Santa Isabel Holidays from £704

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Top Santa Isabel Flight + Hotel Deals

Price found within the past 48 hours. Click for updated prices.
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Save 100% on your flight
Price was £1,306, price is now £704 per person
£704
per person
27 Aug - 31 Aug
found 14 hours ago
Return flight included
Kingston (KIN) to Panama City (PTY)
9.2/10 Wonderful! (1,014 reviews)

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Save 100% on your flight
Price was £1,390, price is now £835 per person
£835
per person
27 Aug - 31 Aug
found 14 hours ago
Return flight included
Kingston (KIN) to Panama City (PTY)
8.4/10 Very good! (1,593 reviews)
N

Reviewed on 25 Jul 2026

Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

4 out of 5
Price was £1,326, price is now £938 per person
£938
per person
8 Oct - 14 Oct
found 1 day ago
Return flight included
Stockholm (ARN) to Panama City (PTY)
8.4/10 Very good! (1,818 reviews)
Loved our stay. Staff wonderful.

Reviewed on 24 Jul 2026

Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
San Francisco
Price was £1,224, price is now £911 per person
£911
per person
8 Oct - 14 Oct
found 1 day ago
Return flight included
Stockholm (ARN) to Panama City (PTY)
8.6/10 Excellent! (1,709 reviews)
Desayuno super bueno. Excelente ubicación con acceso exclusivo al Mall a través de un puente peatonal. Cerca de Avenida Balboa donde se ve el mar. Lo único fue que éramis 3 huéspedes y siempre dejaban 2 qguas y 2 toallas y había q estar llamando para que subieran 1 más.

Reviewed on 24 Jul 2026

Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
San Francisco
Price was £1,322, price is now £1,010 per person
£1,010
per person
8 Oct - 14 Oct
found 1 day ago
Return flight included
Stockholm (ARN) to Panama City (PTY)
9/10 Wonderful! (1,054 reviews)

Santa Isabel Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Population
260
Max Temp Winter
27ºC
Max Temp Summer
27ºC

Top hotels in Santa Isabel

Cocoloco - Catamaran Lagoon 52F SAN BLAS

Cocoloco - Catamaran Lagoon 52F SAN BLAS

3 out of 5
El Porvenir Narganá Guna Yala
Fully refundableReserve now, pay when you stay
The price is £1,635 per night from 25 Aug to 26 Aug
£1,635
25 Aug - 26 Aug
includes taxes & fees
Cocoloco - Catamaran Lagoon 52F SAN BLAS
Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island

2 out of 5
Diablo Island Narganá Guna Yala
The price is £155 per night from 23 Aug to 24 Aug
£155
23 Aug - 24 Aug
includes taxes & fees
10/10 Exceptional! (1 review)
"Staff was wonderful. Room was basic, as described. Basically camping on the beach with a comfortable bed. Fall asleep to ocean waves just feet from the door."

Reviewed on 15 Mar 2026

Private Ocean-Front Cabin with private bathroom on San Blas Island
Caribbean Haven Of Nature 'Preci Beach'

Caribbean Haven Of Nature 'Preci Beach'

Nombre de Dios Colon
10/10 Exceptional! (31 reviews)
Beautiful
"This place is special. The inside of the house could use a deep cleaning. But the outdoor area and beach area are incredible. We explored tide pools and snorkeled open areas and crevices all week long. Our one negative experience was fishing with some young men from the nearby town; they did not ..."

Reviewed on 17 Mar 2025

Get rates
Caribbean Haven Of Nature 'Preci Beach'
See all 39 properties in Santa Isabel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Frequently asked questions

Why should I book my Santa Isabel holiday with Expedia?
Expedia has you covered for all aspects of your next Santa Isabel getaway. You'll always get the best deal possible, but when you bundle your airfares, accommodation and/or car hire into a holiday package, you can save even more. Want to really make the most of your break? Add some fun activities and tours to your customised package. We offer flexible cancellation policies on almost all bookings, so there's no need to worry if your travel plans change. Visit our Customer Service Portal link to learn more.
When is the best time of year to holiday in Santa Isabel?
Santa Isabel can get busy in January, February and October, so if you want to avoid the crowds, travel in August, November and December. With daytime average temperatures of 25ºC, January is the coolest period in Santa Isabel. The warmest time of year is April, when you can expect averages of 26ºC throughout the day. Whatever the weather, you'll discover plenty of things to keep you occupied here.
What is the top hotel for my holiday in Santa Isabel?
Create unforgettable memories in Santa Isabel by choosing Melia Panama Canal as your home base and gateway to fun and adventure.
How do I get a cheap holiday to Santa Isabel?
If you love getting an amazing deal, bundle your bookings into a Santa Isabel holiday. Whether you need flights, hotels, hire cars or activities, you can browse and book them all in one place. You'll have loads of choice at your fingertips as well. Expedia has over 400 airlines and 321,000 hotels around the world to pick from. Fly with who you want, check in where you like and save some cash — now that's the ideal holiday! Learn more about how you can save money on your holiday when you bundle your flight and hotel bookings with Expedia.
Do I need a visa for my Santa Isabel holiday?
Visa requirements for Santa Isabel vary based on your nationality and reason for your visit. Make sure you check official government websites to determine if you need a visa for your holiday. They'll give you the most up-to-date information, including details about application procedures and any supporting documentation you might need. Enquire about your visa requirements well ahead of time to ensure a travel experience that's hassle free. Also make sure your passport has a minimum of six months validity from your return date.
What should I wear on my Santa Isabel holiday?
Though everyone's personal style varies, it can help to have a few guidelines for what to bring during your holiday in Santa Isabel. We recommend searching style blogs before you leave so you can blend in like a local. Be sure to check the local weather forecast so you can pack your bags accordingly. The warmest time of year in Santa Isabel is April, with average daily temperatures of 26ºC. If you plan to travel in the coolest month of January, the mercury averages 25ºC during the day.
What does an Expedia Santa Isabel holiday include?
It all depends on what kind of trip you're contemplating. Santa Isabel travel deals can include flights, car hires and hotels. You can mix and match to create the travel package that suits your style and budget. You can also add on experiences and activities after you've booked to score even bigger discounts. You'll always have the freedom and flexibility to customise your holiday your way with Expedia.
Does Expedia offer Book Now, Pay Later Santa Isabel holidays?
Your bank balance shouldn't prevent you from escaping on holiday, so Expedia has come up with a solution to help. Now that we've formed a partnership with online lender Klarna, it's easier than ever to book your dream getaway without drying up your savings. Klarna offers flexible payment options during the checkout process that take the stress out of budgeting for your trip. Check out these flexible payment options:

  • Pay monthly holidays: Klarna offers payments in multiple transactions that work for all budget sizes, so you can lock in that well-deserved holiday sooner.
  • No-deposit holidays: Hitting the "book now" button is much easier with this option. With no deposit required for your holiday, you can Book Now, Pay Later and start packing your suitcase.

Can I choose my airline with a Santa Isabel Expedia holiday?
You sure can. Expedia has access to more than 400 partner airlines worldwide, so opt for the carrier that suits your budget needs.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.