Search Business Hotels in Southwest Missouri

Check prices for these dates

Tonight
13 Nov - 14 Nov
Tomorrow
14 Nov - 15 Nov
This weekend
13 Nov - 15 Nov
Next weekend
20 Nov - 22 Nov

Our top choices for Southwest Missouri business-friendly hotels

A hotel room with a bed, bedside table, lamp, and a painting of a sunset.

1. Clarion Pointe Springfield Southeast

Clarion Pointe Springfield Southeast
2.5 star property
Galloway Village
9.6 out of 10, Exceptional, (369 reviews)
"Great clean, well lit hotel"
United States
Cesar
The price is £72
includes taxes & fees
6 Dec - 7 Dec
Clarion Pointe Springfield Southeast
A La Quinta hotel entrance with a modern design, featuring a prominent logo, a covered entrance, and a landscaped front with benches and potted plants.

2. La Quinta Inn & Suites by Wyndham Springfield Airport/Rte 66

La Quinta Inn & Suites by Wyndham Springfield Airport/Rte 66
3.0 star property
Tom Watkins
9.0 out of 10, Wonderful, (1,014 reviews)
"The hotel was clean and nicely decorated. The staff was polite and helpful. The breakfast was adequate and food was warm."
United States
Deborah
The price is £83
includes taxes & fees
22 Nov - 23 Nov
La Quinta Inn & Suites by Wyndham Springfield Airport/Rte 66
A modern breakfast area with a central island, bar stools, and a variety of food items and beverages.

3. Tru by Hilton Springfield Downtown

Tru by Hilton Springfield Downtown
2.5 star property
Downtown Springfield
9.2 out of 10, Wonderful, (1,001 reviews)
"Loved our stay, breakfast had many options, and the staff was very helpful."
United States
Gloria
The price is £82
includes taxes & fees
29 Nov - 30 Nov
Tru by Hilton Springfield Downtown
A modern hotel room with a large bed, a desk with a sink, and a view of the cityscape through large windows.

4. Hotel Vandivort

Hotel Vandivort
4.0 star property
Downtown Springfield
9.4 out of 10, Exceptional, (1,006 reviews)
"Great unique property in a historic downtown building. Building is beautiful, staff is great"
United States
Andrew
The price is £146
includes taxes & fees
20 Nov - 21 Nov
Hotel Vandivort
A spacious indoor area with multiple seating arrangements, including tables and chairs, and a bar area with stools.

5. Best Western Premier Springfield Plaza District Hotel

Best Western Premier Springfield Plaza District Hotel
3.0 star property
Oak Grove
9.0 out of 10, Wonderful, (1,001 reviews)
"Unique hotel, room was great, bar n restaurant were perfect for a good quick meal or have a drink and the breakfast was better than most hotels."
United States
brett
The price is £70
includes taxes & fees
23 Nov - 24 Nov
Best Western Premier Springfield Plaza District Hotel
A spacious indoor dining area with multiple tables and chairs, a kitchen area, and large windows allowing natural light.

6. Drury Inn & Suites Springfield, MO

Drury Inn & Suites Springfield, MO
3.0 star property
Springfield
9.4 out of 10, Exceptional, (1,000 reviews)
"Nice hotel!"
United States
Barbara
The price is £88
includes taxes & fees
6 Dec - 7 Dec
Drury Inn & Suites Springfield, MO
An outdoor seating area with wicker chairs and a fire feature.

7. Holiday Inn Express & Suites Springfield North by IHG

Holiday Inn Express & Suites Springfield North by IHG
2.5 star property
Springfield
9.4 out of 10, Exceptional, (1,000 reviews)
"Good place to stay. Would stay again"
United States
Jerry
The price is £85
includes taxes & fees
13 Dec - 14 Dec
Holiday Inn Express & Suites Springfield North by IHG
A spacious lobby with multiple seating areas, a piano, and a large wall with leaf decorations.

8. DoubleTree by Hilton Springfield

DoubleTree by Hilton Springfield
4.0 star property
Doling
8.8 out of 10, Excellent, (1,001 reviews)
"clean and they accommodated me close to elevator."
United States
Nancy
The price is £99
includes taxes & fees
22 Nov - 23 Nov
DoubleTree by Hilton Springfield
A hotel room with a bed, a sofa, a coffee table, a desk, and a mirror.

9. Best Western Plus Springfield Airport Inn

Best Western Plus Springfield Airport Inn
2.5 star property
Springfield
9.0 out of 10, Wonderful, (1,001 reviews)
"Clean room close to the airport with shuttle service."
United States
Charlotte
The price is £94
includes taxes & fees
27 Nov - 28 Nov
Best Western Plus Springfield Airport Inn
A hotel room with a large bed, a desk with a chair, a television, and a microwave.

10. Best Western Route 66 Rail Haven

Best Western Route 66 Rail Haven
2.5 star property
Walnut Street
8.6 out of 10, Excellent, (1,000 reviews)
"Clean room and pet friendly."
United States
Michael
The price is £80
includes taxes & fees
22 Nov - 23 Nov
Best Western Route 66 Rail Haven
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Southwest Missouri Hotel Reviews

A lobby with a fireplace, sofas, a coffee table, and a large window offering a view of the outside.
Lodge Of The Ozarks

Lodge Of The Ozarks

Lodge Of The Ozarks
Branson Theater District

10/10 Excellent

Fantastic location
United Kingdom
Jon
Reviewed September 19, 2025
Lodge Of The Ozarks

Frequently Asked Questions

How much do business hotels in Southwest Missouri cost?

Business hotels in Southwest Missouri range between £70 and £146 per night. This means you can reserve a property with amenities like conference rooms and workspaces at a price that fits your work budget. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.

How many business hotels are there in Southwest Missouri?

Southwest Missouri has 2,246 business hotels to pick from. Whether you're hosting a conference or meeting or simply working remotely, these stays are equipped with the services and amenities you need to be productive.

Why book your business hotel in Southwest Missouri with Expedia?

Here at Expedia, it's our job to help you land the ideal stay at the right price. From fancy, corporate-friendly properties to affordable motels filled with handy amenities, you'll have your next work trip arranged in a few quick clicks.

How can I find cheap business hotels in Southwest Missouri?

Select the "business friendly" filter, listed under the "traveller experience" heading, to find cheap business hotels in Southwest Missouri. Then refine your search by your budget and preferred hotel star rating. Staying away from the centre is another easy way to save.

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