Title: Santa Isabel Holidays 2026 from £335 | Expedia.co.uk [Hotels in Santa Isabel](https://expedia.co.uk/Santa-Isabel-Hotels.d6203540.Travel-Guide-Hotels)[Holiday Rentals in Santa Isabel](https://expedia.co.uk/Santa-Isabel-Holiday-Rentals.d6203540.Travel-Guide-HolidayRentals)[Santa Isabel Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Santa-Isabel.d6203540.Car-Hire-Guide) ![](https://images.trvl-media.com/place/6203540/c7b068e1-573b-4f4f-9d2b-445d757c301a.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Santa Isabel Holidays from £335 ## Book a Hotel + Flight or Car together to unlock savings - ## Plan, book, travel with confidence - ### Better together Save up to £335 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Packages with flights are ATOL protected ## Top Santa Isabel Flight + Hotel Deals Price found within the past 48 hours. Click for updated prices. ![Mahogany Suites](https://images.trvl-media.com/lodging/119000000/118410000/118402400/118402387/179ad971_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Mahogany Suites £335 per person 26 Apr - 1 May found 7 hours ago Return flight included Miami (MIA) to Panama City (PTY) 10/10 Exceptional! (1 review) Excellent apartment on a golf resort. 5 Star. Reviewed on 28 Jan 2026 ![Central Hotel Panama Casco Viejo](https://images.trvl-media.com/lodging/16000000/15690000/15683600/15683502/3165768f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Central Hotel Panama Casco Viejo Casco Viejo Save 100% on your flight £1,210 per person 16 Apr - 23 Apr found 10 hours ago Return direct flight included London (LON) to Panama City (PTY) 9/10 Wonderful! (1,002 reviews) The room had no window to the outside it instead had a large window into an interior hall. Maid service was inconsistent. Breakfast was not a good value. Reviewed on 5 Feb 2026 ![Hotel Riu Plaza Panama](https://images.trvl-media.com/lodging/4000000/3910000/3900400/3900395/1eaf88f5_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel Riu Plaza Panama Bella Vista £932 per person 16 Apr - 23 Apr found 10 hours ago Return direct flight included London (LON) to Panama City (PTY) 9/10 Wonderful! (4,515 reviews) The Riu hotel in Panama City is wonderful ! The buffet breakfast is plentiful. The rooms are spacious and the location is very convenient. They have a beautiful pool and a lovely restaurant adjacent to it. I certainly don’t have any complaints ! Reviewed on 6 Feb 2026 ![Riande Aeropuerto Hotel & Casino](https://images.trvl-media.com/lodging/1000000/30000/26300/26240/b7e843b8_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Riande Aeropuerto Hotel & Casino £515 per person 26 Apr - 1 May found 7 hours ago Return flight included Miami (MIA) to Panama City (PTY) 8.6/10 Excellent! (1,884 reviews) The staff was nice. The room was always clean. We loved the pool. Reviewed on 7 Feb 2026 ![Villa Marina Lodge & Condos](https://images.trvl-media.com/lodging/10000000/9550000/9542300/9542280/8ba948e1_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Villa Marina Lodge & Condos £947 per person 16 Apr - 23 Apr found 10 hours ago Return direct flight included London (LON) to Panama City (PTY) 9/10 Wonderful! (133 reviews) Love that this property is at the other end of the beach from the late night partying. Walkable beach. Great restaurants nearby. The property was adding coffee makers and mini fridges the day we were leaving. Great staff, restaurant and drinks. We’ve been twice with our pooches. Will be back Reviewed on 14 Jul 2025 ## Santa Isabel Essential Information | Language | Spanish | | --------------- | ------------------ | | Currency | Panamanian balboas | | Local Welcome | ¡Hola! | | Local Goodbye | Adiós | | Population | 260 | | Max Temp Winter | 27ºC | | Max Temp Summer | 27ºC | ## Top hotels in Santa Isabel ![Cocoloco - Catamaran Lagoon 52F SAN