reviews)
"Check in was fast and friendly."
United States
Timothy
The price is £105
includes taxes & fees
30 Aug - 31 Aug
DoubleTree by Hilton Collinsville - St. Louis
Standard King Room with Whirlpool - Non Smoking | Desk, laptop workspace, blackout curtains, iron/ironing board

8. Quality Inn O'Fallon - St. Louis - Shiloh

Quality Inn O'Fallon - St. Louis - Shiloh
3.0 star property
5.6 mi from Uptown
7.4 out of 10, Good, (1,001 reviews)
"Great place to stay"
United States
Tammy
The price is £45
includes taxes & fees
20 Aug - 21 Aug
Quality Inn O'Fallon - St. Louis - Shiloh
Free daily buffet breakfast

9. Best Western St. Louis Fairview Heights

Best Western St. Louis Fairview Heights
2.5 star property
4.6 mi from Uptown
7.2 out of 10, Good, (87 reviews)
"The front desk was very nice and helpful the hotel is being remolded but clean. Itwas clean and the Ac blow cold, the breakfast was good for a hotel with different items.Also was in a nice safe area , easy access to the interstate and stores and restaurants me and wife both said we would stay here again"
United States
Joseph
The price is £67
includes taxes & fees
17 Aug - 18 Aug
Best Western St. Louis Fairview Heights
Exterior

10. Holiday Inn Express Troy by IHG

Holiday Inn Express Troy by IHG
2.5 star property
6.2 mi from Uptown
9.2 out of 10, Wonderful, (817 reviews)
"Great hotel."
United States
Farhan
The price is £90
includes taxes & fees
30 Aug - 31 Aug
Holiday Inn Express Troy by IHG
Lobby

11. Drury Inn & Suites St. Louis Fairview Heights

Drury Inn & Suites St. Louis Fairview Heights
3.0 star property
4.5 mi from Uptown
9.2 out of 10, Wonderful, (1,000 reviews)
"The parking was great, the location was easy to get into, the staff was very friendly, and the free breakfast was wonderful!"
United States
Jarrod
The price is £75
includes taxes & fees
23 Aug - 24 Aug
Drury Inn & Suites St. Louis Fairview Heights
Indoor pool

12. Best Western Troy Hotel

Best Western Troy Hotel
2.5 star property
6.3 mi from Uptown
8.0 out of 10, Very good, (1,001 reviews)
"We stayed at the best western in May 2026. The room was very clean, staff was helpful, we had all that we needed. The breakfast was also great. We would definitely stay here again."
United States
Joyce
The price is £73
includes taxes & fees
18 Aug - 19 Aug
Best Western Troy Hotel
Lobby

13. Comfort Inn Edwardsville - St. Louis

Comfort Inn Edwardsville - St. Louis
2.5 star property
6.8 mi from Uptown
8.4 out of 10, Very good, (909 reviews)
"Great and helpful staff , parking and clean property"
United States
Debra
The price is £81
includes taxes & fees
3 Sept - 4 Sept
Comfort Inn Edwardsville - St. Louis
Desk, laptop workspace, blackout curtains

14. Super 8 by Wyndham Fairview Heights-St. Louis

Super 8 by Wyndham Fairview Heights-St. Louis
2.0 star property
4.5 mi from Uptown
6.6 out of 10, (1,000 reviews)
"Convenient to shopping"
United States
Danny G
The price is £43
includes taxes & fees
17 Aug - 18 Aug
Super 8 by Wyndham Fairview Heights-St. Louis
Breakfast, lunch and dinner served

15. Radisson Hotel Fairview Heights - St. Louis

Radisson Hotel Fairview Heights - St. Louis
3.0 star property
4.3 mi from Uptown
7.6 out of 10, Good, (673 reviews)
"Nice Staff"
United States
Shalonda
The price is £83
includes taxes & fees
17 Aug - 18 Aug
Radisson Hotel Fairview Heights - St. Louis
Indoor pool

