Title: Hotels in Santa Isabel - Best Santa Isabel Hotels from £176 - Fully Refundable Options - Expedia.co.uk [Holiday Rentals in Santa Isabel](https://expedia.co.uk/Santa-Isabel-Holiday-Rentals.d6203540.Travel-Guide-HolidayRentals)[Santa Isabel Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Santa-Isabel.d6203540.Car-Hire-Guide)[Santa Isabel Holidays](https://expedia.co.uk/Santa-Isabel.d6203540.Holidays-City-Breaks) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find hotels in Santa Isabel from £176 ![price find illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Santa Isabel House­boat [](https://www.expedia.co.uk/Hotel-Search?destination=Santa+Isabel%2C+Col%C3%B3n%2C+Panama®ionId=6203540&latLong=9.539417%2C-79.195937&adults=2&startDate=2025-10-07&d1=2025-10-07&endDate=2025-10-09&d2=2025-10-09&lodging=HOUSE_BOAT) Sea view [](https://www.expedia.co.uk/Hotel-Search?destination=Santa+Isabel%2C+Col%C3%B3n%2C+Panama®ionId=6203540&latLong=9.539417%2C-79.195937&adults=2&startDate=2025-10-07&d1=2025-10-07&endDate=2025-10-09&d2=2025-10-09&amenities=OCEAN_VIEW) Family friendly [](https://www.expedia.co.uk/Hotel-Search?destination=Santa+Isabel%2C+Col%C3%B3n%2C+Panama®ionId=6203540&latLong=9.539417%2C-79.195937&adults=2&startDate=2025-10-07&d1=2025-10-07&endDate=2025-10-09&d2=2025-10-09&travelerType=family_friendly) ## Check prices for these dates Tonight [23 Sept - 24 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=6203540&startDate=2025-09-23&endDate=2025-09-24&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [24 Sept - 25 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=6203540&startDate=2025-09-24&endDate=2025-09-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [26 Sept - 28 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=6203540&startDate=2025-09-26&endDate=2025-09-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [3 Oct - 5 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6203540&startDate=2025-10-03&endDate=2025-10-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top 10 Santa Isabel hotels and places to stay ![Panoramic Cabin, Ocean View | Beach/ocean view](https://images.trvl-media.com/lodging/38000000/37770000/37767000/37766985/ede84b95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Panoramic Cabin, Ocean View | Bathroom | Towels](https://images.trvl-media.com/lodging/38000000/37770000/37767000/37766985/f9addf9f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Panoramic Cabin, Ocean View | Bed sheets](https://images.trvl-media.com/lodging/38000000/37770000/37767000/37766985/w2878h1920x0y0-df17b8ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/38000000/37770000/37767000/37766985/caaaab49.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Private Ocean-Front Cabin with private bathroom on San Blas Island Narganá [](https://www.expedia.co.uk/San-Blas-Islands-Hotels-Cabins-In-Diablo-Island.h37766985.Hotel-Information) ![Beach](https://images.trvl-media.com/lodging/38000000/37830000/37822600/37822583/8fa7ada5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Basic Shared Dormitory | Bed sheets](https://images.trvl-media.com/lodging/38000000/37830000/37822600/37822583/f8b34eb9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Traditional Cabin | Bed sheets](https://images.trvl-media.com/lodging/38000000/37830000/37822600/37822583/f71dc449.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/38000000/37830000/37822600/37822583/1f4d85cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cabins on paradise San Blas island Narganá [](https://www.expedia.co.uk/Carti-Hotels-Cabins-In-Tuba-Senika-Island.h37822583.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/38000000/37750000/37744700/37744686/10dee59f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Basic Cabin | Bed sheets](https://images.trvl-media.com/lodging/38000000/37750000/37744700/37744686/dda30ac1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Panoramic Cabin, Ocean View | Bed sheets](https://images.trvl-media.com/lodging/38000000/37750000/37744700/37744686/eb4eaf61.