Santa Isabel Holidays from £517
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to £750 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPackages with flights are ATOL protected
Top Santa Isabel Flight + Hotel Deals
Price found within the past 48 hours. Click for updated prices.
Riande Aeropuerto Hotel & Casino
£517
per person
12 Nov - 16 Nov
found 8 hours ago
Return flight included
Kingston (KIN) to Panama City (PTY)
8.6/10 Excellent! (1,811 reviews)
Muy limpio ,restaurant excelente ,personal amable y cordial ,el transporte al aeropuerto fue todo muy eficaz,gracias
Reviewed on 7 Sept 2026
Megapolis Hotel Panamá
San Francisco
£809
per person
12 Oct - 18 Oct
found 1 day ago
Return flight included
Kingston (KIN) to Panama City (PTY)
8.4/10 Very good! (1,692 reviews)
Use to stay here 2x/year since its opening as Hardrock Hotel. Was a great place to stay as Hardrock. Shut down during Covid. Currently they severed their Hardrock afficliation and reopened under "Megopolis". They have the same furnature, art work, resturants, same good free breakfast buffet and etc. Didn't see any real property decline from before Covid. Has been very well taken care of. Rooms are very good, with great views of Panama bay or the City. The only thing I would say is that the staff is not quit as helpful. They are good, don't get me wrong, and some are very helpful (and eager to help) but just seems to be an overall sense of less attentiveness.
Reviewed on 8 Sept 2026
Central Hotel Panama Casco Viejo
Casco Viejo
£795
per person
12 Oct - 18 Oct
found 1 day ago
Return flight included
Kingston (KIN) to Panama City (PTY)
9/10 Wonderful! (1,012 reviews)
The Central Hotel Panama delivers an impeccable experience, combining the historic charm of Casco Antiguo with modern luxury and sophistication.
Reviewed on 8 Sept 2026
Decapolis Hotel Panama City
San Francisco
£688
per person
12 Oct - 18 Oct
found 1 day ago
Return flight included
Kingston (KIN) to Panama City (PTY)
8.6/10 Excellent! (1,708 reviews)
El lugar está céntrico pero fue difícil conseguir hielo paras habitaciones que están más arriba del piso 14 hay que ir al restaurante la piscina es pequeña
Reviewed on 8 Sept 2026
Santa Isabel Essential Information
Language | Spanish |
|---|---|
Currency | Panamanian balboas |
Local Welcome | ¡Hola! |
Local Goodbye | Adiós |
Population | 260 |
Max Temp Winter | 27ºC |
Max Temp Summer | 27ºC |
Top hotels in Santa Isabel
Cocoloco - Catamaran Lagoon 52F SAN BLAS
El Porvenir Narganá Guna Yala
Fully refundableReserve now, pay when you stay
£1,586
9 Oct - 10 Oct
includes taxes & fees
Private Ocean-Front Cabin with private bathroom on San Blas Island
Diablo Island Narganá Guna Yala
£153
10 Sept - 11 Sept
includes taxes & fees
10/10 Exceptional! (1 review)
"Staff was wonderful. Room was basic, as described. Basically camping on the beach with a comfortable bed. Fall asleep to ocean waves just feet from the door."
Reviewed on 15 Mar 2026
Caribbean getaway: beach cottage just on the sand
Palenque Provincia de Colón
9/10 Wonderful! (4 reviews)
"the view is beautiful! We were taken care of well."
Reviewed on 26 Jul 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Why should I book my Santa Isabel holiday with Expedia?
Expedia has you covered for all aspects of your next Santa Isabel getaway. You'll always get the best deal possible, but when you bundle your airfares, accommodation and/or car hire into a holiday package, you can save even more. Want to really make the most of your break? Add some fun activities and tours to your customised package. We offer flexible cancellation policies on almost all bookings, so there's no need to worry if your travel plans change. Visit our Customer Service Portal link to learn more.
When is the best time of year to holiday in Santa Isabel?
Santa Isabel can get busy in January, February and October, so if you want to avoid the crowds, travel in August, November and December. With daytime average temperatures of 25ºC, January is the coolest period in Santa Isabel. The warmest time of year is April, when you can expect averages of 26ºC throughout the day. Whatever the weather, you'll discover plenty of things to keep you occupied here.
What is the top hotel for my holiday in Santa Isabel?
Create unforgettable memories in Santa Isabel by choosing Melia Panama Canal as your home base and gateway to fun and adventure.
How do I get a cheap holiday to Santa Isabel?
If you love getting an amazing deal, bundle your bookings into a Santa Isabel holiday. Whether you need flights, hotels, hire cars or activities, you can browse and book them all in one place. You'll have loads of choice at your fingertips as well. Expedia has over 400 airlines and 321,000 hotels around the world to pick from. Fly with who you want, check in where you like and save some cash — now that's the ideal holiday! Learn more about how you can save money on your holiday when you bundle your flight and hotel bookings with Expedia.
Do I need a visa for my Santa Isabel holiday?
Visa requirements for Santa Isabel vary based on your nationality and reason for your visit. Make sure you check official government websites to determine if you need a visa for your holiday. They'll give you the most up-to-date information, including details about application procedures and any supporting documentation you might need. Enquire about your visa requirements well ahead of time to ensure a travel experience that's hassle free. Also make sure your passport has a minimum of six months validity from your return date.
What should I wear on my Santa Isabel holiday?
Though everyone's personal style varies, it can help to have a few guidelines for what to bring during your holiday in Santa Isabel. We recommend searching style blogs before you leave so you can blend in like a local. Be sure to check the local weather forecast so you can pack your bags accordingly. The warmest time of year in Santa Isabel is April, with average daily temperatures of 26ºC. If you plan to travel in the coolest month of January, the mercury averages 25ºC during the day.
What does an Expedia Santa Isabel holiday include?
It all depends on what kind of trip you're contemplating. Santa Isabel travel deals can include flights, car hires and hotels. You can mix and match to create the travel package that suits your style and budget. You can also add on experiences and activities after you've booked to score even bigger discounts. You'll always have the freedom and flexibility to customise your holiday your way with Expedia.
Does Expedia offer Book Now, Pay Later Santa Isabel holidays?
Your bank balance shouldn't prevent you from escaping on holiday, so Expedia has come up with a solution to help. Now that we've formed a partnership with online lender Klarna, it's easier than ever to book your dream getaway without drying up your savings. Klarna offers flexible payment options during the checkout process that take the stress out of budgeting for your trip. Check out these flexible payment options:
- Pay monthly holidays: Klarna offers payments in multiple transactions that work for all budget sizes, so you can lock in that well-deserved holiday sooner.
- No-deposit holidays: Hitting the "book now" button is much easier with this option. With no deposit required for your holiday, you can Book Now, Pay Later and start packing your suitcase.
Can I choose my airline with a Santa Isabel Expedia holiday?
You sure can. Expedia has access to more than 400 partner airlines worldwide, so opt for the carrier that suits your budget needs.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.
