Santa Fe Holidays from £910

Book a Hotel + Flight or Car together to unlock savings

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    Save up to £750 when you book a flight and hotel together*

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    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Packages with flights are ATOL protected

Top Santa Fe Flight + Hotel Deals

Price found within the past 48 hours. Click for updated prices.
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
San Francisco
Price was £1,219, price is now £910 per person
£910
per person
5 Oct - 11 Oct
found 1 day ago
Return direct flight included
London (LON) to Panama City (PTY)
8.6/10 Excellent! (1,697 reviews)
Todo bien

Reviewed on 16 Jul 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Save 100% on your flight
Price was £1,865, price is now £1,039 per person
£1,039
per person
5 Oct - 11 Oct
found 1 day ago
Return direct flight included
London (LON) to Panama City (PTY)
9.2/10 Wonderful! (1,001 reviews)
I really enjoyed my stay at Casco Viejo. I recommend purchasing the breakfast plan. The food was great. I enjoyed the area for walking. Not too far from Panama City.

Reviewed on 13 Jul 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was £1,529, price is now £995 per person
£995
per person
5 Oct - 11 Oct
found 1 day ago
Return direct flight included
London (LON) to Panama City (PTY)
8.4/10 Very good! (1,574 reviews)
Very nice stay for the price. I did have to ask for the bathroom to be cleaned again because the floor was a little dirty. Another drawback was they do not offer washcloths. This was problematic. The restaurant options were not the great

Reviewed on 16 Jul 2026

Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

4 out of 5
Price was £1,321, price is now £952 per person
£952
per person
5 Oct - 11 Oct
found 1 day ago
Return direct flight included
London (LON) to Panama City (PTY)
8.4/10 Very good! (1,815 reviews)

Hyatt Regency Panama City

Hyatt Regency Panama City

5 out of 5
Bella Vista
Price was £1,293, price is now £1,035 per person
£1,035
per person
5 Oct - 11 Oct
found 1 day ago
Return direct flight included
London (LON) to Panama City (PTY)
9.6/10 Exceptional! (355 reviews)

Santa Fe Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Population
1,500
Max Temp Winter
27ºC
Max Temp Summer
29ºC

Top hotels in Santa Fe

Hospedaje casa cultural wounaan

Hospedaje casa cultural wounaan

2 out of 5
Panama canal, Puerto lara Darien Santa Fe Darien
The price is £14 per night from 28 Jul to 29 Jul
£14
28 Jul - 29 Jul
includes taxes & fees
7.6/10 Good! (4 reviews)
Good but they need better communicatiy
"We had a great time during our visit. Apart from walking the village there isn’t much to do. We still made the most of our time and made friends with many locals. We did feel a little uncomfortable at the end of our trip as the president was complaining that we had paid in advance and he expected ..."

Reviewed on 22 Aug 2025

Hospedaje casa cultural wounaan
See all 3 properties in Santa Fe
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Frequently asked questions

How much does a Santa Fe travel package cost?
Our Santa Fe packages, which start from as low as £910, are the perfect way to save big. Handpick your preferred hotels, flights and rental car to create your perfect escape.
If I'm not able to travel, can I cancel my Santa Fe travel package?
You can. We totally understand that things don't always go to plan, so we're happy to help if you have to make changes to your Santa Fe travel package. You may be able to change or cancel your itinerary for free if you've booked within 24 hours. Your airline, hotel or car rental company may charge you a fee if your booking was made more than 24 hours ago. Look up our Customer Service Portal for further information. Also, check your itinerary for the finer details on change fees.
How do I get a cheap travel package to Santa Fe?
One word: bundle. Hotels, rental cars and flights — combine whatever you need into a Santa Fe travel package to save tons of cash. Score even more bargains when you include extras such as activities or tours to your booking. But that's not the only good part. You have the flexibility to customize your trip your way. We offer more than 550 partner airlines and 1,000,000 hotels all over the world, so that everyone has an opportunity to travel and live out those holiday fantasies.
Does Expedia offer Book Now, Pay Later Santa Fe holidays?
We certainly do. Expedia has partnered with online lender Klarna to help you easily pay for your holiday in manageable instalments. Simply pick the payment plan best suited to your needs during the checkout process and take the stress out of budgeting for your trip. Remember to bundle your accommodation, car hire and flights with Expedia to get the biggest bang for your holiday buck. Take a look at our flexible payment options below:

  • Pay monthly holidays: Klarna offers easy monthly payment plans that work for all budget sizes, so you can take that well-earned holiday now.
  • Pay in instalments holidays: If you want to pay for your getaway in multiple transactions, holidays paid in instalments might be the right option for your Book Now, Pay Later holiday through Klarna.
  • Low deposit holidays: When you spot an amazing deal but your budget doesn't quite go that far, Klarna's low deposit holiday plan will help you lock it in.

What are the top hotels in Santa Fe?
If it's comfort and convenience you're searching for, you can't beat Hospedaje casa cultural wounaan. Spend your nights kicking back here and your days checking out Santa Fe's best attractions.
How far in advance should I book my Santa Fe holiday?
It's hard to pick the perfect time for airfares, but we usually say the earlier, the better. Many international journeys on Expedia become available to compare up to 12 months in advance. If you're booking last minute, fear not. Discounted prices appear from time to time just weeks before departure dates.
What does an Expedia Santa Fe travel package include?
Expedia has everything you need to lock in Santa Fe getaway, but what your package looks like depends on you. Pick from any combination of rental cars, hotels and flights. After some tours or activities to keep you entertained? Once you've made your booking, you can add them too. Whatever your budget or style, there's a deal to match your needs.
What should I know before booking a Santa Fe travel package?
Tailor deals to match your budget with an Expedia package. Flights, hotels, rental cars — we've got all of them. You'll save loads just for bundling your bookings. Whether you're heading away on a skiing adventure or sipping cocktails on a beach, your perfect holiday is just a few clicks away.
Can I choose my airline with a Santa Fe Expedia travel package?
You can, and with over 550 airlines to pick from globally, you have loads of choice. Scroll through the available options and see which airline fits your needs and budget.

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.