Title: Hotels in Santa Isabel - Best Santa Isabel Hotels from £177 - Fully Refundable Options - Expedia.co.uk [Holiday Rentals in Santa Isabel](https://expedia.co.uk/Santa-Isabel-Holiday-Rentals.d6203540.Travel-Guide-HolidayRentals)[Santa Isabel Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Santa-Isabel.d6203540.Car-Hire-Guide)[Santa Isabel Holidays](https://expedia.co.uk/Santa-Isabel.d6203540.Holidays-City-Breaks) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find hotels in Santa Isabel from £177 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Santa Isabel Sea view [](https://www.expedia.co.uk/Hotel-Search?destination=Santa+Isabel%2C+Col%C3%B3n%2C+Panama®ionId=6203540&latLong=9.539417%2C-79.195937&adults=2&startDate=2026-01-06&d1=2026-01-06&endDate=2026-01-08&d2=2026-01-08&amenities=OCEAN_VIEW) House­boat [](https://www.expedia.co.uk/Hotel-Search?destination=Santa+Isabel%2C+Col%C3%B3n%2C+Panama®ionId=6203540&latLong=9.539417%2C-79.195937&adults=2&startDate=2026-01-06&d1=2026-01-06&endDate=2026-01-08&d2=2026-01-08&lodging=HOUSE_BOAT) ## Check prices for these dates Tonight [23 Dec - 24 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6203540&startDate=2025-12-23&endDate=2025-12-24&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [24 Dec - 25 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6203540&startDate=2025-12-24&endDate=2025-12-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [26 Dec - 28 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6203540&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [2 Jan - 4 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6203540&startDate=2026-01-02&endDate=2026-01-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Santa Isabel hotels ![Aerial view](https://images.trvl-media.com/lodging/38000000/37810000/37804600/37804534/7a4cf19e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Basic Cabin, Ocean View | Bed sheets](https://images.trvl-media.com/lodging/38000000/37810000/37804600/37804534/519a6b1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/38000000/37810000/37804600/37804534/587acb7a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/38000000/37810000/37804600/37804534/1370ba19.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### San Blas Paradise Private Cabins on Shipwreck Island - meals included [](https://www.expedia.co.uk/San-Blas-Islands-Hotels-Cabins-In-Perro-Island.h37804534.Hotel-Information) Narganá Escape to this beachfront retreat offering free local cuisine breakfast and vibrant island activities. Enjoy volleyball, kayaking, and snorkelling steps from your cabin. Explore nearby Isla Diablo and Isla Chichime for authentic San Blas adventures. [](https://www.expedia.co.uk/San-Blas-Islands-Hotels-Cabins-In-Perro-Island.h37804534.Hotel-Information) ![Panoramic Cabin, Ocean View | Beach/ocean view](https://images.trvl-media.com/lodging/38000000/37770000/37767000/37766985/ede84b95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/38000000/37770000/37767000/37766985/caaaab49.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Panoramic Cabin, Ocean View | Bathroom | Towels](https://images.trvl-media.com/lodging/38000000/37770000/37767000/37766985/f9addf9f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Panoramic Cabin, Ocean View | Bed sheets](https://images.trvl-media.com/lodging/38000000/37770000/37767000/37766985/w2878h1920x0y0-df17b8ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Private Ocean-Front Cabin with private bathroom on San Blas Island [](https://www.expedia.co.uk/San-Blas-Islands-Hotels-Cabins-In-Diablo-Island.h37766985.Hotel-Information) Narganá Escape to this intimate seaside retreat featuring a private bathroom, free breakfast, and garden setting. Just moments from Isla Diablo and Isla Chichime, this hotel offers a snack bar and airport shuttle for island exploration. [](https://www.expedia.co.uk/San-Blas-Islands-Hotels-Cabins-In-Diablo-Island.h37766985.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/38000000/37750000/37744700/37744686/10dee59f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Basic Cabin | Bed sheets](https://images.trvl-media.com/lodging/38000000/37750000/37744700/37744686/dda30ac1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Basic Cabin | Bed sheets](https://images.trvl-media.com/lodging/38000000/37750000/37744700/37744686/ec710209.