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Check prices for these dates

This weekend
22 May - 24 May
Next weekend
29 May - 31 May

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Our top choices for Santa Cruz hotels

Terrace/patio

HITS PANTANAL HOTEL AEROPORTO

HITS PANTANAL HOTEL AEROPORTO
3.5 star property
6 mi from Santa Cruz
8.4 out of 10, Very good, (509 reviews)
"Cafe"
Brazil
Fábio
The price is £43
includes taxes & fees
5 Jun - 6 Jun
HITS PANTANAL HOTEL AEROPORTO
Comfort Quadruple Room, Air conditioning, Garden View | Free WiFi

Hotel alameda

Hotel alameda
2.5 star property
3.7 mi from Santa Cruz
10.0 out of 10, Exceptional, (3 reviews)
"Localização excelente, muito conveniente para quem viaja a trabalho. Quartos amplos, limpos e equipados. O café da manhã é bem completo. Ótimo custo-benefício."
Brazil
Urivelton
The price is £31
includes taxes & fees
22 May - 23 May
Hotel alameda
Desk, laptop workspace, iron/ironing board, free WiFi

Loft completo e climatizado

Loft completo e climatizado
2.5 star property
3.1 mi from Santa Cruz
8.8 out of 10, Excellent, (9 reviews)
"Apto idêntico as fotos, estava limpo, cheiroso as roupas de cama e toalhas extremamente brancas. O suporte ao hospede foi perfeita também, a princípio a localização parece ser ruim, mais depois percebe que é proximo de tudo e seguro."
Brazil
KEMILLI
The price is £30
includes taxes & fees
22 May - 23 May
Loft completo e climatizado
Exterior

Brisas Flat Style

Brisas Flat Style
3.0 star property
Duque de Caxias, 4.5 mi from Santa Cruz
9.8 out of 10, Exceptional, (123 reviews)
"Amazing!!"
United Kingdom
Wilmer Moniz
The price is £67
includes taxes & fees
24 May - 25 May
Brisas Flat Style
Lobby

Hotel Inter Cuiabá

Hotel Inter Cuiabá
4.5 star property
Jardim das Américas, 2.1 mi from Santa Cruz
9.0 out of 10, Wonderful, (369 reviews)
"Great stay. Best rooms Ive seen so far in Cuiaba, ill be returning"
United States
Joseph
The price is £70
includes taxes & fees
14 Jun - 15 Jun
Hotel Inter Cuiabá
Outdoor pool, open 10 AM to midnight, pool loungers

Hotel 365

Hotel 365
3.0 star property
2.9 mi from Santa Cruz
8.2 out of 10, Very good, (118 reviews)
"Staff was very very friendly, Breakfast was good, would recommend and will stay here again when I travel to Cuiaba in the future."
United States
Prince Sebastian Ragland
The price is £41
includes taxes & fees
8 Jun - 9 Jun
Hotel 365
Reception

Hotel Gran Odara

Hotel Gran Odara
4.0 star property
4.7 mi from Santa Cruz
9.4 out of 10, Exceptional, (667 reviews)
"Nice hotel! "
United States
patricia
The price is £94
includes taxes & fees
23 May - 24 May
Hotel Gran Odara
Outdoor pool, open 9:00 AM to 10:00 PM, pool umbrellas, pool loungers

Hotel Marion Pantanal

Hotel Marion Pantanal
3.0 star property
10.5 mi from Santa Cruz
7.4 out of 10, Good, (35 reviews)
"Gfff"
United States
Zyad
The price is £34
includes taxes & fees
22 May - 23 May
Hotel Marion Pantanal
Free daily buffet breakfast

SLIM Cuiabá Aeroporto

SLIM Cuiabá Aeroporto
3.5 star property
5.9 mi from Santa Cruz
8.4 out of 10, Very good, (862 reviews)
"Great place to stay! Confortable and clean! My family loved the experience"
United States
Tirrel
The price is £49
includes taxes & fees
23 May - 24 May
SLIM Cuiabá Aeroporto
Breakfast, lunch and dinner served

Hotel Deville Prime Cuiabá

Hotel Deville Prime Cuiabá
4.0 star property
Da Goiabeira, 3.9 mi from Santa Cruz
9.2 out of 10, Wonderful, (718 reviews)
"Great hotel"
United States
Jean
The price is £90
includes taxes & fees
20 Jun - 21 Jun
Hotel Deville Prime Cuiabá
Restaurant

Fly Hotel

Fly Hotel
3.0 star property
5.9 mi from Santa Cruz
8.6 out of 10, Excellent, (247 reviews)
"We had an amazing experience at Fly Hotel! Beds were very comfortable and the staff were very helpful and really nice!!!"
United States
Leliane
The price is £42
includes taxes & fees
24 May - 25 May
Fly Hotel
Free daily buffet breakfast

Hotel Sansaed

Hotel Sansaed
3.0 star property
Lixeira, 3 mi from Santa Cruz
8.8 out of 10, Excellent, (33 reviews)
"The hotel was basic but ok."
United States
Katleen
The price is £63
includes taxes & fees
22 May - 23 May
Hotel Sansaed
Outdoor pool

Delcas Hotel

Delcas Hotel
3.0 star property
Coxipó, 1.6 mi from Santa Cruz
8.0 out of 10, Very good, (733 reviews)
"Breakfast was amazing!"
United States
Zoe
The price is £53
includes taxes & fees
2 Jun - 3 Jun
Delcas Hotel
Minibar, blackout curtains, soundproofing, free cots/infant beds

