Title: TOP Luxury Hotels in Southern Minnesota, MN for 2025 - Southern Minnesota Upscale Hotels | Expedia.co.uk [Southern Minnesota Travel Guide](https://expedia.co.uk/Southern-Minnesota.dx6059950)[Hotels in Southern Minnesota](https://expedia.co.uk/Southern-Minnesota-Hotels.d6059950.Travel-Guide-Hotels)[Holiday Rentals in Southern Minnesota](https://expedia.co.uk/Southern-Minnesota-Holiday-Rentals.d6059950.Travel-Guide-HolidayRentals)[Flights to Southern Minnesota](https://expedia.co.uk/Cheap-Flights-To-Southern-Minnesota.d6059950.Travel-Guide-Flights)[Southern Minnesota Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Southern-Minnesota.d6059950.Car-Hire-Guide)[Southern Minnesota Holidays](https://expedia.co.uk/Southern-Minnesota.d6059950.Holidays-City-Breaks) ![Rochester showing skyline and a city](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/63000/63803-Rochester.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find luxury hotels in Southern Minnesota, MN - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Southern Minnesota Luxury Hotels Tonight [3 Nov - 4 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6059950&startDate=2025-11-03&endDate=2025-11-04&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [4 Nov - 5 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6059950&startDate=2025-11-04&endDate=2025-11-05&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [7 Nov - 9 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6059950&startDate=2025-11-07&endDate=2025-11-09&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [14 Nov - 16 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6059950&startDate=2025-11-14&endDate=2025-11-16&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Top Southern Minnesota Luxury Hotels ![Front of property – evening/night](https://images.trvl-media.com/lodging/1000000/30000/25600/25516/a12994da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 2 Double Beds | Premium bedding, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/1000000/30000/25600/25516/f91e65d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Bedrooms | Living area | TV, pay films](https://images.trvl-media.com/lodging/1000000/30000/25600/25516/45535621.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/30000/25600/25516/ecda08e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Kahler Grand Hotel Downtown Rochester 8.2/10 Very good (1707) "Perfect place to stay if you have appointments at Mayo " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tessa £117 includes taxes & fees 5 Nov - 6 Nov [](https://www.expedia.co.uk/Rochester-Hotels-Kahler-Grand-Hotel.h25516.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/1000000/480000/471600/471550/c539222f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/480000/471600/471550/13696772.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast ](https://images.trvl-media.com/lodging/1000000/480000/471600/471550/0fa2acf1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/480000/471600/471550/39a14f28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### AmericInn by Wyndham Blue Earth Blue Earth 7.8/10 Good (455) "This hotel has good breakfast and it's just off I90 and highway 169." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Eilene £72 includes taxes & fees 30 Nov - 1 Dec [](https://www.expedia.co.uk/Fairmont-Hotels-AmericInn-By-Wyndham-Blue-Earth.h471550.Hotel-Information) ![Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/10000/4200/4106/4b21fb74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/10000/4200/4106/f78e7c09.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 indoor pools](https://images.trvl-media.com/lodging/1000000/10000/4200/4106/6897f3e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Arcade](https://images.trvl-media.com/lodging/1000000/10000/4200/4106/ced48756.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Med City Inn & Suites - Mayo Clinic Area Kutzky Park 7.8/10 Good (1015) "Good rate for a reasonable stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mike £63 includes taxes & fees 4 Nov - 5 Nov [](https://www.expedia.co.uk/Rochester-Hotels-GuestHouse-Rochester.h4106.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/9000000/8150000/8145400/8145327/f7403b77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Non Smoking | Desk, blackout curtains, soundproofing, iron/ironing board](https://images.trvl-media.com/lodging/9000000/8150000/8145400/8145327/9f9116a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/9000000/8150000/8145400/8145327/90ab369f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/9000000/8150000/8145400/8145327/416983a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### AmericInn by Wyndham Northfield Northfield 8.2/10 Very good (615) "Had a great stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kristin £74 includes taxes & fees 4 Dec - 5 Dec [](https://www.expedia.co.uk/Owatonna-Hotels-AmericInn-By-Wyndham-Northfield.h8145327.