Title: Hotels in Santa Isabel - Best Santa Isabel Hotels from £177 - Fully Refundable Options - Expedia.co.uk [Holiday Rentals in Santa Isabel](https://expedia.co.uk/Santa-Isabel-Holiday-Rentals.d6203540.Travel-Guide-HolidayRentals)[Santa Isabel Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Santa-Isabel.d6203540.Car-Hire-Guide)[Santa Isabel Holidays](https://expedia.co.uk/Santa-Isabel.d6203540.Holidays-City-Breaks) ![Scenic Coiba Island Aerial View](https://images.trvl-media.com/place/6203540/c7b068e1-573b-4f4f-9d2b-445d757c301a.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6203540/c7b068e1-573b-4f4f-9d2b-445d757c301a.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Santa Isabel House­boat [](https://www.expedia.co.uk/Hotel-Search?destination=Santa+Isabel%2C+Col%C3%B3n%2C+Panama®ionId=6203540&latLong=9.539417%2C-79.195937&adults=2&startDate=2026-03-23&d1=2026-03-23&endDate=2026-03-25&d2=2026-03-25&lodging=HOUSE_BOAT) ## Check prices for these dates Tonight [9 Mar - 10 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6203540&startDate=2026-03-09&endDate=2026-03-10&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [10 Mar - 11 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6203540&startDate=2026-03-10&endDate=2026-03-11&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [13 Mar - 15 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6203540&startDate=2026-03-13&endDate=2026-03-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [20 Mar - 22 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6203540&startDate=2026-03-20&endDate=2026-03-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Santa Isabel hotels ![Aerial view](https://images.trvl-media.com/lodging/38000000/37770000/37767000/37766985/a23e7585.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/38000000/37770000/37767000/37766985/11577e1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Panoramic Cabin, Ocean View | Bed sheets](https://images.trvl-media.com/lodging/38000000/37770000/37767000/37766985/7708eca7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Panoramic Cabin, Ocean View | Bathroom | Towels](https://images.trvl-media.com/lodging/38000000/37770000/37767000/37766985/fafdc67a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Private Ocean-Front Cabin with private bathroom on San Blas Island [](https://www.expedia.co.uk/San-Blas-Islands-Hotels-Cabins-In-Diablo-Island.h37766985.Hotel-Information) Narganá [](https://www.expedia.co.uk/San-Blas-Islands-Hotels-Cabins-In-Diablo-Island.h37766985.Hotel-Information) ![Economy Bungalow | Bed sheets](https://images.trvl-media.com/lodging/104000000/103730000/103726800/103726734/w714h952x0y0-03c55ba8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/104000000/103730000/103726800/103726734/9e5e20c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/104000000/103730000/103726800/103726734/w576h935x0y0-5a1d7985.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/104000000/103730000/103726800/103726734/4e2f141d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Trips Guna Yala [](https://www.expedia.co.uk/Nargana-Hotels-Trips-Guna-Yala.h103726734.Hotel-Information) Narganá £177 includes taxes & fees 10 Mar - 11 Mar [](https://www.expedia.co.uk/Nargana-Hotels-Trips-Guna-Yala.h103726734.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/47000000/46950000/46948400/46948372/1c2dafbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![On the beach, white sand](https://images.trvl-media.com/lodging/47000000/46950000/46948400/46948372/633fd22f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Panoramic Cabin, 2 Double Beds, Ocean View, Overwater | Individually decorated, individually furnished](https://images.trvl-media.com/lodging/47000000/46950000/46948400/46948372/0564bbf7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Panoramic Cabin, 2 Double Beds, Ocean View, Overwater | Individually decorated, individually furnished](https://images.trvl-media.com/lodging/47000000/46950000/46948400/46948372/d8c32202.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Paradise Over the Water Cabins in San Blas [](https://www.expedia.co.uk/El-Porvenir-Hotels-Newly-Built-Paradise-Cabins-In-San-Blas.h46948372.Hotel-Information) Narganá 6.0/10 (1 review) "29/22 i stay with my family for three nights and 4 days the beds are not comfortable and the fan doesn't work the bathroom need cleaning, the worst part is the sandflyies we got bitten all over our bodies, the owners can do better with proper new nets and fan and maybe spray the place, after the first night we want to leave so bad. The island is not so bad its peaceful and claim but after the bites we could take it we were prepared with bug spray but it was not enough for the bugs. The island... ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dominik [](https://www.expedia.co.uk/El-Porvenir-Hotels-Newly-Built-Paradise-Cabins-In-San-Blas.h46948372.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/30000000/29060000/29059200/29059167/0a0df4a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fishing](https://images.trvl-media.com/lodging/30000000/29060000/29059200/29059167/b1d7420b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Cabin, 3 Bedrooms, Shared Bathroom](https://images.trvl-media.com/lodging/30000000/29060000/29059200/29059167/5a27ff88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/30000000/29060000/29059200/29059167/6db455b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cabañas Isla Nubesidub San Blas [](https://www.expedia.co.uk/El-Porvenir-Hotels-Cabanas-Isla-Nubesidub-San-Blas.h29059167.Hotel-Information) Narganá [](https://www.expedia.co.uk/El-Porvenir-Hotels-Cabanas-Isla-Nubesidub-San-Blas.h29059167.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/30000000/29060000/29059400/29059389/2dfa07ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Basic Double Room, 1 Double Bed, Shared Bathroom](https://images.trvl-media.com/lodging/30000000/29060000/29059400/29059389/2948d1a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/30000000/29060000/29059400/29059389/f2ef88d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/30000000/29060000/29059400/29059389/b867d3b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cabañas Nalunega San Blas [](https://www.expedia.co.uk/El-Porvenir-Hotels-Cabanas-Nalunega-San-Blas.h29059389.Hotel-Information) Narganá [](https://www.expedia.co.uk/El-Porvenir-Hotels-Cabanas-Nalunega-San-Blas.h29059389.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/38000000/37830000/37822600/37822583/1f4d85cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bed sheets](https://images.trvl-media.com/lodging/38000000/37830000/37822600/37822583/87f53a00.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Basic Shared Dormitory | Bed sheets](https://images.trvl-media.com/lodging/38000000/37830000/37822600/37822583/f8b34eb9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Panoramic Cabin, Ocean View | Bed sheets](https://images.trvl-media.com/lodging/38000000/37830000/37822600/37822583/597f1134.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cabins on paradise San Blas island [](https://www.expedia.co.uk/Carti-Hotels-Cabins-In-Tuba-Senika-Island.h37822583.Hotel-Information) Narganá [](https://www.expedia.co.uk/Carti-Hotels-Cabins-In-Tuba-Senika-Island.h37822583.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/96000000/95810000/95807400/95807391/7d3884ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/96000000/95810000/95807400/95807391/a5df9745.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/96000000/95810000/95807400/95807391/5ebfc967.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/96000000/95810000/95807400/95807391/a3e9a150.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cocoloco - Catamaran Lagoon 52F SAN BLAS [](https://www.expedia.co.uk/Nargana-Hotels-Cocoloco-Catamaran-Lagoon-52F-SAN-BLAS.h95807391.Hotel-Information) Narganá £1,463 includes taxes & fees 5 Apr - 6 Apr [](https://www.expedia.co.uk/Nargana-Hotels-Cocoloco-Catamaran-Lagoon-52F-SAN-BLAS.h95807391.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-03-23&endDate=2026-03-24®ionId=6203540&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-uk-fr-de.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Holiday Sale Members save up to 40% on hotels and holiday homes. Plan this year’s big trip and save. [Book now](https://expedia.co.uk/cheap-deals?rfrr=HTG_SPRING_PROMO_6203540) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSanta-Isabel-Hotels.d6203540.