BLAS](https://images.trvl-media.com/lodging/96000000/95810000/95807400/95807391/1b4156f6_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Cocoloco - Catamaran Lagoon 52F SAN BLAS El Porvenir Narganá Guna Yala Fully refundableReserve now, pay when you stay £1,539 10 Mar - 11 Mar includes taxes & fees [](https://expedia.co.uk/Hotel-Search?startDate=10%2F03%2F2026&endDate=11%2F03%2F2026&selected=95807391&PinnedHotelID=95807391&HadPinnedHotel=true®ionId=6203540) ![Private Over the Water Cabin on San Blas Island](https://images.trvl-media.com/lodging/38000000/37720000/37715900/37715808/f17df0ed_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Private Over the Water Cabin on San Blas Island 9.542876, -78.899058 Narganá San Blas 7/10 Good! (6 reviews) Very nice. And I liked the food Reviewed on 14 Aug 2025 [Get rates](https://expedia.co.uk/Hotel-Search?startDate=21%2F02%2F2026&endDate=22%2F02%2F2026&selected=37715808&PinnedHotelID=37715808&HadPinnedHotel=true®ionId=6203540) [](https://expedia.co.uk/Hotel-Search?startDate=21%2F02%2F2026&endDate=22%2F02%2F2026&selected=37715808&PinnedHotelID=37715808&HadPinnedHotel=true®ionId=6203540) ![ San Blas Paradise Private Cabins on Shipwreck Island - meals included](https://images.trvl-media.com/lodging/38000000/37810000/37804600/37804534/7a4cf19e_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### San Blas Paradise Private Cabins on Shipwreck Island - meals included Perro Island Narganá Guna Yala [Get rates](https://expedia.co.uk/Hotel-Search?startDate=21%2F02%2F2026&endDate=22%2F02%2F2026&selected=37804534&PinnedHotelID=37804534&HadPinnedHotel=true®ionId=6203540) [](https://expedia.co.uk/Hotel-Search?startDate=21%2F02%2F2026&endDate=22%2F02%2F2026&selected=37804534&PinnedHotelID=37804534&HadPinnedHotel=true®ionId=6203540) [See all 43 properties in Santa Isabel](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=08%2F02%2F2026&endDate=09%2F02%2F2026®ionId=6203540) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Holidays [](https://expedia.co.uk/lp/theme-holidays/all-inclusive-holidays?rfrr=editorial.All_Inclusive%20Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Holidays [](https://expedia.co.uk/lp/theme-holidays/beach-holidays?rfrr=editorial.Beach_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Family Friendly Holidays [](https://expedia.co.uk/lp/theme-holidays/kid-friendly-holidays?rfrr=editorial.Family_Friendly%20Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Holidays [](https://expedia.co.uk/lp/theme-holidays/golf-holidays?rfrr=editorial.Golf_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Holidays [](https://expedia.co.uk/lp/theme-holidays/luxury-holidays?rfrr=editorial.Luxury_Holidays.click) ![gay friendly holidays](https://forever.travel-assets.com/flex/flexmanager/images/2023/06/15/LGBTQIA_Holiday_Package.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) LGBTQ+ Holidays [](https://expedia.co.uk/lp/theme-holidays/gay-friendly-holidays?rfrr=editorial.LGBTQ+_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Holidays [](https://expedia.co.uk/lp/theme-holidays/romantic-holidays?rfrr=editorial.Romantic_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Holidays [](https://expedia.co.uk/lp/theme-holidays/ski-holidays?rfrr=editorial.Ski_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/22/hero-image-pet-friendly_copy.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Pet Friendly Holidays [](https://expedia.co.uk/lp/theme-holidays/pet-friendly-holidays?rfrr=editorial.Pet_Friendly%20Holidays.click) ![Holiday in Month](https://forever.travel-assets.com/flex/flexmanager/images/2023/05/10/mesog-34434-card-venice.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Where to go when [](https://expedia.co.uk/lp/b/where-to-go-when?rfrr=editorial.Where_to%20go%20when.click) ## Explore a world of travel with Expedia \* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected. ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app