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Basic Cabin | Bed sheets](https://images.trvl-media.com/lodging/38000000/37750000/37744700/37744686/ceab5053.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cabins in Asserya Island - San Blas paradise - meals included Narganá [](https://www.expedia.co.uk/San-Blas-Islands-Hotels-Cabins-In-Aroma-Island.h37744686.Hotel-Information) ![Aerial view](https://images.trvl-media.com/lodging/38000000/37810000/37804600/37804534/7a4cf19e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/38000000/37810000/37804600/37804534/1370ba19.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/38000000/37810000/37804600/37804534/587acb7a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Basic Room, 2 Double Beds | Garden view](https://images.trvl-media.com/lodging/38000000/37810000/37804600/37804534/1cc9d52d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### San Blas Paradise Private Cabins on Shipwreck Island - meals included Narganá [](https://www.expedia.co.uk/San-Blas-Islands-Hotels-Cabins-In-Perro-Island.h37804534.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/104000000/103730000/103726800/103726734/9e5e20c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/104000000/103730000/103726800/103726734/w576h935x0y0-5a1d7985.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/104000000/103730000/103726800/103726734/4e2f141d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Economy Bungalow | Bed sheets](https://images.trvl-media.com/lodging/104000000/103730000/103726800/103726734/w714h952x0y0-03c55ba8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Trips Guna Yala Narganá £176 includes taxes & fees 1 Oct - 2 Oct [](https://www.expedia.co.uk/Nargana-Hotels-Trips-Guna-Yala.h103726734.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/96000000/95810000/95807400/95807391/1b4156f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi](https://images.trvl-media.com/lodging/96000000/95810000/95807400/95807391/7fd698a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/96000000/95810000/95807400/95807391/309e8ef7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/96000000/95810000/95807400/95807391/a3e9a150.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cocoloco - Catamaran Lagoon 52F SAN BLAS Narganá £1,653 includes taxes & fees 24 Sept - 25 Sept [](https://www.expedia.co.uk/Nargana-Hotels-Cocoloco-Catamaran-Lagoon-52F-SAN-BLAS.h95807391.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-10-07&endDate=2025-10-08®ionId=6203540&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSanta-Isabel-Hotels.d6203540.Travel-Guide-Hotels)[Sign up, it's free](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSanta-Isabel-Hotels.d6203540.Travel-Guide-Hotels) ## Top Santa Isabel Hotel Reviews ![Private Over the Water Cabin on San Blas Island](//images.trvl-media.com/lodging/38000000/37720000/37715900/37715808/f17df0ed_y.jpg) ### Private Over the Water Cabin on San Blas Island 10/10 Excellent "Very nice. And I liked the food " [](https://expedia.co.uk/San-Blas-Islands-Hotels-Cabins-Over-The-Water-Wailidup-Island.h37715808.Hotel-Information) ## More cheap stays in Santa Isabel ![Private Ocean-Front Cabin with private bathroom on San Blas Island](https://images.trvl-media.com/lodging/38000000/37770000/37767000/37766985/ede84b95_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Private Ocean-Front Cabin with private bathroom on San Blas Island Diablo Island, Narganá, Guna Yala [Get rates](https://expedia.co.uk/Hotel-Search?startDate=07%2F10%2F2025&endDate=08%2F10%2F2025&selected=37766985&PinnedHotelID=37766985&HadPinnedHotel=true®ionId=6203540) [](https://expedia.co.uk/San-Blas-Islands-Hotels-Cabins-In-Diablo-Island.h37766985.Hotel-Information) ![ San Blas Paradise Private Cabins on Shipwreck Island - meals included](https://images.trvl-media.com/lodging/38000000/37810000/37804600/37804534/7a4cf19e_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### San Blas Paradise Private Cabins on Shipwreck Island - meals included Perro Island, Narganá, Guna Yala [Get