Midtown Travel Guide
St. Louis
Popular places to visit
St. Louis University
Explore the campus of St. Louis University during your stay in St. Louis. Wander around the area's picturesque gardens or experience its great live music.
Scott Joplin House State Historic Site
Learn about the local history of St. Louis when you take a trip to Scott Joplin House State Historic Site. Experience the area's great live music or attend a baseball game.
St. Louis Union Station
You can learn more about the history of St. Louis during your trip to a well-known site such as St. Louis Union Station. Experience the area's acclaimed art galleries or attend a baseball game.
Busch Stadium
Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's great live music or attend a baseball game.
Gateway Arch
Enjoy 360-degree views and learn about the history of St. Louis at this world-famous landmark.
St. Louis Zoo
In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.
Things to do
St. Louis Ghost Tour: Sinister Sins & Shadows
Downtown St. Louis Smartphone Guided Audio Walking Tour App
St Louis Ghost Tours: Sinister Sins & Shadows Ghost Tour
St. Louis Premium Small Group Tour With Arch & River Cruise
St Louis Self-Guided Driving and Walking Audio Tour
St. Louis Premium Driving Tour with Boat Ride & Arch
Top hotels in Midtown
Element St. Louis Midtown
Staff was excellent amenities are plentiful. Just the details of the room have to be approved upon, loose fixtures, and the showerhead was half clogged. To the point where it was hard to rinse off. Faucet was loose. The heater was not working correctly. Appliances were beat up in dinged
Reviewed on 1 Feb 2026
21C Museum Hotel St Louis
Hotel was very quiet and staff helpful and courteous. The coffee shop was great for coffee and breakfast and the rooms were clean with hot water and great water pressure. The only thing I would change was the mattress - bed was very firm, kind of felt like lying on a table. Gallery was a fun feature ...
Reviewed on 3 Feb 2026
Clayton Plaza Hotel & Extended Stay
Staff always pleasant
Reviewed on 2 Feb 2026
Pear Tree Inn St. Louis Airport
Staff was incredibly kind and helpful. They sent a shuttle to pick me up at the car rental place! The room was clean, the beds were comfortable, and the breakfast buffet had great options, even for our gluten-free family member.
Reviewed on 5 Feb 2026
Drury Plaza Hotel St. Louis at the Arch
Yes… never was in a hotel where complimentary dinner included.
Reviewed on 5 Feb 2026
Hyatt Regency St. Louis at The Arch
View of Gateway Arch, early check-in, friendly staff, walkable
Reviewed on 4 Feb 2026
Other neighbourhoods around Midtown
The Gate
While The Gate may not have many sights to explore, venturing just a little farther will lead you to top things to see and do like St. Louis Union Station and Busch Stadium.
Downtown West
While visiting Downtown West, you might make a stop by sights like St. Louis Union Station and St. Louis Aquarium at Union Station.
Lafayette Square
The restaurants and shopping are a few reasons travellers visit Lafayette Square. Want to see more of the surrounding area? St. Louis Union Station and Busch Stadium are a few top sights nearby.
The Grove
While there might not be top attractions in The Grove, you can explore the larger area and discover places like St. Louis Science Center and Missouri Botanical Gardens and Arboretum.
Shaw
Shaw might not have many top sights, but Missouri Botanical Gardens and Arboretum and St. Louis Science Center are two attractions nearby that you can check out.
Central West End
If you're looking for things to see and do in Central West End, ample dining options and lush forests are highlights. You might also check out World Chess Hall of Fame while you're visiting, and jump aboard the metro at Central West End Station to get around town.