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSanta-Isabel-Hotels.d6203540.Travel-Guide-Hotels) ## Learn more about Santa Isabel Explore pristine beaches along Santa Isabel's coastline where local fishermen can take you to nearby coral reefs for snorkelling. Hike through lush rainforest trails to spot colourful birds, then visit the town's central plaza where vendors sell fresh tropical fruits and handcrafted souvenirs. [See all hotels in Santa Isabel](https://www.expedia.co.uk/Hotel-Search?startDate=2026-03-23&endDate=2026-03-24&adults=2®ionId=6203540) ![Scenic Coiba Island Aerial View](https://images.trvl-media.com/place/6203540/c7b068e1-573b-4f4f-9d2b-445d757c301a.jpg?impolicy=fcrop&w=900&h=506&p=1&q=high) ## Top Santa Isabel Hotel Reviews ![BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES](https://images.trvl-media.com/lodging/31000000/30800000/30792300/30792236/e39b72a8_y.jpg) ### BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES 10/10 Excellent "This was an incredible stay with so many lovely preparation of meals from Lucy and Jose. They were helpful and so thoughtful. We rested, relaxed, and spent leisurely days being together as a family. If only this happened more often! What a great trip. I am sad it ended so soon. Thank you to a wonderful host, Leticia, who went above and beyond helpful. " [](https://expedia.co.uk/Palenque-Hotels-Palenque-Spectacular-Caribbean-Ocean-Front-Property-In-Panama.h30792236.Hotel-Information) ![Exclusive sailboat for 2 people all inclusive in San Blas islands](https://images.trvl-media.com/lodging/114000000/113060000/113058600/113058539/a2a99590_y.jpg) ### Exclusive sailboat for 2 people all inclusive in San Blas islands 10/10 Excellent "Anita e Federico sono state il valore aggiunto in queste isole meravigliose. La loro disponibilita, le loro attenzioni, i sorridenti contatti di Anita con la popolazione dei Guna e la cucina superlativa di Federico hanno reso speciale la nostra vacanza che ha soddisfatto appieno le nostre aspettative. Discreta e deliziosa la presenza della gattina (la principessa di bordo) Shanu. Grazie di tutto!" [](https://expedia.co.uk/Ailigandi-Hotels-Vrbo-Property.h113058539.Hotel-Information) ![Caribbean getaway: beach cottage just on the sand](https://images.trvl-media.com/lodging/72000000/71150000/71150000/71149949/ddaf5491_y.jpg) ### Caribbean getaway: beach cottage just on the sand 10/10 Excellent "The beach view was perfect! I loved hearing the waves all day and throughout the night. My dog and I enjoyed everything and felt very comfortable. " [](https://expedia.co.uk/Palenque-Hotels-Caribbean-Getaway-Beach-Cottage-Just-On-The-Sand.h71149949.Hotel-Information) ![Caribbean Haven Of Nature 'Preci Beach'](https://images.trvl-media.com/lodging/33000000/32710000/32703600/32703593/b18130b7_y.jpg) ### Caribbean Haven Of Nature 'Preci Beach' 10/10 Excellent "This place is special. The inside of the house could use a deep cleaning. But the outdoor area and beach area are incredible. We explored tide pools and snorkeled open areas and crevices all week long. Our one negative experience was fishing with some young men from the nearby town; they did not have fishing gear, made us pay for their oil and gas, made fun of us in Spanish, and didn't actually care about catching fish. We didn't catch any fish and did not feel safe. Rodrigo is a wonderful host and always communicated with us quickly." [](https://expedia.co.uk/Nombre-De-Dios-Hotels-Caribbean-Haven-Of-Nature-Preci-Beach.h32703593.Hotel-Information) ## More cheap stays in Santa Isabel ![Trips Guna Yala](https://images.trvl-media.com/lodging/104000000/103730000/103726800/103726734/w714h952x0y0-03c55ba8_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Trips Guna Yala Urgandi, Mamardub Narganá Guna Yala £177 10 Mar - 11 Mar includes taxes & fees [](https://expedia.co.uk/Nargana-Hotels-Trips-Guna-Yala.h103726734.Hotel-Information) ![Private Ocean-Front Cabin with private bathroom on San Blas Island](https://images.trvl-media.com/lodging/38000000/37770000/37767000/37766985/a23e7585_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Private Ocean-Front Cabin with private bathroom on San Blas Island Diablo Island Narganá Guna Yala [Get rates](https://expedia.co.uk/Hotel-Search?startDate=23%2F03%2F2026&endDate=24%2F03%2F2026&selected=37766985&PinnedHotelID=37766985&HadPinnedHotel=true®ionId=6203540) [](https://expedia.co.uk/San-Blas-Islands-Hotels-Cabins-In-Diablo-Island.h37766985.Hotel-Information) ![ Paradise Over the Water Cabins in San Blas](https://images.trvl-media.com/lodging/47000000/46950000/46948400/46948372/1c2dafbf_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Paradise Over the Water Cabins in San Blas G4V2 48 Narganá Guna Yala [Get rates](https://expedia.co.uk/Hotel-Search?startDate=23%2F03%2F2026&endDate=24%2F03%2F2026&selected=46948372&PinnedHotelID=46948372&HadPinnedHotel=true®ionId=6203540) 