Title: TOP Luxury Hotels in Southern Minnesota, MN for 2026 - Southern Minnesota Upscale Hotels | Expedia.co.uk [Southern Minnesota Travel Guide](https://expedia.co.uk/Southern-Minnesota.dx6059950)[Hotels in Southern Minnesota](https://expedia.co.uk/Southern-Minnesota-Hotels.d6059950.Travel-Guide-Hotels)[Holiday Rentals in Southern Minnesota](https://expedia.co.uk/Southern-Minnesota-Holiday-Rentals.d6059950.Travel-Guide-HolidayRentals)[Flights to Southern Minnesota](https://expedia.co.uk/Cheap-Flights-To-Southern-Minnesota.d6059950.Travel-Guide-Flights)[Southern Minnesota Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Southern-Minnesota.d6059950.Car-Hire-Guide)[Southern Minnesota Holidays](https://expedia.co.uk/Southern-Minnesota.d6059950.Holidays-City-Breaks) ![Lake Pepin & Mississippi River Scenic View](https://images.trvl-media.com/place/553248621532649642/b0facbcd-16cb-4461-946e-105f314f35fc.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/553248621532649642/b0facbcd-16cb-4461-946e-105f314f35fc.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Southern Minnesota Luxury Hotels Tonight [4 Feb - 5 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6059950&startDate=2026-02-04&endDate=2026-02-05&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [5 Feb - 6 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6059950&startDate=2026-02-05&endDate=2026-02-06&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [6 Feb - 8 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6059950&startDate=2026-02-06&endDate=2026-02-08&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [13 Feb - 15 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6059950&startDate=2026-02-13&endDate=2026-02-15&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Our top choices for Southern Minnesota luxury hotels ![Front of property – evening/night](https://images.trvl-media.com/lodging/17000000/16120000/16119600/16119557/978fdbcd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/17000000/16120000/16119600/16119557/c5ed6677.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Concierge desk](https://images.trvl-media.com/lodging/17000000/16120000/16119600/16119557/5b562205.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/17000000/16120000/16119600/16119557/acf22658.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Towers At Kahler Grand Hotel [](https://www.expedia.co.uk/Rochester-Hotels-The-Towers-At-Kahler-Grand-Hotel.h16119557.Hotel-Information) Downtown Rochester 9.4/10 Exceptional (96 reviews) "Excellent accommodations, amazing staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Shannon £337 includes taxes & fees 6 Feb - 7 Feb [](https://www.expedia.co.uk/Rochester-Hotels-The-Towers-At-Kahler-Grand-Hotel.h16119557.Hotel-Information) ![Courtyard](https://images.trvl-media.com/lodging/60000000/59620000/59619600/59619526/21638bcd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/60000000/59620000/59619600/59619526/937e6b61.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast and dinner served](https://images.trvl-media.com/lodging/60000000/59620000/59619600/59619526/fc2af524.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/60000000/59620000/59619600/59619526/6a0aeefd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### EVEN Hotel Rochester - Mayo Clinic Area by IHG [](https://www.expedia.co.uk/Rochester-Hotels-Even-Rochester-St-Marys-Area.h59619526.Hotel-Information) Kutzky Park 9.4/10 Exceptional (989 reviews) "Great hotel!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Narcedalia £86 includes taxes & fees 7 Feb - 8 Feb [](https://www.expedia.co.uk/Rochester-Hotels-Even-Rochester-St-Marys-Area.h59619526.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/1000000/10000/2300/2270/03b116ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/10000/2300/2270/6351153f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Suite, 1 King Bed | Hypo-allergenic bedding, in-room safe, desk, blackout curtains](https://images.trvl-media.com/lodging/1000000/10000/2300/2270/047b14ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/2300/2270/75ebda11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### DoubleTree by Hilton Austin, MN [](https://www.expedia.co.uk/Rochester-Hotels-Holiday-Inn-Austin.h2270.Hotel-Information) Austin 8.4/10 Very good (565 reviews) "Room was excellent and the staff was very friendly and accommodating. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) William £62 includes taxes & fees 11 Feb - 12 Feb [](https://www.expedia.co.uk/Rochester-Hotels-Holiday-Inn-Austin.h2270.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/57000000/56950000/56949100/56949056/3051fae1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/57000000/56950000/56949100/56949056/3d82dd2d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Suite, Multiple Beds, Non Smoking | Desk, bed sheets](https://images.trvl-media.com/lodging/57000000/56950000/56949100/56949056/a8e72694.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Suite, Multiple Beds, Non Smoking | Desk, bed sheets](https://images.trvl-media.com/lodging/57000000/56950000/56949100/56949056/49e68d23.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### DoubleTree by Hilton Owatonna [](https://www.expedia.co.uk/Owatonna-Hotels-DoubleTree-By-Hilton-Owatonna.h56949056.Hotel-Information) Owatonna 8.4/10 Very good (21 reviews) "Beautiful facility" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lee £79 includes taxes & fees 11 Feb - 12 Feb [](https://www.expedia.co.uk/Owatonna-Hotels-DoubleTree-By-Hilton-Owatonna.h56949056.Hotel-Information) ![Premium bedding, down duvets, in-room safe, desk](https://images.trvl-media.com/lodging/55000000/54180000/54172300/54172209/90f9b86d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down duvets, in-room safe, desk](https://images.trvl-media.com/lodging/55000000/54180000/54172300/54172209/w4498h3227x2y2-67ce004d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/55000000/54180000/54172300/54172209/b65aee43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down duvets, in-room safe, desk](https://images.trvl-media.com/lodging/55000000/54180000/54172300/54172209/w4500h3279x0y2-db2e0240.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Omni Viking Lakes Hotel [](https://www.expedia.co.uk/Minneapolis-St-Paul-Hotels-Omni-Viking-Lakes-Hotel.h54172209.Hotel-Information) Eagan 9.6/10 Exceptional (1,003 reviews) "Great stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lee £137 includes taxes & fees 8 Feb - 9 Feb [](https://www.expedia.co.uk/Minneapolis-St-Paul-Hotels-Omni-Viking-Lakes-Hotel.h54172209.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/11000000/10530000/10520400/10520324/0ce9e41f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/11000000/10530000/10520400/10520324/2980f0ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillow-top beds, in-room safe, individually decorated](https://images.trvl-media.com/lodging/11000000/10530000/10520400/10520324/06383925.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fireplace](https://images.trvl-media.com/lodging/11000000/10530000/10520400/10520324/2a1c1b2d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Charmant Hotel [](https://www.expedia.co.uk/La-Crosse-Hotels-The-Charmant-Hotel.h10520324.Hotel-Information) Historic Downtown La Crosse 9.6/10 Exceptional (1,000 reviews) "Great place!! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lynn £129 includes taxes & fees 8 Feb - 9 Feb [](https://www.expedia.co.uk/La-Crosse-Hotels-The-Charmant-Hotel.h10520324.