Santa Isabel Holidays from £731

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Top Santa Isabel Flight + Hotel Deals

Price found within the past 48 hours. Click for updated prices.
MARINN Tropical Vibes Hotel

MARINN Tropical Vibes Hotel

3.5 out of 5
Amador
per person
28 Oct - 1 Nov
found 1 day ago
Return flight included
London (LON) to Panama City (PTY)
8/10 Very Good! (111 reviews)
Friendly and knowledgeable staff, helpful with ideas and other travel needs. Very reassuring.

Reviewed on 29 Jul 2025

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
per person
28 Oct - 1 Nov
found 1 day ago
Return flight included
London (LON) to Panama City (PTY)
9/10 Wonderful! (956 reviews)
Nuestra experiencia en el hotel fue excelente. Las instalaciones se mantienen impecablemente limpias y bien cuidadas, lo que hace que la estadía sea muy agradable. El personal es sumamente atento y gentil, siempre dispuesto a ayudar y hacer sentir a los huéspedes bienvenidos. Nos encantó la música en vivo que ofrecen, creando un ambiente relajado y acogedor. Además, la ubicación es perfecta: está muy cerca de los principales lugares turísticos, lo que facilita explorar la zona sin complicaciones. ¡Definitivamente volveríamos!

Reviewed on 25 Jul 2025

Hotel Plaza Herrera

Hotel Plaza Herrera

4 out of 5
Casco Viejo
per person
28 Oct - 1 Nov
found 1 day ago
Return flight included
London (LON) to Panama City (PTY)
10/10 Exceptional! (3 reviews)
Staying at Hotel Herrera in Casco Viejo was truly unforgettable-one of those rare experiences where everything just feels right from the moment you arrive. Nestled right in the heart of Plaza Herrera, the hotel’s beautifully restored colonial façade immediately drew me in, but it was the warm welcome from the staff that really set the tone for my stay. My suite was a perfect blend of historic charm and modern comfort, with gorgeous handcrafted furniture, and a balcony that overlooked the lively Plaza Herrera below. Every detail, from the plush bedding to the luxurious marble bathroom, made it feel like a boutique retreat. I loved waking up to the sounds of the city and sipping coffee while watching the world go by from my private balcony. The hotel’s location made it easy to explore the best of Casco Viejo on foot-charming cafes, art galleries, and vibrant nightlife were all just steps away. The staff went above and beyond, offering great recommendations and even arranging a guided tour to the Panama Canal and a day trip to the Emberá community, which was a highlight of my trip. Dining at Hotel Herrera was another standout. I treated myself to a special dinner in THEcellar, their exclusive private dining room, and it was an experience I’ll never forget. The food was incredible, and the intimate setting made it feel truly special. If you’re looking for a place that combines history, luxury, and genuine hospitality, I can’t recommend Hotel Herrera enough.

Reviewed on 5 May 2025

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
per person
28 Oct - 1 Nov
found 1 day ago
Return flight included
London (LON) to Panama City (PTY)
8.4/10 Very Good! (936 reviews)
This hotel is very conveniently located. It offers easy access to all major highways, malls, casco viejo and restaurants.

Reviewed on 1 Aug 2025

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Bella Vista
per person
28 Oct - 1 Nov
found 1 day ago
Return flight included
London (LON) to Panama City (PTY)
9/10 Wonderful! (4,145 reviews)
Muy conveniente y agradable, excelente desayuno e instalaciones, excelente ubicación y personal de primera

Reviewed on 1 Aug 2025

Santa Isabel Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Population
260
Max Temp Winter
27ºC
Max Temp Summer
27ºC

Top hotels in Santa Isabel

Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island

2 out of 5
Diablo Island, Narganá, Guna Yala
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Private Ocean-Front Cabin with private bathroom on San Blas Island
Private Over the Water Cabin on San Blas Island

Private Over the Water Cabin on San Blas Island

2 out of 5
9.542876, -78.899058, Narganá, San Blas
"Communication was good and highly organized. We felt safe and didn’t need to lock up our bags or valuables at all times. Weather was rough (not their fault) so the stay was a challenge with super high winds and rain. The island was covered in trash nearly all the way around. Our cabin doors were ..."