rates](https://expedia.co.uk/Hotel-Search?startDate=07%2F10%2F2025&endDate=08%2F10%2F2025&selected=37804534&PinnedHotelID=37804534&HadPinnedHotel=true®ionId=6203540) [](https://expedia.co.uk/San-Blas-Islands-Hotels-Cabins-In-Perro-Island.h37804534.Hotel-Information) ![Private Over the Water Cabin on San Blas Island](https://images.trvl-media.com/lodging/38000000/37720000/37715900/37715808/f17df0ed_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Private Over the Water Cabin on San Blas Island 9.542876, -78.899058, Narganá, San Blas [Get rates](https://expedia.co.uk/Hotel-Search?startDate=07%2F10%2F2025&endDate=08%2F10%2F2025&selected=37715808&PinnedHotelID=37715808&HadPinnedHotel=true®ionId=6203540) 7/10 Good! (6 reviews) [](https://expedia.co.uk/San-Blas-Islands-Hotels-Cabins-Over-The-Water-Wailidup-Island.h37715808.Hotel-Information) ![Cabins in Asserya Island - San Blas paradise - meals included](https://images.trvl-media.com/lodging/38000000/37750000/37744700/37744686/10dee59f_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Cabins in Asserya Island - San Blas paradise - meals included Aroma Island (Isla Anzuelo), Narganá, Guna Yala [Get rates](https://expedia.co.uk/Hotel-Search?startDate=07%2F10%2F2025&endDate=08%2F10%2F2025&selected=37744686&PinnedHotelID=37744686&HadPinnedHotel=true®ionId=6203540) [](https://expedia.co.uk/San-Blas-Islands-Hotels-Cabins-In-Aroma-Island.h37744686.Hotel-Information) ![ Paradise Over the Water Cabins in San Blas](https://images.trvl-media.com/lodging/47000000/46950000/46948400/46948372/fe0394dd_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Paradise Over the Water Cabins in San Blas G4V2 48, Narganá, Guna Yala [Get rates](https://expedia.co.uk/Hotel-Search?startDate=07%2F10%2F2025&endDate=08%2F10%2F2025&selected=46948372&PinnedHotelID=46948372&HadPinnedHotel=true®ionId=6203540) [](https://expedia.co.uk/El-Porvenir-Hotels-Newly-Built-Paradise-Cabins-In-San-Blas.h46948372.Hotel-Information) ![Private wood Cabins on San Blas island - private bathroom](https://images.trvl-media.com/lodging/38000000/37750000/37743100/37743019/b9c5df53_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Private wood Cabins on San Blas island - private bathroom Wailidup Island, Narganá, Guna Yala [Get rates](https://expedia.co.uk/Hotel-Search?startDate=07%2F10%2F2025&endDate=08%2F10%2F2025&selected=37743019&PinnedHotelID=37743019&HadPinnedHotel=true®ionId=6203540) [](https://expedia.co.uk/San-Blas-Islands-Hotels-Cabins-In-Wailidup-Island.h37743019.Hotel-Information) ## Frequently asked questions ### Can I cancel my hotel reservation on Expedia? > You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Santa Isabel. ### How can I save on a Santa Isabel hotel booking with Expedia? > Before booking your Santa Isabel hotel, remember to join Expedia's free travel rewards program. Just sign up and sign in to access our lowest Member Prices as well as members-only perks. You could also enjoy savings by bundling together your hotel and flights on Expedia. ### How much is the nightly rate at a Santa Isabel hotel? > Prices for hotels in Santa Isabel often vary, but you can find a great deal from £176 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate. ## Explore a world of travel with Expedia - Accommodation - Packages - [La Guaira Hotels](https://www.expedia.co.uk/La-Guaira-Hotels.d3000439511.Travel-Guide-Hotels) - [Miramar Hotels](https://www.expedia.co.uk/Miramar-Hotels.d553248623282266307.Travel-Guide-Hotels) - [Nombre de Dios Hotels](https://www.expedia.co.uk/Nombre-De-Dios-Hotels.d3000462548.Travel-Guide-Hotels) - [Palenque Hotels](https://www.expedia.co.uk/Palenque-Hotels.d553248623282267036.Travel-Guide-Hotels) - [Playa Chiquita Hotels](https://www.expedia.co.uk/Playa-Chiquita-Hotels.d553248635975847835.Travel-Guide-Hotels) - [Visit La Guaira](https://www.expedia.co.uk/La-Guaira.dx3000439511) - [Nombre de Dios Holidays](https://www.expedia.co.uk/Nombre-De-Dios.d3000462548.Holidays-City-Breaks) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app ![QR code to download the app](data:image/png;base64,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)