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Panoramic Cabin, Ocean View | Bed sheets](https://images.trvl-media.com/lodging/38000000/37750000/37744700/37744686/eb4eaf61.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cabins in Asserya Island - San Blas paradise - meals included [](https://www.expedia.co.uk/San-Blas-Islands-Hotels-Cabins-In-Aroma-Island.h37744686.Hotel-Information) Narganá [](https://www.expedia.co.uk/San-Blas-Islands-Hotels-Cabins-In-Aroma-Island.h37744686.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/104000000/103730000/103726800/103726734/9e5e20c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Economy Bungalow | Bed sheets](https://images.trvl-media.com/lodging/104000000/103730000/103726800/103726734/c36bcffd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/104000000/103730000/103726800/103726734/4e2f141d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Economy Bungalow | Bed sheets](https://images.trvl-media.com/lodging/104000000/103730000/103726800/103726734/w714h952x0y0-03c55ba8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Trips Guna Yala [](https://www.expedia.co.uk/Nargana-Hotels-Trips-Guna-Yala.h103726734.Hotel-Information) Narganá Set in gorgeous Guna Yala, this charming B&B offers a refreshing outdoor pool and complimentary daily breakfast. Museum exploration awaits nearby, while thoughtful amenities like daily housekeeping ensure a carefree tropical escape. £177 includes taxes & fees 24 Dec - 25 Dec [](https://www.expedia.co.uk/Nargana-Hotels-Trips-Guna-Yala.h103726734.Hotel-Information) ![Beach](https://images.trvl-media.com/lodging/38000000/37830000/37822600/37822583/8fa7ada5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/38000000/37830000/37822600/37822583/e2771f8b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/38000000/37830000/37822600/37822583/1f4d85cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Traditional Cabin | Bed sheets](https://images.trvl-media.com/lodging/38000000/37830000/37822600/37822583/f71dc449.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cabins on paradise San Blas island [](https://www.expedia.co.uk/Carti-Hotels-Cabins-In-Tuba-Senika-Island.h37822583.Hotel-Information) Narganá Experience serene island getaway in Narganá with complimentary breakfast and convenient airport shuttle options. This hotel sits near the Museum and offers a charming snack bar/deli for midday cravings. [](https://www.expedia.co.uk/Carti-Hotels-Cabins-In-Tuba-Senika-Island.h37822583.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/96000000/95810000/95807400/95807391/1b4156f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/96000000/95810000/95807400/95807391/309e8ef7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/96000000/95810000/95807400/95807391/a3e9a150.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi](https://images.trvl-media.com/lodging/96000000/95810000/95807400/95807391/7fd698a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cocoloco - Catamaran Lagoon 52F SAN BLAS [](https://www.expedia.co.uk/Nargana-Hotels-Cocoloco-Catamaran-Lagoon-52F-SAN-BLAS.h95807391.Hotel-Information) Narganá Soak in tropical paradise at this unique San Blas retreat. Located near Porvenir Museum and Isla Chichime, the catamaran offers free breakfast, WiFi, and convenient amenities. Enjoy drinks at the bar or treats at the café. £1,567 includes taxes & fees 11 Jan - 12 Jan 2026 [](https://www.expedia.co.uk/Nargana-Hotels-Cocoloco-Catamaran-Lagoon-52F-SAN-BLAS.h95807391.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-01-06&endDate=2026-01-07®ionId=6203540&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSanta-Isabel-Hotels.d6203540.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSanta-Isabel-Hotels.d6203540.Travel-Guide-Hotels) ## Top Santa Isabel Hotel Reviews ![Private Over the Water Cabin on San Blas Island](https://images.trvl-media.com/lodging/38000000/37720000/37715900/37715808/f17df0ed_y.jpg) ### Private Over the Water Cabin on San Blas Island 10/10 Excellent "Very nice. And I liked the food " [](https://expedia.co.uk/San-Blas-Islands-Hotels-Cabins-Over-The-Water-Wailidup-Island.h37715808.Hotel-Information) ## More cheap stays in Santa Isabel ![ San Blas Paradise Private Cabins on Shipwreck Island - meals