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-02-19&endDate=2026-02-20®ionId=6059950&adults=2&sort=LUXURY&star=40,50&openPlayBack=true) ## Find out more about Southern Minnesota ### Southern Minnesotaand its attractions for luxury travelers Southern Minnesota is a hidden gem for luxury travellers seeking a blend of natural beauty and refined experiences. Start your journey in Rochester, home to the exquisite Mayo Clinic and the nearby serene Quarry Hill Nature Center, where you can explore scenic trails and enjoy peaceful picnics amidst lush landscapes. For a taste of culture, visit the historic city of Mankato, where the vibrant arts scene and local wineries offer delightful tastings and events, perfect for indulging your palate. The picturesque scenery of the Minnesota River Valley invites guests to enjoy scenic boat tours or private wine tastings at local vineyards, providing a splendid way to unwind. Nature lovers can also immerse themselves in the breathtaking vistas of the bluff country in and around Winona, where luxury lodgings allow you to wake up to stunning river views. For an unforgettable stay, consider the luxurious hotels in Rochester, which offer top amenities and exceptional service, ensuring every aspect of your visit is pampered and tailored to your preferences. ## Top Southern Minnesota Hotel Reviews ![Kahler Inn and Suites - Mayo Clinic Area](https://images.trvl-media.com/lodging/1000000/180000/171600/171566/e56e7dae_y.jpg) ### Kahler Inn and Suites - Mayo Clinic Area 10/10 Excellent "clean w friendly staff" [](https://expedia.co.uk/Rochester-Hotels-Kahler-Inn-And-Suites-Mayo-Clinic-Area.h171566.Hotel-Information) ![Kahler Grand Hotel](https://images.trvl-media.com/lodging/1000000/30000/25600/25516/a12994da_y.jpg) ### Kahler Grand Hotel 10/10 Excellent "Overall hospitality " [](https://expedia.co.uk/Rochester-Hotels-Kahler-Grand-Hotel.h25516.Hotel-Information) ![Holiday Inn Express Rochester South - Mayo Area by IHG](https://images.trvl-media.com/lodging/3000000/2190000/2185000/2184971/62a372dd_y.jpg) ### Holiday Inn Express Rochester South - Mayo Area by IHG 10/10 Excellent "Staff was very friendly, facilities were clean, nice breakfast area, pool area was clean. Room was very nice and large. We had no issues and will stay again at our next Mayo visit! " [](https://expedia.co.uk/Rochester-Hotels-Comfort-Suites.h2184971.Hotel-Information) ![AmericInn by Wyndham Rochester Near Mayo Clinic](https://images.trvl-media.com/lodging/1000000/10000/8100/8008/71b6fb30_y.jpg) ### AmericInn by Wyndham Rochester Near Mayo Clinic 10/10 Excellent "The room was beautiful and spacious for my family and I. The staff I encountered was very friendly and helpful but a specific gentleman was especially helpful with every greeting, he had a smile and was extremely informational even with my kods Playstation! 5 stars and i would definitely stay here again as well as recommend others to stay here. 😃 ❤️ 💙 " [](https://expedia.co.uk/Rochester-Hotels-Ramada-By-Wyndham-Rochester-Mayo-Clinic-Area.h8008.Hotel-Information) ![Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area](https://images.trvl-media.com/lodging/1000000/10000/3600/3556/b33056f7_y.jpg) ### Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area 10/10 Excellent "The hotel was clean. I still do not like your small pillows, but the rest of the bedding were super comfortable. The staff were friendly and helpful. " [](https://expedia.co.uk/Rochester-Hotels-Centerstone-Plaza-Hotel-Soldiers-FieldMayo-Clinic-Area.h3556.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S](https://images.trvl-media.com/lodging/8000000/7780000/7772100/7772018/569eb353_y.jpg) ### La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S 10/10 Excellent "It was nice and clean. The halls was quiet " [](https://expedia.co.uk/Rochester-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Rochester-Mayo-Clinic-S.h7772018.Hotel-Information) ![Brentwood Inn & Suites](https://images.trvl-media.com/lodging/11000000/10010000/10007700/10007613/d36e6ac3_y.jpg) ### Brentwood Inn & Suites 10/10 Excellent "Clean" [](https://expedia.co.uk/Rochester-Hotels-Brentwood-Inn-Suites.h10007613.Hotel-Information) ![St James Hotel, a Historic Hotel of America](https://images.trvl-media.com/lodging/1000000/10000/8900/8820/c90b9231_y.jpg) ### St James Hotel, a Historic Hotel of America 10/10 Excellent "The location from the train was perfect! We were met with helpful and kind staff. Our room was sweet and comfortable. We ate at both the Scarlet and The Port. Both were excellent." 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