Hotel Portal da Amazônia

Hotel Portal da Amazônia
3.0 star property
5.7 mi from Santa Cruz
9.0 out of 10, Wonderful, (55 reviews)
"The staff were friendly and helpful and the room was clean."
United States
Michael Christopher
The price is £42
includes taxes & fees
5 Jun - 6 Jun
Hotel Portal da Amazônia
Front of property

Roari Hotel

Roari Hotel
3.0 star property
3 mi from Santa Cruz
8.8 out of 10, Excellent, (113 reviews)
"O quarto é ótimo unica coisa que fica a desejar é a tv. Somente 7 canais disponíveis e não tem streaming."
Brazil
João Francisco
The price is £64
includes taxes & fees
8 Jun - 9 Jun
Roari Hotel
Outdoor banquet area

Hotel Tapajós

Hotel Tapajós
3.0 star property
3.1 mi from Santa Cruz
8.6 out of 10, Excellent, (63 reviews)
"Equipe simpática, deixa o hóspede a vontade, microondas e bebedouro disponíveis, preço, limpeza."
Brazil
THIAGO
The price is £29
includes taxes & fees
22 May - 23 May
Hotel Tapajós
Front of property

Hotel Almanara

Hotel Almanara
3.0 star property
Lixeira, 2.9 mi from Santa Cruz
7.4 out of 10, Good, (16 reviews)
"Bem"
Brazil
Pedro
The price is £56
includes taxes & fees
22 May - 23 May
Hotel Almanara
Living area

PESQUE PAGUE JANGO

PESQUE PAGUE JANGO
3.0 star property
12.6 mi from Santa Cruz
7.0 out of 10, Good, (2 reviews)
"O lugar é lindo e bem cuidado! Ambiente totalmente familiar, respeitoso. Pessoas gentis, cuidadoras e muito educadas, senti como se fosse uma extensão da minha casa. Sou reservada, gosto de ler e estar em silêncio e lá, isto foi respeitado. É um ambiente família mesmo, se a intenção é descansar, relaxar a pousada é o destino certo, se quer só passar o dia, pescar e relaxar um pouco da correria do grande centro, pode ir tranquilo. As pessoas são atenciosas e cuidadosas com a gente. Se pretende...
Brazil
Negisléia
The price is £73
includes taxes & fees
6 Jun - 7 Jun
PESQUE PAGUE JANGO
Lobby

Hotel Tainá - Aeroporto Cuiabá

Hotel Tainá - Aeroporto Cuiabá
3.0 star property
5.9 mi from Santa Cruz
8.2 out of 10, Very good, (436 reviews)
"Bom hotel"
Brazil
CHRISTIAN
The price is £46
includes taxes & fees
22 May - 23 May
Hotel Tainá - Aeroporto Cuiabá
Family Studio | Blackout curtains, iron/ironing board, free WiFi

Studios Jocatita

Studios Jocatita
2.0 star property
5.3 mi from Santa Cruz
10.0 out of 10, Exceptional, (1 review)
"Acomodação muito organizada, e responsável do local atenciosa. "
Brazil
Diego
The price is £52
includes taxes & fees
2 Jun - 3 Jun
Studios Jocatita
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Santa Cruz

Find the best Santa Cruz areas for the activities you enjoy most.

Centro Político Administrativo

Parks and riverfront are just a few things travellers like about Centro Político Administrativo. A stop by Massairo Okamura Park is also recommended if you've got time to explore the area.

Central North

You'll enjoy the waterfalls and riverfront in Central North. You might want to make time for a stop at Cine Teatro Cuiaba or Republic Square.

UFMT

Travellers like the museums in UFMT, and UFMT Zoo is a top attraction you might want to visit.

Coxipó

Travellers like the parks in Coxipó, and Ze Bolo Flo Park is a top attraction you might want to visit.

Jardim Cuiabá

While Jardim Cuiabá may not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Shopping Estação Cuiabá and Goiabeiras Shopping.

Top Santa Cruz Hotel Reviews

SLIM Cuiabá Aeroporto

SLIM Cuiabá Aeroporto

8/10 Good
"Close to airport with decent restaurant."
Clark 1-night trip
Posted 4 days ago
SLIM Cuiabá Aeroporto

Frequently asked questions

When is the best time to go to Santa Cruz?
The best time to visit Santa Cruz, Mato Grosso, Brazil, is during the dry season, which runs from May to September.

This period offers consistently pleasant weather, with lower humidity and less rainfall, making it ideal for exploring the region's natural attractions. Temperatures are warm but comfortable, typically ranging from 20°C to 30°C, great for outdoor activities.

Families will find this time particularly suitable, as the drier conditions make wildlife spotting in the Pantanal more accessible. The lower water levels concentrate animals around remaining water sources, increasing your chances of seeing capybaras, caimans, and a variety of birds.

Couples looking for a romantic and adventurous getaway will also appreciate the dry season.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Santa Cruz.
How can I save on a Santa Cruz hotel booking with Expedia?
Members always get our best prices. Find our best Santa Cruz hotel deals by joining Expedia's free travel rewards program today. As a member, you can unlock instant savings and member perks when you're logged in to your account. Another tip is to book your hotel and flights together on Expedia, where bundling can result in significant savings.
How much is the nightly rate at a Santa Cruz hotel?
Hotel prices in Santa Cruz often vary, but you can find a great deal on Expedia. Different factors affect nightly hotel rates, such as the time of year or the days of the week you want to book. To find the best deals for your stay, be flexible with your dates, and sort search results by "Price: low to high" for our cheapest rates.