Reviewed on 16 Feb 2022

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Private Over the Water Cabin on San Blas Island
San Blas Paradise Private Cabins on Shipwreck Island - meals included

San Blas Paradise Private Cabins on Shipwreck Island - meals included

2 out of 5
Perro Island, Narganá, Guna Yala
Get rates
San Blas Paradise Private Cabins on Shipwreck Island - meals included
See all 45 properties in Santa Isabel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Frequently asked questions

Why should I book my Santa Isabel holiday with Expedia?
Expedia has you covered for all aspects of your next Santa Isabel getaway. You'll always get the best deal possible, but when you bundle your airfares, accommodation and/or car hire into a holiday package, you can save even more. Want to really make the most of your break? Add some fun activities and tours to your customised package. We offer flexible cancellation policies on almost all bookings, so there's no need to worry if your travel plans change. Visit our Customer Service Portal link to learn more.
When is the best time of year to holiday in Santa Isabel?
Santa Isabel can get busy in January, February and October, so if you want to avoid the crowds, travel in August, November and December. With daytime average temperatures of 25ºC, January is the coolest period in Santa Isabel. The warmest time of year is April, when you can expect averages of 26ºC throughout the day. Whatever the weather, you'll discover plenty of things to keep you occupied here.
What is the top hotel for my holiday in Santa Isabel?
Create unforgettable memories in Santa Isabel by choosing Melia Panama Canal as your home base and gateway to fun and adventure.
How do I get a cheap holiday to Santa Isabel?
If you love getting an amazing deal, bundle your bookings into a Santa Isabel holiday. Whether you need flights, hotels, hire cars or activities, you can browse and book them all in one place. You'll have loads of choice at your fingertips as well. Expedia has over 400 airlines and 321,000 hotels around the world to pick from. Fly with who you want, check in where you like and save some cash — now that's the ideal holiday! Learn more about how you can save money on your holiday when you bundle your flight and hotel bookings with Expedia.
Do I need a visa for my Santa Isabel holiday?
Visa requirements for Santa Isabel vary based on your nationality and reason for your visit. Make sure you check official government websites to determine if you need a visa for your holiday. They'll give you the most up-to-date information, including details about application procedures and any supporting documentation you might need. Enquire about your visa requirements well ahead of time to ensure a travel experience that's hassle free. Also make sure your passport has a minimum of six months validity from your return date.
What should I wear on my Santa Isabel holiday?
Though everyone's personal style varies, it can help to have a few guidelines for what to bring during your holiday in Santa Isabel. We recommend searching style blogs before you leave so you can blend in like a local. Be sure to check the local weather forecast so you can pack your bags accordingly. The warmest time of year in Santa Isabel is April, with average daily temperatures of 26ºC. If you plan to travel in the coolest month of January, the mercury averages 25ºC during the day.
What does an Expedia Santa Isabel holiday include?
It all depends on what kind of trip you're contemplating. Santa Isabel travel deals can include flights, car hires and hotels. You can mix and match to create the travel package that suits your style and budget. You can also add on experiences and activities after you've booked to score even bigger discounts. You'll always have the freedom and flexibility to customise your holiday your way with Expedia.
Does Expedia offer Book Now, Pay Later Santa Isabel holidays?
Your bank balance shouldn't prevent you from escaping on holiday, so Expedia has come up with a solution to help. Now that we've formed a partnership with online lender Klarna, it's easier than ever to book your dream getaway without drying up your savings. Klarna offers flexible payment options during the checkout process that take the stress out of budgeting for your trip. Check out these flexible payment options:

  • Pay monthly holidays: Klarna offers payments in multiple transactions that work for all budget sizes, so you can lock in that well-deserved holiday sooner.
  • No-deposit holidays: Hitting the "book now" button is much easier with this option. With no deposit required for your holiday, you can Book Now, Pay Later and start packing your suitcase.

Can I choose my airline with a Santa Isabel Expedia holiday?
You sure can. Expedia has access to more than 400 partner airlines worldwide, so opt for the carrier that suits your budget needs.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.