16. Hampton Inn O'Fallon

Hampton Inn O'Fallon
2.5 star property
6.8 mi from Uptown
9.2 out of 10, Wonderful, (867 reviews)
"Clean rooms and exactellent staff"
United States
Gary
The price is £94
includes taxes & fees
23 Aug - 24 Aug
Hampton Inn O'Fallon
Breakfast and dinner served

17. Holiday Inn St. Louis Fairview Heights by IHG

Holiday Inn St. Louis Fairview Heights by IHG
3.0 star property
4.5 mi from Uptown
8.6 out of 10, Excellent, (702 reviews)
"The room was really nice and helpful! The pool was very nice and it’s very clean!"
United States
Janay
The price is £96
includes taxes & fees
13 Sept - 14 Sept
Holiday Inn St. Louis Fairview Heights by IHG
Standard Room, 2 Queen Beds, Non Smoking | Premium bedding, pillow-top beds, desk, blackout curtains

18. Econo Lodge Inn & Suites Fairview Heights - St. Louis

Econo Lodge Inn & Suites Fairview Heights - St. Louis
2.0 star property
4.5 mi from Uptown
7.4 out of 10, Good, (641 reviews)
"Great place and location very clean"
United States
devon
The price is £57
includes taxes & fees
13 Sept - 14 Sept
Econo Lodge Inn & Suites Fairview Heights - St. Louis
Indoor pool

19. Sleep Inn O'Fallon near I-64

Sleep Inn O'Fallon near I-64
2.5 star property
5.8 mi from Uptown
6.8 out of 10, (995 reviews)
"Nice. Thanks for giving us a safe place to sleep on our journey."
United States
Lark
The price is £56
includes taxes & fees
17 Aug - 18 Aug
Sleep Inn O'Fallon near I-64
Lobby lounge

20. Red Roof Inn St Louis - Troy, IL

Red Roof Inn St Louis - Troy, IL
2.0 star property
6.3 mi from Uptown
7.8 out of 10, Good, (1,001 reviews)
"The bed is comfy; the shower is hot; the coffee is delicious."
United States
Rebecca
The price is £59
includes taxes & fees
20 Aug - 21 Aug
Red Roof Inn St Louis - Troy, IL
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Uptown

Find the best Uptown areas for the activities you enjoy most.
An aerial view of a city with a prominent river, a large bridge, and surrounding buildings.

Eastport

While visiting Eastport, you might make a stop by sights like Gateway Conference Center and Splash City Family Waterpark.

Mulberry Hills

Though Mulberry Hills may not have many top sights, you can venture to the surrounding area to see attractions like World's Largest Catsup Bottle and Gateway Conference Center.

A large, historic building with arched windows and a prominent corner entrance.

Historic Downtown Collinsville

Though Historic Downtown Collinsville may not have many top sights, you can venture to the surrounding area to see attractions like World's Largest Catsup Bottle and Gateway Conference Center.

Top Uptown Hotel Reviews

River City Casino & Hotel

River City Casino & Hotel

10/10 Excellent
"Overall very good"
CHRISTINE 1-night trip
Posted 1 hour ago
River City Casino & Hotel

Frequently asked questions

When is the best time to go to Uptown?
The best time to go to Uptown is from late spring (May) to early autumn (September), when the weather is most pleasant for exploring the area.

During these months, you'll find comfortable temperatures, typically ranging from 18°C to 28°C, which is ideal for walking around and enjoying outdoor attractions. The longer daylight hours also mean more time for sightseeing and relaxing by the lakefront. This period also sees various outdoor events and festivals, adding to the local experience.

Couples looking for a romantic getaway will appreciate the warmer months when they can take leisurely strolls along the lakefront or enjoy an evening meal at one of the many alfresco dining spots. The mild evenings are superb for catching a show at the historic venues in the district.

Solo travellers will find late spring and early autumn convenient for exploring Uptown's diverse offerings without the extreme heat or cold.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Uptown.
How much is the nightly rate at a Uptown hotel?
Hotel prices in Uptown often vary, but you can find a great deal on Expedia. Different factors affect nightly hotel rates, such as the time of year or the days of the week you want to book. To find the best deals for your stay, be flexible with your dates, and sort search results by "Price: low to high" for our cheapest rates.