Santo Holidays from £255

Book a Hotel + Flight or Car together to unlock savings

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  • Better together

    Save up to £750 when you book a flight and hotel together*
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    With over 300,000 hotels worldwide, it's easy to create a perfect package
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    Packages with flights are ATOL protected

Top Santo flight + hotel deals

Price found within the past 48 hours. Click for updated prices.
  • 11 Jan - 15 Jan

    Hotel Villa Liana + Flight

    Historic Centre of Florence
    4 nights
    3.0 star property
    8.8/10 - Excellent (380 reviews)
    Return • London (LGW) - Florence (FLR)
    LGW - FLR • 1 stop FLR - LGW • Direct
    £403
    £255
    per traveller
    found 1 day ago
    Hotel Villa Liana
  • 12 Jan - 16 Jan

    Aurum Uffizi + Flight

    Historic Centre of Florence
    4 nights
    4.0 star property
    7.6/10 - Good (1,003 reviews)
    Return • London (LHR) - Florence (FLR)
    LHR - FLR • 1 stop FLR - LHR • 1 stop
    £602
    £333
    per traveller
    found 1 day ago
    Aurum Uffizi
  • 11 Jan - 15 Jan

    Alfieri9 + Flight

    Historic Centre of Florence
    4 nights
    3.0 star property
    9.6/10 - Exceptional (176 reviews)
    "It was a great experience. Not far from the center but in a quieter neighborhood. Clean and well kept property."
    Reviewed November 7, 2026
    Return • London (LGW) - Florence (FLR)
    LGW - FLR • 1 stop FLR - LGW • Direct
    £468
    £287
    per traveller
    found 1 day ago
    Alfieri9
  • 28 Dec - 1 Jan

    Hotel La Scaletta Al Ponte Vecchio + Flight

    Historic Centre of Florence
    4 nights
    4.0 star property
    9.0/10 - Wonderful (1,003 reviews)
    "Giovanni was so very helpful, as well as the rest of the staff. The hotel’s location is very nice. It’s close to the bridge, but in a section that’s not too terribly busy. The terrace upstairs was absolutely amazing, as well as the restaurant. I highly recommend this hotel"
    Reviewed November 8, 2026
    Return • London (LGW) - Florence (FLR)
    LGW - FLR • Direct FLR - LGW • Direct
    Save 100% on your flight
    £1,101
    £687
    per traveller
    found 1 day ago
    Hotel La Scaletta Al Ponte Vecchio
  • 22 Jan - 25 Jan

    Eurostars Florence Boutique + Flight

    Historic Centre of Florence
    3 nights
    4.0 star property
    8.6/10 - Excellent (510 reviews)
    Return • Manchester (MAN) - Florence (FLR)
    MAN - FLR • 1 stop FLR - MAN • 1 stop
    £509
    £347
    per traveller
    found 1 day ago
    Eurostars Florence Boutique

Santo Hotel Deals

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently Asked Questions

Why should I book my Santo holiday with Expedia?

Expedia has your back for every aspect of your next Santo getaway. You'll always land the best deals around, but when you bundle your hotel, flights and/or car hire into a holiday package, you can save even more. Keen to really make the most of your escape? Add some fun activities and tours to your package. We offer flexible cancellation policies on almost all bookings, so there's no need to worry if your plans change. Visit our Customer Service Portal link to learn more.

When is the best time of year to holiday in Santo?

To enjoy the atmosphere of peak season, take off in May, July and August. November, December and January are generally quieter and a smart idea if you want to get away from the crowds. Plan your escape to Santo according to what type of holiday you're looking for. January is the coolest time of year, when average daytime temperatures are 4ºC. In July, the warmest month, expect averages of 24ºC during the day.

What is the top hotel for my holiday in Santo?

Offering many of the creature comforts of home, La Locanda Del Ponte will make the ideal base for your Santo trip.

How do I get a cheap holiday to Santo?

One of the simplest ways to save money (and time) is to bundle your bookings with Expedia. Flights, hire cars, hotels and activities — we've got them all covered. Pick and choose the combination that suits you and watch your savings grow. Of course, holidays are never one-size-fits-all. That's why Expedia offers over 400 partner airlines and 321,000 hotels across the globe, which lets you customise your Santo holiday your way. Learn more about how you can save money on your holiday when you book a flight and hotel together with Expedia.

Do I need a visa for my Santo holiday?

Official government websites have all the information you need on visa requirements, application procedures and necessary documentation. Your nationality and reason for visiting, whether it be for holidays or business, will determine if you'll need a visa for Santo. Also make sure your passport is up to date and has a minimum of six months validity remaining after the date of your return. Finalise all your travel planning well ahead of time to avoid any last-minute surprises.

What should I wear on my Santo holiday?

Consider the types of activities you'll be doing during your trip to Santo and choose versatile pieces that you can mix and match. For fashion inspiration or information on any dress codes, look up style blogs or social media accounts. Daytime temperatures in January, Santo's coolest month, average 4ºC. July marks this destination's warmest month when the average reaches 24ºC. Our advice? Take the guesswork out of what to pack and check the local weather conditions.

What does an Expedia Santo holiday include?

Hotels, flights and a shiny set of wheels for all your fun road trip adventures. Simply mix and match your preferred bundle and gain access to great discounts. Once you've made your booking, add on a couple of tours and experiences and watch your savings stack up. When it comes to planning your Santo break, you're the boss! Apartments and villas are two of the most popular property types in Santo. No matter your holiday style or size of your group, you can count on Expedia for the flexibility to customise your escape.

Does Expedia offer Book Now, Pay Later Santo holidays?

Expedia has joined forces with online lender Klarna to make your next break a little easier on the wallet. Paying by instalment means you can spread the costs of your dream holiday, leaving you with more money to play with while you're travelling. Klarna has several payment plans to choose from, so you're sure to find something that fits into your budget. Take a look at these flexible payment options:

  • Pay monthly holidays: Klarna offers payments in multiple instalments that work for all types of budgets, so you can book that well-deserved holiday sooner.
  • No-deposit holidays: Clicking the "book now" button is easier with this payment plan. With no upfront fee for your escape, you can Book Now, Pay Later and start packing your bags.

Can I choose my airline with a Santo Expedia holiday?

You can, and with over 400 airlines to choose from throughout the world, you're not short on choice. Browse the available options and see which airline suits your needs and budget.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.