included](https://images.trvl-media.com/lodging/38000000/37810000/37804600/37804534/7a4cf19e_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### San Blas Paradise Private Cabins on Shipwreck Island - meals included Perro Island Narganá Guna Yala [Get rates](https://expedia.co.uk/Hotel-Search?startDate=06%2F01%2F2026&endDate=07%2F01%2F2026&selected=37804534&PinnedHotelID=37804534&HadPinnedHotel=true®ionId=6203540) [](https://expedia.co.uk/San-Blas-Islands-Hotels-Cabins-In-Perro-Island.h37804534.Hotel-Information) ![Private Ocean-Front Cabin with private bathroom on San Blas Island](https://images.trvl-media.com/lodging/38000000/37770000/37767000/37766985/ede84b95_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Private Ocean-Front Cabin with private bathroom on San Blas Island Diablo Island Narganá Guna Yala [Get rates](https://expedia.co.uk/Hotel-Search?startDate=06%2F01%2F2026&endDate=07%2F01%2F2026&selected=37766985&PinnedHotelID=37766985&HadPinnedHotel=true®ionId=6203540) [](https://expedia.co.uk/San-Blas-Islands-Hotels-Cabins-In-Diablo-Island.h37766985.Hotel-Information) ![Private Over the Water Cabin on San Blas Island](https://images.trvl-media.com/lodging/38000000/37720000/37715900/37715808/f17df0ed_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Private Over the Water Cabin on San Blas Island 9.542876, -78.899058 Narganá San Blas [Get rates](https://expedia.co.uk/Hotel-Search?startDate=06%2F01%2F2026&endDate=07%2F01%2F2026&selected=37715808&PinnedHotelID=37715808&HadPinnedHotel=true®ionId=6203540) 7/10 Good! (6 reviews) [](https://expedia.co.uk/San-Blas-Islands-Hotels-Cabins-Over-The-Water-Wailidup-Island.h37715808.Hotel-Information) ![Cabins in Asserya Island - San Blas paradise - meals included](https://images.trvl-media.com/lodging/38000000/37750000/37744700/37744686/10dee59f_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Cabins in Asserya Island - San Blas paradise - meals included Aroma Island (Isla Anzuelo) Narganá Guna Yala [Get rates](https://expedia.co.uk/Hotel-Search?startDate=06%2F01%2F2026&endDate=07%2F01%2F2026&selected=37744686&PinnedHotelID=37744686&HadPinnedHotel=true®ionId=6203540) [](https://expedia.co.uk/San-Blas-Islands-Hotels-Cabins-In-Aroma-Island.h37744686.Hotel-Information) ![ Paradise Over the Water Cabins in San Blas](https://images.trvl-media.com/lodging/47000000/46950000/46948400/46948372/fe0394dd_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Paradise Over the Water Cabins in San Blas G4V2 48 Narganá Guna Yala [Get rates](https://expedia.co.uk/Hotel-Search?startDate=06%2F01%2F2026&endDate=07%2F01%2F2026&selected=46948372&PinnedHotelID=46948372&HadPinnedHotel=true®ionId=6203540) [](https://expedia.co.uk/El-Porvenir-Hotels-Newly-Built-Paradise-Cabins-In-San-Blas.h46948372.Hotel-Information) ![Private wood Cabins on San Blas island - private bathroom](https://images.trvl-media.com/lodging/38000000/37750000/37743100/37743019/b9c5df53_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Private wood Cabins on San Blas island - private bathroom Wailidup Island Narganá Guna Yala [Get rates](https://expedia.co.uk/Hotel-Search?startDate=06%2F01%2F2026&endDate=07%2F01%2F2026&selected=37743019&PinnedHotelID=37743019&HadPinnedHotel=true®ionId=6203540) [](https://expedia.co.uk/San-Blas-Islands-Hotels-Cabins-In-Wailidup-Island.h37743019.Hotel-Information) ## Frequently asked questions ### Can I cancel my hotel reservation on Expedia? ### How can I save on a Santa Isabel hotel booking with Expedia? ### How much is the nightly rate at a Santa Isabel hotel? ## Explore a world of travel with Expedia - Accommodation - Packages - [La Guaira Hotels ](https://www.expedia.co.uk/La-Guaira-Hotels.d3000439511.Travel-Guide-Hotels) - [Miramar Hotels ](https://www.expedia.co.uk/Miramar-Hotels.d553248623282266307.Travel-Guide-Hotels) - [Nombre de Dios Hotels ](https://www.expedia.co.uk/Nombre-De-Dios-Hotels.d3000462548.Travel-Guide-Hotels) - [Palenque Hotels ](https://www.expedia.co.uk/Palenque-Hotels.d553248623282267036.Travel-Guide-Hotels) - [Playa Chiquita Hotels ](https://www.expedia.co.uk/Playa-Chiquita-Hotels.d553248635975847835.Travel-Guide-Hotels) - [Visit La Guaira ](https://www.expedia.co.uk/La-Guaira.dx3000439511) - [Nombre de Dios Holidays ](https://www.expedia.co.uk/Nombre-De-Dios.d3000462548.Holidays-City-Breaks) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. 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