6/10 (1 review) [](https://expedia.co.uk/El-Porvenir-Hotels-Newly-Built-Paradise-Cabins-In-San-Blas.h46948372.Hotel-Information) ![Private wood Cabins on San Blas island - private bathroom](https://images.trvl-media.com/lodging/38000000/37750000/37743100/37743019/cd50febe_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Private wood Cabins on San Blas island - private bathroom Wailidup Island Narganá Guna Yala [Get rates](https://expedia.co.uk/Hotel-Search?startDate=23%2F03%2F2026&endDate=24%2F03%2F2026&selected=37743019&PinnedHotelID=37743019&HadPinnedHotel=true®ionId=6203540) [](https://expedia.co.uk/San-Blas-Islands-Hotels-Cabins-In-Wailidup-Island.h37743019.Hotel-Information) ![Cabins on paradise San Blas island](https://images.trvl-media.com/lodging/38000000/37830000/37822600/37822583/1f4d85cf_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Cabins on paradise San Blas island 9.587566, -78.879820 Narganá San Blas [Get rates](https://expedia.co.uk/Hotel-Search?startDate=23%2F03%2F2026&endDate=24%2F03%2F2026&selected=37822583&PinnedHotelID=37822583&HadPinnedHotel=true®ionId=6203540) [](https://expedia.co.uk/Carti-Hotels-Cabins-In-Tuba-Senika-Island.h37822583.Hotel-Information) ![The Camp at Kalu Yala](https://images.trvl-media.com/lodging/71000000/70850000/70847500/70847418/d1dc8a08_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### The Camp at Kalu Yala San Martín San Martín Panama Province [Get rates](https://expedia.co.uk/Hotel-Search?startDate=23%2F03%2F2026&endDate=24%2F03%2F2026&selected=70847418&PinnedHotelID=70847418&HadPinnedHotel=true®ionId=6203540) [](https://expedia.co.uk/Kalu-Yala.h70847418.Hotel-Information) ## Frequently asked questions ### What is the best area to stay in Santa Isabel? > This area offers direct access to the Caribbean Sea and is known for its serene environment. You'll find a selection of accommodations, from boutique hotels to more secluded resorts, typically located just off the main coastal road, providing easy access while maintaining a sense of privacy. > > > Couples often find this area ideal for a romantic getaway. The focus here is on relaxation and enjoying the natural beauty, with opportunities for quiet walks along the beach, swimming in the clear waters, and enjoying meals with ocean views. Some establishments offer private balconies overlooking the sea, superb for morning coffee or evening drinks. > > > For those looking for a luxurious and secluded experience, the properties further along the coast, offering private beach access and extensive grounds, are an excellent choice. ### When is the best time to go to Santa Isabel? > During these months, you'll experience less rainfall and lower humidity, making outdoor activities like beach visits, jungle treks, and boat trips far more enjoyable. The calm waters are also ideal for snorkelling and diving, allowing for clear views of the marine life. > > > Couples looking for a relaxing escape will find this time particularly appealing. The consistent good weather means you can confidently plan days by the coast or explore the natural beauty without concerns about sudden downpours. It's superb for enjoying the pristine beaches and the serene atmosphere. > > > Travellers interested in exploring the natural parks and engaging in outdoor adventures will also benefit from the dry season. The trails are more accessible, and wildlife spotting is often easier when the weather is clear. ### Can I cancel my hotel reservation on Expedia? ### How can I save on a Santa Isabel hotel booking with Expedia? ### How much is the nightly rate at a Santa Isabel hotel? ## Explore a world of travel with Expedia - Accommodation - Packages - [La Guaira Hotels ](https://www.expedia.co.uk/La-Guaira-Hotels.d3000439511.Travel-Guide-Hotels) - [Miramar Hotels ](https://www.expedia.co.uk/Miramar-Hotels.d553248623282266307.Travel-Guide-Hotels) - [Nombre de Dios Hotels ](https://www.expedia.co.uk/Nombre-De-Dios-Hotels.d3000462548.Travel-Guide-Hotels) - [Palenque Hotels ](https://www.expedia.co.uk/Palenque-Hotels.d553248623282267036.Travel-Guide-Hotels) - [Playa Chiquita Hotels ](https://www.expedia.co.uk/Playa-Chiquita-Hotels.d553248635975847835.Travel-Guide-Hotels) - [Visit La Guaira ](https://www.expedia.co.uk/La-Guaira.dx3000439511) - [Nombre de Dios Holidays ](https://www.expedia.co.uk/Nombre-De-Dios.d3000462548.Holidays-City-Breaks) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. 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