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/855300/855258/71230855.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/855300/855258/2ce5782f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/855300/855258/5b2b2f4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Non Smoking, Kitchenette | In-room safe, desk, blackout curtains, soundproofing](https://images.trvl-media.com/lodging/1000000/860000/855300/855258/eb63d9ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Jackson MN Jackson 8.0/10 Very good (598) "The staff was very helpful, the building is well kept, rooms were clean and spacious. I would stay there again " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Daniel £61 includes taxes & fees 29 Nov - 30 Nov [](https://www.expedia.co.uk/Worthington-Hotels-Super-8-By-Wyndham-Jackson-MN.h855258.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/1000000/460000/459800/459757/f9d660c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/460000/459800/459757/39bea812.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/460000/459800/459757/c50d2d73.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/bathtub, designer toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/1000000/460000/459800/459757/c00e3044.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Coratel Inn & Suites By Jasper Northfield Northfield 6.2/10 (642) "For a 2 star hotel, it beat my expectations!! Staff is awesome, rooms are not that bad. A little old building and rooms not 5star level, but you get what you pay for . Would come here again. Easy parking as well. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Andrey £50 includes taxes & fees 9 Nov - 10 Nov [](https://www.expedia.co.uk/Owatonna-Hotels-Coratel-Inn-Suites-Northfield.h459757.Hotel-Information) ![Room, 2 Queen Beds | Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/180000/171600/171566/e56e7dae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Flat-screen TV, pay films](https://images.trvl-media.com/lodging/1000000/180000/171600/171566/9d7d5e02.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/180000/171600/171566/053999c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/180000/171600/171566/5e158908.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Kahler Inn and Suites - Mayo Clinic Area Downtown Rochester 8.0/10 Very good (1485) "Very friendly and helpful staff " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Monte £116 includes taxes & fees 8 Nov - 9 Nov [](https://www.expedia.co.uk/Rochester-Hotels-Kahler-Inn-And-Suites-Mayo-Clinic-Area.h171566.Hotel-Information) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/11000000/10010000/10007700/10007613/d36e6ac3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/11000000/10010000/10007700/10007613/abb2c83e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/11000000/10010000/10007700/10007613/10fbc765.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/11000000/10010000/10007700/10007613/a518fccf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Brentwood Inn & Suites Downtown Rochester 8.8/10 Excellent (1007) "This hotel is very convenient and affordable for appointments at Mayo. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mary £98 includes taxes & fees 5 Nov - 6 Nov [](https://www.expedia.co.uk/Rochester-Hotels-Brentwood-Inn-Suites.h10007613.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/25400/25338/046c7ce7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/30000/25400/25338/95539a8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/30000/25400/25338/71dead3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast ](https://images.trvl-media.com/lodging/1000000/30000/25400/25338/45a7c6c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Winona Winona 7.8/10 Good (1001) "Really nice area and very nice Days Inn room clean and cozy. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Robert £47 includes taxes & fees 9 Nov - 10 Nov [](https://www.expedia.co.uk/Winona-Hotels-Days-Inn-By-Wyndham-Winona.h25338.Hotel-Information) ![Standard Room, 1 Queen Bed, Non Smoking | Blackout curtains, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/50000/43500/43416/c82aecae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/43500/43416/c992fc57.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/1000000/50000/43500/43416/90117589.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/43500/43416/2bd6f3e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Regency Inn & Suites Faribault 7.4/10 Good (626) "The air conditioner did not seem to work, the temps were cool enough outside to have the window open. Not a big deal at the time. Our stay was just great. and quiet...Thank You Very Much!!! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) LIsa £65 includes taxes & fees 4 Nov - 5 Nov [](https://www.expedia.co.uk/Owatonna-Hotels-Regency-Inn-Suites.h43416.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-11-17&endDate=2025-11-18®ionId=6059950&adults=2&star=50&sort=RECOMMENDED&openPlayBack=true) ## Find out more about Southern Minnesota ### Southern Minnesotaand its attractions for luxury travelers Southern Minnesota is a hidden gem for luxury travellers seeking a blend of natural beauty and refined experiences. Start your journey in Rochester, home to the exquisite Mayo Clinic and the nearby serene Quarry Hill Nature Center, where you can explore scenic trails and enjoy peaceful picnics amidst lush landscapes. For a taste of culture, visit the historic city of Mankato, where the vibrant arts scene and local wineries offer delightful tastings and events, perfect for indulging your palate. The picturesque scenery of the Minnesota River Valley invites guests to enjoy scenic boat tours or private wine tastings at local vineyards, providing a splendid way to unwind. Nature lovers can also immerse themselves in the breathtaking vistas of the bluff country in and around Winona, where luxury lodgings allow you to wake up to stunning river views. For an unforgettable stay, consider the luxurious hotels in Rochester, which offer top amenities and exceptional service, ensuring every aspect of your visit is pampered and tailored to your preferences. ## Top Southern Minnesota Hotel Reviews ![Brentwood Inn & Suites](//images.trvl-media.com/lodging/11000000/10010000/10007700/10007613/d36e6ac3_y.jpg) ### Brentwood Inn & Suites 10/10 Excellent "This hotel is one of the cleanest hotels I have ever stayed in. And we travel A LOT. It’s not the most up to date. But we have stayed here twice and both times, every single corner is spotless. Also, the service is amazing. They also clean the rooms every single day, which since Covid, most hotels don’t anymore. The continental breakfast is small. It does offer omelettes, French toast and sausage. It’s cold and needs to be heated up. But it wasn’t bad tasting. The subway to the hospital is convenient. Always had hot water, air conditioning worked amazing, very quiet…… I have ZERO complaints. " [](https://expedia.co.uk/Rochester-Hotels-Brentwood-Inn-Suites.h10007613.Hotel-Information) ![Kahler Inn and Suites - Mayo Clinic Area](//images.trvl-media.com/lodging/1000000/180000/171600/171566/e56e7dae_y.jpg) ### Kahler Inn and Suites - Mayo Clinic Area 10/10 Excellent "Rooms very clean staff was very helpful. Could of had a bar. Thank you very much" [](https://expedia.co.uk/Rochester-Hotels-Kahler-Inn-And-Suites-Mayo-Clinic-Area.h171566.Hotel-Information) ![Kahler Grand Hotel](//images.trvl-media.com/lodging/1000000/30000/25600/25516/a12994da_y.jpg) ### Kahler Grand Hotel 10/10 Excellent "clean room" [](https://expedia.co.uk/Rochester-Hotels-Kahler-Grand-Hotel.h25516.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S](//images.trvl-media.com/lodging/8000000/7780000/7772100/7772018/569eb353_y.jpg) ### La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S 10/10 Excellent "Room was clean and quiet" [](https://expedia.co.uk/Rochester-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Rochester-Mayo-Clinic-S.h7772018.Hotel-Information) ![Med City Inn & Suites - Mayo Clinic Area](//images.trvl-media.com/lodging/1000000/10000/4200/4106/4b21fb74_y.jpg) ### Med City Inn & Suites - Mayo Clinic Area 10/10 Excellent "I stayed a week while my dad was at Mayo. If you arrive at night you may have to wait 30 minutes or more to check in, as they have very limited night staff. Good price, everything worked as it should. Lap pool, kiddie pool with slide & waterfall, jacuzzi, gym, laundry, etc. No complaints. " [](https://expedia.co.uk/Rochester-Hotels-GuestHouse-Rochester.h4106.Hotel-Information) ![Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area](//images.trvl-media.com/lodging/1000000/10000/3600/3556/b33056f7_y.jpg) ### Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area 10/10 Excellent "Everyone was great. Room was clean. They have a shuttle that runs to Mayo & surrounding areas which was real convenient for us. I have more appointments at Mayo so I will be staying there again. Great staff & House keeping :-)" [](https://expedia.co.uk/Rochester-Hotels-Centerstone-Plaza-Hotel-Soldiers-FieldMayo-Clinic-Area.h3556.Hotel-Information) ![AmericInn by Wyndham Rochester Near Mayo Clinic](//images.trvl-media.com/lodging/1000000/10000/8100/8008/71b6fb30_y.jpg) ### AmericInn by Wyndham Rochester Near Mayo Clinic 10/10 Excellent "Clean room but lots of permanent stains on walls. Yet by far the best 2 star hotel I’ve stayed at. Need a place to crash and not worry about bugs? This is it! Look no further. 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