The Best Hotels in East End, Sanibel - 2026 Updated Prices

A coastal scene with a lighthouse, beach, and ocean.

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Where to stay in East End

Find the best East End areas for the activities you enjoy most.

Mid Island

If you're spending some time in Mid Island, Periwinkle Way and Sanibel Island Southern Beach are top sights worth seeing.

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West End

If you're spending some time in West End, J. N. Ding Darling National Wildlife Refuge and Bowman's Beach are top sights worth seeing.

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A cyclist on a paved path alongside a road with cars, palm trees, and a liquor store sign.

Beachview Country Club Estates

While visiting Beachview Country Club Estates, you might make a stop by sights like Periwinkle Way and Sanibel Island Golf Club.

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Sanctuary

While there might not be top attractions in Sanctuary, you can explore the larger area and discover places like Blind Pass Beach and Turner Beach.

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Gulf Shores

When in Gulf Shores, you can plan a visit to Bowman's Beach and J. N. Ding Darling National Wildlife Refuge, some noteworthy sights in the nearby area.

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Top East End Hotel Reviews

Sanibel Inn

10/10 Excellent

"Nothing we didn't like. Room was clean and well maintained. Bathroom and kitchenette were both very nice. A 2-3 minute walk from our room to our lounge chairs on the beach. Beautiful water and sand. Pool also very nice even though it was pretty warm most days. But that's to be expected in August in Florida. Poolside tiki bar had cool bartenders and a nice happy hour. Highly recommend."

Wake up to sweeping Gulf views from every room in this upscale 3BR/3BA townhome in Sanibel’s exclusive Cyprina Complex. Enjoy effortless island living with a whole-home carbon-filter water filtration system!

10/10 Excellent

"This is a great townhome with outstanding ocean views. We really enjoyed the pool and the layout of the home."

Beachfront Condo + Heated Pool, Hot Tub, Tennis + Walk to Dining

10/10 Excellent

"We loved Jill's condo! The location was excellent. Short walk over the boardwalk to the beach was lovely. Water station to rinse off sandy feet and beach items was so handy too. The newly renovated community pool was outstanding. Lots of pool items to use from floats to noodles...we were so thankful to have access to them because we didn't bring our own since we flew down. The condo was great and fit our family of 5. The kitchen was all we needed for a week stay and many meals at the condo. The screened in balcony had a beautiful view of the ocean and pool and the screen kept out the pesky no-see-um flies. There was also a closet filled with beach chairs, beach umbrellas, and beach toys. Beach towels and bath towels were also included. So wonderful to have these! Thank you!! :)"

Luxury Villa Lighthouse Across from the Beach

10/10 Excellent

"We have stayed in Sanibel many times over the last 25 years but this is the first time we have used VRBO. We had a lovely time, the house was beautiful and very well stocked with everything you could need. We live on the East Coast so had brought beach chairs, towels etc none of which were necessary.The unit we had was on the water and it was magical to sit and look out at the water and there were daily Manatee visitors across the canal.We hope to be back soon! Thank you for a lovely time!"

The Lovebird-sleeps 3! Great value on Sanibel-walk to dining, shops and Historic East End Lighthouse

10/10 Excellent

"We loved our stay! The property is walking distance to the beach with a very nice bike path all the way there. There are also several business just around the corner - ice cream shop, breakfast, souvenir store, restaurant. We loved it. The cottage was spacious and the AC was very effective. The shower is small, but you can see that from the listing pictures. It was close to everything and we thought great value for the price. Would definitely stay again!"

Frequently asked questions

What's it like in East End?

Travellers will be sure to find plenty to entertain them in Sanibel's East End neighbourhood. Make sure that you visit Sanibel Island Northern Beach and Sanibel Island Lighthouse as part of your East End travel plans.

Where is the best place to stay in East End?

Based on our traveller data, Sanibel Inn is one of the top choices for your stay in East End. This hotel is a short 6-minute walk from Sanibel Island Southern Beach, and it offers a private beach and a restaurant. Other good choices for your stay in the neighbourhood include Sunshine Island Inn and Seahorse Cottages on Sanibel - Adults Only.

How many hotels will I find in the East End area?

Expedia has 628 hotels and other accommodation options in East End to choose from, making this an ideal home base for exploring the greater Sanibel area.

If I need to cancel my hotel reservation in East End, will I receive a refund?

Yes, the majority of hotel room reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you have a reservation that's non-refundable, you might be able to still cancel and receive a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then filter by "fully refundable" to view top deals in East End.

What are the top things to see and do in East End?

Dip your toes in the water at Sanibel Island Northern Beach, Sanibel Island Southern Beach and Causeway Islands Beaches while you're in East End. Sanibel Island Lighthouse and Periwinkle Way are also a couple of places to visit in the neighbourhood. Sanibel Sea School, Sanibel Moorings Botanical Gardens and Bailey's Beach are just a few of the places to visit in and around East End. Dunes Golf and Tennis Club and Causeway Islands Beach are also worth a visit when you're out sightseeing in Sanibel.

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Our top choices for East End hotels

1. Sanibel Inn

2. Tarpon Tale Inn

3. The Anchor Inn

4. Sanibel Island Beach Resort

5. Residence Inn by Marriott Fort Myers Sanibel

6. Kona Kai Motel

7. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

8. Marriott Sanibel Harbour Resort & Spa

9. Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

10. Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

11. Latitude 26 Waterfront Resort & Marina

12. Margaritaville Beach Resort Fort Myers

13. Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

14. The Westin Cape Coral Resort At Marina Village

15. Candlewood Suites Fort Myers Sanibel Gateway by IHG

16. The Lighthouse Resort Inn & Suites

17. Lani Kai Beachfront Resort

18. Matanzas Inn Bayside Resort and Marina

19. Allure Suites

20. Edison Beach House

Where to stay in East End

Mid Island

West End

Beachview Country Club Estates

Sanctuary

Gulf Shores

Top East End Hotel Reviews

Sanibel Inn

Frequently asked questions