A tropical island with a sandy beach and turquoise waters.

Santa Catalina Holidays from £910

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to £750 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Packages with flights are ATOL protected

Top Santa Catalina flight + hotel deals

Price found within the past 48 hours. Click for updated prices.
  • 5 Oct - 11 Oct

    Decapolis Hotel Panama City + Flight

    San Francisco
    6 nights
    4.0 star property
    8.6/10 - Excellent (1,708 reviews)
    "Todo bien"
    Reviewed July 16, 2026
    Return London (LON) - Panama City (PTY)
    LGW - PTY1 stop PTY - LGW1 stop
    £1,220
    £910
    per traveller
    found 1 day ago
    Decapolis Hotel Panama City
  • 5 Oct - 11 Oct

    Central Hotel Panama Casco Viejo + Flight

    Casco Viejo
    6 nights
    4.0 star property
    9.2/10 - Wonderful (1,000 reviews)
    "We only stayed for one night but had a great overall experience. Staff were very helpful and courteous. The hotel amenities were high quality and our room was very clean. The only "con" to report is that the hotel could use a little TLC in some areas."
    Reviewed July 12, 2026
    Return London (LON) - Panama City (PTY)
    LGW - PTY1 stop PTY - LGW1 stop
    Save 100% on your flight
    £1,866
    £1,039
    per traveller
    found 1 day ago
    Central Hotel Panama Casco Viejo
  • 5 Oct - 11 Oct

    Megapolis Hotel Panamá + Flight

    San Francisco
    6 nights
    4.5 star property
    8.4/10 - Very good (1,601 reviews)
    "Very nice stay for the price. I did have to ask for the bathroom to be cleaned again because the floor was a little dirty. Another drawback was they do not offer washcloths. This was problematic. The restaurant options were not the great"
    Reviewed July 16, 2026
    Return London (LON) - Panama City (PTY)
    LGW - PTY1 stop PTY - LGW1 stop
    £1,530
    £996
    per traveller
    found 1 day ago
    Megapolis Hotel Panamá
  • 5 Oct - 11 Oct

    Riande Aeropuerto Hotel & Casino + Flight

    Tocumen
    6 nights
    4.0 star property
    8.4/10 - Very good (1,802 reviews)
    Return London (LON) - Panama City (PTY)
    LGW - PTY1 stop PTY - LGW1 stop
    £1,321
    £952
    per traveller
    found 1 day ago
    Riande Aeropuerto Hotel & Casino
  • 5 Oct - 11 Oct

    Hyatt Regency Panama City + Flight

    Bella Vista
    6 nights
    5.0 star property
    9.6/10 - Exceptional (374 reviews)
    Return London (LON) - Panama City (PTY)
    LGW - PTY1 stop PTY - LGW1 stop
    £1,294
    £1,036
    per traveller
    found 1 day ago
    Hyatt Regency Panama City

Discover the most popular places to visit in Santa Catalina

Santa Catalina Hotel Deals

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently Asked Questions

Why should I book my Santa Catalina holiday with Expedia?

Choose Expedia to arrange your next break easily and all in one place. Our top tip for scoring a terrific deal on a Santa Catalina getaway? Bundle your airfares, hotel and/or hire car into a package holiday. Then throw in a couple of fun tours and activities. Most bookings also include flexible cancellation policies, so there's no need to stress if you have to change your travel plans. Round-the-clock assistance with making changes to your trip is available via our Customer Service Portal link.

When is the best time of year to holiday in Santa Catalina?

Peak season falls in January, May and September and is a thrilling time to visit — if you don't mind the crowds. March, April and November are generally quieter times of the year. Organise your visit to Santa Catalina based on what type of adventure you want. October is the coolest month, when average daytime temperatures are 24ºC. In March, the warmest period, you can expect averages of 27ºC during the day.

What is the top hotel for my holiday in Santa Catalina?

hostal la perla is the perfect base for a fabulous escape in Santa Catalina, offering all the conveniences you need and more.

How do I get a cheap holiday to Santa Catalina?

Browse and lock in everything all in one place with our Santa Catalina holidays. You'll discover deals on flights, hotels and more that'll keep your pocket happy and your adventurous side busy. And, with more than 400 airlines and 321,000 properties globally to choose from, you have countless opportunities to mix and match as you please. Learn more about how you can save money on your next holiday when you combine your hotel and flight bookings with Expedia.

What should I do on my Santa Catalina holiday?

Make sure your holiday in Santa Catalina is an unforgettable one by checking out its best attractions. El Banco Beach, Santa Catalina Island, Estero Beach and Arrimadero Beach are just some of the things you should see while you're in the area.

Do I need a visa for my Santa Catalina holiday?

Official government websites are the best source of information on visa requirements, application procedures and necessary documentation. Your nationality and purpose for visiting, whether it be for work or holidays, will determine if you need a visa for Santa Catalina. Also be sure that your passport is up to date and has a minimum of six months validity remaining after your intended return date. Do all your travel planning well ahead of time to avoid any last-minute surprises.

What should I wear on my Santa Catalina holiday?

First, consider the activities planned during your Santa Catalina trip and create a travel wardrobe that can be mixed and matched. For fashion inspiration or information on any dress codes, browse style blogs or relevant social media accounts. Be sure to check the local weather forecast so you can pack your bags accordingly. The warmest month in Santa Catalina is March, with average daytime temperatures of 27ºC. If you're on holiday in the coolest month of October, the mercury hovers around 24ºC during the day.

What does an Expedia Santa Catalina holiday include?

Flights, hire cars and hotels — we've got them covered. With Expedia, you can create your Santa Catalina travel package however you want. All you have to do is figure out what you need. Once you've made your booking, why not add extras like activities and experiences? The more you bundle, the greater the savings! Hotels and private holiday homes are a few highly sought-after property types in Santa Catalina. Whatever your preference or size of your group, you can rely on Expedia for the freedom to personalise your dream escape.

Does Expedia offer Book Now, Pay Later Santa Catalina holidays?

Your bank balance shouldn't stop you from going on holiday, so Expedia has come up with a solution to help. Now that we've partnered with online lender Klarna, it's easier than ever to book a fabulous getaway without drying up your savings. Klarna offers flexible payment options during the checkout process that take the stress out of budgeting for your trip. Check out these flexible payment options:

  • Pay monthly holidays: If paying in multiple transactions is something that would work for you, Klarna can help. Paying in several transactions will make your holiday dreams come true.
  • No-deposit holidays: When you come across an amazing deal but don't have the full amount yet, Klarna's no-deposit holiday plan will allow you to Book Now, Pay Later to get what you want.

Can I choose my airline with a Santa Catalina Expedia holiday?

With a holiday package, you're always in charge. Whether you'd prefer to fly to Santa Catalina in first class or coach, simply select from the available airline options. Expedia has access to more than 400 airline partners globally.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.