Title: Cheap Car Hire in Santa Fe, PAN - Expedia.co.uk [Santa Fe Travel Guide](https://expedia.co.uk/Santa-Fe.dx553248623287535268)[Hotels in Santa Fe](https://expedia.co.uk/Santa-Fe-Hotels.d553248623287535268.Travel-Guide-Hotels)[Flights to Santa Fe](https://expedia.co.uk/Cheap-Flights-To-Santa-Fe.d553248623287535268.Travel-Guide-Flights)[Santa Fe Holidays](https://expedia.co.uk/Santa-Fe.d553248623287535268.Holidays-City-Breaks) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_car.jpeg?impolicy=fcrop&w=1200&h=300&q=medium) # Car Rentals in Santa Fe, PAN ## Search and Compare from Car Companies in Santa Fe ## Featured car rental suppliers Compare from agencies ![car supplier logos](https://forever.travel-assets.com/flex/flexmanager/images/2022/05/16/BEXUK-car-suppliers-logo-desktop.jpg) - ![protection illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__protection.svg) ### Change your mind Penalty-free cancellation on many/select car hire - ![trophy illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Treat yourself One Key members save 10% or more on over 1 million car hire [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![package illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__package.svg) ### Shop smart Compare car suppliers and package your flight, hotel, and car to save ## Top Rental Car Deals in Santa Fe \* Price found within the past 6 days. Click for updated prices. ### Economy Chevrolet Spark or similar - 4 people Santa Fe, Darién Province, PAN ![Chevrolet Spark](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_EC.png) [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Santa%20Fe,%20Dari%C3%A9n%20Province,%20Panama&dpln=553248623287535268&date1=06/03/2026&date2=08/03/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22economy%22]) ### Compact Ford Focus or similar - 4 people Santa Fe, Darién Province, PAN ![Ford Focus](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_CC.png) [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Santa%20Fe,%20Dari%C3%A9n%20Province,%20Panama&dpln=553248623287535268&date1=06/03/2026&date2=08/03/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22compact%22]) ### Midsize Toyota Corolla or similar - 5 people Santa Fe, Darién Province, PAN ![Toyota Corolla](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_IC.png) [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Santa%20Fe,%20Dari%C3%A9n%20Province,%20Panama&dpln=553248623287535268&date1=06/03/2026&date2=08/03/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22midsize%22]) ### SUV Jeep Compass or similar - 5 people Santa Fe, Darién Province, PAN ![Jeep Compass](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_SF.png) [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Santa%20Fe,%20Dari%C3%A9n%20Province,%20Panama&dpln=553248623287535268&date1=06/03/2026&date2=08/03/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22suv%22]) ### Don't see what you're looking for? See all car hire in Santa Fe [View all cars](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Santa%20Fe,%20Dari%C3%A9n%20Province,%20Panama&dpln=553248623287535268&date1=06/03/2026&date2=08/03/2026&crfrr=defaultFlex&SearchType=Place) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-uk-fr-de.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Holiday Sale Members save up to 40% on hotels and holiday homes. Plan this year’s big trip and save. [Book now](https://expedia.co.uk/cheap-deals?rfrr=CTG_SPRING_PROMO_553248623287535268) ## Frequently asked questions ### How much is a rental car per day in Santa Fe? ### What happens if I need to cancel my Santa Fe car reservation? ### What types of cars can I rent in Santa Fe? ### Where can I go on a road trip from Santa Fe? > - You'll feel the vibrant spirit of a city bursting with life the second you pull into San Miguelito. Some 95 miles from Santa Fe, it's home to a ton of wonderful places to discover, like Metromall Panama. > - Chepo, around 75 miles away, also promises a good time. Wondering what there is to see? San Cristobal Church is our top pick. > - Get away from city life at Venao Beach. Approximately 160 miles from Santa Fe, it's the perfect place to get your nature fix. ### How do I find the best car hire deals in Santa Fe with Expedia? ### What do you need to rent a car in Santa Fe? ### What is the cheapest car hire in Santa Fe? ### Can I hire a car for a month or longer in Santa Fe? ### Where can I find a Santa Fe hire car if I am younger than 25? ### Why should I rent a Santa Fe car with Expedia? ## Car Hire Information | Popular car types: | [SUV](https://www.expedia.co.uk/lp/b/car-rental/suv?rfrr=car.table.SUV), [Full Size](https://www.expedia.co.uk/lp/b/car-rental/fullsize?rfrr=car.table.FullSize), [Economy](https://www.expedia.co.uk/lp/b/car-rental/economy?rfrr=car.table.Economy) | | -------------------------------- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | | Car suppliers available: | | | Our best deal of the day: | | | Our second best deal of the day: | | | Our third best deal of the day: | | | From the airport to your hotel: | [Airport Transportation](https://www.expedia.co.uk/ground-transfers?rfrr=car.table.AirportTransportation) | ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. 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